Values CatLog read from this paper
The role of factor XIa (FXIa) catalytic domain exosite residues in substrate catalysis and inhibition by the Kunitz protease inhibitor domain of protease nexin 2
PMID 21778227doi:10.1074/jbc.m111.257527Open in Browse
The paper itself is not on this site: read it at the publisher. This page lists only the values CatLog read from it.
CatLog read 16 records (30 values) from this paper: factor XIa (FXIa) from Homo sapiens.
Read from the paper by an AI model and checked against the paper by a second, separate AI run; code converted the units. Values are in CatLog's units; each record opens in Browse with the line the paper prints and the checks. CatLog calculated the 14 kcat/Km values marked “calc.” from kcat and Km; no printed kcat/Km was read for those records.
| Enzyme | Organism | Substrate | kcat (s⁻¹) | Km (mM) | kcat/Km (mM⁻¹ s⁻¹) | Conditions | Open record |
|---|---|---|---|---|---|---|---|
| factor XIa (FXIa) | Homo sapiens | coagulation factor IX | 0.73 | 3 × 10⁻⁴ | 2.4 × 10³ calc. | pH 7.4, 37 °C | Open record: factor XIa (FXIa), coagulation factor IX |
| factor XIa (FXIa) | Homo sapiens | L-pyroglutamyl-L-prolyl-L-arginyl-p-nitroaniline hydrochloride | 201 | 0.339 | 593 calc. | pH 7.4, 37 °C | Open record: factor XIa (FXIa), L-pyroglutamyl-L-prolyl-L-arginyl-p-nitroaniline hydrochloride |
| factor XIa (FXIa)variant E98A | Homo sapiens | L-pyroglutamyl-L-prolyl-L-arginyl-p-nitroaniline hydrochloride | 95 | 0.4 | 240 calc. | pH 7.4, 37 °C | Open record: factor XIa (FXIa) variant E98A, L-pyroglutamyl-L-prolyl-L-arginyl-p-nitroaniline hydrochloride |
| factor XIa (FXIa)variant E98D | Homo sapiens | L-pyroglutamyl-L-prolyl-L-arginyl-p-nitroaniline hydrochloride | 5.8 | 0.383 | 15 calc. | pH 7.4, 37 °C | Open record: factor XIa (FXIa) variant E98D, L-pyroglutamyl-L-prolyl-L-arginyl-p-nitroaniline hydrochloride |
| factor XIa (FXIa)variant E98V | Homo sapiens | L-pyroglutamyl-L-prolyl-L-arginyl-p-nitroaniline hydrochloride | 21 | 0.525 | 40 calc. | pH 7.4, 37 °C | Open record: factor XIa (FXIa) variant E98V, L-pyroglutamyl-L-prolyl-L-arginyl-p-nitroaniline hydrochloride |
| factor XIa (FXIa)variant I151A | Homo sapiens | coagulation factor IX | 0.2 | — | — | pH 7.4, 37 °C | Open record: factor XIa (FXIa) variant I151A, coagulation factor IX |
| factor XIa (FXIa)variant I151A | Homo sapiens | L-pyroglutamyl-L-prolyl-L-arginyl-p-nitroaniline hydrochloride | 58 | 0.828 | 70 calc. | pH 7.4, 37 °C | Open record: factor XIa (FXIa) variant I151A, L-pyroglutamyl-L-prolyl-L-arginyl-p-nitroaniline hydrochloride |
| factor XIa (FXIa)variant K192A | Homo sapiens | L-pyroglutamyl-L-prolyl-L-arginyl-p-nitroaniline hydrochloride | 95 | 0.852 | 110 calc. | pH 7.4, 37 °C | Open record: factor XIa (FXIa) variant K192A, L-pyroglutamyl-L-prolyl-L-arginyl-p-nitroaniline hydrochloride |
| factor XIa (FXIa)variant K192E | Homo sapiens | L-pyroglutamyl-L-prolyl-L-arginyl-p-nitroaniline hydrochloride | 86 | 0.315 | 270 calc. | pH 7.4, 37 °C | Open record: factor XIa (FXIa) variant K192E, L-pyroglutamyl-L-prolyl-L-arginyl-p-nitroaniline hydrochloride |
| factor XIa (FXIa)variant K192Q | Homo sapiens | L-pyroglutamyl-L-prolyl-L-arginyl-p-nitroaniline hydrochloride | 30 | 0.603 | 50 calc. | pH 7.4, 37 °C | Open record: factor XIa (FXIa) variant K192Q, L-pyroglutamyl-L-prolyl-L-arginyl-p-nitroaniline hydrochloride |
| factor XIa (FXIa)variant K192R | Homo sapiens | L-pyroglutamyl-L-prolyl-L-arginyl-p-nitroaniline hydrochloride | 14 | 0.205 | 68 calc. | pH 7.4, 37 °C | Open record: factor XIa (FXIa) variant K192R, L-pyroglutamyl-L-prolyl-L-arginyl-p-nitroaniline hydrochloride |
| factor XIa (FXIa)variant R3704A | Homo sapiens | L-pyroglutamyl-L-prolyl-L-arginyl-p-nitroaniline hydrochloride | 8 | 0.268 | 30 calc. | pH 7.4, 37 °C | Open record: factor XIa (FXIa) variant R3704A, L-pyroglutamyl-L-prolyl-L-arginyl-p-nitroaniline hydrochloride |
| factor XIa (FXIa)variant Y143A | Homo sapiens | L-pyroglutamyl-L-prolyl-L-arginyl-p-nitroaniline hydrochloride | 7 | 0.538 | 13 calc. | pH 7.4, 37 °C | Open record: factor XIa (FXIa) variant Y143A, L-pyroglutamyl-L-prolyl-L-arginyl-p-nitroaniline hydrochloride |
| factor XIa (FXIa)variant Y5901A | Homo sapiens | coagulation factor IX | 0.2 | — | — | pH 7.4, 37 °C | Open record: factor XIa (FXIa) variant Y5901A, coagulation factor IX |
| factor XIa (FXIa)variant Y5901A | Homo sapiens | L-pyroglutamyl-L-prolyl-L-arginyl-p-nitroaniline hydrochloride | 29 | 0.292 | 99 calc. | pH 7.4, 37 °C | Open record: factor XIa (FXIa) variant Y5901A, L-pyroglutamyl-L-prolyl-L-arginyl-p-nitroaniline hydrochloride |
| factor XIa (FXIa)variant Y5901V | Homo sapiens | L-pyroglutamyl-L-prolyl-L-arginyl-p-nitroaniline hydrochloride | 42 | 0.336 | 120 calc. | pH 7.4, 37 °C | Open record: factor XIa (FXIa) variant Y5901V, L-pyroglutamyl-L-prolyl-L-arginyl-p-nitroaniline hydrochloride |