EC 3.4.24.23: matrilysin
HydrolasesOpen in Browse
CatLog read 36 records for EC 3.4.24.23 from 3 papers, for 1 organism. Names in these papers: MMP-7, matrix metalloproteinase 7 (MMP-7, matrilysin), matrilysin (MMP-7).
Read from the paper by an AI model and checked against the paper by a second, separate AI run; code converted the units.
CatLog also holds 3 records for EC 3.4.24.23 that are not yet re-read: from its earlier version, built from the enzyme databases and partly checked against the papers. All records for EC 3.4.24.23 in Browse.
Papers
| Paper | Organisms | Records |
|---|---|---|
| New insights into the substrate specificity of macrophage elastase MMP-12 | Homo sapiens | 17 |
| Tyr219 of human matrix metalloproteinase 7 is not critical for catalytic activity, but is involved in the broad pH-dependence of the activity | Homo sapiens | 14 |
| Site-directed mutagenesis of the active site glutamate in human matrilysin: investigation of its role in catalysis | Homo sapiens | 5 |
Records
| Enzyme | Organism | Substrate | kcat (s⁻¹) | Km (mM) | kcat/Km (mM⁻¹ s⁻¹) | Conditions | Paper | Open record |
|---|---|---|---|---|---|---|---|---|
| matrilysin (MMP-7) | Homo sapiens | 5-(dimethylamino)naphthalene-1-sulfonyl-Pro-Leu-Ala-Leu-Trp-Ala-Arg | 2.7 | 0.024 | 120 | pH 7.5, 25 °C | PMID 9398337 | Open record: matrilysin (MMP-7), 5-(dimethylamino)naphthalene-1-sulfonyl-Pro-Leu-Ala-Leu-Trp-Ala-Arg |
| matrilysin (MMP-7)variant E198A | Homo sapiens | 5-(dimethylamino)naphthalene-1-sulfonyl-Pro-Leu-Ala-Leu-Trp-Ala-Arg | 5.1 × 10⁻⁴ | 0.0079 | 0.065 | pH 7.5, 25 °C | PMID 9398337 | Open record: matrilysin (MMP-7) variant E198A, 5-(dimethylamino)naphthalene-1-sulfonyl-Pro-Leu-Ala-Leu-Trp-Ala-Arg |
| matrilysin (MMP-7)variant E198C | Homo sapiens | 5-(dimethylamino)naphthalene-1-sulfonyl-Pro-Leu-Ala-Leu-Trp-Ala-Arg | 0.014 | 0.018 | 0.77 | pH 7.5, 25 °C | PMID 9398337 | Open record: matrilysin (MMP-7) variant E198C, 5-(dimethylamino)naphthalene-1-sulfonyl-Pro-Leu-Ala-Leu-Trp-Ala-Arg |
| matrilysin (MMP-7)variant E198D | Homo sapiens | 5-(dimethylamino)naphthalene-1-sulfonyl-Pro-Leu-Ala-Leu-Trp-Ala-Arg | 0.61 | 0.021 | 29 | pH 7.5, 25 °C | PMID 9398337 | Open record: matrilysin (MMP-7) variant E198D, 5-(dimethylamino)naphthalene-1-sulfonyl-Pro-Leu-Ala-Leu-Trp-Ala-Arg |
| matrilysin (MMP-7)variant E198Q | Homo sapiens | 5-(dimethylamino)naphthalene-1-sulfonyl-Pro-Leu-Ala-Leu-Trp-Ala-Arg | 0.0036 | 0.018 | 0.2 | pH 7.5, 25 °C | PMID 9398337 | Open record: matrilysin (MMP-7) variant E198Q, 5-(dimethylamino)naphthalene-1-sulfonyl-Pro-Leu-Ala-Leu-Trp-Ala-Arg |
| matrix metalloproteinase 7 (MMP-7, matrilysin) | Homo sapiens | (7-methoxycoumarin-4-yl)acetyl-L-Pro-L-Leu-Gly-L-Leu-[N3-(2,4-dinitrophenyl)-L-2,3-diaminopropionyl]-L-Ala-L-Arg-NH2 | — | — | 120 | 25 °C | PMID 21593056 | Open record: matrix metalloproteinase 7 (MMP-7, matrilysin), (7-methoxycoumarin-4-yl)acetyl-L-Pro-L-Leu-Gly-L-Leu-[N3-(2,4-dinitrophenyl)-L-2,3-diaminopropionyl]-L-Ala-L-Arg-NH2 |
| matrix metalloproteinase 7 (MMP-7, matrilysin) | Homo sapiens | (7-methoxycoumarin-4-yl)acetyl-L-Pro-L-Leu-Gly-L-Leu-[N3-(2,4-dinitrophenyl)-L-2,3-diaminopropionyl]-L-Ala-L-Arg-NH2 | 6.43 | 0.0736 | 87 | pH 7.5, 25 °C | PMID 21593056 | Open record: matrix metalloproteinase 7 (MMP-7, matrilysin), (7-methoxycoumarin-4-yl)acetyl-L-Pro-L-Leu-Gly-L-Leu-[N3-(2,4-dinitrophenyl)-L-2,3-diaminopropionyl]-L-Ala-L-Arg-NH2 |
| matrix metalloproteinase 7 (MMP-7, matrilysin)variant Y193F | Homo sapiens | (7-methoxycoumarin-4-yl)acetyl-L-Pro-L-Leu-Gly-L-Leu-[N3-(2,4-dinitrophenyl)-L-2,3-diaminopropionyl]-L-Ala-L-Arg-NH2 | — | — | 53 | 25 °C | PMID 21593056 | Open record: matrix metalloproteinase 7 (MMP-7, matrilysin) variant Y193F, (7-methoxycoumarin-4-yl)acetyl-L-Pro-L-Leu-Gly-L-Leu-[N3-(2,4-dinitrophenyl)-L-2,3-diaminopropionyl]-L-Ala-L-Arg-NH2 |
| matrix metalloproteinase 7 (MMP-7, matrilysin)variant Y216F | Homo sapiens | (7-methoxycoumarin-4-yl)acetyl-L-Pro-L-Leu-Gly-L-Leu-[N3-(2,4-dinitrophenyl)-L-2,3-diaminopropionyl]-L-Ala-L-Arg-NH2 | — | — | 104 | 25 °C | PMID 21593056 | Open record: matrix metalloproteinase 7 (MMP-7, matrilysin) variant Y216F, (7-methoxycoumarin-4-yl)acetyl-L-Pro-L-Leu-Gly-L-Leu-[N3-(2,4-dinitrophenyl)-L-2,3-diaminopropionyl]-L-Ala-L-Arg-NH2 |
| matrix metalloproteinase 7 (MMP-7, matrilysin)variant Y219A | Homo sapiens | (7-methoxycoumarin-4-yl)acetyl-L-Pro-L-Leu-Gly-L-Leu-[N3-(2,4-dinitrophenyl)-L-2,3-diaminopropionyl]-L-Ala-L-Arg-NH2 | — | — | 60 | 25 °C | PMID 21593056 | Open record: matrix metalloproteinase 7 (MMP-7, matrilysin) variant Y219A, (7-methoxycoumarin-4-yl)acetyl-L-Pro-L-Leu-Gly-L-Leu-[N3-(2,4-dinitrophenyl)-L-2,3-diaminopropionyl]-L-Ala-L-Arg-NH2 |
| matrix metalloproteinase 7 (MMP-7, matrilysin)variant Y219A | Homo sapiens | (7-methoxycoumarin-4-yl)acetyl-L-Pro-L-Leu-Gly-L-Leu-[N3-(2,4-dinitrophenyl)-L-2,3-diaminopropionyl]-L-Ala-L-Arg-NH2 | 3.53 | 0.0788 | 45 | pH 7.5, 25 °C | PMID 21593056 | Open record: matrix metalloproteinase 7 (MMP-7, matrilysin) variant Y219A, (7-methoxycoumarin-4-yl)acetyl-L-Pro-L-Leu-Gly-L-Leu-[N3-(2,4-dinitrophenyl)-L-2,3-diaminopropionyl]-L-Ala-L-Arg-NH2 |
| matrix metalloproteinase 7 (MMP-7, matrilysin)variant Y219C | Homo sapiens | (7-methoxycoumarin-4-yl)acetyl-L-Pro-L-Leu-Gly-L-Leu-[N3-(2,4-dinitrophenyl)-L-2,3-diaminopropionyl]-L-Ala-L-Arg-NH2 | — | — | 42 | 25 °C | PMID 21593056 | Open record: matrix metalloproteinase 7 (MMP-7, matrilysin) variant Y219C, (7-methoxycoumarin-4-yl)acetyl-L-Pro-L-Leu-Gly-L-Leu-[N3-(2,4-dinitrophenyl)-L-2,3-diaminopropionyl]-L-Ala-L-Arg-NH2 |
| matrix metalloproteinase 7 (MMP-7, matrilysin)variant Y219C | Homo sapiens | (7-methoxycoumarin-4-yl)acetyl-L-Pro-L-Leu-Gly-L-Leu-[N3-(2,4-dinitrophenyl)-L-2,3-diaminopropionyl]-L-Ala-L-Arg-NH2 | 1.61 | 0.0511 | 32 | pH 7.5, 25 °C | PMID 21593056 | Open record: matrix metalloproteinase 7 (MMP-7, matrilysin) variant Y219C, (7-methoxycoumarin-4-yl)acetyl-L-Pro-L-Leu-Gly-L-Leu-[N3-(2,4-dinitrophenyl)-L-2,3-diaminopropionyl]-L-Ala-L-Arg-NH2 |
| matrix metalloproteinase 7 (MMP-7, matrilysin)variant Y219D | Homo sapiens | (7-methoxycoumarin-4-yl)acetyl-L-Pro-L-Leu-Gly-L-Leu-[N3-(2,4-dinitrophenyl)-L-2,3-diaminopropionyl]-L-Ala-L-Arg-NH2 | — | — | 108 | 25 °C | PMID 21593056 | Open record: matrix metalloproteinase 7 (MMP-7, matrilysin) variant Y219D, (7-methoxycoumarin-4-yl)acetyl-L-Pro-L-Leu-Gly-L-Leu-[N3-(2,4-dinitrophenyl)-L-2,3-diaminopropionyl]-L-Ala-L-Arg-NH2 |
| matrix metalloproteinase 7 (MMP-7, matrilysin)variant Y219D | Homo sapiens | (7-methoxycoumarin-4-yl)acetyl-L-Pro-L-Leu-Gly-L-Leu-[N3-(2,4-dinitrophenyl)-L-2,3-diaminopropionyl]-L-Ala-L-Arg-NH2 | 6.35 | 0.0865 | 74 | pH 7.5, 25 °C | PMID 21593056 | Open record: matrix metalloproteinase 7 (MMP-7, matrilysin) variant Y219D, (7-methoxycoumarin-4-yl)acetyl-L-Pro-L-Leu-Gly-L-Leu-[N3-(2,4-dinitrophenyl)-L-2,3-diaminopropionyl]-L-Ala-L-Arg-NH2 |
| matrix metalloproteinase 7 (MMP-7, matrilysin)variant Y219F | Homo sapiens | (7-methoxycoumarin-4-yl)acetyl-L-Pro-L-Leu-Gly-L-Leu-[N3-(2,4-dinitrophenyl)-L-2,3-diaminopropionyl]-L-Ala-L-Arg-NH2 | — | — | 119 | 25 °C | PMID 21593056 | Open record: matrix metalloproteinase 7 (MMP-7, matrilysin) variant Y219F, (7-methoxycoumarin-4-yl)acetyl-L-Pro-L-Leu-Gly-L-Leu-[N3-(2,4-dinitrophenyl)-L-2,3-diaminopropionyl]-L-Ala-L-Arg-NH2 |
| matrix metalloproteinase 7 (MMP-7, matrilysin)variant Y219F | Homo sapiens | (7-methoxycoumarin-4-yl)acetyl-L-Pro-L-Leu-Gly-L-Leu-[N3-(2,4-dinitrophenyl)-L-2,3-diaminopropionyl]-L-Ala-L-Arg-NH2 | 6.18 | 0.0732 | 84 | pH 7.5, 25 °C | PMID 21593056 | Open record: matrix metalloproteinase 7 (MMP-7, matrilysin) variant Y219F, (7-methoxycoumarin-4-yl)acetyl-L-Pro-L-Leu-Gly-L-Leu-[N3-(2,4-dinitrophenyl)-L-2,3-diaminopropionyl]-L-Ala-L-Arg-NH2 |
| matrix metalloproteinase 7 (MMP-7, matrilysin)variant Y219S | Homo sapiens | (7-methoxycoumarin-4-yl)acetyl-L-Pro-L-Leu-Gly-L-Leu-[N3-(2,4-dinitrophenyl)-L-2,3-diaminopropionyl]-L-Ala-L-Arg-NH2 | — | — | 29 | 25 °C | PMID 21593056 | Open record: matrix metalloproteinase 7 (MMP-7, matrilysin) variant Y219S, (7-methoxycoumarin-4-yl)acetyl-L-Pro-L-Leu-Gly-L-Leu-[N3-(2,4-dinitrophenyl)-L-2,3-diaminopropionyl]-L-Ala-L-Arg-NH2 |
| matrix metalloproteinase 7 (MMP-7, matrilysin)variant Y219S | Homo sapiens | (7-methoxycoumarin-4-yl)acetyl-L-Pro-L-Leu-Gly-L-Leu-[N3-(2,4-dinitrophenyl)-L-2,3-diaminopropionyl]-L-Ala-L-Arg-NH2 | 5.41 | 0.211 | 26 | pH 7.5, 25 °C | PMID 21593056 | Open record: matrix metalloproteinase 7 (MMP-7, matrilysin) variant Y219S, (7-methoxycoumarin-4-yl)acetyl-L-Pro-L-Leu-Gly-L-Leu-[N3-(2,4-dinitrophenyl)-L-2,3-diaminopropionyl]-L-Ala-L-Arg-NH2 |
| MMP-7 | Homo sapiens | 2-aminobenzoyl-Ala-Ser-Val-Ala-Thr-Glu-Leu-Arg-Ala-Gln-N-(2,4-dinitrophenyl)ethylenediamine | — | — | 33 | pH 7.5, 30 °C | PMID 26760307 | Open record: MMP-7, 2-aminobenzoyl-Ala-Ser-Val-Ala-Thr-Glu-Leu-Arg-Ala-Gln-N-(2,4-dinitrophenyl)ethylenediamine |
| MMP-7 | Homo sapiens | 2-aminobenzoyl-Arg-Pro-Leu-Ala-Leu-Arg-Arg-Ser-Gln-N-(2,4-dinitrophenyl)ethylenediamine | — | — | 395 | pH 7.5, 30 °C | PMID 26760307 | Open record: MMP-7, 2-aminobenzoyl-Arg-Pro-Leu-Ala-Leu-Arg-Arg-Ser-Gln-N-(2,4-dinitrophenyl)ethylenediamine |
| MMP-7 | Homo sapiens | 2-aminobenzoyl-Arg-Pro-Leu-Ala-Leu-Glu-Glu-Ser-Gln-N-(2,4-dinitrophenyl)ethylenediamine | — | — | 119 | pH 7.5, 30 °C | PMID 26760307 | Open record: MMP-7, 2-aminobenzoyl-Arg-Pro-Leu-Ala-Leu-Glu-Glu-Ser-Gln-N-(2,4-dinitrophenyl)ethylenediamine |
| MMP-7 | Homo sapiens | 2-aminobenzoyl-Arg-Pro-Leu-Ala-Leu-Trp-Arg-Ser-Gln-N-(2,4-dinitrophenyl)ethylenediamine | — | — | 151 | pH 7.5, 30 °C | PMID 26760307 | Open record: MMP-7, 2-aminobenzoyl-Arg-Pro-Leu-Ala-Leu-Trp-Arg-Ser-Gln-N-(2,4-dinitrophenyl)ethylenediamine |
| MMP-7 | Homo sapiens | 2-aminobenzoyl-Arg-Pro-Leu-Ala-Leu-Trp-Glu-Glu-Gln-N-(2,4-dinitrophenyl)ethylenediamine | — | — | 133 | pH 7.5, 30 °C | PMID 26760307 | Open record: MMP-7, 2-aminobenzoyl-Arg-Pro-Leu-Ala-Leu-Trp-Glu-Glu-Gln-N-(2,4-dinitrophenyl)ethylenediamine |
| MMP-7 | Homo sapiens | 2-aminobenzoyl-Arg-Pro-Leu-Ala-Leu-Trp-Glu-Ser-Gln-N-(2,4-dinitrophenyl)ethylenediamine | — | — | 142 | pH 7.5, 30 °C | PMID 26760307 | Open record: MMP-7, 2-aminobenzoyl-Arg-Pro-Leu-Ala-Leu-Trp-Glu-Ser-Gln-N-(2,4-dinitrophenyl)ethylenediamine |
| MMP-7 | Homo sapiens | 2-aminobenzoyl-Arg-Pro-Leu-Glu-Leu-Trp-Arg-Ser-Gln-N-(2,4-dinitrophenyl)ethylenediamine | — | — | 87 | pH 7.5, 30 °C | PMID 26760307 | Open record: MMP-7, 2-aminobenzoyl-Arg-Pro-Leu-Glu-Leu-Trp-Arg-Ser-Gln-N-(2,4-dinitrophenyl)ethylenediamine |
| MMP-7 | Homo sapiens | 2-aminobenzoyl-Arg-Pro-Leu-Gly-Leu-Glu-Glu-Ala-N-(2,4-dinitrophenyl)ethylenediamine | — | — | 80 | pH 7.5, 30 °C | PMID 26760307 | Open record: MMP-7, 2-aminobenzoyl-Arg-Pro-Leu-Gly-Leu-Glu-Glu-Ala-N-(2,4-dinitrophenyl)ethylenediamine |
| MMP-7 | Homo sapiens | 2-aminobenzoyl-Arg-Pro-Leu-Gly-Leu-Gly-Ala-Ala-Gln-N-(2,4-dinitrophenyl)ethylenediamine | — | — | 56 | pH 7.5, 30 °C | PMID 26760307 | Open record: MMP-7, 2-aminobenzoyl-Arg-Pro-Leu-Gly-Leu-Gly-Ala-Ala-Gln-N-(2,4-dinitrophenyl)ethylenediamine |
| MMP-7 | Homo sapiens | 2-aminobenzoyl-Arg-Pro-Leu-Gly-Leu-Gly-Gly-Ala-Gln-N-(2,4-dinitrophenyl)ethylenediamine | — | — | 8 | pH 7.5, 30 °C | PMID 26760307 | Open record: MMP-7, 2-aminobenzoyl-Arg-Pro-Leu-Gly-Leu-Gly-Gly-Ala-Gln-N-(2,4-dinitrophenyl)ethylenediamine |
| MMP-7 | Homo sapiens | 2-aminobenzoyl-Arg-Pro-Leu-Gly-Leu-Trp-Gly-Ala-Gln-N-(2,4-dinitrophenyl)ethylenediamine | — | — | 227 | pH 7.5, 30 °C | PMID 26760307 | Open record: MMP-7, 2-aminobenzoyl-Arg-Pro-Leu-Gly-Leu-Trp-Gly-Ala-Gln-N-(2,4-dinitrophenyl)ethylenediamine |
| MMP-7 | Homo sapiens | 2-aminobenzoyl-Glu-Pro-Leu-Ala-Leu-Trp-Arg-Ser-Gln-N-(2,4-dinitrophenyl)ethylenediamine | — | — | 59 | pH 7.5, 30 °C | PMID 26760307 | Open record: MMP-7, 2-aminobenzoyl-Glu-Pro-Leu-Ala-Leu-Trp-Arg-Ser-Gln-N-(2,4-dinitrophenyl)ethylenediamine |
| MMP-7 | Homo sapiens | 2-aminobenzoyl-Gly-Ala-Met-Phe-Leu-Glu-Ala-Ile-Pro-Met-Ser-Ile-Pro-N-(2,4-dinitrophenyl)ethylenediamine | — | — | 33 | pH 7.5, 30 °C | PMID 26760307 | Open record: MMP-7, 2-aminobenzoyl-Gly-Ala-Met-Phe-Leu-Glu-Ala-Ile-Pro-Met-Ser-Ile-Pro-N-(2,4-dinitrophenyl)ethylenediamine |
| MMP-7 | Homo sapiens | 2-aminobenzoyl-Gly-Pro-Leu-Glu-Leu-Glu-Glu-Ala-Gln-N-(2,4-dinitrophenyl)ethylenediamine | — | — | 73 | pH 7.5, 30 °C | PMID 26760307 | Open record: MMP-7, 2-aminobenzoyl-Gly-Pro-Leu-Glu-Leu-Glu-Glu-Ala-Gln-N-(2,4-dinitrophenyl)ethylenediamine |
| MMP-7 | Homo sapiens | 2-aminobenzoyl-Gly-Pro-Leu-Gly-Leu-Arg-Glu-Ala-Gln-N-(2,4-dinitrophenyl)ethylenediamine | — | — | 184 | pH 7.5, 30 °C | PMID 26760307 | Open record: MMP-7, 2-aminobenzoyl-Gly-Pro-Leu-Gly-Leu-Arg-Glu-Ala-Gln-N-(2,4-dinitrophenyl)ethylenediamine |
| MMP-7 | Homo sapiens | 2-aminobenzoyl-Gly-Pro-Leu-Gly-Leu-Glu-Arg-Ala-Gln-N-(2,4-dinitrophenyl)ethylenediamine | — | — | 30 | pH 7.5, 30 °C | PMID 26760307 | Open record: MMP-7, 2-aminobenzoyl-Gly-Pro-Leu-Gly-Leu-Glu-Arg-Ala-Gln-N-(2,4-dinitrophenyl)ethylenediamine |
| MMP-7 | Homo sapiens | 2-aminobenzoyl-Pro-Leu-Ala-Leu-Trp-Arg-Ser-Gln-N-(2,4-dinitrophenyl)ethylenediamine | — | — | 24 | pH 7.5, 30 °C | PMID 26760307 | Open record: MMP-7, 2-aminobenzoyl-Pro-Leu-Ala-Leu-Trp-Arg-Ser-Gln-N-(2,4-dinitrophenyl)ethylenediamine |