Values CatLog read from this paper
The mechanism of substrate inhibition in human indoleamine 2,3-dioxygenase
PMID 22299628doi:10.1021/ja208694gOpen in Browse
The paper itself is not on this site: read it at the publisher. This page lists only the values CatLog read from it.
CatLog read 9 records (17 values) from this paper: indoleamine 2,3-dioxygenase from Homo sapiens.
Read from the paper by an AI model and checked against the paper by a second, separate AI run; code converted the units. Values are in CatLog's units; each record opens in Browse with the line the paper prints and the checks. CatLog calculated the 8 kcat/Km values marked “calc.” from kcat and Km; no printed kcat/Km was read for those records.
| Enzyme | Organism | Substrate | kcat (s⁻¹) | Km (mM) | kcat/Km (mM⁻¹ s⁻¹) | Conditions | Open record |
|---|---|---|---|---|---|---|---|
| indoleamine 2,3-dioxygenase | Homo sapiens | L-tryptophan | 1.4 | 0.005 | 280 calc. | pH 8, 20 °C | Open record: indoleamine 2,3-dioxygenase, L-tryptophan |
| indoleamine 2,3-dioxygenasevariant F163A | Homo sapiens | L-tryptophan | 0.04 | 0.068 | 0.59 calc. | pH 8, 20 °C | Open record: indoleamine 2,3-dioxygenase variant F163A, L-tryptophan |
| indoleamine 2,3-dioxygenasevariant F164A | Homo sapiens | L-tryptophan | 0.68 | 0.16 | 4.2 calc. | pH 8, 20 °C | Open record: indoleamine 2,3-dioxygenase variant F164A, L-tryptophan |
| indoleamine 2,3-dioxygenasevariant F226A | Homo sapiens | L-tryptophan | 0.12 | 0.31 | 0.39 calc. | pH 8, 20 °C | Open record: indoleamine 2,3-dioxygenase variant F226A, L-tryptophan |
| indoleamine 2,3-dioxygenasevariant F226Y | Homo sapiens | L-tryptophan | 6 | 0.16 | 38 calc. | pH 8, 20 °C | Open record: indoleamine 2,3-dioxygenase variant F226Y, L-tryptophan |
| indoleamine 2,3-dioxygenasevariant F227A | Homo sapiens | L-tryptophan | 0.4 | 0.015 | 27 calc. | pH 8, 20 °C | Open record: indoleamine 2,3-dioxygenase variant F227A, L-tryptophan |
| indoleamine 2,3-dioxygenasevariant R231K | Homo sapiens | L-tryptophan | 0.3 | — | — | pH 8, 20 °C | Open record: indoleamine 2,3-dioxygenase variant R231K, L-tryptophan |
| indoleamine 2,3-dioxygenasevariant S167A | Homo sapiens | L-tryptophan | 1.6 | 0.022 | 73 calc. | pH 8, 20 °C | Open record: indoleamine 2,3-dioxygenase variant S167A, L-tryptophan |
| indoleamine 2,3-dioxygenasevariant S167H | Homo sapiens | L-tryptophan | 0.006 | 0.026 | 0.23 calc. | pH 8, 20 °C | Open record: indoleamine 2,3-dioxygenase variant S167H, L-tryptophan |