Values CatLog read from this paper
Comparative active-site mutation study of human and Caenorhabditis elegans thymidine kinase 1
PMID 22385435doi:10.1111/j.1742-4658.2012.08554.xOpen in Browse
The paper itself is not on this site: read it at the publisher. This page lists only the values CatLog read from it.
CatLog read 24 records (62 values) from this paper: thymidine kinase 1 (CeTK1), thymidine kinase 1 (HuTK1) from Caenorhabditis elegans, Homo sapiens.
Read from the paper by an AI model and checked against the paper by a second, separate AI run; code converted the units. Values are in CatLog's units; each record opens in Browse with the line the paper prints and the checks.
| Enzyme | Organism | Substrate | kcat (s⁻¹) | Km (mM) | kcat/Km (mM⁻¹ s⁻¹) | Conditions | Open record |
|---|---|---|---|---|---|---|---|
| thymidine kinase 1 (CeTK1) | Caenorhabditis elegans | 3'-azido-3'-deoxythymidine | 9.3 | 0.012 | 780 | pH 7.5 | Open record: thymidine kinase 1 (CeTK1), 3'-azido-3'-deoxythymidine |
| thymidine kinase 1 (CeTK1) | Caenorhabditis elegans | deoxyguanosine | — | — | 0.082 | pH 7.5 | Open record: thymidine kinase 1 (CeTK1), deoxyguanosine |
| thymidine kinase 1 (CeTK1) | Caenorhabditis elegans | thymidine | 6.4 | 0.0023 | 2.8 × 10³ | pH 7.5 | Open record: thymidine kinase 1 (CeTK1), thymidine |
| thymidine kinase 1 (CeTK1)variant L143A | Caenorhabditis elegans | 3'-azido-3'-deoxythymidine | — | — | 0.49 | pH 7.5 | Open record: thymidine kinase 1 (CeTK1) variant L143A, 3'-azido-3'-deoxythymidine |
| thymidine kinase 1 (CeTK1)variant L143A | Caenorhabditis elegans | deoxycytidine | — | — | 0.0019 | pH 7.5 | Open record: thymidine kinase 1 (CeTK1) variant L143A, deoxycytidine |
| thymidine kinase 1 (CeTK1)variant L143A | Caenorhabditis elegans | thymidine | 4.9 | 0.336 | 15 | pH 7.5 | Open record: thymidine kinase 1 (CeTK1) variant L143A, thymidine |
| thymidine kinase 1 (CeTK1)variant M42I | Caenorhabditis elegans | 3'-azido-3'-deoxythymidine | 0.81 | 2.318 | 0.35 | pH 7.5 | Open record: thymidine kinase 1 (CeTK1) variant M42I, 3'-azido-3'-deoxythymidine |
| thymidine kinase 1 (CeTK1)variant M42I | Caenorhabditis elegans | deoxycytidine | 1.7 × 10⁻⁴ | 0.0036 | 0.048 | pH 7.5 | Open record: thymidine kinase 1 (CeTK1) variant M42I, deoxycytidine |
| thymidine kinase 1 (CeTK1)variant M42I | Caenorhabditis elegans | thymidine | 2.8 | 0.565 | 5 | pH 7.5 | Open record: thymidine kinase 1 (CeTK1) variant M42I, thymidine |
| thymidine kinase 1 (CeTK1)variant S182A | Caenorhabditis elegans | 3'-azido-3'-deoxythymidine | 0.58 | 0.406 | 1.4 | pH 7.5 | Open record: thymidine kinase 1 (CeTK1) variant S182A, 3'-azido-3'-deoxythymidine |
| thymidine kinase 1 (CeTK1)variant S182A | Caenorhabditis elegans | deoxyguanosine | — | — | 0.0066 | pH 7.5 | Open record: thymidine kinase 1 (CeTK1) variant S182A, deoxyguanosine |
| thymidine kinase 1 (CeTK1)variant S182A | Caenorhabditis elegans | thymidine | 0.74 | 0.074 | 10 | pH 7.5 | Open record: thymidine kinase 1 (CeTK1) variant S182A, thymidine |
| thymidine kinase 1 (CeTK1)variant S182T | Caenorhabditis elegans | 3'-azido-3'-deoxythymidine | 1.5 | 0.018 | 98 | pH 7.5 | Open record: thymidine kinase 1 (CeTK1) variant S182T, 3'-azido-3'-deoxythymidine |
| thymidine kinase 1 (CeTK1)variant S182T | Caenorhabditis elegans | deoxyguanosine | — | — | 0.23 | pH 7.5 | Open record: thymidine kinase 1 (CeTK1) variant S182T, deoxyguanosine |
| thymidine kinase 1 (CeTK1)variant S182T | Caenorhabditis elegans | thymidine | 0.97 | 0.0013 | 750 | pH 7.5 | Open record: thymidine kinase 1 (CeTK1) variant S182T, thymidine |
| thymidine kinase 1 (HuTK1) | Homo sapiens | 3'-azido-3'-deoxythymidine | 3.5 | 5.2 × 10⁻⁴ | 6.7 × 10³ | pH 7.5 | Open record: thymidine kinase 1 (HuTK1), 3'-azido-3'-deoxythymidine |
| thymidine kinase 1 (HuTK1)variant L124A | Homo sapiens | 3'-azido-3'-deoxythymidine | 1.4 | 0.033 | 44 | pH 7.5 | Open record: thymidine kinase 1 (HuTK1) variant L124A, 3'-azido-3'-deoxythymidine |
| thymidine kinase 1 (HuTK1)variant L124A | Homo sapiens | thymidine | 1.8 | 0.036 | 51 | pH 7.5 | Open record: thymidine kinase 1 (HuTK1) variant L124A, thymidine |
| thymidine kinase 1 (HuTK1)variant M28A | Homo sapiens | 3'-azido-3'-deoxythymidine | 0.34 | 0.204 | 1.7 | pH 7.5 | Open record: thymidine kinase 1 (HuTK1) variant M28A, 3'-azido-3'-deoxythymidine |
| thymidine kinase 1 (HuTK1)variant M28A | Homo sapiens | thymidine | 1.4 | 0.317 | 4.5 | pH 7.5 | Open record: thymidine kinase 1 (HuTK1) variant M28A, thymidine |
| thymidine kinase 1 (HuTK1)variant M28I | Homo sapiens | 3'-azido-3'-deoxythymidine | 0.24 | 0.254 | 0.94 | pH 7.5 | Open record: thymidine kinase 1 (HuTK1) variant M28I, 3'-azido-3'-deoxythymidine |
| thymidine kinase 1 (HuTK1)variant M28I | Homo sapiens | thymidine | 1.5 | 0.349 | 4.2 | pH 7.5 | Open record: thymidine kinase 1 (HuTK1) variant M28I, thymidine |
| thymidine kinase 1 (HuTK1)variant T163S | Homo sapiens | 3'-azido-3'-deoxythymidine | 1.3 | 4.3 × 10⁻⁴ | 3.1 × 10³ | pH 7.5 | Open record: thymidine kinase 1 (HuTK1) variant T163S, 3'-azido-3'-deoxythymidine |
| thymidine kinase 1 (HuTK1)variant T163S | Homo sapiens | thymidine | 2.7 | 0.059 | 46 | pH 7.5 | Open record: thymidine kinase 1 (HuTK1) variant T163S, thymidine |