Values CatLog read from this paper
Substituted hippurates and hippurate analogs as substrates and inhibitors of peptidylglycine alpha-hydroxylating monooxygenase (PHM)
PMID 18952446doi:10.1016/j.bmc.2008.10.013Open in Browse
The paper itself is not on this site: read it at the publisher. This page lists only the values CatLog read from it.
CatLog read 57 records (167 values) from this paper: peptidylglycine alpha-amidating monooxygenase (bifunctional PAM; PHM activity) from Rattus norvegicus.
Read from the paper by an AI model and checked against the paper by a second, separate AI run; code converted the units. Values are in CatLog's units; each record opens in Browse with the line the paper prints and the checks.
| Enzyme | Organism | Substrate | kcat (s⁻¹) | Km (mM) | kcat/Km (mM⁻¹ s⁻¹) | Conditions | Open record |
|---|---|---|---|---|---|---|---|
| peptidylglycine alpha-amidating monooxygenase (bifunctional PAM; PHM activity) | Rattus norvegicus | L-pyroglutamylglycine | 9.3 | 0.31 | 30 | pH 6, 37 °C | Open record: peptidylglycine alpha-amidating monooxygenase (bifunctional PAM; PHM activity), L-pyroglutamylglycine |
| peptidylglycine alpha-amidating monooxygenase (bifunctional PAM; PHM activity) | Rattus norvegicus | N-(1H-indol-3-ylacetyl)glycine | 7.3 | 0.3 | 25 | pH 6, 37 °C | Open record: peptidylglycine alpha-amidating monooxygenase (bifunctional PAM; PHM activity), N-(1H-indol-3-ylacetyl)glycine |
| peptidylglycine alpha-amidating monooxygenase (bifunctional PAM; PHM activity) | Rattus norvegicus | N-(2,6-difluorobenzoyl)glycine | 4.3 | 19 | 0.23 | pH 6, 37 °C | Open record: peptidylglycine alpha-amidating monooxygenase (bifunctional PAM; PHM activity), N-(2,6-difluorobenzoyl)glycine |
| peptidylglycine alpha-amidating monooxygenase (bifunctional PAM; PHM activity) | Rattus norvegicus | N-(2-aminobenzoyl)glycine | 4.2 | 1.4 | 2.9 | pH 6, 37 °C | Open record: peptidylglycine alpha-amidating monooxygenase (bifunctional PAM; PHM activity), N-(2-aminobenzoyl)glycine |
| peptidylglycine alpha-amidating monooxygenase (bifunctional PAM; PHM activity) | Rattus norvegicus | N-(2-furoyl)glycine | 7.5 | 2.7 | 2.8 | pH 6, 37 °C | Open record: peptidylglycine alpha-amidating monooxygenase (bifunctional PAM; PHM activity), N-(2-furoyl)glycine |
| peptidylglycine alpha-amidating monooxygenase (bifunctional PAM; PHM activity) | Rattus norvegicus | N-(2-hydroxybenzoyl)glycine | 4.9 | 0.86 | 7.1 | pH 6, 37 °C | Open record: peptidylglycine alpha-amidating monooxygenase (bifunctional PAM; PHM activity), N-(2-hydroxybenzoyl)glycine |
| peptidylglycine alpha-amidating monooxygenase (bifunctional PAM; PHM activity) | Rattus norvegicus | N-(2-iodobenzoyl)glycine | 3.1 | 3.4 | 0.91 | pH 6, 37 °C | Open record: peptidylglycine alpha-amidating monooxygenase (bifunctional PAM; PHM activity), N-(2-iodobenzoyl)glycine |
| peptidylglycine alpha-amidating monooxygenase (bifunctional PAM; PHM activity) | Rattus norvegicus | N-(2-methyl-3-phenylpropanoyl)glycine | 18 | 4.1 | 4.3 | pH 6, 37 °C | Open record: peptidylglycine alpha-amidating monooxygenase (bifunctional PAM; PHM activity), N-(2-methyl-3-phenylpropanoyl)glycine |
| peptidylglycine alpha-amidating monooxygenase (bifunctional PAM; PHM activity) | Rattus norvegicus | N-(2-methylbenzoyl)glycine | 7.9 | 4.3 | 1.8 | pH 6, 37 °C | Open record: peptidylglycine alpha-amidating monooxygenase (bifunctional PAM; PHM activity), N-(2-methylbenzoyl)glycine |
| peptidylglycine alpha-amidating monooxygenase (bifunctional PAM; PHM activity) | Rattus norvegicus | N-(2-phenylethanethioyl)glycine | 2.4 | 0.024 | 100 | pH 6, 37 °C | Open record: peptidylglycine alpha-amidating monooxygenase (bifunctional PAM; PHM activity), N-(2-phenylethanethioyl)glycine |
| peptidylglycine alpha-amidating monooxygenase (bifunctional PAM; PHM activity) | Rattus norvegicus | N-(3-chlorobenzoyl)glycine | 7.8 | 2.2 | 3.6 | pH 6, 37 °C | Open record: peptidylglycine alpha-amidating monooxygenase (bifunctional PAM; PHM activity), N-(3-chlorobenzoyl)glycine |
| peptidylglycine alpha-amidating monooxygenase (bifunctional PAM; PHM activity) | Rattus norvegicus | N-(3-methylbenzoyl)glycine | 6.4 | 1.4 | 4.7 | pH 6, 37 °C | Open record: peptidylglycine alpha-amidating monooxygenase (bifunctional PAM; PHM activity), N-(3-methylbenzoyl)glycine |
| peptidylglycine alpha-amidating monooxygenase (bifunctional PAM; PHM activity) | Rattus norvegicus | N-(3-phenylpropanethioyl)glycine | 1.6 | 0.038 | 42 | pH 6, 37 °C | Open record: peptidylglycine alpha-amidating monooxygenase (bifunctional PAM; PHM activity), N-(3-phenylpropanethioyl)glycine |
| peptidylglycine alpha-amidating monooxygenase (bifunctional PAM; PHM activity) | Rattus norvegicus | N-(3-phenylpropanoyl)glycine | 9.9 | 0.94 | 11 | pH 6, 37 °C | Open record: peptidylglycine alpha-amidating monooxygenase (bifunctional PAM; PHM activity), N-(3-phenylpropanoyl)glycine |
| peptidylglycine alpha-amidating monooxygenase (bifunctional PAM; PHM activity) | Rattus norvegicus | N-(4-aminobenzoyl)glycine | 5.6 | 2.6 | 2.2 | pH 6, 37 °C | Open record: peptidylglycine alpha-amidating monooxygenase (bifunctional PAM; PHM activity), N-(4-aminobenzoyl)glycine |
| peptidylglycine alpha-amidating monooxygenase (bifunctional PAM; PHM activity) | Rattus norvegicus | N-(4-bromobenzoyl)glycine | 2.5 | 0.52 | 4.9 | pH 6, 37 °C | Open record: peptidylglycine alpha-amidating monooxygenase (bifunctional PAM; PHM activity), N-(4-bromobenzoyl)glycine |
| peptidylglycine alpha-amidating monooxygenase (bifunctional PAM; PHM activity) | Rattus norvegicus | N-(4-chlorobenzoyl)glycine | 4.1 | 0.62 | 6.6 | pH 6, 37 °C | Open record: peptidylglycine alpha-amidating monooxygenase (bifunctional PAM; PHM activity), N-(4-chlorobenzoyl)glycine |
| peptidylglycine alpha-amidating monooxygenase (bifunctional PAM; PHM activity) | Rattus norvegicus | N-(4-ethylbenzoyl)glycine | 3.6 | 1.2 | 3.1 | pH 6, 37 °C | Open record: peptidylglycine alpha-amidating monooxygenase (bifunctional PAM; PHM activity), N-(4-ethylbenzoyl)glycine |
| peptidylglycine alpha-amidating monooxygenase (bifunctional PAM; PHM activity) | Rattus norvegicus | N-(4-hydroxybenzoyl)glycine | 5.8 | 1.7 | 3.5 | pH 6, 37 °C | Open record: peptidylglycine alpha-amidating monooxygenase (bifunctional PAM; PHM activity), N-(4-hydroxybenzoyl)glycine |
| peptidylglycine alpha-amidating monooxygenase (bifunctional PAM; PHM activity) | Rattus norvegicus | N-(4-methoxybenzoyl)glycine | 5.3 | 0.82 | 6.4 | pH 6, 37 °C | Open record: peptidylglycine alpha-amidating monooxygenase (bifunctional PAM; PHM activity), N-(4-methoxybenzoyl)glycine |
| peptidylglycine alpha-amidating monooxygenase (bifunctional PAM; PHM activity) | Rattus norvegicus | N-(4-methylbenzoyl)glycine | 5.7 | 1.8 | 3.2 | pH 6, 37 °C | Open record: peptidylglycine alpha-amidating monooxygenase (bifunctional PAM; PHM activity), N-(4-methylbenzoyl)glycine |
| peptidylglycine alpha-amidating monooxygenase (bifunctional PAM; PHM activity) | Rattus norvegicus | N-(4-methylpentanoyl)glycine | 6.6 | 0.28 | 23 | pH 6, 37 °C | Open record: peptidylglycine alpha-amidating monooxygenase (bifunctional PAM; PHM activity), N-(4-methylpentanoyl)glycine |
| peptidylglycine alpha-amidating monooxygenase (bifunctional PAM; PHM activity) | Rattus norvegicus | N-(4-nitrobenzoyl)glycine | 4.2 | 0.47 | 8.9 | pH 6, 37 °C | Open record: peptidylglycine alpha-amidating monooxygenase (bifunctional PAM; PHM activity), N-(4-nitrobenzoyl)glycine |
| peptidylglycine alpha-amidating monooxygenase (bifunctional PAM; PHM activity) | Rattus norvegicus | N-(4-nitrobenzoyl)glycylglycine | 8.7 | 0.11 | 76 | pH 6, 37 °C | Open record: peptidylglycine alpha-amidating monooxygenase (bifunctional PAM; PHM activity), N-(4-nitrobenzoyl)glycylglycine |
| peptidylglycine alpha-amidating monooxygenase (bifunctional PAM; PHM activity) | Rattus norvegicus | N-(4-phenylbutanoyl)glycine | 11 | 0.16 | 70 | pH 6, 37 °C | Open record: peptidylglycine alpha-amidating monooxygenase (bifunctional PAM; PHM activity), N-(4-phenylbutanoyl)glycine |
| peptidylglycine alpha-amidating monooxygenase (bifunctional PAM; PHM activity) | Rattus norvegicus | N-(4-propylbenzoyl)glycine | 5.1 | 1.2 | 4.2 | pH 6, 37 °C | Open record: peptidylglycine alpha-amidating monooxygenase (bifunctional PAM; PHM activity), N-(4-propylbenzoyl)glycine |
| peptidylglycine alpha-amidating monooxygenase (bifunctional PAM; PHM activity) | Rattus norvegicus | N-(5-phenylpentanoyl)glycine | 12 | 0.15 | 76 | pH 6, 37 °C | Open record: peptidylglycine alpha-amidating monooxygenase (bifunctional PAM; PHM activity), N-(5-phenylpentanoyl)glycine |
| peptidylglycine alpha-amidating monooxygenase (bifunctional PAM; PHM activity) | Rattus norvegicus | N-(6-phenylhexanoyl)glycine | 11 | 0.051 | 200 | pH 6, 37 °C | Open record: peptidylglycine alpha-amidating monooxygenase (bifunctional PAM; PHM activity), N-(6-phenylhexanoyl)glycine |
| peptidylglycine alpha-amidating monooxygenase (bifunctional PAM; PHM activity) | Rattus norvegicus | N-(8-phenyloctanoyl)glycine | 8 | 0.1 | 76 | pH 6, 37 °C | Open record: peptidylglycine alpha-amidating monooxygenase (bifunctional PAM; PHM activity), N-(8-phenyloctanoyl)glycine |
| peptidylglycine alpha-amidating monooxygenase (bifunctional PAM; PHM activity) | Rattus norvegicus | N-(benzyloxycarbonyl)-D-alanine | 1.4 | 35 | 0.041 | pH 6, 37 °C | Open record: peptidylglycine alpha-amidating monooxygenase (bifunctional PAM; PHM activity), N-(benzyloxycarbonyl)-D-alanine |
| peptidylglycine alpha-amidating monooxygenase (bifunctional PAM; PHM activity) | Rattus norvegicus | N-(benzyloxycarbonyl)glycine | 8.6 | 0.59 | 15 | pH 6, 37 °C | Open record: peptidylglycine alpha-amidating monooxygenase (bifunctional PAM; PHM activity), N-(benzyloxycarbonyl)glycine |
| peptidylglycine alpha-amidating monooxygenase (bifunctional PAM; PHM activity) | Rattus norvegicus | N-(chloroacetyl)glycylglycine | 8.9 | 0.42 | 21 | pH 6, 37 °C | Open record: peptidylglycine alpha-amidating monooxygenase (bifunctional PAM; PHM activity), N-(chloroacetyl)glycylglycine |
| peptidylglycine alpha-amidating monooxygenase (bifunctional PAM; PHM activity) | Rattus norvegicus | N-(phenylacetyl)glycine | 7.4 | 0.16 | 46 | pH 6, 37 °C | Open record: peptidylglycine alpha-amidating monooxygenase (bifunctional PAM; PHM activity), N-(phenylacetyl)glycine |
| peptidylglycine alpha-amidating monooxygenase (bifunctional PAM; PHM activity) | Rattus norvegicus | N-(phenylcarbamoyl)glycine | 9.7 | 0.36 | 27 | pH 6, 37 °C | Open record: peptidylglycine alpha-amidating monooxygenase (bifunctional PAM; PHM activity), N-(phenylcarbamoyl)glycine |
| peptidylglycine alpha-amidating monooxygenase (bifunctional PAM; PHM activity) | Rattus norvegicus | N-(pyridine-3-carbonyl)glycine | 8 | 1.9 | 4.2 | pH 6, 37 °C | Open record: peptidylglycine alpha-amidating monooxygenase (bifunctional PAM; PHM activity), N-(pyridine-3-carbonyl)glycine |
| peptidylglycine alpha-amidating monooxygenase (bifunctional PAM; PHM activity) | Rattus norvegicus | N-(tert-butoxycarbonyl)glycine | 6.3 | 3.7 | 1.7 | pH 6, 37 °C | Open record: peptidylglycine alpha-amidating monooxygenase (bifunctional PAM; PHM activity), N-(tert-butoxycarbonyl)glycine |
| peptidylglycine alpha-amidating monooxygenase (bifunctional PAM; PHM activity) | Rattus norvegicus | N-(tert-butoxycarbonyl)glycylglycine | 7.5 | 0.3 | 25 | pH 6, 37 °C | Open record: peptidylglycine alpha-amidating monooxygenase (bifunctional PAM; PHM activity), N-(tert-butoxycarbonyl)glycylglycine |
| peptidylglycine alpha-amidating monooxygenase (bifunctional PAM; PHM activity) | Rattus norvegicus | N-(thiophene-2-carbonyl)glycine | 9.3 | 1.6 | 6 | pH 6, 37 °C | Open record: peptidylglycine alpha-amidating monooxygenase (bifunctional PAM; PHM activity), N-(thiophene-2-carbonyl)glycine |
| peptidylglycine alpha-amidating monooxygenase (bifunctional PAM; PHM activity) | Rattus norvegicus | N-[(2-Phenylcyclopropyl)carbonyl] glycine | 10 | 0.9 | 11 | pH 6, 37 °C | Open record: peptidylglycine alpha-amidating monooxygenase (bifunctional PAM; PHM activity), N-[(2-Phenylcyclopropyl)carbonyl] glycine |
| peptidylglycine alpha-amidating monooxygenase (bifunctional PAM; PHM activity) | Rattus norvegicus | N-[(benzylsulfanyl)carbonyl]glycine | 0.69 | 0.059 | 12 | pH 6, 37 °C | Open record: peptidylglycine alpha-amidating monooxygenase (bifunctional PAM; PHM activity), N-[(benzylsulfanyl)carbonyl]glycine |
| peptidylglycine alpha-amidating monooxygenase (bifunctional PAM; PHM activity) | Rattus norvegicus | N-[(phenylsulfanyl)acetyl]glycine | 4.6 | 0.19 | 25 | pH 6, 37 °C | Open record: peptidylglycine alpha-amidating monooxygenase (bifunctional PAM; PHM activity), N-[(phenylsulfanyl)acetyl]glycine |
| peptidylglycine alpha-amidating monooxygenase (bifunctional PAM; PHM activity) | Rattus norvegicus | N-[(propan-2-ylsulfanyl)acetyl]glycine | 1.8 | 0.22 | 8.2 | pH 6, 37 °C | Open record: peptidylglycine alpha-amidating monooxygenase (bifunctional PAM; PHM activity), N-[(propan-2-ylsulfanyl)acetyl]glycine |
| peptidylglycine alpha-amidating monooxygenase (bifunctional PAM; PHM activity) | Rattus norvegicus | N-[(pyridin-2-ylsulfanyl)acetyl]glycine | 3 | 0.036 | 83 | pH 6, 37 °C | Open record: peptidylglycine alpha-amidating monooxygenase (bifunctional PAM; PHM activity), N-[(pyridin-2-ylsulfanyl)acetyl]glycine |
| peptidylglycine alpha-amidating monooxygenase (bifunctional PAM; PHM activity) | Rattus norvegicus | N-[3-(furan-2-yl)acryloyl]glycine | 3.4 | 1.2 | 2.8 | pH 6, 37 °C | Open record: peptidylglycine alpha-amidating monooxygenase (bifunctional PAM; PHM activity), N-[3-(furan-2-yl)acryloyl]glycine |
| peptidylglycine alpha-amidating monooxygenase (bifunctional PAM; PHM activity) | Rattus norvegicus | N-[4-(trifluoromethyl)benzoyl]glycine | 2.8 | 0.77 | 3.6 | pH 6, 37 °C | Open record: peptidylglycine alpha-amidating monooxygenase (bifunctional PAM; PHM activity), N-[4-(trifluoromethyl)benzoyl]glycine |
| peptidylglycine alpha-amidating monooxygenase (bifunctional PAM; PHM activity) | Rattus norvegicus | N-acetyl-D-alanine | 1.3 | 1.4 × 10³ | 9.5 × 10⁻⁴ | pH 6, 37 °C | Open record: peptidylglycine alpha-amidating monooxygenase (bifunctional PAM; PHM activity), N-acetyl-D-alanine |
| peptidylglycine alpha-amidating monooxygenase (bifunctional PAM; PHM activity) | Rattus norvegicus | N-acetylglycine | 8 | 9.3 | 0.86 | pH 6, 37 °C | Open record: peptidylglycine alpha-amidating monooxygenase (bifunctional PAM; PHM activity), N-acetylglycine |
| peptidylglycine alpha-amidating monooxygenase (bifunctional PAM; PHM activity) | Rattus norvegicus | N-acetylglycine2.5% (v/v) DMSO | — | 15 | — | pH 6, 37 °C | Open record: peptidylglycine alpha-amidating monooxygenase (bifunctional PAM; PHM activity), N-acetylglycine |
| peptidylglycine alpha-amidating monooxygenase (bifunctional PAM; PHM activity) | Rattus norvegicus | N-acetylglycylglycine | 8.9 | 1.5 | 5.9 | pH 6, 37 °C | Open record: peptidylglycine alpha-amidating monooxygenase (bifunctional PAM; PHM activity), N-acetylglycylglycine |
| peptidylglycine alpha-amidating monooxygenase (bifunctional PAM; PHM activity) | Rattus norvegicus | N-benzoyl-D-alanine | 0.27 | 84 | 0.0032 | pH 6, 37 °C | Open record: peptidylglycine alpha-amidating monooxygenase (bifunctional PAM; PHM activity), N-benzoyl-D-alanine |
| peptidylglycine alpha-amidating monooxygenase (bifunctional PAM; PHM activity) | Rattus norvegicus | N-benzoylglycine | 8.2 | 1.3 | 6.2 | pH 6, 37 °C | Open record: peptidylglycine alpha-amidating monooxygenase (bifunctional PAM; PHM activity), N-benzoylglycine |
| peptidylglycine alpha-amidating monooxygenase (bifunctional PAM; PHM activity) | Rattus norvegicus | N-benzoylglycylglycine | 12 | 0.078 | 160 | pH 6, 37 °C | Open record: peptidylglycine alpha-amidating monooxygenase (bifunctional PAM; PHM activity), N-benzoylglycylglycine |
| peptidylglycine alpha-amidating monooxygenase (bifunctional PAM; PHM activity) | Rattus norvegicus | N-benzoylglycylglycylglycine | 8.8 | 0.31 | 29 | pH 6, 37 °C | Open record: peptidylglycine alpha-amidating monooxygenase (bifunctional PAM; PHM activity), N-benzoylglycylglycylglycine |
| peptidylglycine alpha-amidating monooxygenase (bifunctional PAM; PHM activity) | Rattus norvegicus | N-cinnamoylglycine | 8.4 | 0.23 | 36 | pH 6, 37 °C | Open record: peptidylglycine alpha-amidating monooxygenase (bifunctional PAM; PHM activity), N-cinnamoylglycine |
| peptidylglycine alpha-amidating monooxygenase (bifunctional PAM; PHM activity) | Rattus norvegicus | N-dansyl-Tyr-Val-D-Ala | 0.91 | 0.031 | 30 | pH 6, 37 °C | Open record: peptidylglycine alpha-amidating monooxygenase (bifunctional PAM; PHM activity), N-dansyl-Tyr-Val-D-Ala |
| peptidylglycine alpha-amidating monooxygenase (bifunctional PAM; PHM activity) | Rattus norvegicus | N-dansyl-Tyr-Val-Gly1% (v/v) ethanol; (5.0 mM) and O2 (200 uM), fixed | 1.4 | 0.0027 | 500 | pH 6, 37 °C | Open record: peptidylglycine alpha-amidating monooxygenase (bifunctional PAM; PHM activity), N-dansyl-Tyr-Val-Gly |
| peptidylglycine alpha-amidating monooxygenase (bifunctional PAM; PHM activity) | Rattus norvegicus | N-dansyl-Tyr-Val-Gly1.0% (v/v) ethanol; 6.0 mM sodium ascorbate; 2.5% (v/v) DMSO | — | 0.0149 | — | pH 6, 37 °C | Open record: peptidylglycine alpha-amidating monooxygenase (bifunctional PAM; PHM activity), N-dansyl-Tyr-Val-Gly |