Values CatLog read from this paper
Mutational analysis of catecholamine binding in tyrosine hydroxylase
PMID 21235236doi:10.1021/bi101455bOpen in Browse
The paper itself is not on this site: read it at the publisher. This page lists only the values CatLog read from it.
CatLog read 24 records (56 values) from this paper: tyrosine hydroxylase from Homo sapiens.
Read from the paper by an AI model and checked against the paper by a second, separate AI run; code converted the units. Values are in CatLog's units; each record opens in Browse with the line the paper prints and the checks.
| Enzyme | Organism | Substrate | kcat (s⁻¹) | Km (mM) | kcat/Km (mM⁻¹ s⁻¹) | Conditions | Open record |
|---|---|---|---|---|---|---|---|
| tyrosine hydroxylase | Homo sapiens | tetrahydrobiopterinnonphosphorylated TH (not treated with PKA); no dopamine | 0.58 | 0.014 | 45.7 | pH 7.2, 30 °C | Open record: tyrosine hydroxylase, tetrahydrobiopterin |
| tyrosine hydroxylase | Homo sapiens | tetrahydrobiopterinno dopamine; BH4 varied 0-200 μM; Table 2 | 0.47 | 0.0056 | 89.3 | pH 7.2, 30 °C | Open record: tyrosine hydroxylase, tetrahydrobiopterin |
| tyrosine hydroxylase | Homo sapiens | tetrahydrobiopterinphosphorylated TH (phosphorylated by PKA); apparent Km | — | 0.507 | — | pH 7.2, 30 °C | Open record: tyrosine hydroxylase, tetrahydrobiopterin |
| tyrosine hydroxylase | Homo sapiens | tetrahydrobiopterinnonphosphorylated TH; BH4 varied 0-1500 μM; apparent Km | — | 0.356 | — | pH 7.2, 30 °C | Open record: tyrosine hydroxylase, tetrahydrobiopterin |
| tyrosine hydroxylase | Homo sapiens | tetrahydrobiopterinnonphosphorylated TH; BH4 varied 0-1500 μM; apparent kcat | 0.017 | — | — | pH 7.2, 30 °C | Open record: tyrosine hydroxylase, tetrahydrobiopterin |
| tyrosine hydroxylase | Homo sapiens | tetrahydrobiopterinapparent Km; in the text | — | 0.134 | — | pH 7.2, 30 °C | Open record: tyrosine hydroxylase, tetrahydrobiopterin |
| tyrosine hydroxylase | Homo sapiens | tetrahydrobiopterinapparent Km; in the text | — | 0.0068 | — | pH 7.2, 30 °C | Open record: tyrosine hydroxylase, tetrahydrobiopterin |
| tyrosine hydroxylasevariant A297L | Homo sapiens | tetrahydrobiopterinnonphosphorylated TH (not treated with PKA); no dopamine | 0.27 | 0.02 | 13.7 | pH 7.2, 30 °C | Open record: tyrosine hydroxylase variant A297L, tetrahydrobiopterin |
| tyrosine hydroxylasevariant A297L | Homo sapiens | tetrahydrobiopterinno dopamine; BH4 varied 0-200 μM | 0.22 | 0.017 | 12.5 | pH 7.2, 30 °C | Open record: tyrosine hydroxylase variant A297L, tetrahydrobiopterin |
| tyrosine hydroxylasevariant A297L | Homo sapiens | tetrahydrobiopterin | — | 0.027 | — | pH 7.2, 30 °C | Open record: tyrosine hydroxylase variant A297L, tetrahydrobiopterin |
| tyrosine hydroxylasevariant E332D | Homo sapiens | tetrahydrobiopterinnonphosphorylated TH (not treated with PKA); no dopamine | 0.06 | 0.0083 | 7.3 | pH 7.2, 30 °C | Open record: tyrosine hydroxylase variant E332D, tetrahydrobiopterin |
| tyrosine hydroxylasevariant E332D | Homo sapiens | tetrahydrobiopterinno dopamine; BH4 varied 0-200 μM | 0.047 | 0.0072 | 6.5 | pH 7.2, 30 °C | Open record: tyrosine hydroxylase variant E332D, tetrahydrobiopterin |
| tyrosine hydroxylasevariant E332D | Homo sapiens | tetrahydrobiopterin | — | 0.034 | — | pH 7.2, 30 °C | Open record: tyrosine hydroxylase variant E332D, tetrahydrobiopterin |
| tyrosine hydroxylasevariant F300A | Homo sapiens | tetrahydrobiopterinnonphosphorylated TH (not treated with PKA) | 0.088 | 0.054 | 1.7 | pH 7.2, 30 °C | Open record: tyrosine hydroxylase variant F300A, tetrahydrobiopterin |
| tyrosine hydroxylasevariant F300A | Homo sapiens | tetrahydrobiopterin | 0.112 | 0.07 | 1.7 | pH 7.2, 30 °C | Open record: tyrosine hydroxylase variant F300A, tetrahydrobiopterin |
| tyrosine hydroxylasevariant F300Y | Homo sapiens | tetrahydrobiopterinnonphosphorylated TH (not treated with PKA) | 0.3 | 0.026 | 11.2 | pH 7.2, 30 °C | Open record: tyrosine hydroxylase variant F300Y, tetrahydrobiopterin |
| tyrosine hydroxylasevariant F300Y | Homo sapiens | tetrahydrobiopterin | 0.27 | 0.012 | 21.8 | pH 7.2, 30 °C | Open record: tyrosine hydroxylase variant F300Y, tetrahydrobiopterin |
| tyrosine hydroxylasevariant L294A | Homo sapiens | tetrahydrobiopterinnonphosphorylated TH (not treated with PKA) | 0.18 | 0.014 | 13 | pH 7.2, 30 °C | Open record: tyrosine hydroxylase variant L294A, tetrahydrobiopterin |
| tyrosine hydroxylasevariant L294A | Homo sapiens | tetrahydrobiopterin | 0.142 | 0.029 | 5 | pH 7.2, 30 °C | Open record: tyrosine hydroxylase variant L294A, tetrahydrobiopterin |
| tyrosine hydroxylasevariant L294Y | Homo sapiens | tetrahydrobiopterinnonphosphorylated TH (not treated with PKA) | 0.118 | 0.015 | 7.7 | pH 7.2, 30 °C | Open record: tyrosine hydroxylase variant L294Y, tetrahydrobiopterin |
| tyrosine hydroxylasevariant L294Y | Homo sapiens | tetrahydrobiopterin | 0.068 | 0.0099 | 7 | pH 7.2, 30 °C | Open record: tyrosine hydroxylase variant L294Y, tetrahydrobiopterin |
| tyrosine hydroxylasevariant Y371F | Homo sapiens | tetrahydrobiopterinnonphosphorylated TH (not treated with PKA); no dopamine | 0.2 | 0.017 | 11.7 | pH 7.2, 30 °C | Open record: tyrosine hydroxylase variant Y371F, tetrahydrobiopterin |
| tyrosine hydroxylasevariant Y371F | Homo sapiens | tetrahydrobiopterinno dopamine; BH4 varied 0-200 μM | 0.3 | 0.029 | 10.7 | pH 7.2, 30 °C | Open record: tyrosine hydroxylase variant Y371F, tetrahydrobiopterin |
| tyrosine hydroxylasevariant Y371F | Homo sapiens | tetrahydrobiopterin | — | 0.027 | — | pH 7.2, 30 °C | Open record: tyrosine hydroxylase variant Y371F, tetrahydrobiopterin |