EC 5.6.2.3: DNA 5'-3' helicase
IsomerasesOpen in Browse
CatLog read 51 records for EC 5.6.2.3 from 2 papers, for 2 organisms. Names in these papers: mitochondrial DNA helicase (p72, Twinkle), apicoplast DNA polymerase (apPOL, 3'-5' exonuclease), apicoplast DNA polymerase (apPOLexo-, exonuclease-deficient).
Read from the paper by an AI model and checked against the paper by a second, separate AI run; code converted the units.
CatLog also holds 21 records for EC 5.6.2.3 that are not yet re-read: from its earlier version, built from the enzyme databases and partly checked against the papers. All records for EC 5.6.2.3 in Browse.
Papers
| Paper | Organisms | Records |
|---|---|---|
| Fidelity, mismatch extension, and proofreading activity of the Plasmodium falciparum apicoplast DNA polymerase | Plasmodium falciparum | 29 |
| Disease variants of the human mitochondrial DNA helicase encoded by C10orf2 differentially alter protein stability, nucleotide hydrolysis, and helicase activity | Homo sapiens | 22 |
Records
| Enzyme | Organism | Substrate | kcat (s⁻¹) | Km (mM) | kcat/Km (mM⁻¹ s⁻¹) | Conditions | Paper | Open record |
|---|---|---|---|---|---|---|---|---|
| apicoplast DNA polymerase (apPOL, 3'-5' exonuclease) | Plasmodium falciparum | A:A primer:template DNA (3'-terminal primer base : template base) | 0.14 | — | — | PMID 24147857 | Open record: apicoplast DNA polymerase (apPOL, 3'-5' exonuclease), A:A primer:template DNA (3'-terminal primer base : template base) | |
| apicoplast DNA polymerase (apPOL, 3'-5' exonuclease) | Plasmodium falciparum | A:C primer:template DNA (3'-terminal primer base : template base) | 0.36 | — | — | PMID 24147857 | Open record: apicoplast DNA polymerase (apPOL, 3'-5' exonuclease), A:C primer:template DNA (3'-terminal primer base : template base) | |
| apicoplast DNA polymerase (apPOL, 3'-5' exonuclease) | Plasmodium falciparum | A:G primer:template DNA (3'-terminal primer base : template base) | 0.15 | — | — | PMID 24147857 | Open record: apicoplast DNA polymerase (apPOL, 3'-5' exonuclease), A:G primer:template DNA (3'-terminal primer base : template base) | |
| apicoplast DNA polymerase (apPOL, 3'-5' exonuclease) | Plasmodium falciparum | A:T primer:template DNA (3'-terminal primer base : template base) | 0.07 | — | — | PMID 24147857 | Open record: apicoplast DNA polymerase (apPOL, 3'-5' exonuclease), A:T primer:template DNA (3'-terminal primer base : template base) | |
| apicoplast DNA polymerase (apPOL, 3'-5' exonuclease) | Plasmodium falciparum | C:A primer:template DNA (3'-terminal primer base : template base) | 0.26 | — | — | PMID 24147857 | Open record: apicoplast DNA polymerase (apPOL, 3'-5' exonuclease), C:A primer:template DNA (3'-terminal primer base : template base) | |
| apicoplast DNA polymerase (apPOL, 3'-5' exonuclease) | Plasmodium falciparum | C:C primer:template DNA (3'-terminal primer base : template base) | 0.41 | — | — | PMID 24147857 | Open record: apicoplast DNA polymerase (apPOL, 3'-5' exonuclease), C:C primer:template DNA (3'-terminal primer base : template base) | |
| apicoplast DNA polymerase (apPOL, 3'-5' exonuclease) | Plasmodium falciparum | C:G primer:template DNA (3'-terminal primer base : template base) | 0.03 | — | — | PMID 24147857 | Open record: apicoplast DNA polymerase (apPOL, 3'-5' exonuclease), C:G primer:template DNA (3'-terminal primer base : template base) | |
| apicoplast DNA polymerase (apPOL, 3'-5' exonuclease) | Plasmodium falciparum | C:T primer:template DNA (3'-terminal primer base : template base) | 0.28 | — | — | PMID 24147857 | Open record: apicoplast DNA polymerase (apPOL, 3'-5' exonuclease), C:T primer:template DNA (3'-terminal primer base : template base) | |
| apicoplast DNA polymerase (apPOL, 3'-5' exonuclease) | Plasmodium falciparum | G:A primer:template DNA (3'-terminal primer base : template base) | 0.27 | — | — | PMID 24147857 | Open record: apicoplast DNA polymerase (apPOL, 3'-5' exonuclease), G:A primer:template DNA (3'-terminal primer base : template base) | |
| apicoplast DNA polymerase (apPOL, 3'-5' exonuclease) | Plasmodium falciparum | G:C primer:template DNA (3'-terminal primer base : template base) | 0.06 | — | — | PMID 24147857 | Open record: apicoplast DNA polymerase (apPOL, 3'-5' exonuclease), G:C primer:template DNA (3'-terminal primer base : template base) | |
| apicoplast DNA polymerase (apPOL, 3'-5' exonuclease) | Plasmodium falciparum | G:G primer:template DNA (3'-terminal primer base : template base) | 0.37 | — | — | PMID 24147857 | Open record: apicoplast DNA polymerase (apPOL, 3'-5' exonuclease), G:G primer:template DNA (3'-terminal primer base : template base) | |
| apicoplast DNA polymerase (apPOL, 3'-5' exonuclease) | Plasmodium falciparum | G:T primer:template DNA (3'-terminal primer base : template base) | 0.32 | — | — | PMID 24147857 | Open record: apicoplast DNA polymerase (apPOL, 3'-5' exonuclease), G:T primer:template DNA (3'-terminal primer base : template base) | |
| apicoplast DNA polymerase (apPOL, 3'-5' exonuclease) | Plasmodium falciparum | T:A primer:template DNA (3'-terminal primer base : template base) | 0.06 | — | — | PMID 24147857 | Open record: apicoplast DNA polymerase (apPOL, 3'-5' exonuclease), T:A primer:template DNA (3'-terminal primer base : template base) | |
| apicoplast DNA polymerase (apPOL, 3'-5' exonuclease) | Plasmodium falciparum | T:C primer:template DNA (3'-terminal primer base : template base) | 0.37 | — | — | PMID 24147857 | Open record: apicoplast DNA polymerase (apPOL, 3'-5' exonuclease), T:C primer:template DNA (3'-terminal primer base : template base) | |
| apicoplast DNA polymerase (apPOL, 3'-5' exonuclease) | Plasmodium falciparum | T:G primer:template DNA (3'-terminal primer base : template base) | 0.3 | — | — | PMID 24147857 | Open record: apicoplast DNA polymerase (apPOL, 3'-5' exonuclease), T:G primer:template DNA (3'-terminal primer base : template base) | |
| apicoplast DNA polymerase (apPOL, 3'-5' exonuclease) | Plasmodium falciparum | T:T primer:template DNA (3'-terminal primer base : template base) | 0.29 | — | — | PMID 24147857 | Open record: apicoplast DNA polymerase (apPOL, 3'-5' exonuclease), T:T primer:template DNA (3'-terminal primer base : template base) | |
| apicoplast DNA polymerase (apPOLexo-, exonuclease-deficient)variant D1470N/E1472Q (apPOLexo-) | Plasmodium falciparum | 2'-deoxyadenosine 5'-triphosphate80 or 200 nM apPOLexo⁻ | 0.0026 | 0.148 | 0.0176 | 25 °C | PMID 24147857 | Open record: apicoplast DNA polymerase (apPOLexo-, exonuclease-deficient) variant D1470N/E1472Q (apPOLexo-), 2'-deoxyadenosine 5'-triphosphate |
| apicoplast DNA polymerase (apPOLexo-, exonuclease-deficient)variant D1470N/E1472Q (apPOLexo-) | Plasmodium falciparum | 2'-deoxyadenosine 5'-triphosphate8 nM apPOLexo⁻ | 0.34 | 0.0017 | 200 | 25 °C | PMID 24147857 | Open record: apicoplast DNA polymerase (apPOLexo-, exonuclease-deficient) variant D1470N/E1472Q (apPOLexo-), 2'-deoxyadenosine 5'-triphosphate |
| apicoplast DNA polymerase (apPOLexo-, exonuclease-deficient)variant D1470N/E1472Q (apPOLexo-) | Plasmodium falciparum | 2'-deoxyadenosine 5'-triphosphate80 or 200 nM apPOLexo⁻ | 0.0033 | 0.903 | 0.00365 | 25 °C | PMID 24147857 | Open record: apicoplast DNA polymerase (apPOLexo-, exonuclease-deficient) variant D1470N/E1472Q (apPOLexo-), 2'-deoxyadenosine 5'-triphosphate |
| apicoplast DNA polymerase (apPOLexo-, exonuclease-deficient)variant D1470N/E1472Q (apPOLexo-) | Plasmodium falciparum | 2'-deoxyadenosine 5'-triphosphate80 or 200 nM apPOLexo⁻ | 0.0061 | 0.241 | 0.0253 | 25 °C | PMID 24147857 | Open record: apicoplast DNA polymerase (apPOLexo-, exonuclease-deficient) variant D1470N/E1472Q (apPOLexo-), 2'-deoxyadenosine 5'-triphosphate |
| apicoplast DNA polymerase (apPOLexo-, exonuclease-deficient)variant D1470N/E1472Q (apPOLexo-) | Plasmodium falciparum | 2'-deoxycytidine 5'-triphosphate80 or 200 nM apPOLexo⁻ | 0.0013 | 0.345 | 0.00377 | 25 °C | PMID 24147857 | Open record: apicoplast DNA polymerase (apPOLexo-, exonuclease-deficient) variant D1470N/E1472Q (apPOLexo-), 2'-deoxycytidine 5'-triphosphate |
| apicoplast DNA polymerase (apPOLexo-, exonuclease-deficient)variant D1470N/E1472Q (apPOLexo-) | Plasmodium falciparum | 2'-deoxycytidine 5'-triphosphate8 nM apPOLexo⁻ | 0.24 | 0.0073 | 33 | 25 °C | PMID 24147857 | Open record: apicoplast DNA polymerase (apPOLexo-, exonuclease-deficient) variant D1470N/E1472Q (apPOLexo-), 2'-deoxycytidine 5'-triphosphate |
| apicoplast DNA polymerase (apPOLexo-, exonuclease-deficient)variant D1470N/E1472Q (apPOLexo-) | Plasmodium falciparum | 2'-deoxyguanosine 5'-triphosphate80 or 200 nM apPOLexo⁻ | 0.0012 | 0.262 | 0.00458 | 25 °C | PMID 24147857 | Open record: apicoplast DNA polymerase (apPOLexo-, exonuclease-deficient) variant D1470N/E1472Q (apPOLexo-), 2'-deoxyguanosine 5'-triphosphate |
| apicoplast DNA polymerase (apPOLexo-, exonuclease-deficient)variant D1470N/E1472Q (apPOLexo-) | Plasmodium falciparum | 2'-deoxyguanosine 5'-triphosphate80 or 200 nM apPOLexo⁻ | 0.0034 | 0.073 | 0.0466 | 25 °C | PMID 24147857 | Open record: apicoplast DNA polymerase (apPOLexo-, exonuclease-deficient) variant D1470N/E1472Q (apPOLexo-), 2'-deoxyguanosine 5'-triphosphate |
| apicoplast DNA polymerase (apPOLexo-, exonuclease-deficient)variant D1470N/E1472Q (apPOLexo-) | Plasmodium falciparum | 2'-deoxyguanosine 5'-triphosphate80 or 200 nM apPOLexo⁻ | 6 × 10⁻⁴ | 0.562 | 0.00107 | 25 °C | PMID 24147857 | Open record: apicoplast DNA polymerase (apPOLexo-, exonuclease-deficient) variant D1470N/E1472Q (apPOLexo-), 2'-deoxyguanosine 5'-triphosphate |
| apicoplast DNA polymerase (apPOLexo-, exonuclease-deficient)variant D1470N/E1472Q (apPOLexo-) | Plasmodium falciparum | 2'-deoxyguanosine 5'-triphosphate8 nM apPOLexo⁻ | 0.33 | 7 × 10⁻⁴ | 470 | 25 °C | PMID 24147857 | Open record: apicoplast DNA polymerase (apPOLexo-, exonuclease-deficient) variant D1470N/E1472Q (apPOLexo-), 2'-deoxyguanosine 5'-triphosphate |
| apicoplast DNA polymerase (apPOLexo-, exonuclease-deficient)variant D1470N/E1472Q (apPOLexo-) | Plasmodium falciparum | 2'-deoxythymidine 5'-triphosphate8 nM apPOLexo⁻ | 0.33 | 0.0051 | 65 | 25 °C | PMID 24147857 | Open record: apicoplast DNA polymerase (apPOLexo-, exonuclease-deficient) variant D1470N/E1472Q (apPOLexo-), 2'-deoxythymidine 5'-triphosphate |
| apicoplast DNA polymerase (apPOLexo-, exonuclease-deficient)variant D1470N/E1472Q (apPOLexo-) | Plasmodium falciparum | 2'-deoxythymidine 5'-triphosphate80 or 200 nM apPOLexo⁻ | 0.0018 | 0.142 | 0.0127 | 25 °C | PMID 24147857 | Open record: apicoplast DNA polymerase (apPOLexo-, exonuclease-deficient) variant D1470N/E1472Q (apPOLexo-), 2'-deoxythymidine 5'-triphosphate |
| apicoplast DNA polymerase (apPOLexo-, exonuclease-deficient)variant D1470N/E1472Q (apPOLexo-) | Plasmodium falciparum | 2'-deoxythymidine 5'-triphosphate80 or 200 nM apPOLexo⁻ | 8 × 10⁻⁴ | 0.159 | 0.00503 | 25 °C | PMID 24147857 | Open record: apicoplast DNA polymerase (apPOLexo-, exonuclease-deficient) variant D1470N/E1472Q (apPOLexo-), 2'-deoxythymidine 5'-triphosphate |
| mitochondrial DNA helicase (p72, Twinkle) | Homo sapiens | adenosine 5'-triphosphateno affinity tag | 2.18 | 1.43 | 1.53 | pH 7.8, 37 °C | PMID 20659899 | Open record: mitochondrial DNA helicase (p72, Twinkle), adenosine 5'-triphosphate |
| mitochondrial DNA helicase (p72, Twinkle) | Homo sapiens | adenosine 5'-triphosphate | 1.9 | 1.22 | 1.55 | pH 7.8, 37 °C | PMID 20659899 | Open record: mitochondrial DNA helicase (p72, Twinkle), adenosine 5'-triphosphate |
| mitochondrial DNA helicase (p72, Twinkle)variant A318T | Homo sapiens | adenosine 5'-triphosphate | 1.19 | 0.84 | 1.42 | pH 7.8, 37 °C | PMID 20659899 | Open record: mitochondrial DNA helicase (p72, Twinkle) variant A318T, adenosine 5'-triphosphate |
| mitochondrial DNA helicase (p72, Twinkle)variant A359T | Homo sapiens | adenosine 5'-triphosphate | 1.06 | 1.3 | 0.81 | pH 7.8, 37 °C | PMID 20659899 | Open record: mitochondrial DNA helicase (p72, Twinkle) variant A359T, adenosine 5'-triphosphate |
| mitochondrial DNA helicase (p72, Twinkle)variant A475P | Homo sapiens | adenosine 5'-triphosphate | 0.66 | 1.22 | 0.54 | pH 7.8, 37 °C | PMID 20659899 | Open record: mitochondrial DNA helicase (p72, Twinkle) variant A475P, adenosine 5'-triphosphate |
| mitochondrial DNA helicase (p72, Twinkle)variant F485L | Homo sapiens | adenosine 5'-triphosphate | 1.15 | 1.44 | 0.8 | pH 7.8, 37 °C | PMID 20659899 | Open record: mitochondrial DNA helicase (p72, Twinkle) variant F485L, adenosine 5'-triphosphate |
| mitochondrial DNA helicase (p72, Twinkle)variant I367T | Homo sapiens | adenosine 5'-triphosphate | 2.89 | 2.23 | 1.3 | pH 7.8, 37 °C | PMID 20659899 | Open record: mitochondrial DNA helicase (p72, Twinkle) variant I367T, adenosine 5'-triphosphate |
| mitochondrial DNA helicase (p72, Twinkle)variant K319E | Homo sapiens | adenosine 5'-triphosphate | 2.24 | 1.82 | 1.23 | pH 7.8, 37 °C | PMID 20659899 | Open record: mitochondrial DNA helicase (p72, Twinkle) variant K319E, adenosine 5'-triphosphate |
| mitochondrial DNA helicase (p72, Twinkle)variant K319T | Homo sapiens | adenosine 5'-triphosphate | 0.98 | 1.02 | 0.96 | pH 7.8, 37 °C | PMID 20659899 | Open record: mitochondrial DNA helicase (p72, Twinkle) variant K319T, adenosine 5'-triphosphate |
| mitochondrial DNA helicase (p72, Twinkle)variant L381P | Homo sapiens | adenosine 5'-triphosphate | 8.31 | 4.55 | 1.83 | pH 7.8, 37 °C | PMID 20659899 | Open record: mitochondrial DNA helicase (p72, Twinkle) variant L381P, adenosine 5'-triphosphate |
| mitochondrial DNA helicase (p72, Twinkle)variant P335L | Homo sapiens | adenosine 5'-triphosphate | 1.08 | 1.32 | 0.82 | pH 7.8, 37 °C | PMID 20659899 | Open record: mitochondrial DNA helicase (p72, Twinkle) variant P335L, adenosine 5'-triphosphate |
| mitochondrial DNA helicase (p72, Twinkle)variant R303W | Homo sapiens | adenosine 5'-triphosphate | 2.29 | 1.81 | 1.27 | pH 7.8, 37 °C | PMID 20659899 | Open record: mitochondrial DNA helicase (p72, Twinkle) variant R303W, adenosine 5'-triphosphate |
| mitochondrial DNA helicase (p72, Twinkle)variant R334Q | Homo sapiens | adenosine 5'-triphosphate | 1.01 | 1.04 | 0.97 | pH 7.8, 37 °C | PMID 20659899 | Open record: mitochondrial DNA helicase (p72, Twinkle) variant R334Q, adenosine 5'-triphosphate |
| mitochondrial DNA helicase (p72, Twinkle)variant R354P | Homo sapiens | adenosine 5'-triphosphate | 1.18 | 1.03 | 1.15 | pH 7.8, 37 °C | PMID 20659899 | Open record: mitochondrial DNA helicase (p72, Twinkle) variant R354P, adenosine 5'-triphosphate |
| mitochondrial DNA helicase (p72, Twinkle)variant R357P | Homo sapiens | adenosine 5'-triphosphate | 1.52 | 1.24 | 1.23 | pH 7.8, 37 °C | PMID 20659899 | Open record: mitochondrial DNA helicase (p72, Twinkle) variant R357P, adenosine 5'-triphosphate |
| mitochondrial DNA helicase (p72, Twinkle)variant R374Q | Homo sapiens | adenosine 5'-triphosphate | 2.17 | 2.48 | 0.88 | pH 7.8, 37 °C | PMID 20659899 | Open record: mitochondrial DNA helicase (p72, Twinkle) variant R374Q, adenosine 5'-triphosphate |
| mitochondrial DNA helicase (p72, Twinkle)variant S369P | Homo sapiens | adenosine 5'-triphosphate | 2.09 | 1.89 | 1.11 | pH 7.8, 37 °C | PMID 20659899 | Open record: mitochondrial DNA helicase (p72, Twinkle) variant S369P, adenosine 5'-triphosphate |
| mitochondrial DNA helicase (p72, Twinkle)variant S369Y | Homo sapiens | adenosine 5'-triphosphate | 1.94 | 1.17 | 1.67 | pH 7.8, 37 °C | PMID 20659899 | Open record: mitochondrial DNA helicase (p72, Twinkle) variant S369Y, adenosine 5'-triphosphate |
| mitochondrial DNA helicase (p72, Twinkle)variant T457I | Homo sapiens | adenosine 5'-triphosphate | 0.88 | 1.08 | 0.81 | pH 7.8, 37 °C | PMID 20659899 | Open record: mitochondrial DNA helicase (p72, Twinkle) variant T457I, adenosine 5'-triphosphate |
| mitochondrial DNA helicase (p72, Twinkle)variant W315L | Homo sapiens | adenosine 5'-triphosphate | 1.13 | 1 | 1.13 | pH 7.8, 37 °C | PMID 20659899 | Open record: mitochondrial DNA helicase (p72, Twinkle) variant W315L, adenosine 5'-triphosphate |
| mitochondrial DNA helicase (p72, Twinkle)variant W474C | Homo sapiens | adenosine 5'-triphosphate | 0.7 | 1.1 | 0.64 | pH 7.8, 37 °C | PMID 20659899 | Open record: mitochondrial DNA helicase (p72, Twinkle) variant W474C, adenosine 5'-triphosphate |
| mitochondrial DNA helicase (p72, Twinkle)variant Y508C | Homo sapiens | adenosine 5'-triphosphate | 2.04 | 1.96 | 1.04 | pH 7.8, 37 °C | PMID 20659899 | Open record: mitochondrial DNA helicase (p72, Twinkle) variant Y508C, adenosine 5'-triphosphate |