Values CatLog read from this paper
Kinetics and stereochemistry of hydrolysis of an N-(phenylacetyl)-α-hydroxyglycine ester catalyzed by serine β-lactamases and DD-peptidases
PMID 22851054doi:10.1039/c2ob25585eOpen in Browse
The paper itself is not on this site: read it at the publisher. This page lists only the values CatLog read from it.
CatLog read 8 records (18 values) from this paper: AmpC β-lactamase (class C), P99 β-lactamase (class C), OXA-1 β-lactamase (class D) and 3 more from Escherichia coli, Enterobacter cloacae, Actinomadura sp. R39 and 1 more.
Read from the paper by an AI model and checked against the paper by a second, separate AI run; code converted the units. Values are in CatLog's units; each record opens in Browse with the line the paper prints and the checks.
| Enzyme | Organism | Substrate | kcat (s⁻¹) | Km (mM) | kcat/Km (mM⁻¹ s⁻¹) | Conditions | Open record |
|---|---|---|---|---|---|---|---|
| AmpC β-lactamase (class C) | Escherichia coli | 3-carboxyphenyl N-(phenylacetyl)-α-hydroxyglycinate (D(R) enantiomer) | — | — | 340 | pH 7.5, 25 °C | Open record: AmpC β-lactamase (class C), 3-carboxyphenyl N-(phenylacetyl)-α-hydroxyglycinate (D(R) enantiomer) |
| AmpC β-lactamase (class C) | Escherichia coli | 3-carboxyphenyl N-(phenylacetyl)-α-hydroxyglycinate (L(S) enantiomer) | — | — | 9.4 | pH 7.5, 25 °C | Open record: AmpC β-lactamase (class C), 3-carboxyphenyl N-(phenylacetyl)-α-hydroxyglycinate (L(S) enantiomer) |
| OXA-1 β-lactamase (class D) | Escherichia coli | 3-carboxyphenyl N-(phenylacetyl)-α-hydroxyglycinate (D(R) enantiomer) | — | — | 1.8 | pH 7.5, 25 °C | Open record: OXA-1 β-lactamase (class D), 3-carboxyphenyl N-(phenylacetyl)-α-hydroxyglycinate (D(R) enantiomer) |
| P99 β-lactamase (class C) | Enterobacter cloacae | 3-carboxyphenyl N-(phenylacetyl)-α-hydroxyglycinate (D(R) enantiomer) | 137 | 0.13 | 1 × 10³ | pH 7.5, 25 °C | Open record: P99 β-lactamase (class C), 3-carboxyphenyl N-(phenylacetyl)-α-hydroxyglycinate (D(R) enantiomer) |
| P99 β-lactamase (class C) | Enterobacter cloacae | 3-carboxyphenyl N-(phenylacetyl)-α-hydroxyglycinate (L(S) enantiomer) | 59 | 0.84 | 71 | pH 7.5, 25 °C | Open record: P99 β-lactamase (class C), 3-carboxyphenyl N-(phenylacetyl)-α-hydroxyglycinate (L(S) enantiomer) |
| R39 DD-peptidase (LMM class C) | Actinomadura sp. R39 | 3-carboxyphenyl N-(phenylacetyl)-α-hydroxyglycinate (D(R) enantiomer) | 10.4 | 4.3 | 2.4 | pH 7.5, 25 °C | Open record: R39 DD-peptidase (LMM class C), 3-carboxyphenyl N-(phenylacetyl)-α-hydroxyglycinate (D(R) enantiomer) |
| R61 DD-peptidase (LMM class B) | Streptomyces sp. R61 | 3-carboxyphenyl N-(phenylacetyl)-α-hydroxyglycinate (D(R) enantiomer) | 6.9 | 0.36 | 19 | pH 7.5, 25 °C | Open record: R61 DD-peptidase (LMM class B), 3-carboxyphenyl N-(phenylacetyl)-α-hydroxyglycinate (D(R) enantiomer) |
| TEM-2 β-lactamase (class A) | Escherichia coli | 3-carboxyphenyl N-(phenylacetyl)-α-hydroxyglycinate (D(R) enantiomer) | 46 | 2.7 | 17 | pH 7.5, 25 °C | Open record: TEM-2 β-lactamase (class A), 3-carboxyphenyl N-(phenylacetyl)-α-hydroxyglycinate (D(R) enantiomer) |