Values CatLog read from this paper

Functional role of the linker region in purified human P-glycoprotein

PMID 19490125doi:10.1111/j.1742-4658.2009.07072.xOpen in Browse

The paper itself is not on this site: read it at the publisher. This page lists only the values CatLog read from it.

CatLog read 35 records (95 values) from this paper: P-glycoprotein (P-gp, ABCB1/MDR1) from Homo sapiens.

Read from the paper by an AI model and checked against the paper by a second, separate AI run; code converted the units. Values are in CatLog's units; each record opens in Browse with the line the paper prints and the checks.

EC 7.6.2.1, EC 7.6.2.2

Records read from this paper
Enzyme	Organism	Substrate	k_cat (s⁻¹)	K_m (mM)	k_cat/K_m (mM⁻¹ s⁻¹)	Conditions	Open record
P-glycoprotein (P-gp, ABCB1/MDR1)	Homo sapiens	3',6'-di(O-acetyl)-4',5'-bis[N,N-bis(carboxymethyl)aminomethyl]fluorescein tetraacetoxymethyl ester	3.19	0.00203	1.57 × 10³	pH 7.4, 37 °C	Open record: P-glycoprotein (P-gp, ABCB1/MDR1), 3',6'-di(O-acetyl)-4',5'-bis[N,N-bis(carboxymethyl)aminomethyl]fluorescein tetraacetoxymethyl ester
P-glycoprotein (P-gp, ABCB1/MDR1)	Homo sapiens	adenosine 5'-triphosphate5 mM MgATP; basal ATPase; no transport substrate	0.189	—	—	pH 7.4, 37 °C	Open record: P-glycoprotein (P-gp, ABCB1/MDR1), adenosine 5'-triphosphate
P-glycoprotein (P-gp, ABCB1/MDR1)	Homo sapiens	adenosine 5'-triphosphateMgATP varied; in the presence of 50 µM verapamil	—	0.59	—	pH 7.4, 37 °C	Open record: P-glycoprotein (P-gp, ABCB1/MDR1), adenosine 5'-triphosphate
P-glycoprotein (P-gp, ABCB1/MDR1)	Homo sapiens	Colchicine	1.25	0.72	1.66	pH 7.4, 37 °C	Open record: P-glycoprotein (P-gp, ABCB1/MDR1), Colchicine
P-glycoprotein (P-gp, ABCB1/MDR1)	Homo sapiens	Digoxin	0.791	0.187	4.23	pH 7.4, 37 °C	Open record: P-glycoprotein (P-gp, ABCB1/MDR1), Digoxin
P-glycoprotein (P-gp, ABCB1/MDR1)	Homo sapiens	Nicardipine	3.48	0.00191	1.82 × 10³	pH 7.4, 37 °C	Open record: P-glycoprotein (P-gp, ABCB1/MDR1), Nicardipine
P-glycoprotein (P-gp, ABCB1/MDR1)	Homo sapiens	Paclitaxel	0.41	8.74 × 10⁻⁴	469	pH 7.4, 37 °C	Open record: P-glycoprotein (P-gp, ABCB1/MDR1), Paclitaxel
P-glycoprotein (P-gp, ABCB1/MDR1)	Homo sapiens	Rhodamine 123	1.84	0.0354	52	pH 7.4, 37 °C	Open record: P-glycoprotein (P-gp, ABCB1/MDR1), Rhodamine 123
P-glycoprotein (P-gp, ABCB1/MDR1)	Homo sapiens	Rhodamine B	2.23	0.0298	74.9	pH 7.4, 37 °C	Open record: P-glycoprotein (P-gp, ABCB1/MDR1), Rhodamine B
P-glycoprotein (P-gp, ABCB1/MDR1)	Homo sapiens	Valinomycin	2.95	3.95 × 10⁻⁴	7.46 × 10³	pH 7.4, 37 °C	Open record: P-glycoprotein (P-gp, ABCB1/MDR1), Valinomycin
P-glycoprotein (P-gp, ABCB1/MDR1)	Homo sapiens	Verapamil	3.28	0.00423	775	pH 7.4, 37 °C	Open record: P-glycoprotein (P-gp, ABCB1/MDR1), Verapamil
P-glycoprotein (P-gp, ABCB1/MDR1)	Homo sapiens	Vinblastine	1.9	0.00121	1.56 × 10³	pH 7.4, 37 °C	Open record: P-glycoprotein (P-gp, ABCB1/MDR1), Vinblastine
P-glycoprotein (P-gp, ABCB1/MDR1)variant chymotrypsin-cleaved	Homo sapiens	3',6'-di(O-acetyl)-4',5'-bis[N,N-bis(carboxymethyl)aminomethyl]fluorescein tetraacetoxymethyl ester	11.2	0.00335	3.36 × 10³	pH 7.4, 37 °C	Open record: P-glycoprotein (P-gp, ABCB1/MDR1) variant chymotrypsin-cleaved, 3',6'-di(O-acetyl)-4',5'-bis[N,N-bis(carboxymethyl)aminomethyl]fluorescein tetraacetoxymethyl ester
P-glycoprotein (P-gp, ABCB1/MDR1)variant chymotrypsin-cleaved	Homo sapiens	adenosine 5'-triphosphate	2.95	—	—	pH 7.4, 37 °C	Open record: P-glycoprotein (P-gp, ABCB1/MDR1) variant chymotrypsin-cleaved, adenosine 5'-triphosphate
P-glycoprotein (P-gp, ABCB1/MDR1)variant chymotrypsin-cleaved	Homo sapiens	Colchicine	6.4	0.28	22.9	pH 7.4, 37 °C	Open record: P-glycoprotein (P-gp, ABCB1/MDR1) variant chymotrypsin-cleaved, Colchicine
P-glycoprotein (P-gp, ABCB1/MDR1)variant chymotrypsin-cleaved	Homo sapiens	Digoxin	5.99	0.101	59.2	pH 7.4, 37 °C	Open record: P-glycoprotein (P-gp, ABCB1/MDR1) variant chymotrypsin-cleaved, Digoxin
P-glycoprotein (P-gp, ABCB1/MDR1)variant chymotrypsin-cleaved	Homo sapiens	Nicardipine	7.8	3.83 × 10⁻⁴	2.04 × 10⁴	pH 7.4, 37 °C	Open record: P-glycoprotein (P-gp, ABCB1/MDR1) variant chymotrypsin-cleaved, Nicardipine
P-glycoprotein (P-gp, ABCB1/MDR1)variant chymotrypsin-cleaved	Homo sapiens	Paclitaxel	3.69	6.65 × 10⁻⁴	5.63 × 10³	pH 7.4, 37 °C	Open record: P-glycoprotein (P-gp, ABCB1/MDR1) variant chymotrypsin-cleaved, Paclitaxel
P-glycoprotein (P-gp, ABCB1/MDR1)variant chymotrypsin-cleaved	Homo sapiens	Rhodamine 123	8.56	0.0175	489	pH 7.4, 37 °C	Open record: P-glycoprotein (P-gp, ABCB1/MDR1) variant chymotrypsin-cleaved, Rhodamine 123
P-glycoprotein (P-gp, ABCB1/MDR1)variant chymotrypsin-cleaved	Homo sapiens	Rhodamine B	7.22	0.0142	509	pH 7.4, 37 °C	Open record: P-glycoprotein (P-gp, ABCB1/MDR1) variant chymotrypsin-cleaved, Rhodamine B
P-glycoprotein (P-gp, ABCB1/MDR1)variant chymotrypsin-cleaved	Homo sapiens	Valinomycin	11.7	0.00151	7.77 × 10³	pH 7.4, 37 °C	Open record: P-glycoprotein (P-gp, ABCB1/MDR1) variant chymotrypsin-cleaved, Valinomycin
P-glycoprotein (P-gp, ABCB1/MDR1)variant chymotrypsin-cleaved	Homo sapiens	Verapamil	7.71	6.37 × 10⁻⁴	1.21 × 10⁴	pH 7.4, 37 °C	Open record: P-glycoprotein (P-gp, ABCB1/MDR1) variant chymotrypsin-cleaved, Verapamil
P-glycoprotein (P-gp, ABCB1/MDR1)variant chymotrypsin-cleaved	Homo sapiens	Vinblastine	6.54	0.00236	2.77 × 10³	pH 7.4, 37 °C	Open record: P-glycoprotein (P-gp, ABCB1/MDR1) variant chymotrypsin-cleaved, Vinblastine
P-glycoprotein (P-gp, ABCB1/MDR1)variant trypsin-cleaved	Homo sapiens	3',6'-di(O-acetyl)-4',5'-bis[N,N-bis(carboxymethyl)aminomethyl]fluorescein tetraacetoxymethyl ester	11.2	0.00243	4.59 × 10³	pH 7.4, 37 °C	Open record: P-glycoprotein (P-gp, ABCB1/MDR1) variant trypsin-cleaved, 3',6'-di(O-acetyl)-4',5'-bis[N,N-bis(carboxymethyl)aminomethyl]fluorescein tetraacetoxymethyl ester
P-glycoprotein (P-gp, ABCB1/MDR1)variant trypsin-cleaved	Homo sapiens	adenosine 5'-triphosphate5 mM MgATP; basal ATPase; no transport substrate	2.38	—	—	pH 7.4, 37 °C	Open record: P-glycoprotein (P-gp, ABCB1/MDR1) variant trypsin-cleaved, adenosine 5'-triphosphate
P-glycoprotein (P-gp, ABCB1/MDR1)variant trypsin-cleaved	Homo sapiens	adenosine 5'-triphosphateMgATP varied; in the presence of 50 µM verapamil	—	0.89	—	pH 7.4, 37 °C	Open record: P-glycoprotein (P-gp, ABCB1/MDR1) variant trypsin-cleaved, adenosine 5'-triphosphate
P-glycoprotein (P-gp, ABCB1/MDR1)variant trypsin-cleaved	Homo sapiens	Colchicine	7.81	0.278	28.2	pH 7.4, 37 °C	Open record: P-glycoprotein (P-gp, ABCB1/MDR1) variant trypsin-cleaved, Colchicine
P-glycoprotein (P-gp, ABCB1/MDR1)variant trypsin-cleaved	Homo sapiens	Digoxin	5.65	0.119	47.3	pH 7.4, 37 °C	Open record: P-glycoprotein (P-gp, ABCB1/MDR1) variant trypsin-cleaved, Digoxin
P-glycoprotein (P-gp, ABCB1/MDR1)variant trypsin-cleaved	Homo sapiens	Nicardipine	8.44	6.52 × 10⁻⁴	1.29 × 10⁴	pH 7.4, 37 °C	Open record: P-glycoprotein (P-gp, ABCB1/MDR1) variant trypsin-cleaved, Nicardipine
P-glycoprotein (P-gp, ABCB1/MDR1)variant trypsin-cleaved	Homo sapiens	Paclitaxel	3.44	7.75 × 10⁻⁴	4.44 × 10³	pH 7.4, 37 °C	Open record: P-glycoprotein (P-gp, ABCB1/MDR1) variant trypsin-cleaved, Paclitaxel
P-glycoprotein (P-gp, ABCB1/MDR1)variant trypsin-cleaved	Homo sapiens	Rhodamine 123	8.19	0.0118	692	pH 7.4, 37 °C	Open record: P-glycoprotein (P-gp, ABCB1/MDR1) variant trypsin-cleaved, Rhodamine 123
P-glycoprotein (P-gp, ABCB1/MDR1)variant trypsin-cleaved	Homo sapiens	Rhodamine B	6.99	0.0109	641	pH 7.4, 37 °C	Open record: P-glycoprotein (P-gp, ABCB1/MDR1) variant trypsin-cleaved, Rhodamine B
P-glycoprotein (P-gp, ABCB1/MDR1)variant trypsin-cleaved	Homo sapiens	Valinomycin	11.1	0.00111	1 × 10⁴	pH 7.4, 37 °C	Open record: P-glycoprotein (P-gp, ABCB1/MDR1) variant trypsin-cleaved, Valinomycin
P-glycoprotein (P-gp, ABCB1/MDR1)variant trypsin-cleaved	Homo sapiens	Verapamil	8.27	6.14 × 10⁻⁴	1.35 × 10⁴	pH 7.4, 37 °C	Open record: P-glycoprotein (P-gp, ABCB1/MDR1) variant trypsin-cleaved, Verapamil
P-glycoprotein (P-gp, ABCB1/MDR1)variant trypsin-cleaved	Homo sapiens	Vinblastine	6.39	0.00201	3.17 × 10³	pH 7.4, 37 °C	Open record: P-glycoprotein (P-gp, ABCB1/MDR1) variant trypsin-cleaved, Vinblastine