Values CatLog read from this paper
Disease variants of the human mitochondrial DNA helicase encoded by C10orf2 differentially alter protein stability, nucleotide hydrolysis, and helicase activity
PMID 20659899doi:10.1074/jbc.m110.151795Open in Browse
The paper itself is not on this site: read it at the publisher. This page lists only the values CatLog read from it.
CatLog read 22 records (66 values) from this paper: mitochondrial DNA helicase (p72, Twinkle) from Homo sapiens.
Read from the paper by an AI model and checked against the paper by a second, separate AI run; code converted the units. Values are in CatLog's units; each record opens in Browse with the line the paper prints and the checks.
| Enzyme | Organism | Substrate | kcat (s⁻¹) | Km (mM) | kcat/Km (mM⁻¹ s⁻¹) | Conditions | Open record |
|---|---|---|---|---|---|---|---|
| mitochondrial DNA helicase (p72, Twinkle) | Homo sapiens | adenosine 5'-triphosphateno affinity tag | 2.18 | 1.43 | 1.53 | pH 7.8, 37 °C | Open record: mitochondrial DNA helicase (p72, Twinkle), adenosine 5'-triphosphate |
| mitochondrial DNA helicase (p72, Twinkle) | Homo sapiens | adenosine 5'-triphosphate | 1.9 | 1.22 | 1.55 | pH 7.8, 37 °C | Open record: mitochondrial DNA helicase (p72, Twinkle), adenosine 5'-triphosphate |
| mitochondrial DNA helicase (p72, Twinkle)variant A318T | Homo sapiens | adenosine 5'-triphosphate | 1.19 | 0.84 | 1.42 | pH 7.8, 37 °C | Open record: mitochondrial DNA helicase (p72, Twinkle) variant A318T, adenosine 5'-triphosphate |
| mitochondrial DNA helicase (p72, Twinkle)variant A359T | Homo sapiens | adenosine 5'-triphosphate | 1.06 | 1.3 | 0.81 | pH 7.8, 37 °C | Open record: mitochondrial DNA helicase (p72, Twinkle) variant A359T, adenosine 5'-triphosphate |
| mitochondrial DNA helicase (p72, Twinkle)variant A475P | Homo sapiens | adenosine 5'-triphosphate | 0.66 | 1.22 | 0.54 | pH 7.8, 37 °C | Open record: mitochondrial DNA helicase (p72, Twinkle) variant A475P, adenosine 5'-triphosphate |
| mitochondrial DNA helicase (p72, Twinkle)variant F485L | Homo sapiens | adenosine 5'-triphosphate | 1.15 | 1.44 | 0.8 | pH 7.8, 37 °C | Open record: mitochondrial DNA helicase (p72, Twinkle) variant F485L, adenosine 5'-triphosphate |
| mitochondrial DNA helicase (p72, Twinkle)variant I367T | Homo sapiens | adenosine 5'-triphosphate | 2.89 | 2.23 | 1.3 | pH 7.8, 37 °C | Open record: mitochondrial DNA helicase (p72, Twinkle) variant I367T, adenosine 5'-triphosphate |
| mitochondrial DNA helicase (p72, Twinkle)variant K319E | Homo sapiens | adenosine 5'-triphosphate | 2.24 | 1.82 | 1.23 | pH 7.8, 37 °C | Open record: mitochondrial DNA helicase (p72, Twinkle) variant K319E, adenosine 5'-triphosphate |
| mitochondrial DNA helicase (p72, Twinkle)variant K319T | Homo sapiens | adenosine 5'-triphosphate | 0.98 | 1.02 | 0.96 | pH 7.8, 37 °C | Open record: mitochondrial DNA helicase (p72, Twinkle) variant K319T, adenosine 5'-triphosphate |
| mitochondrial DNA helicase (p72, Twinkle)variant L381P | Homo sapiens | adenosine 5'-triphosphate | 8.31 | 4.55 | 1.83 | pH 7.8, 37 °C | Open record: mitochondrial DNA helicase (p72, Twinkle) variant L381P, adenosine 5'-triphosphate |
| mitochondrial DNA helicase (p72, Twinkle)variant P335L | Homo sapiens | adenosine 5'-triphosphate | 1.08 | 1.32 | 0.82 | pH 7.8, 37 °C | Open record: mitochondrial DNA helicase (p72, Twinkle) variant P335L, adenosine 5'-triphosphate |
| mitochondrial DNA helicase (p72, Twinkle)variant R303W | Homo sapiens | adenosine 5'-triphosphate | 2.29 | 1.81 | 1.27 | pH 7.8, 37 °C | Open record: mitochondrial DNA helicase (p72, Twinkle) variant R303W, adenosine 5'-triphosphate |
| mitochondrial DNA helicase (p72, Twinkle)variant R334Q | Homo sapiens | adenosine 5'-triphosphate | 1.01 | 1.04 | 0.97 | pH 7.8, 37 °C | Open record: mitochondrial DNA helicase (p72, Twinkle) variant R334Q, adenosine 5'-triphosphate |
| mitochondrial DNA helicase (p72, Twinkle)variant R354P | Homo sapiens | adenosine 5'-triphosphate | 1.18 | 1.03 | 1.15 | pH 7.8, 37 °C | Open record: mitochondrial DNA helicase (p72, Twinkle) variant R354P, adenosine 5'-triphosphate |
| mitochondrial DNA helicase (p72, Twinkle)variant R357P | Homo sapiens | adenosine 5'-triphosphate | 1.52 | 1.24 | 1.23 | pH 7.8, 37 °C | Open record: mitochondrial DNA helicase (p72, Twinkle) variant R357P, adenosine 5'-triphosphate |
| mitochondrial DNA helicase (p72, Twinkle)variant R374Q | Homo sapiens | adenosine 5'-triphosphate | 2.17 | 2.48 | 0.88 | pH 7.8, 37 °C | Open record: mitochondrial DNA helicase (p72, Twinkle) variant R374Q, adenosine 5'-triphosphate |
| mitochondrial DNA helicase (p72, Twinkle)variant S369P | Homo sapiens | adenosine 5'-triphosphate | 2.09 | 1.89 | 1.11 | pH 7.8, 37 °C | Open record: mitochondrial DNA helicase (p72, Twinkle) variant S369P, adenosine 5'-triphosphate |
| mitochondrial DNA helicase (p72, Twinkle)variant S369Y | Homo sapiens | adenosine 5'-triphosphate | 1.94 | 1.17 | 1.67 | pH 7.8, 37 °C | Open record: mitochondrial DNA helicase (p72, Twinkle) variant S369Y, adenosine 5'-triphosphate |
| mitochondrial DNA helicase (p72, Twinkle)variant T457I | Homo sapiens | adenosine 5'-triphosphate | 0.88 | 1.08 | 0.81 | pH 7.8, 37 °C | Open record: mitochondrial DNA helicase (p72, Twinkle) variant T457I, adenosine 5'-triphosphate |
| mitochondrial DNA helicase (p72, Twinkle)variant W315L | Homo sapiens | adenosine 5'-triphosphate | 1.13 | 1 | 1.13 | pH 7.8, 37 °C | Open record: mitochondrial DNA helicase (p72, Twinkle) variant W315L, adenosine 5'-triphosphate |
| mitochondrial DNA helicase (p72, Twinkle)variant W474C | Homo sapiens | adenosine 5'-triphosphate | 0.7 | 1.1 | 0.64 | pH 7.8, 37 °C | Open record: mitochondrial DNA helicase (p72, Twinkle) variant W474C, adenosine 5'-triphosphate |
| mitochondrial DNA helicase (p72, Twinkle)variant Y508C | Homo sapiens | adenosine 5'-triphosphate | 2.04 | 1.96 | 1.04 | pH 7.8, 37 °C | Open record: mitochondrial DNA helicase (p72, Twinkle) variant Y508C, adenosine 5'-triphosphate |