Values CatLog read from this paper
Targeting the active site gate to yield hyperactive variants of 5-aminolevulinate synthase
PMID 20194506doi:10.1074/jbc.m109.074237Open in Browse
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CatLog read 20 records (50 values) from this paper: mALAS-2 (murine erythroid 5-aminolevulinate synthase) from Mus musculus.
Read from the paper by an AI model and checked against the paper by a second, separate AI run; code converted the units. Values are in CatLog's units; each record opens in Browse with the line the paper prints and the checks.
| Enzyme | Organism | Substrate | kcat (s⁻¹) | Km (mM) | kcat/Km (mM⁻¹ s⁻¹) | Conditions | Open record |
|---|---|---|---|---|---|---|---|
| mALAS-2 (murine erythroid 5-aminolevulinate synthase) | Mus musculus | glycine | 0.02 | 14 | 0.0011 | 20 °C | Open record: mALAS-2 (murine erythroid 5-aminolevulinate synthase), glycine |
| mALAS-2 (murine erythroid 5-aminolevulinate synthase) | Mus musculus | succinyl-coenzyme A | — | 0.011 | 1.8 | 20 °C | Open record: mALAS-2 (murine erythroid 5-aminolevulinate synthase), succinyl-coenzyme A |
| mALAS-2 (murine erythroid 5-aminolevulinate synthase)variant A425G/Y428H/R433H/G434N/E435K/L437K (F3) | Mus musculus | glycine | 0.2 | 13 | 0.02 | 20 °C | Open record: mALAS-2 (murine erythroid 5-aminolevulinate synthase) variant A425G/Y428H/R433H/G434N/E435K/L437K (F3), glycine |
| mALAS-2 (murine erythroid 5-aminolevulinate synthase)variant A425G/Y428H/R433H/G434N/E435K/L437K (F3) | Mus musculus | succinyl-coenzyme A | — | 0.0026 | 80 | 20 °C | Open record: mALAS-2 (murine erythroid 5-aminolevulinate synthase) variant A425G/Y428H/R433H/G434N/E435K/L437K (F3), succinyl-coenzyme A |
| mALAS-2 (murine erythroid 5-aminolevulinate synthase)variant A425T (A8) | Mus musculus | glycine | 0.07 | 25 | 0.0028 | 20 °C | Open record: mALAS-2 (murine erythroid 5-aminolevulinate synthase) variant A425T (A8), glycine |
| mALAS-2 (murine erythroid 5-aminolevulinate synthase)variant A425T (A8) | Mus musculus | succinyl-coenzyme A | — | 0.0023 | 30 | 20 °C | Open record: mALAS-2 (murine erythroid 5-aminolevulinate synthase) variant A425T (A8), succinyl-coenzyme A |
| mALAS-2 (murine erythroid 5-aminolevulinate synthase)variant L437Q (D8) | Mus musculus | glycine | 0.03 | 24 | 0.0013 | 20 °C | Open record: mALAS-2 (murine erythroid 5-aminolevulinate synthase) variant L437Q (D8), glycine |
| mALAS-2 (murine erythroid 5-aminolevulinate synthase)variant L437Q (D8) | Mus musculus | succinyl-coenzyme A | — | 0.0017 | 180 | 20 °C | Open record: mALAS-2 (murine erythroid 5-aminolevulinate synthase) variant L437Q (D8), succinyl-coenzyme A |
| mALAS-2 (murine erythroid 5-aminolevulinate synthase)variant N427H (G7) | Mus musculus | glycine | 0.07 | 15 | 0.0046 | 20 °C | Open record: mALAS-2 (murine erythroid 5-aminolevulinate synthase) variant N427H (G7), glycine |
| mALAS-2 (murine erythroid 5-aminolevulinate synthase)variant N427H (G7) | Mus musculus | succinyl-coenzyme A | — | 0.0015 | 50 | 20 °C | Open record: mALAS-2 (murine erythroid 5-aminolevulinate synthase) variant N427H (G7), succinyl-coenzyme A |
| mALAS-2 (murine erythroid 5-aminolevulinate synthase)variant R433K/G434K/E435Q/L437Q (F1) | Mus musculus | glycine | 0.2 | 16 | 0.01 | 20 °C | Open record: mALAS-2 (murine erythroid 5-aminolevulinate synthase) variant R433K/G434K/E435Q/L437Q (F1), glycine |
| mALAS-2 (murine erythroid 5-aminolevulinate synthase)variant R433K/G434K/E435Q/L437Q (F1) | Mus musculus | succinyl-coenzyme A | — | 0.0029 | 70 | 20 °C | Open record: mALAS-2 (murine erythroid 5-aminolevulinate synthase) variant R433K/G434K/E435Q/L437Q (F1), succinyl-coenzyme A |
| mALAS-2 (murine erythroid 5-aminolevulinate synthase)variant V423I/A425P/Y428C/P432R/R433K/E435N (A4) | Mus musculus | glycine | 0.16 | 14 | 0.01 | 20 °C | Open record: mALAS-2 (murine erythroid 5-aminolevulinate synthase) variant V423I/A425P/Y428C/P432R/R433K/E435N (A4), glycine |
| mALAS-2 (murine erythroid 5-aminolevulinate synthase)variant V423I/A425P/Y428C/P432R/R433K/E435N (A4) | Mus musculus | succinyl-coenzyme A | — | 0.0023 | 70 | 20 °C | Open record: mALAS-2 (murine erythroid 5-aminolevulinate synthase) variant V423I/A425P/Y428C/P432R/R433K/E435N (A4), succinyl-coenzyme A |
| mALAS-2 (murine erythroid 5-aminolevulinate synthase)variant V423L/Y428R/P432E/R433I/G434N/E435Q/L437K (SS2) | Mus musculus | glycine | 0.31 | 12 | 0.02 | 20 °C | Open record: mALAS-2 (murine erythroid 5-aminolevulinate synthase) variant V423L/Y428R/P432E/R433I/G434N/E435Q/L437K (SS2), glycine |
| mALAS-2 (murine erythroid 5-aminolevulinate synthase)variant V423L/Y428R/P432E/R433I/G434N/E435Q/L437K (SS2) | Mus musculus | succinyl-coenzyme A | — | 0.003 | 100 | 20 °C | Open record: mALAS-2 (murine erythroid 5-aminolevulinate synthase) variant V423L/Y428R/P432E/R433I/G434N/E435Q/L437K (SS2), succinyl-coenzyme A |
| mALAS-2 (murine erythroid 5-aminolevulinate synthase)variant Y428I/R433Q/G434N/E435T/L437N (F10) | Mus musculus | glycine | 0.17 | 16 | 0.01 | 20 °C | Open record: mALAS-2 (murine erythroid 5-aminolevulinate synthase) variant Y428I/R433Q/G434N/E435T/L437N (F10), glycine |
| mALAS-2 (murine erythroid 5-aminolevulinate synthase)variant Y428I/R433Q/G434N/E435T/L437N (F10) | Mus musculus | succinyl-coenzyme A | — | 0.0011 | 150 | 20 °C | Open record: mALAS-2 (murine erythroid 5-aminolevulinate synthase) variant Y428I/R433Q/G434N/E435T/L437N (F10), succinyl-coenzyme A |
| mALAS-2 (murine erythroid 5-aminolevulinate synthase)variant Y428N/P432N/R433I/G434E/E435K/L437K (H1) | Mus musculus | glycine | 0.23 | 13 | 0.02 | 20 °C | Open record: mALAS-2 (murine erythroid 5-aminolevulinate synthase) variant Y428N/P432N/R433I/G434E/E435K/L437K (H1), glycine |
| mALAS-2 (murine erythroid 5-aminolevulinate synthase)variant Y428N/P432N/R433I/G434E/E435K/L437K (H1) | Mus musculus | succinyl-coenzyme A | — | 0.002 | 110 | 20 °C | Open record: mALAS-2 (murine erythroid 5-aminolevulinate synthase) variant Y428N/P432N/R433I/G434E/E435K/L437K (H1), succinyl-coenzyme A |