CatLogenzyme kinetics catalog

EC 3.4.21.27: coagulation factor XIa

HydrolasesOpen in Browse

CatLog read 30 records for EC 3.4.21.27 from 2 papers, for 2 organisms. Names in these papers: factor XIa (FXIa), factor XIa.

Read from the paper by an AI model and checked against the paper by a second, separate AI run; code converted the units.

CatLog also holds 14 records for EC 3.4.21.27 that are not yet re-read: from its earlier version, built from the enzyme databases and partly checked against the papers. All records for EC 3.4.21.27 in Browse.

Papers

PaperOrganismsRecords
The role of factor XIa (FXIa) catalytic domain exosite residues in substrate catalysis and inhibition by the Kunitz protease inhibitor domain of protease nexin 2Homo sapiens16
Active-site mapping of bovine and human blood coagulation serine proteases using synthetic peptide 4-nitroanilide and thio ester substratesBos taurus14

Records

EnzymeOrganismSubstratekcat (s⁻¹)Km (mM)kcat/Km (mM⁻¹ s⁻¹)ConditionsPaper
factor XIaBos taurusN-benzyloxycarbonyl-L-alanyl-glycyl-L-arginine 4-nitroanilide——1.4pH 7.5, 25 °CPMID 6370301Open
factor XIaBos taurusN-benzyloxycarbonyl-L-alanyl-L-phenylalanyl-L-arginine 4-nitroanilide——1.6pH 7.5, 25 °CPMID 6370301Open
factor XIaBos taurusN-benzyloxycarbonyl-L-alpha-glutamyl-glycyl-L-arginine 4-nitroanilide122.94.1pH 7.5, 25 °CPMID 6370301Open
factor XIaBos taurusN-benzyloxycarbonyl-L-alpha-glutamyl-L-phenylalanyl-L-arginine 4-nitroanilide3.83.81pH 7.5, 25 °CPMID 6370301Open
factor XIaBos taurusN-benzyloxycarbonyl-L-asparaginyl-glycyl-L-arginine 4-nitroanilide21141.5pH 7.5, 25 °CPMID 6370301Open
factor XIaBos taurusN-benzyloxycarbonyl-L-asparaginyl-L-phenylalanyl-L-arginine 4-nitroanilide20.712.8pH 7.5, 25 °CPMID 6370301Open
factor XIaBos taurusN-benzyloxycarbonyl-L-lysyl-glycyl-L-arginine 4-nitroanilide21121.8pH 7.5, 25 °CPMID 6370301Open
factor XIaBos taurusN-benzyloxycarbonyl-L-lysyl-L-phenylalanyl-L-arginine 4-nitroanilide2.52.70.93pH 7.5, 25 °CPMID 6370301Open
factor XIaBos taurusN-benzyloxycarbonyl-L-phenylalanyl-glycyl-L-arginine 4-nitroanilide——3.8pH 7.5, 25 °CPMID 6370301Open
factor XIaBos taurusN-benzyloxycarbonyl-L-phenylalanyl-L-phenylalanyl-L-arginine 4-nitroanilide12150.81pH 7.5, 25 °CPMID 6370301Open
factor XIaBos taurusN-benzyloxycarbonyl-L-prolyl-glycyl-L-arginine 4-nitroanilide3.38.40.39pH 7.5, 25 °CPMID 6370301Open
factor XIaBos taurusN-benzyloxycarbonyl-L-prolyl-L-phenylalanyl-L-arginine 4-nitroanilide——0.29pH 7.5, 25 °CPMID 6370301Open
factor XIaBos taurusN-benzyloxycarbonyl-L-seryl-glycyl-L-arginine 4-nitroanilide7.12.43pH 7.5, 25 °CPMID 6370301Open
factor XIaBos taurusN-benzyloxycarbonyl-L-seryl-L-phenylalanyl-L-arginine 4-nitroanilide4.51.23.8pH 7.5, 25 °CPMID 6370301Open
factor XIa (FXIa)Homo sapienscoagulation factor IX0.733 × 10⁻⁴2.4 × 10³ calc.pH 7.4, 37 °CPMID 21778227Open
factor XIa (FXIa)Homo sapiensL-pyroglutamyl-L-prolyl-L-arginyl-p-nitroaniline hydrochloride2010.339593 calc.pH 7.4, 37 °CPMID 21778227Open
factor XIa (FXIa)variant E98AHomo sapiensL-pyroglutamyl-L-prolyl-L-arginyl-p-nitroaniline hydrochloride950.4240 calc.pH 7.4, 37 °CPMID 21778227Open
factor XIa (FXIa)variant E98DHomo sapiensL-pyroglutamyl-L-prolyl-L-arginyl-p-nitroaniline hydrochloride5.80.38315 calc.pH 7.4, 37 °CPMID 21778227Open
factor XIa (FXIa)variant E98VHomo sapiensL-pyroglutamyl-L-prolyl-L-arginyl-p-nitroaniline hydrochloride210.52540 calc.pH 7.4, 37 °CPMID 21778227Open
factor XIa (FXIa)variant I151AHomo sapienscoagulation factor IX0.2——pH 7.4, 37 °CPMID 21778227Open
factor XIa (FXIa)variant I151AHomo sapiensL-pyroglutamyl-L-prolyl-L-arginyl-p-nitroaniline hydrochloride580.82870 calc.pH 7.4, 37 °CPMID 21778227Open
factor XIa (FXIa)variant K192AHomo sapiensL-pyroglutamyl-L-prolyl-L-arginyl-p-nitroaniline hydrochloride950.852110 calc.pH 7.4, 37 °CPMID 21778227Open
factor XIa (FXIa)variant K192EHomo sapiensL-pyroglutamyl-L-prolyl-L-arginyl-p-nitroaniline hydrochloride860.315270 calc.pH 7.4, 37 °CPMID 21778227Open
factor XIa (FXIa)variant K192QHomo sapiensL-pyroglutamyl-L-prolyl-L-arginyl-p-nitroaniline hydrochloride300.60350 calc.pH 7.4, 37 °CPMID 21778227Open
factor XIa (FXIa)variant K192RHomo sapiensL-pyroglutamyl-L-prolyl-L-arginyl-p-nitroaniline hydrochloride140.20568 calc.pH 7.4, 37 °CPMID 21778227Open
factor XIa (FXIa)variant R3704AHomo sapiensL-pyroglutamyl-L-prolyl-L-arginyl-p-nitroaniline hydrochloride80.26830 calc.pH 7.4, 37 °CPMID 21778227Open
factor XIa (FXIa)variant Y143AHomo sapiensL-pyroglutamyl-L-prolyl-L-arginyl-p-nitroaniline hydrochloride70.53813 calc.pH 7.4, 37 °CPMID 21778227Open
factor XIa (FXIa)variant Y5901AHomo sapienscoagulation factor IX0.2——pH 7.4, 37 °CPMID 21778227Open
factor XIa (FXIa)variant Y5901AHomo sapiensL-pyroglutamyl-L-prolyl-L-arginyl-p-nitroaniline hydrochloride290.29299 calc.pH 7.4, 37 °CPMID 21778227Open
factor XIa (FXIa)variant Y5901VHomo sapiensL-pyroglutamyl-L-prolyl-L-arginyl-p-nitroaniline hydrochloride420.336120 calc.pH 7.4, 37 °CPMID 21778227Open