Values CatLog read from this paper
Site-directed mutagenesis of arginine 179 of thymidylate synthase. A nonessential substrate-binding residue
PMID 2182628doi:10.1016/s0021-9258(19)39215-4Open in Browse
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CatLog read 10 records (25 values) from this paper: thymidylate synthase from Lactobacillus casei.
Read from the paper by an AI model and checked against the paper by a second, separate AI run; code converted the units. Values are in CatLog's units; each record opens in Browse with the line the paper prints and the checks.
| Enzyme | Organism | Substrate | kcat (s⁻¹) | Km (mM) | kcat/Km (mM⁻¹ s⁻¹) | Conditions | Open record |
|---|---|---|---|---|---|---|---|
| thymidylate synthase | Lactobacillus casei | 2'-deoxyuridine 5'-monophosphate | 7.8 | 0.0027 | 2.9 × 10³ | Open record: thymidylate synthase, 2'-deoxyuridine 5'-monophosphate | |
| thymidylate synthase | Lactobacillus casei | 5,10-methylenetetrahydrofolate | — | 0.02 | 390 | Open record: thymidylate synthase, 5,10-methylenetetrahydrofolate | |
| thymidylate synthasevariant R179A | Lactobacillus casei | 2'-deoxyuridine 5'-monophosphate | 2.4 | 0.0052 | 460 | Open record: thymidylate synthase variant R179A, 2'-deoxyuridine 5'-monophosphate | |
| thymidylate synthasevariant R179A | Lactobacillus casei | 5,10-methylenetetrahydrofolate | — | 0.02 | 120 | Open record: thymidylate synthase variant R179A, 5,10-methylenetetrahydrofolate | |
| thymidylate synthasevariant R179E | Lactobacillus casei | 2'-deoxyuridine 5'-monophosphate | 1.9 | 0.017 | 110 | Open record: thymidylate synthase variant R179E, 2'-deoxyuridine 5'-monophosphate | |
| thymidylate synthasevariant R179E | Lactobacillus casei | 5,10-methylenetetrahydrofolate | — | 0.016 | 120 | Open record: thymidylate synthase variant R179E, 5,10-methylenetetrahydrofolate | |
| thymidylate synthasevariant R179K | Lactobacillus casei | 2'-deoxyuridine 5'-monophosphate | 2 | 0.038 | 50 | Open record: thymidylate synthase variant R179K, 2'-deoxyuridine 5'-monophosphate | |
| thymidylate synthasevariant R179K | Lactobacillus casei | 5,10-methylenetetrahydrofolate | — | 0.066 | 30 | Open record: thymidylate synthase variant R179K, 5,10-methylenetetrahydrofolate | |
| thymidylate synthasevariant R179T | Lactobacillus casei | 2'-deoxyuridine 5'-monophosphate | 1.9 | 0.0069 | 280 | Open record: thymidylate synthase variant R179T, 2'-deoxyuridine 5'-monophosphate | |
| thymidylate synthasevariant R179T | Lactobacillus casei | 5,10-methylenetetrahydrofolate | — | 0.02 | 90 | Open record: thymidylate synthase variant R179T, 5,10-methylenetetrahydrofolate |