EC 2.3.1.37: 5-aminolevulinate synthase

TransferasesOpen in Browse

CatLog read 132 records for EC 2.3.1.37 from 8 papers, for 5 organisms. Names in these papers: 5-aminolevulinate synthase (murine erythroid ALAS, eALAS), 5-aminolevulinate synthase (RpALAS), mALAS-2 (murine erythroid 5-aminolevulinate synthase), erythroid-specific 5'-aminolevulinate synthase ALAS2 (hsALAS2) and 6 more.

Read from the paper by an AI model and checked against the paper by a second, separate AI run; code converted the units.

CatLog also holds 47 records for EC 2.3.1.37 that are not yet re-read: from its earlier version, built from the enzyme databases and partly checked against the papers. All records for EC 2.3.1.37 in Browse.

Papers

Papers with records for EC 2.3.1.37
Paper	Organisms	Records
Arg-85 and Thr-430 in murine 5-aminolevulinate synthase coordinate acyl-CoA-binding and contribute to substrate specificity	Mus musculus	38
Exploring the Structure-Function Relationships in a 5-Aminolevulinic Acid Synthase and the Use of Protein Engineering to Expand its Substrate Range	Rhodopseudomonas palustris	21
Targeting the active site gate to yield hyperactive variants of 5-aminolevulinate synthase	Mus musculus	20
Human aminolevulinate synthase structure reveals a eukaryotic-specific autoinhibitory loop regulating substrate binding and product release	Homo sapiens	17
Asn-150 of Murine Erythroid 5-Aminolevulinate Synthase Modulates the Catalytic Balance between the Rates of the Reversible Reaction	Mus musculus	16
Resolving the roles of the Rhodobacter sphaeroides HemA and HemT 5-aminolevulinic acid synthases	Rhodobacter sphaeroides	8
Heme-dependent Inactivation of 5-Aminolevulinate Synthase from Caulobacter crescentus	Caulobacter crescentus	8
Functional asymmetry for the active sites of linked 5-aminolevulinate synthase and 8-amino-7-oxononanoate synthase	Mus musculus	4

Records

Records for EC 2.3.1.37 read from the paper
Enzyme	Organism	Substrate	k_cat (s⁻¹)	K_m (mM)	k_cat/K_m (mM⁻¹ s⁻¹)	Conditions	Paper	Open record
5-aminolevulinate synthase (cALAS)	Caulobacter crescentus	glycine	1.73	3.31	0.523 calc.	pH 7.4, 25 °C	PMID 30242198	Open record: 5-aminolevulinate synthase (cALAS), glycine
5-aminolevulinate synthase (cALAS)	Caulobacter crescentus	succinyl-coenzyme A	—	0.00242	—	pH 7.4, 25 °C	PMID 30242198	Open record: 5-aminolevulinate synthase (cALAS), succinyl-coenzyme A
5-aminolevulinate synthase (cALAS)variant C398A	Caulobacter crescentus	glycine	1.69	3.4	0.50 calc.	pH 7.4, 25 °C	PMID 30242198	Open record: 5-aminolevulinate synthase (cALAS) variant C398A, glycine
5-aminolevulinate synthase (cALAS)variant C398A	Caulobacter crescentus	succinyl-coenzyme A	—	0.00255	—	pH 7.4, 25 °C	PMID 30242198	Open record: 5-aminolevulinate synthase (cALAS) variant C398A, succinyl-coenzyme A
5-aminolevulinate synthase (cALAS)variant H340A	Caulobacter crescentus	glycine	1.61	3.52	0.457 calc.	pH 7.4, 25 °C	PMID 30242198	Open record: 5-aminolevulinate synthase (cALAS) variant H340A, glycine
5-aminolevulinate synthase (cALAS)variant H340A	Caulobacter crescentus	succinyl-coenzyme A	—	0.0024	—	pH 7.4, 25 °C	PMID 30242198	Open record: 5-aminolevulinate synthase (cALAS) variant H340A, succinyl-coenzyme A
5-aminolevulinate synthase (cALAS)variant H340A/C398A	Caulobacter crescentus	glycine	1.79	3.57	0.501 calc.	pH 7.4, 25 °C	PMID 30242198	Open record: 5-aminolevulinate synthase (cALAS) variant H340A/C398A, glycine
5-aminolevulinate synthase (cALAS)variant H340A/C398A	Caulobacter crescentus	succinyl-coenzyme A	—	0.00258	—	pH 7.4, 25 °C	PMID 30242198	Open record: 5-aminolevulinate synthase (cALAS) variant H340A/C398A, succinyl-coenzyme A
5-aminolevulinate synthase (erythroid ALAS)variant K313A (C-terminal subunit)	Mus musculus	glycine	0.073	11.8	0.0062	30 °C	PMID 21600186	Open record: 5-aminolevulinate synthase (erythroid ALAS) variant K313A (C-terminal subunit), glycine
5-aminolevulinate synthase (erythroid ALAS)variant K313A (C-terminal subunit)	Mus musculus	succinyl-coenzyme A	—	0.0018	40	30 °C	PMID 21600186	Open record: 5-aminolevulinate synthase (erythroid ALAS) variant K313A (C-terminal subunit), succinyl-coenzyme A
5-aminolevulinate synthase (erythroid ALAS)variant K313A (N-terminal subunit)	Mus musculus	glycine	0.36	14.8	0.0243	30 °C	PMID 21600186	Open record: 5-aminolevulinate synthase (erythroid ALAS) variant K313A (N-terminal subunit), glycine
5-aminolevulinate synthase (erythroid ALAS)variant K313A (N-terminal subunit)	Mus musculus	succinyl-coenzyme A	—	3.2 × 10⁻⁴	1125	30 °C	PMID 21600186	Open record: 5-aminolevulinate synthase (erythroid ALAS) variant K313A (N-terminal subunit), succinyl-coenzyme A
5-aminolevulinate synthase (mALAS2)	Mus musculus	glycine	0.25	8	0.031	pH 7.5, 37 °C	PMID 26511319	Open record: 5-aminolevulinate synthase (mALAS2), glycine
5-aminolevulinate synthase (mALAS2)	Mus musculus	succinyl-coenzyme A	—	0.001	250	pH 7.5, 37 °C	PMID 26511319	Open record: 5-aminolevulinate synthase (mALAS2), succinyl-coenzyme A
5-aminolevulinate synthase (mALAS2)variant N150A	Mus musculus	glycine	0.13	16	0.0081	pH 7.5, 30 °C	PMID 26511319	Open record: 5-aminolevulinate synthase (mALAS2) variant N150A, glycine
5-aminolevulinate synthase (mALAS2)variant N150A	Mus musculus	succinyl-coenzyme A	—	0.0038	34	pH 7.5, 30 °C	PMID 26511319	Open record: 5-aminolevulinate synthase (mALAS2) variant N150A, succinyl-coenzyme A
5-aminolevulinate synthase (mALAS2)variant N150F	Mus musculus	glycine	0.06	12	0.005	pH 7.5, 30 °C	PMID 26511319	Open record: 5-aminolevulinate synthase (mALAS2) variant N150F, glycine
5-aminolevulinate synthase (mALAS2)variant N150F	Mus musculus	glycine	0.11	13	0.0085	pH 7.5, 37 °C	PMID 26511319	Open record: 5-aminolevulinate synthase (mALAS2) variant N150F, glycine
5-aminolevulinate synthase (mALAS2)variant N150F	Mus musculus	succinyl-coenzyme A	—	0.0022	27	pH 7.5, 30 °C	PMID 26511319	Open record: 5-aminolevulinate synthase (mALAS2) variant N150F, succinyl-coenzyme A
5-aminolevulinate synthase (mALAS2)variant N150F	Mus musculus	succinyl-coenzyme A	—	0.0023	47	pH 7.5, 37 °C	PMID 26511319	Open record: 5-aminolevulinate synthase (mALAS2) variant N150F, succinyl-coenzyme A
5-aminolevulinate synthase (mALAS2)variant N150H	Mus musculus	glycine	0.04	16	0.0025	pH 7.5, 30 °C	PMID 26511319	Open record: 5-aminolevulinate synthase (mALAS2) variant N150H, glycine
5-aminolevulinate synthase (mALAS2)variant N150H	Mus musculus	glycine	0.09	32	0.0028	pH 7.5, 37 °C	PMID 26511319	Open record: 5-aminolevulinate synthase (mALAS2) variant N150H, glycine
5-aminolevulinate synthase (mALAS2)variant N150H	Mus musculus	succinyl-coenzyme A	—	0.0012	33	pH 7.5, 30 °C	PMID 26511319	Open record: 5-aminolevulinate synthase (mALAS2) variant N150H, succinyl-coenzyme A
5-aminolevulinate synthase (mALAS2)variant N150H	Mus musculus	succinyl-coenzyme A	—	0.0012	75	pH 7.5, 37 °C	PMID 26511319	Open record: 5-aminolevulinate synthase (mALAS2) variant N150H, succinyl-coenzyme A
5-aminolevulinate synthase (mALAS2)variant N150S	Mus musculus	glycine	0.15	11	0.0136	pH 7.5, 30 °C	PMID 26511319	Open record: 5-aminolevulinate synthase (mALAS2) variant N150S, glycine
5-aminolevulinate synthase (mALAS2)variant N150S	Mus musculus	succinyl-coenzyme A	—	0.0021	71	pH 7.5, 30 °C	PMID 26511319	Open record: 5-aminolevulinate synthase (mALAS2) variant N150S, succinyl-coenzyme A
5-aminolevulinate synthase (mALAS2)variant N150W	Mus musculus	glycine	0.09	39	0.0023	pH 7.5, 30 °C	PMID 26511319	Open record: 5-aminolevulinate synthase (mALAS2) variant N150W, glycine
5-aminolevulinate synthase (mALAS2)variant N150W	Mus musculus	succinyl-coenzyme A	—	0.0011	82	pH 7.5, 30 °C	PMID 26511319	Open record: 5-aminolevulinate synthase (mALAS2) variant N150W, succinyl-coenzyme A
5-aminolevulinate synthase (murine erythroid ALAS, eALAS)	Mus musculus	butyryl-coenzyme A	0.105	0.0061	17	30 °C	PMID 19562746	Open record: 5-aminolevulinate synthase (murine erythroid ALAS, eALAS), butyryl-coenzyme A
5-aminolevulinate synthase (murine erythroid ALAS, eALAS)	Mus musculus	glutaryl-coenzyme A	0.117	0.017	6.8	30 °C	PMID 19562746	Open record: 5-aminolevulinate synthase (murine erythroid ALAS, eALAS), glutaryl-coenzyme A
5-aminolevulinate synthase (murine erythroid ALAS, eALAS)	Mus musculus	glycinecosubstrate succinyl-CoA	—	24.2	0.0072	30 °C	PMID 19562746	Open record: 5-aminolevulinate synthase (murine erythroid ALAS, eALAS), glycine
5-aminolevulinate synthase (murine erythroid ALAS, eALAS)	Mus musculus	glycinecosubstrate octanoyl-CoA	—	17.1	0.0023	30 °C	PMID 19562746	Open record: 5-aminolevulinate synthase (murine erythroid ALAS, eALAS), glycine
5-aminolevulinate synthase (murine erythroid ALAS, eALAS)	Mus musculus	glycinecosubstrate butyryl-CoA	—	29.3	0.0043	30 °C	PMID 19562746	Open record: 5-aminolevulinate synthase (murine erythroid ALAS, eALAS), glycine
5-aminolevulinate synthase (murine erythroid ALAS, eALAS)	Mus musculus	glycinecosubstrate β-hydroxybutyryl-CoA	—	22.1	0.0028	30 °C	PMID 19562746	Open record: 5-aminolevulinate synthase (murine erythroid ALAS, eALAS), glycine
5-aminolevulinate synthase (murine erythroid ALAS, eALAS)	Mus musculus	glycinecosubstrate glutaryl-CoA	—	28.4	0.0048	30 °C	PMID 19562746	Open record: 5-aminolevulinate synthase (murine erythroid ALAS, eALAS), glycine
5-aminolevulinate synthase (murine erythroid ALAS, eALAS)	Mus musculus	octanoyl-coenzyme A	0.057	5.1 × 10⁻⁴	113	30 °C	PMID 19562746	Open record: 5-aminolevulinate synthase (murine erythroid ALAS, eALAS), octanoyl-coenzyme A
5-aminolevulinate synthase (murine erythroid ALAS, eALAS)	Mus musculus	succinyl-coenzyme A	0.167	0.0029	60	30 °C	PMID 19562746	Open record: 5-aminolevulinate synthase (murine erythroid ALAS, eALAS), succinyl-coenzyme A
5-aminolevulinate synthase (murine erythroid ALAS, eALAS)	Mus musculus	β-hydroxybutyryl-coenzyme A	0.067	0.0098	6.8	30 °C	PMID 19562746	Open record: 5-aminolevulinate synthase (murine erythroid ALAS, eALAS), β-hydroxybutyryl-coenzyme A
5-aminolevulinate synthase (murine erythroid ALAS, eALAS)variant R85K	Mus musculus	butyryl-coenzyme A	0.17	0.0027	62	30 °C	PMID 19562746	Open record: 5-aminolevulinate synthase (murine erythroid ALAS, eALAS) variant R85K, butyryl-coenzyme A
5-aminolevulinate synthase (murine erythroid ALAS, eALAS)variant R85K	Mus musculus	glutaryl-coenzyme A	0.005	0.0075	0.67	30 °C	PMID 19562746	Open record: 5-aminolevulinate synthase (murine erythroid ALAS, eALAS) variant R85K, glutaryl-coenzyme A
5-aminolevulinate synthase (murine erythroid ALAS, eALAS)variant R85K	Mus musculus	glycinecosubstrate succinyl-CoA	—	20	0.0053	30 °C	PMID 19562746	Open record: 5-aminolevulinate synthase (murine erythroid ALAS, eALAS) variant R85K, glycine
5-aminolevulinate synthase (murine erythroid ALAS, eALAS)variant R85K	Mus musculus	glycinecosubstrate octanoyl-CoA	—	25.2	0.0087	30 °C	PMID 19562746	Open record: 5-aminolevulinate synthase (murine erythroid ALAS, eALAS) variant R85K, glycine
5-aminolevulinate synthase (murine erythroid ALAS, eALAS)variant R85K	Mus musculus	glycinecosubstrate butyryl-CoA	—	17.2	0.0083	30 °C	PMID 19562746	Open record: 5-aminolevulinate synthase (murine erythroid ALAS, eALAS) variant R85K, glycine
5-aminolevulinate synthase (murine erythroid ALAS, eALAS)variant R85K	Mus musculus	glycinecosubstrate β-hydroxybutyryl-CoA	—	18.2	0.0023	30 °C	PMID 19562746	Open record: 5-aminolevulinate synthase (murine erythroid ALAS, eALAS) variant R85K, glycine
5-aminolevulinate synthase (murine erythroid ALAS, eALAS)variant R85K	Mus musculus	glycinecosubstrate glutaryl-CoA	—	21.2	1.7 × 10⁻⁴	30 °C	PMID 19562746	Open record: 5-aminolevulinate synthase (murine erythroid ALAS, eALAS) variant R85K, glycine
5-aminolevulinate synthase (murine erythroid ALAS, eALAS)variant R85K	Mus musculus	octanoyl-coenzyme A	0.172	0.0015	117	30 °C	PMID 19562746	Open record: 5-aminolevulinate synthase (murine erythroid ALAS, eALAS) variant R85K, octanoyl-coenzyme A
5-aminolevulinate synthase (murine erythroid ALAS, eALAS)variant R85K	Mus musculus	succinyl-coenzyme A	0.107	0.0124	8.8	30 °C	PMID 19562746	Open record: 5-aminolevulinate synthase (murine erythroid ALAS, eALAS) variant R85K, succinyl-coenzyme A
5-aminolevulinate synthase (murine erythroid ALAS, eALAS)variant R85K	Mus musculus	β-hydroxybutyryl-coenzyme A	0.047	0.0055	8.5	30 °C	PMID 19562746	Open record: 5-aminolevulinate synthase (murine erythroid ALAS, eALAS) variant R85K, β-hydroxybutyryl-coenzyme A
5-aminolevulinate synthase (murine erythroid ALAS, eALAS)variant R85L	Mus musculus	butyryl-coenzyme A	0.0335	0.0093	3.5	30 °C	PMID 19562746	Open record: 5-aminolevulinate synthase (murine erythroid ALAS, eALAS) variant R85L, butyryl-coenzyme A
5-aminolevulinate synthase (murine erythroid ALAS, eALAS)variant R85L	Mus musculus	glutaryl-coenzyme A	0.037	0.0301	1.2	30 °C	PMID 19562746	Open record: 5-aminolevulinate synthase (murine erythroid ALAS, eALAS) variant R85L, glutaryl-coenzyme A
5-aminolevulinate synthase (murine erythroid ALAS, eALAS)variant R85L	Mus musculus	glycinecosubstrate succinyl-CoA	—	63.1	1.7 × 10⁻⁴	30 °C	PMID 19562746	Open record: 5-aminolevulinate synthase (murine erythroid ALAS, eALAS) variant R85L, glycine
5-aminolevulinate synthase (murine erythroid ALAS, eALAS)variant R85L	Mus musculus	glycinecosubstrate octanoyl-CoA	—	55.2	5 × 10⁻⁴	30 °C	PMID 19562746	Open record: 5-aminolevulinate synthase (murine erythroid ALAS, eALAS) variant R85L, glycine
5-aminolevulinate synthase (murine erythroid ALAS, eALAS)variant R85L	Mus musculus	glycinecosubstrate butyryl-CoA	—	70.3	5 × 10⁻⁴	30 °C	PMID 19562746	Open record: 5-aminolevulinate synthase (murine erythroid ALAS, eALAS) variant R85L, glycine
5-aminolevulinate synthase (murine erythroid ALAS, eALAS)variant R85L	Mus musculus	glycinecosubstrate β-hydroxybutyryl-CoA	—	59.1	1.8 × 10⁻⁴	30 °C	PMID 19562746	Open record: 5-aminolevulinate synthase (murine erythroid ALAS, eALAS) variant R85L, glycine
5-aminolevulinate synthase (murine erythroid ALAS, eALAS)variant R85L	Mus musculus	glycinecosubstrate glutaryl-CoA	—	70.6	1.33 × 10⁻⁵	30 °C	PMID 19562746	Open record: 5-aminolevulinate synthase (murine erythroid ALAS, eALAS) variant R85L, glycine
5-aminolevulinate synthase (murine erythroid ALAS, eALAS)variant R85L	Mus musculus	octanoyl-coenzyme A	0.03	5.5 × 10⁻⁴	55	30 °C	PMID 19562746	Open record: 5-aminolevulinate synthase (murine erythroid ALAS, eALAS) variant R85L, octanoyl-coenzyme A
5-aminolevulinate synthase (murine erythroid ALAS, eALAS)variant R85L	Mus musculus	succinyl-coenzyme A	0.0157	0.0203	0.83	30 °C	PMID 19562746	Open record: 5-aminolevulinate synthase (murine erythroid ALAS, eALAS) variant R85L, succinyl-coenzyme A
5-aminolevulinate synthase (murine erythroid ALAS, eALAS)variant R85L	Mus musculus	β-hydroxybutyryl-coenzyme A	0.0108	0.0061	1.8	30 °C	PMID 19562746	Open record: 5-aminolevulinate synthase (murine erythroid ALAS, eALAS) variant R85L, β-hydroxybutyryl-coenzyme A
5-aminolevulinate synthase (murine erythroid ALAS, eALAS)variant R85L/T430V	Mus musculus	butyryl-coenzyme A	0.001	5.4 × 10⁻⁴	0.5	30 °C	PMID 19562746	Open record: 5-aminolevulinate synthase (murine erythroid ALAS, eALAS) variant R85L/T430V, butyryl-coenzyme A
5-aminolevulinate synthase (murine erythroid ALAS, eALAS)variant R85L/T430V	Mus musculus	glycinecosubstrate succinyl-CoA	—	98.4	1.7 × 10⁻⁵	30 °C	PMID 19562746	Open record: 5-aminolevulinate synthase (murine erythroid ALAS, eALAS) variant R85L/T430V, glycine
5-aminolevulinate synthase (murine erythroid ALAS, eALAS)variant R85L/T430V	Mus musculus	glycinecosubstrate octanoyl-CoA	—	74.2	1.7 × 10⁻⁷	30 °C	PMID 19562746	Open record: 5-aminolevulinate synthase (murine erythroid ALAS, eALAS) variant R85L/T430V, glycine
5-aminolevulinate synthase (murine erythroid ALAS, eALAS)variant R85L/T430V	Mus musculus	glycinecosubstrate butyryl-CoA	—	88.2	1.02 × 10⁻⁵	30 °C	PMID 19562746	Open record: 5-aminolevulinate synthase (murine erythroid ALAS, eALAS) variant R85L/T430V, glycine
5-aminolevulinate synthase (murine erythroid ALAS, eALAS)variant R85L/T430V	Mus musculus	glycinecosubstrate β-hydroxybutyryl-CoA	—	92.2	1.7 × 10⁻⁸	30 °C	PMID 19562746	Open record: 5-aminolevulinate synthase (murine erythroid ALAS, eALAS) variant R85L/T430V, glycine
5-aminolevulinate synthase (murine erythroid ALAS, eALAS)variant R85L/T430V	Mus musculus	octanoyl-coenzyme A	1.7 × 10⁻⁵	0.0172	9.3 × 10⁻⁴	30 °C	PMID 19562746	Open record: 5-aminolevulinate synthase (murine erythroid ALAS, eALAS) variant R85L/T430V, octanoyl-coenzyme A
5-aminolevulinate synthase (murine erythroid ALAS, eALAS)variant R85L/T430V	Mus musculus	succinyl-coenzyme A	0.0018	0.0096	0.17	30 °C	PMID 19562746	Open record: 5-aminolevulinate synthase (murine erythroid ALAS, eALAS) variant R85L/T430V, succinyl-coenzyme A
5-aminolevulinate synthase (murine erythroid ALAS, eALAS)variant R85L/T430V	Mus musculus	β-hydroxybutyryl-coenzyme A	1.7 × 10⁻⁶	0.0742	2.2 × 10⁻⁵	30 °C	PMID 19562746	Open record: 5-aminolevulinate synthase (murine erythroid ALAS, eALAS) variant R85L/T430V, β-hydroxybutyryl-coenzyme A
5-aminolevulinate synthase (RpALAS)	Rhodopseudomonas palustris	succinyl-CoA	1.2	—	—		PMID 39688068	Open record: 5-aminolevulinate synthase (RpALAS), succinyl-CoA
5-aminolevulinate synthase (RpALAS)variant R21N	Rhodopseudomonas palustris	butyryl-CoA	0.018	0.9	0.2	pH 7.5, 25 °C	PMID 39688068	Open record: 5-aminolevulinate synthase (RpALAS) variant R21N, butyryl-CoA
5-aminolevulinate synthase (RpALAS)variant R21N/N84L	Rhodopseudomonas palustris	butyryl-CoA	0.049	1.1	0.044	pH 7.5, 25 °C	PMID 39688068	Open record: 5-aminolevulinate synthase (RpALAS) variant R21N/N84L, butyryl-CoA
5-aminolevulinate synthase (RpALAS)variant R21N/N84L	Rhodopseudomonas palustris	glycine	—	3.4	0.014	pH 7.5, 25 °C	PMID 39688068	Open record: 5-aminolevulinate synthase (RpALAS) variant R21N/N84L, glycine
5-aminolevulinate synthase (RpALAS)variant R21N/N84L/T362V	Rhodopseudomonas palustris	butyryl-CoA	0.37	0.32	1.2	pH 7.5, 25 °C	PMID 39688068	Open record: 5-aminolevulinate synthase (RpALAS) variant R21N/N84L/T362V, butyryl-CoA
5-aminolevulinate synthase (RpALAS)variant R21N/N84L/T362V	Rhodopseudomonas palustris	glycine	—	0.8	0.5	pH 7.5, 25 °C	PMID 39688068	Open record: 5-aminolevulinate synthase (RpALAS) variant R21N/N84L/T362V, glycine
5-aminolevulinate synthase (RpALAS)variant R21N/T362V	Rhodopseudomonas palustris	butyryl-CoA	0.099	1.3	0.076	pH 7.5, 25 °C	PMID 39688068	Open record: 5-aminolevulinate synthase (RpALAS) variant R21N/T362V, butyryl-CoA
5-aminolevulinate synthase (RpALAS)variant R21N/T362V	Rhodopseudomonas palustris	glycine	—	6	0.015	pH 7.5, 25 °C	PMID 39688068	Open record: 5-aminolevulinate synthase (RpALAS) variant R21N/T362V, glycine
5-aminolevulinate synthase (RpALAS)variant R21N/T82A	Rhodopseudomonas palustris	butyryl-CoA	0.16	0.33	0.48	pH 7.5, 25 °C	PMID 39688068	Open record: 5-aminolevulinate synthase (RpALAS) variant R21N/T82A, butyryl-CoA
5-aminolevulinate synthase (RpALAS)variant R21N/T82A	Rhodopseudomonas palustris	glycine	—	1.7	—	pH 7.5, 25 °C	PMID 39688068	Open record: 5-aminolevulinate synthase (RpALAS) variant R21N/T82A, glycine
5-aminolevulinate synthase (RpALAS)variant R21N/T82A/T362V	Rhodopseudomonas palustris	butyryl-CoA	0.62	0.15	4.1	pH 7.5, 25 °C	PMID 39688068	Open record: 5-aminolevulinate synthase (RpALAS) variant R21N/T82A/T362V, butyryl-CoA
5-aminolevulinate synthase (RpALAS)variant R21N/T82A/T362V	Rhodopseudomonas palustris	glycine	—	4.4	0.14	pH 7.5, 25 °C	PMID 39688068	Open record: 5-aminolevulinate synthase (RpALAS) variant R21N/T82A/T362V, glycine
5-aminolevulinate synthase (RpALAS)variant R21P	Rhodopseudomonas palustris	butyryl-CoA	0.027	1.4	0.019	pH 7.5, 25 °C	PMID 39688068	Open record: 5-aminolevulinate synthase (RpALAS) variant R21P, butyryl-CoA
5-aminolevulinate synthase (RpALAS)variant R21P/N84L	Rhodopseudomonas palustris	butyryl-CoA	0.076	0.23	0.33	pH 7.5, 25 °C	PMID 39688068	Open record: 5-aminolevulinate synthase (RpALAS) variant R21P/N84L, butyryl-CoA
5-aminolevulinate synthase (RpALAS)variant R21P/N84L	Rhodopseudomonas palustris	glycine	—	1.6	0.048	pH 7.5, 25 °C	PMID 39688068	Open record: 5-aminolevulinate synthase (RpALAS) variant R21P/N84L, glycine
5-aminolevulinate synthase (RpALAS)variant R21P/N84L/T362V	Rhodopseudomonas palustris	butyryl-CoA	0.5	0.52	0.96	pH 7.5, 25 °C	PMID 39688068	Open record: 5-aminolevulinate synthase (RpALAS) variant R21P/N84L/T362V, butyryl-CoA
5-aminolevulinate synthase (RpALAS)variant R21P/N84L/T362V	Rhodopseudomonas palustris	glycine	—	1.3	0.38	pH 7.5, 25 °C	PMID 39688068	Open record: 5-aminolevulinate synthase (RpALAS) variant R21P/N84L/T362V, glycine
5-aminolevulinate synthase (RpALAS)variant R21P/T82S/N84L	Rhodopseudomonas palustris	butyryl-CoA	0.44	0.37	1.2	pH 7.5, 25 °C	PMID 39688068	Open record: 5-aminolevulinate synthase (RpALAS) variant R21P/T82S/N84L, butyryl-CoA
5-aminolevulinate synthase (RpALAS)variant R21P/T82S/N84L	Rhodopseudomonas palustris	glycine	—	1	0.44	pH 7.5, 25 °C	PMID 39688068	Open record: 5-aminolevulinate synthase (RpALAS) variant R21P/T82S/N84L, glycine
5-aminolevulinate synthase (RpALAS)variant R21P/T82S/N84L/T362V	Rhodopseudomonas palustris	butyryl-CoA	0.4	0.6	0.7	pH 7.5, 25 °C	PMID 39688068	Open record: 5-aminolevulinate synthase (RpALAS) variant R21P/T82S/N84L/T362V, butyryl-CoA
5-aminolevulinate synthase (RpALAS)variant R21P/T82S/N84L/T362V	Rhodopseudomonas palustris	glycine	—	0.8	0.5	pH 7.5, 25 °C	PMID 39688068	Open record: 5-aminolevulinate synthase (RpALAS) variant R21P/T82S/N84L/T362V, glycine
5-aminolevulinic acid synthase HemA (2.4.1-HemA)	Rhodobacter sphaeroides	glycine	1.099	43.4	0.0255		PMID 30232811	Open record: 5-aminolevulinic acid synthase HemA (2.4.1-HemA), glycine
5-aminolevulinic acid synthase HemA (2.4.1-HemA)	Rhodobacter sphaeroides	succinyl-CoA	—	0.0176	62.47		PMID 30232811	Open record: 5-aminolevulinic acid synthase HemA (2.4.1-HemA), succinyl-CoA
5-aminolevulinic acid synthase HemA (2.4.3-HemA)	Rhodobacter sphaeroides	glycine	1.293	26.4	0.04897		PMID 30232811	Open record: 5-aminolevulinic acid synthase HemA (2.4.3-HemA), glycine
5-aminolevulinic acid synthase HemA (2.4.3-HemA)	Rhodobacter sphaeroides	succinyl-CoA	—	0.0184	70.28		PMID 30232811	Open record: 5-aminolevulinic acid synthase HemA (2.4.3-HemA), succinyl-CoA
5-aminolevulinic acid synthase HemT (2.4.9-HemT)	Rhodobacter sphaeroides	glycine	1.008	52.5	0.0192		PMID 30232811	Open record: 5-aminolevulinic acid synthase HemT (2.4.9-HemT), glycine
5-aminolevulinic acid synthase HemT (2.4.9-HemT)	Rhodobacter sphaeroides	succinyl-CoA	—	0.015	67.17		PMID 30232811	Open record: 5-aminolevulinic acid synthase HemT (2.4.9-HemT), succinyl-CoA
5-aminolevulinic acid synthase HemT (2.4.9-HemT)variant C281P	Rhodobacter sphaeroides	glycine	0.9244	46.8	0.01972		PMID 30232811	Open record: 5-aminolevulinic acid synthase HemT (2.4.9-HemT) variant C281P, glycine
5-aminolevulinic acid synthase HemT (2.4.9-HemT)variant C281P	Rhodobacter sphaeroides	succinyl-CoA	—	0.0261	35.42		PMID 30232811	Open record: 5-aminolevulinic acid synthase HemT (2.4.9-HemT) variant C281P, succinyl-CoA
erythroid-specific 5'-aminolevulinate synthase ALAS2 (hsALAS2)	Homo sapiens	glycinehsALAS2ΔN142; residues 143-587; tag-free (His6-tag removed)	—	5.7	0.0087	pH 7.4, 37 °C	PMID 32499479	Open record: erythroid-specific 5'-aminolevulinate synthase ALAS2 (hsALAS2), glycine
erythroid-specific 5'-aminolevulinate synthase ALAS2 (hsALAS2)	Homo sapiens	glycinehsALAS2ΔN142; residues 143-587; N-terminal His6-tagged	—	5	0.0107	pH 7.4, 37 °C	PMID 32499479	Open record: erythroid-specific 5'-aminolevulinate synthase ALAS2 (hsALAS2), glycine
erythroid-specific 5'-aminolevulinate synthase ALAS2 (hsALAS2)	Homo sapiens	glycinehsALAS2ΔN78; residues 79-587; N-terminal His6-tagged	—	8.5	0.0068	pH 7.4, 37 °C	PMID 32499479	Open record: erythroid-specific 5'-aminolevulinate synthase ALAS2 (hsALAS2), glycine
erythroid-specific 5'-aminolevulinate synthase ALAS2 (hsALAS2)	Homo sapiens	succinyl-coenzyme AhsALAS2ΔN142; residues 143-587; tag-free (His6-tag removed)	0.05	0.039	1.25	pH 7.4, 37 °C	PMID 32499479	Open record: erythroid-specific 5'-aminolevulinate synthase ALAS2 (hsALAS2), succinyl-coenzyme A
erythroid-specific 5'-aminolevulinate synthase ALAS2 (hsALAS2)	Homo sapiens	succinyl-coenzyme AhsALAS2ΔN142; residues 143-587; N-terminal His6-tagged	0.053	0.042	1.27	pH 7.4, 37 °C	PMID 32499479	Open record: erythroid-specific 5'-aminolevulinate synthase ALAS2 (hsALAS2), succinyl-coenzyme A
erythroid-specific 5'-aminolevulinate synthase ALAS2 (hsALAS2)	Homo sapiens	succinyl-coenzyme AhsALAS2ΔN78; residues 79-587; N-terminal His6-tagged	0.058	0.032	1.83	pH 7.4, 37 °C	PMID 32499479	Open record: erythroid-specific 5'-aminolevulinate synthase ALAS2 (hsALAS2), succinyl-coenzyme A
erythroid-specific 5'-aminolevulinate synthase ALAS2 (hsALAS2)	Homo sapiens	succinyl-coenzyme AN-terminally truncated hsALAS2 expressed in Sf9 insect cells	—	0.031	—	pH 7.4, 37 °C	PMID 32499479	Open record: erythroid-specific 5'-aminolevulinate synthase ALAS2 (hsALAS2), succinyl-coenzyme A
erythroid-specific 5'-aminolevulinate synthase ALAS2 (hsALAS2)variant Q548X	Homo sapiens	glycine	—	12.4	0.0233	pH 7.4, 37 °C	PMID 32499479	Open record: erythroid-specific 5'-aminolevulinate synthase ALAS2 (hsALAS2) variant Q548X, glycine
erythroid-specific 5'-aminolevulinate synthase ALAS2 (hsALAS2)variant Q548X	Homo sapiens	succinyl-coenzyme A	0.288	0.055	5.2	pH 7.4, 37 °C	PMID 32499479	Open record: erythroid-specific 5'-aminolevulinate synthase ALAS2 (hsALAS2) variant Q548X, succinyl-coenzyme A
erythroid-specific 5'-aminolevulinate synthase ALAS2 (hsALAS2)variant R511E	Homo sapiens	glycinetag-free (His6-tag removed)	—	26	0.004	pH 7.4, 37 °C	PMID 32499479	Open record: erythroid-specific 5'-aminolevulinate synthase ALAS2 (hsALAS2) variant R511E, glycine
erythroid-specific 5'-aminolevulinate synthase ALAS2 (hsALAS2)variant R511E	Homo sapiens	glycineN-terminal His6-tagged	—	22	0.0048	pH 7.4, 37 °C	PMID 32499479	Open record: erythroid-specific 5'-aminolevulinate synthase ALAS2 (hsALAS2) variant R511E, glycine
erythroid-specific 5'-aminolevulinate synthase ALAS2 (hsALAS2)variant R511E	Homo sapiens	succinyl-coenzyme Atag-free (His6-tag removed)	0.105	0.053	2	pH 7.4, 37 °C	PMID 32499479	Open record: erythroid-specific 5'-aminolevulinate synthase ALAS2 (hsALAS2) variant R511E, succinyl-coenzyme A
erythroid-specific 5'-aminolevulinate synthase ALAS2 (hsALAS2)variant R511E	Homo sapiens	succinyl-coenzyme AN-terminal His6-tagged	0.107	0.043	2.5	pH 7.4, 37 °C	PMID 32499479	Open record: erythroid-specific 5'-aminolevulinate synthase ALAS2 (hsALAS2) variant R511E, succinyl-coenzyme A
erythroid-specific 5'-aminolevulinate synthase ALAS2 (hsALAS2)variant delAT	Homo sapiens	glycine	—	10.3	0.025	pH 7.4, 37 °C	PMID 32499479	Open record: erythroid-specific 5'-aminolevulinate synthase ALAS2 (hsALAS2) variant delAT, glycine
erythroid-specific 5'-aminolevulinate synthase ALAS2 (hsALAS2)variant delAT	Homo sapiens	succinyl-coenzyme A	0.257	0.056	4.7	pH 7.4, 37 °C	PMID 32499479	Open record: erythroid-specific 5'-aminolevulinate synthase ALAS2 (hsALAS2) variant delAT, succinyl-coenzyme A
erythroid-specific 5'-aminolevulinate synthase ALAS2 (hsALAS2)variant delG	Homo sapiens	glycine	—	6.7	0.011	pH 7.4, 37 °C	PMID 32499479	Open record: erythroid-specific 5'-aminolevulinate synthase ALAS2 (hsALAS2) variant delG, glycine
erythroid-specific 5'-aminolevulinate synthase ALAS2 (hsALAS2)variant delG	Homo sapiens	succinyl-coenzyme A	0.075	0.02	3.8	pH 7.4, 37 °C	PMID 32499479	Open record: erythroid-specific 5'-aminolevulinate synthase ALAS2 (hsALAS2) variant delG, succinyl-coenzyme A
mALAS-2 (murine erythroid 5-aminolevulinate synthase)	Mus musculus	glycine	0.02	14	0.0011	20 °C	PMID 20194506	Open record: mALAS-2 (murine erythroid 5-aminolevulinate synthase), glycine
mALAS-2 (murine erythroid 5-aminolevulinate synthase)	Mus musculus	succinyl-coenzyme A	—	0.011	1.8	20 °C	PMID 20194506	Open record: mALAS-2 (murine erythroid 5-aminolevulinate synthase), succinyl-coenzyme A
mALAS-2 (murine erythroid 5-aminolevulinate synthase)variant A425G/Y428H/R433H/G434N/E435K/L437K (F3)	Mus musculus	glycine	0.2	13	0.02	20 °C	PMID 20194506	Open record: mALAS-2 (murine erythroid 5-aminolevulinate synthase) variant A425G/Y428H/R433H/G434N/E435K/L437K (F3), glycine
mALAS-2 (murine erythroid 5-aminolevulinate synthase)variant A425G/Y428H/R433H/G434N/E435K/L437K (F3)	Mus musculus	succinyl-coenzyme A	—	0.0026	80	20 °C	PMID 20194506	Open record: mALAS-2 (murine erythroid 5-aminolevulinate synthase) variant A425G/Y428H/R433H/G434N/E435K/L437K (F3), succinyl-coenzyme A
mALAS-2 (murine erythroid 5-aminolevulinate synthase)variant A425T (A8)	Mus musculus	glycine	0.07	25	0.0028	20 °C	PMID 20194506	Open record: mALAS-2 (murine erythroid 5-aminolevulinate synthase) variant A425T (A8), glycine
mALAS-2 (murine erythroid 5-aminolevulinate synthase)variant A425T (A8)	Mus musculus	succinyl-coenzyme A	—	0.0023	30	20 °C	PMID 20194506	Open record: mALAS-2 (murine erythroid 5-aminolevulinate synthase) variant A425T (A8), succinyl-coenzyme A
mALAS-2 (murine erythroid 5-aminolevulinate synthase)variant L437Q (D8)	Mus musculus	glycine	0.03	24	0.0013	20 °C	PMID 20194506	Open record: mALAS-2 (murine erythroid 5-aminolevulinate synthase) variant L437Q (D8), glycine
mALAS-2 (murine erythroid 5-aminolevulinate synthase)variant L437Q (D8)	Mus musculus	succinyl-coenzyme A	—	0.0017	180	20 °C	PMID 20194506	Open record: mALAS-2 (murine erythroid 5-aminolevulinate synthase) variant L437Q (D8), succinyl-coenzyme A
mALAS-2 (murine erythroid 5-aminolevulinate synthase)variant N427H (G7)	Mus musculus	glycine	0.07	15	0.0046	20 °C	PMID 20194506	Open record: mALAS-2 (murine erythroid 5-aminolevulinate synthase) variant N427H (G7), glycine
mALAS-2 (murine erythroid 5-aminolevulinate synthase)variant N427H (G7)	Mus musculus	succinyl-coenzyme A	—	0.0015	50	20 °C	PMID 20194506	Open record: mALAS-2 (murine erythroid 5-aminolevulinate synthase) variant N427H (G7), succinyl-coenzyme A
mALAS-2 (murine erythroid 5-aminolevulinate synthase)variant R433K/G434K/E435Q/L437Q (F1)	Mus musculus	glycine	0.2	16	0.01	20 °C	PMID 20194506	Open record: mALAS-2 (murine erythroid 5-aminolevulinate synthase) variant R433K/G434K/E435Q/L437Q (F1), glycine
mALAS-2 (murine erythroid 5-aminolevulinate synthase)variant R433K/G434K/E435Q/L437Q (F1)	Mus musculus	succinyl-coenzyme A	—	0.0029	70	20 °C	PMID 20194506	Open record: mALAS-2 (murine erythroid 5-aminolevulinate synthase) variant R433K/G434K/E435Q/L437Q (F1), succinyl-coenzyme A
mALAS-2 (murine erythroid 5-aminolevulinate synthase)variant V423I/A425P/Y428C/P432R/R433K/E435N (A4)	Mus musculus	glycine	0.16	14	0.01	20 °C	PMID 20194506	Open record: mALAS-2 (murine erythroid 5-aminolevulinate synthase) variant V423I/A425P/Y428C/P432R/R433K/E435N (A4), glycine
mALAS-2 (murine erythroid 5-aminolevulinate synthase)variant V423I/A425P/Y428C/P432R/R433K/E435N (A4)	Mus musculus	succinyl-coenzyme A	—	0.0023	70	20 °C	PMID 20194506	Open record: mALAS-2 (murine erythroid 5-aminolevulinate synthase) variant V423I/A425P/Y428C/P432R/R433K/E435N (A4), succinyl-coenzyme A
mALAS-2 (murine erythroid 5-aminolevulinate synthase)variant V423L/Y428R/P432E/R433I/G434N/E435Q/L437K (SS2)	Mus musculus	glycine	0.31	12	0.02	20 °C	PMID 20194506	Open record: mALAS-2 (murine erythroid 5-aminolevulinate synthase) variant V423L/Y428R/P432E/R433I/G434N/E435Q/L437K (SS2), glycine
mALAS-2 (murine erythroid 5-aminolevulinate synthase)variant V423L/Y428R/P432E/R433I/G434N/E435Q/L437K (SS2)	Mus musculus	succinyl-coenzyme A	—	0.003	100	20 °C	PMID 20194506	Open record: mALAS-2 (murine erythroid 5-aminolevulinate synthase) variant V423L/Y428R/P432E/R433I/G434N/E435Q/L437K (SS2), succinyl-coenzyme A
mALAS-2 (murine erythroid 5-aminolevulinate synthase)variant Y428I/R433Q/G434N/E435T/L437N (F10)	Mus musculus	glycine	0.17	16	0.01	20 °C	PMID 20194506	Open record: mALAS-2 (murine erythroid 5-aminolevulinate synthase) variant Y428I/R433Q/G434N/E435T/L437N (F10), glycine
mALAS-2 (murine erythroid 5-aminolevulinate synthase)variant Y428I/R433Q/G434N/E435T/L437N (F10)	Mus musculus	succinyl-coenzyme A	—	0.0011	150	20 °C	PMID 20194506	Open record: mALAS-2 (murine erythroid 5-aminolevulinate synthase) variant Y428I/R433Q/G434N/E435T/L437N (F10), succinyl-coenzyme A
mALAS-2 (murine erythroid 5-aminolevulinate synthase)variant Y428N/P432N/R433I/G434E/E435K/L437K (H1)	Mus musculus	glycine	0.23	13	0.02	20 °C	PMID 20194506	Open record: mALAS-2 (murine erythroid 5-aminolevulinate synthase) variant Y428N/P432N/R433I/G434E/E435K/L437K (H1), glycine
mALAS-2 (murine erythroid 5-aminolevulinate synthase)variant Y428N/P432N/R433I/G434E/E435K/L437K (H1)	Mus musculus	succinyl-coenzyme A	—	0.002	110	20 °C	PMID 20194506	Open record: mALAS-2 (murine erythroid 5-aminolevulinate synthase) variant Y428N/P432N/R433I/G434E/E435K/L437K (H1), succinyl-coenzyme A