Values CatLog read from this paper
Tyr219 of human matrix metalloproteinase 7 is not critical for catalytic activity, but is involved in the broad pH-dependence of the activity
PMID 21593056doi:10.1093/jb/mvr050Open in Browse
The paper itself is not on this site: read it at the publisher. This page lists only the values CatLog read from it.
CatLog read 14 records (26 values) from this paper: matrix metalloproteinase 7 (MMP-7, matrilysin) from Homo sapiens.
Read from the paper by an AI model and checked against the paper by a second, separate AI run; code converted the units. Values are in CatLog's units; each record opens in Browse with the line the paper prints and the checks.
| Enzyme | Organism | Substrate | kcat (s⁻¹) | Km (mM) | kcat/Km (mM⁻¹ s⁻¹) | Conditions | Open record |
|---|---|---|---|---|---|---|---|
| matrix metalloproteinase 7 (MMP-7, matrilysin) | Homo sapiens | (7-methoxycoumarin-4-yl)acetyl-L-Pro-L-Leu-Gly-L-Leu-[N3-(2,4-dinitrophenyl)-L-2,3-diaminopropionyl]-L-Ala-L-Arg-NH2 | — | — | 120 | 25 °C | Open record: matrix metalloproteinase 7 (MMP-7, matrilysin), (7-methoxycoumarin-4-yl)acetyl-L-Pro-L-Leu-Gly-L-Leu-[N3-(2,4-dinitrophenyl)-L-2,3-diaminopropionyl]-L-Ala-L-Arg-NH2 |
| matrix metalloproteinase 7 (MMP-7, matrilysin) | Homo sapiens | (7-methoxycoumarin-4-yl)acetyl-L-Pro-L-Leu-Gly-L-Leu-[N3-(2,4-dinitrophenyl)-L-2,3-diaminopropionyl]-L-Ala-L-Arg-NH2 | 6.43 | 0.0736 | 87 | pH 7.5, 25 °C | Open record: matrix metalloproteinase 7 (MMP-7, matrilysin), (7-methoxycoumarin-4-yl)acetyl-L-Pro-L-Leu-Gly-L-Leu-[N3-(2,4-dinitrophenyl)-L-2,3-diaminopropionyl]-L-Ala-L-Arg-NH2 |
| matrix metalloproteinase 7 (MMP-7, matrilysin)variant Y193F | Homo sapiens | (7-methoxycoumarin-4-yl)acetyl-L-Pro-L-Leu-Gly-L-Leu-[N3-(2,4-dinitrophenyl)-L-2,3-diaminopropionyl]-L-Ala-L-Arg-NH2 | — | — | 53 | 25 °C | Open record: matrix metalloproteinase 7 (MMP-7, matrilysin) variant Y193F, (7-methoxycoumarin-4-yl)acetyl-L-Pro-L-Leu-Gly-L-Leu-[N3-(2,4-dinitrophenyl)-L-2,3-diaminopropionyl]-L-Ala-L-Arg-NH2 |
| matrix metalloproteinase 7 (MMP-7, matrilysin)variant Y216F | Homo sapiens | (7-methoxycoumarin-4-yl)acetyl-L-Pro-L-Leu-Gly-L-Leu-[N3-(2,4-dinitrophenyl)-L-2,3-diaminopropionyl]-L-Ala-L-Arg-NH2 | — | — | 104 | 25 °C | Open record: matrix metalloproteinase 7 (MMP-7, matrilysin) variant Y216F, (7-methoxycoumarin-4-yl)acetyl-L-Pro-L-Leu-Gly-L-Leu-[N3-(2,4-dinitrophenyl)-L-2,3-diaminopropionyl]-L-Ala-L-Arg-NH2 |
| matrix metalloproteinase 7 (MMP-7, matrilysin)variant Y219A | Homo sapiens | (7-methoxycoumarin-4-yl)acetyl-L-Pro-L-Leu-Gly-L-Leu-[N3-(2,4-dinitrophenyl)-L-2,3-diaminopropionyl]-L-Ala-L-Arg-NH2 | — | — | 60 | 25 °C | Open record: matrix metalloproteinase 7 (MMP-7, matrilysin) variant Y219A, (7-methoxycoumarin-4-yl)acetyl-L-Pro-L-Leu-Gly-L-Leu-[N3-(2,4-dinitrophenyl)-L-2,3-diaminopropionyl]-L-Ala-L-Arg-NH2 |
| matrix metalloproteinase 7 (MMP-7, matrilysin)variant Y219A | Homo sapiens | (7-methoxycoumarin-4-yl)acetyl-L-Pro-L-Leu-Gly-L-Leu-[N3-(2,4-dinitrophenyl)-L-2,3-diaminopropionyl]-L-Ala-L-Arg-NH2 | 3.53 | 0.0788 | 45 | pH 7.5, 25 °C | Open record: matrix metalloproteinase 7 (MMP-7, matrilysin) variant Y219A, (7-methoxycoumarin-4-yl)acetyl-L-Pro-L-Leu-Gly-L-Leu-[N3-(2,4-dinitrophenyl)-L-2,3-diaminopropionyl]-L-Ala-L-Arg-NH2 |
| matrix metalloproteinase 7 (MMP-7, matrilysin)variant Y219C | Homo sapiens | (7-methoxycoumarin-4-yl)acetyl-L-Pro-L-Leu-Gly-L-Leu-[N3-(2,4-dinitrophenyl)-L-2,3-diaminopropionyl]-L-Ala-L-Arg-NH2 | — | — | 42 | 25 °C | Open record: matrix metalloproteinase 7 (MMP-7, matrilysin) variant Y219C, (7-methoxycoumarin-4-yl)acetyl-L-Pro-L-Leu-Gly-L-Leu-[N3-(2,4-dinitrophenyl)-L-2,3-diaminopropionyl]-L-Ala-L-Arg-NH2 |
| matrix metalloproteinase 7 (MMP-7, matrilysin)variant Y219C | Homo sapiens | (7-methoxycoumarin-4-yl)acetyl-L-Pro-L-Leu-Gly-L-Leu-[N3-(2,4-dinitrophenyl)-L-2,3-diaminopropionyl]-L-Ala-L-Arg-NH2 | 1.61 | 0.0511 | 32 | pH 7.5, 25 °C | Open record: matrix metalloproteinase 7 (MMP-7, matrilysin) variant Y219C, (7-methoxycoumarin-4-yl)acetyl-L-Pro-L-Leu-Gly-L-Leu-[N3-(2,4-dinitrophenyl)-L-2,3-diaminopropionyl]-L-Ala-L-Arg-NH2 |
| matrix metalloproteinase 7 (MMP-7, matrilysin)variant Y219D | Homo sapiens | (7-methoxycoumarin-4-yl)acetyl-L-Pro-L-Leu-Gly-L-Leu-[N3-(2,4-dinitrophenyl)-L-2,3-diaminopropionyl]-L-Ala-L-Arg-NH2 | — | — | 108 | 25 °C | Open record: matrix metalloproteinase 7 (MMP-7, matrilysin) variant Y219D, (7-methoxycoumarin-4-yl)acetyl-L-Pro-L-Leu-Gly-L-Leu-[N3-(2,4-dinitrophenyl)-L-2,3-diaminopropionyl]-L-Ala-L-Arg-NH2 |
| matrix metalloproteinase 7 (MMP-7, matrilysin)variant Y219D | Homo sapiens | (7-methoxycoumarin-4-yl)acetyl-L-Pro-L-Leu-Gly-L-Leu-[N3-(2,4-dinitrophenyl)-L-2,3-diaminopropionyl]-L-Ala-L-Arg-NH2 | 6.35 | 0.0865 | 74 | pH 7.5, 25 °C | Open record: matrix metalloproteinase 7 (MMP-7, matrilysin) variant Y219D, (7-methoxycoumarin-4-yl)acetyl-L-Pro-L-Leu-Gly-L-Leu-[N3-(2,4-dinitrophenyl)-L-2,3-diaminopropionyl]-L-Ala-L-Arg-NH2 |
| matrix metalloproteinase 7 (MMP-7, matrilysin)variant Y219F | Homo sapiens | (7-methoxycoumarin-4-yl)acetyl-L-Pro-L-Leu-Gly-L-Leu-[N3-(2,4-dinitrophenyl)-L-2,3-diaminopropionyl]-L-Ala-L-Arg-NH2 | — | — | 119 | 25 °C | Open record: matrix metalloproteinase 7 (MMP-7, matrilysin) variant Y219F, (7-methoxycoumarin-4-yl)acetyl-L-Pro-L-Leu-Gly-L-Leu-[N3-(2,4-dinitrophenyl)-L-2,3-diaminopropionyl]-L-Ala-L-Arg-NH2 |
| matrix metalloproteinase 7 (MMP-7, matrilysin)variant Y219F | Homo sapiens | (7-methoxycoumarin-4-yl)acetyl-L-Pro-L-Leu-Gly-L-Leu-[N3-(2,4-dinitrophenyl)-L-2,3-diaminopropionyl]-L-Ala-L-Arg-NH2 | 6.18 | 0.0732 | 84 | pH 7.5, 25 °C | Open record: matrix metalloproteinase 7 (MMP-7, matrilysin) variant Y219F, (7-methoxycoumarin-4-yl)acetyl-L-Pro-L-Leu-Gly-L-Leu-[N3-(2,4-dinitrophenyl)-L-2,3-diaminopropionyl]-L-Ala-L-Arg-NH2 |
| matrix metalloproteinase 7 (MMP-7, matrilysin)variant Y219S | Homo sapiens | (7-methoxycoumarin-4-yl)acetyl-L-Pro-L-Leu-Gly-L-Leu-[N3-(2,4-dinitrophenyl)-L-2,3-diaminopropionyl]-L-Ala-L-Arg-NH2 | — | — | 29 | 25 °C | Open record: matrix metalloproteinase 7 (MMP-7, matrilysin) variant Y219S, (7-methoxycoumarin-4-yl)acetyl-L-Pro-L-Leu-Gly-L-Leu-[N3-(2,4-dinitrophenyl)-L-2,3-diaminopropionyl]-L-Ala-L-Arg-NH2 |
| matrix metalloproteinase 7 (MMP-7, matrilysin)variant Y219S | Homo sapiens | (7-methoxycoumarin-4-yl)acetyl-L-Pro-L-Leu-Gly-L-Leu-[N3-(2,4-dinitrophenyl)-L-2,3-diaminopropionyl]-L-Ala-L-Arg-NH2 | 5.41 | 0.211 | 26 | pH 7.5, 25 °C | Open record: matrix metalloproteinase 7 (MMP-7, matrilysin) variant Y219S, (7-methoxycoumarin-4-yl)acetyl-L-Pro-L-Leu-Gly-L-Leu-[N3-(2,4-dinitrophenyl)-L-2,3-diaminopropionyl]-L-Ala-L-Arg-NH2 |