Values CatLog read from this paper
Conflicting requirements of Plasmodium falciparum dihydrofolate reductase mutations conferring resistance to pyrimethamine-WR99210 combination
PMID 17875995doi:10.1128/aac.00577-07Open in Browse
The paper itself is not on this site: read it at the publisher. This page lists only the values CatLog read from it.
CatLog read 16 records (23 values) from this paper: PfDHFR, PfDHFR-TS from Plasmodium falciparum.
Read from the paper by an AI model and checked against the paper by a second, separate AI run; code converted the units. Values are in CatLog's units; each record opens in Browse with the line the paper prints and the checks. CatLog calculated the 7 kcat/Km values marked “calc.” from kcat and Km; no printed kcat/Km was read for those records.
| Enzyme | Organism | Substrate | kcat (s⁻¹) | Km (mM) | kcat/Km (mM⁻¹ s⁻¹) | Conditions | Open record |
|---|---|---|---|---|---|---|---|
| PfDHFRvariant I51N/C59R/N108S/I164L (WR resist 1) | Plasmodium falciparum | dihydrofolate | 0.2 | 0.0083 | 24 calc. | Open record: PfDHFR variant I51N/C59R/N108S/I164L (WR resist 1), dihydrofolate | |
| PfDHFRvariant I51N/C59R/N108S/I164L (WR resist 1) | Plasmodium falciparum | NADPH | — | 0.0267 | — | Open record: PfDHFR variant I51N/C59R/N108S/I164L (WR resist 1), NADPH | |
| PfDHFRvariant N51I/C59R/N108S/I164L (WR resist 2) | Plasmodium falciparum | dihydrofolate | 1.5 | 0.0052 | 290 calc. | Open record: PfDHFR variant N51I/C59R/N108S/I164L (WR resist 2), dihydrofolate | |
| PfDHFRvariant N51I/C59R/N108S/I164L (WR resist 2) | Plasmodium falciparum | NADPH | — | 0.052 | — | Open record: PfDHFR variant N51I/C59R/N108S/I164L (WR resist 2), NADPH | |
| PfDHFRvariant N51I/C59R/N108T/I164L (WR resist 3) | Plasmodium falciparum | dihydrofolate | 1.9 | 0.005 | 380 calc. | Open record: PfDHFR variant N51I/C59R/N108T/I164L (WR resist 3), dihydrofolate | |
| PfDHFRvariant N51I/C59R/N108T/I164L (WR resist 3) | Plasmodium falciparum | NADPH | — | 0.00595 | — | Open record: PfDHFR variant N51I/C59R/N108T/I164L (WR resist 3), NADPH | |
| PfDHFRvariant N51I/C59R/S108N/I164L (PfDHFR-QM template) | Plasmodium falciparum | dihydrofolate | 44.5 | — | — | Open record: PfDHFR variant N51I/C59R/S108N/I164L (PfDHFR-QM template), dihydrofolate | |
| PfDHFRvariant N51I/C59R/S108N/I164L/D187A (PYR resist 1) | Plasmodium falciparum | dihydrofolate | 13.6 | 0.01453 | 936 calc. | Open record: PfDHFR variant N51I/C59R/S108N/I164L/D187A (PYR resist 1), dihydrofolate | |
| PfDHFRvariant N51I/C59R/S108N/I164L/D187A (PYR resist 1) | Plasmodium falciparum | NADPH | — | 0.0065 | — | Open record: PfDHFR variant N51I/C59R/S108N/I164L/D187A (PYR resist 1), NADPH | |
| PfDHFRvariant N51I/C59R/S108N/I164L/I150V/N182I/N201D (PYR resist 3) | Plasmodium falciparum | dihydrofolate | 11.4 | 0.01465 | 778 calc. | Open record: PfDHFR variant N51I/C59R/S108N/I164L/I150V/N182I/N201D (PYR resist 3), dihydrofolate | |
| PfDHFRvariant N51I/C59R/S108N/I164L/I150V/N182I/N201D (PYR resist 3) | Plasmodium falciparum | NADPH | — | 0.01126 | — | Open record: PfDHFR variant N51I/C59R/S108N/I164L/I150V/N182I/N201D (PYR resist 3), NADPH | |
| PfDHFRvariant N51I/C59R/S108N/I164L/K96N (PYR resist 2) | Plasmodium falciparum | dihydrofolate | 28.3 | 0.0081 | 3.5 × 10³ calc. | Open record: PfDHFR variant N51I/C59R/S108N/I164L/K96N (PYR resist 2), dihydrofolate | |
| PfDHFRvariant N51I/C59R/S108N/I164L/K96N (PYR resist 2) | Plasmodium falciparum | NADPH | — | 0.0072 | — | Open record: PfDHFR variant N51I/C59R/S108N/I164L/K96N (PYR resist 2), NADPH | |
| PfDHFR-TSvariant I51N/C59R/N108S/L164I/D54N (WR resist A) | Plasmodium falciparum | dihydrofolate | 0.78 | — | — | Open record: PfDHFR-TS variant I51N/C59R/N108S/L164I/D54N (WR resist A), dihydrofolate | |
| PfDHFR-TSvariant N51I/C59R/S108N/I164L (PfDHFR-TS-QM template) | Plasmodium falciparum | dihydrofolate | 72 | 0.01332 | 5.4 × 10³ calc. | Open record: PfDHFR-TS variant N51I/C59R/S108N/I164L (PfDHFR-TS-QM template), dihydrofolate | |
| PfDHFR-TSvariant N51I/C59R/S108N/I164L (PfDHFR-TS-QM template) | Plasmodium falciparum | NADPH | — | 0.00643 | — | Open record: PfDHFR-TS variant N51I/C59R/S108N/I164L (PfDHFR-TS-QM template), NADPH |