Values CatLog read from this paper
Conformational changes in orotidine 5'-monophosphate decarboxylase: a structure-based explanation for how the 5'-phosphate group activates the enzyme
PMID 23030629doi:10.1021/bi301188kOpen in Browse
The paper itself is not on this site: read it at the publisher. This page lists only the values CatLog read from it.
CatLog read 41 records (67 values) from this paper: orotidine 5'-monophosphate decarboxylase (MtOMPDC) from Methanothermobacter thermautotrophicus.
Read from the paper by an AI model and checked against the paper by a second, separate AI run; code converted the units. Values are in CatLog's units; each record opens in Browse with the line the paper prints and the checks.
| Enzyme | Organism | Substrate | kcat (s⁻¹) | Km (mM) | kcat/Km (mM⁻¹ s⁻¹) | Conditions | Open record |
|---|---|---|---|---|---|---|---|
| orotidine 5'-monophosphate decarboxylase (MtOMPDC) | Methanothermobacter thermautotrophicus | 1-(beta-D-erythrofuranosyl)orotic acid | — | — | 1.24 × 10⁻⁵ | pH 7.1, 25 °C | Open record: orotidine 5'-monophosphate decarboxylase (MtOMPDC), 1-(beta-D-erythrofuranosyl)orotic acid |
| orotidine 5'-monophosphate decarboxylase (MtOMPDC) | Methanothermobacter thermautotrophicus | 5-fluoro-1-(beta-D-erythrofuranosyl)orotic acid | — | — | 0.0048 | pH 7.1, 25 °C | Open record: orotidine 5'-monophosphate decarboxylase (MtOMPDC), 5-fluoro-1-(beta-D-erythrofuranosyl)orotic acid |
| orotidine 5'-monophosphate decarboxylase (MtOMPDC) | Methanothermobacter thermautotrophicus | orotidine 5'-monophosphate | 5.3 | 0.0018 | 2.9 × 10³ | pH 7.1, 25 °C | Open record: orotidine 5'-monophosphate decarboxylase (MtOMPDC), orotidine 5'-monophosphate |
| orotidine 5'-monophosphate decarboxylase (MtOMPDC)variant Q185A | Methanothermobacter thermautotrophicus | 1-(beta-D-erythrofuranosyl)orotic acid | — | — | 2 × 10⁻⁶ | pH 7.1, 25 °C | Open record: orotidine 5'-monophosphate decarboxylase (MtOMPDC) variant Q185A, 1-(beta-D-erythrofuranosyl)orotic acid |
| orotidine 5'-monophosphate decarboxylase (MtOMPDC)variant Q185A | Methanothermobacter thermautotrophicus | 5-fluoro-1-(beta-D-erythrofuranosyl)orotic acid | — | — | 9.2 × 10⁻⁴ | pH 7.1, 25 °C | Open record: orotidine 5'-monophosphate decarboxylase (MtOMPDC) variant Q185A, 5-fluoro-1-(beta-D-erythrofuranosyl)orotic acid |
| orotidine 5'-monophosphate decarboxylase (MtOMPDC)variant Q185A | Methanothermobacter thermautotrophicus | orotidine 5'-monophosphate | 1.4 | 0.11 | 13 | pH 7.1, 25 °C | Open record: orotidine 5'-monophosphate decarboxylase (MtOMPDC) variant Q185A, orotidine 5'-monophosphate |
| orotidine 5'-monophosphate decarboxylase (MtOMPDC)variant Q185A/R203A | Methanothermobacter thermautotrophicus | 1-(beta-D-erythrofuranosyl)orotic acid | — | — | 3.2 × 10⁻⁶ | pH 7.1, 25 °C | Open record: orotidine 5'-monophosphate decarboxylase (MtOMPDC) variant Q185A/R203A, 1-(beta-D-erythrofuranosyl)orotic acid |
| orotidine 5'-monophosphate decarboxylase (MtOMPDC)variant Q185A/R203A | Methanothermobacter thermautotrophicus | orotidine 5'-monophosphate | — | — | 0.0096 | pH 7.1, 25 °C | Open record: orotidine 5'-monophosphate decarboxylase (MtOMPDC) variant Q185A/R203A, orotidine 5'-monophosphate |
| orotidine 5'-monophosphate decarboxylase (MtOMPDC)variant R160A | Methanothermobacter thermautotrophicus | 1-(beta-D-erythrofuranosyl)orotic acid | — | — | 2 × 10⁻⁷ | pH 7.1, 25 °C | Open record: orotidine 5'-monophosphate decarboxylase (MtOMPDC) variant R160A, 1-(beta-D-erythrofuranosyl)orotic acid |
| orotidine 5'-monophosphate decarboxylase (MtOMPDC)variant R160A | Methanothermobacter thermautotrophicus | 5-fluoro-1-(beta-D-erythrofuranosyl)orotic acid | — | — | 2.1 × 10⁻⁴ | pH 7.1, 25 °C | Open record: orotidine 5'-monophosphate decarboxylase (MtOMPDC) variant R160A, 5-fluoro-1-(beta-D-erythrofuranosyl)orotic acid |
| orotidine 5'-monophosphate decarboxylase (MtOMPDC)variant R160A | Methanothermobacter thermautotrophicus | orotidine 5'-monophosphate | 2 | 0.03 | 67 | pH 7.1, 25 °C | Open record: orotidine 5'-monophosphate decarboxylase (MtOMPDC) variant R160A, orotidine 5'-monophosphate |
| orotidine 5'-monophosphate decarboxylase (MtOMPDC)variant R160A/R203A | Methanothermobacter thermautotrophicus | 1-(beta-D-erythrofuranosyl)orotic acid | — | — | 2 × 10⁻⁷ | pH 7.1, 25 °C | Open record: orotidine 5'-monophosphate decarboxylase (MtOMPDC) variant R160A/R203A, 1-(beta-D-erythrofuranosyl)orotic acid |
| orotidine 5'-monophosphate decarboxylase (MtOMPDC)variant R160A/R203A | Methanothermobacter thermautotrophicus | orotidine 5'-monophosphate | — | — | 0.016 | pH 7.1, 25 °C | Open record: orotidine 5'-monophosphate decarboxylase (MtOMPDC) variant R160A/R203A, orotidine 5'-monophosphate |
| orotidine 5'-monophosphate decarboxylase (MtOMPDC)variant R160A/V182A | Methanothermobacter thermautotrophicus | 5-fluoro-1-(beta-D-erythrofuranosyl)orotic acid | — | — | 2.5 × 10⁻⁵ | pH 7.1, 25 °C | Open record: orotidine 5'-monophosphate decarboxylase (MtOMPDC) variant R160A/V182A, 5-fluoro-1-(beta-D-erythrofuranosyl)orotic acid |
| orotidine 5'-monophosphate decarboxylase (MtOMPDC)variant R160A/V182A | Methanothermobacter thermautotrophicus | orotidine 5'-monophosphate | 1 | 0.6 | 1.7 | pH 7.1, 25 °C | Open record: orotidine 5'-monophosphate decarboxylase (MtOMPDC) variant R160A/V182A, orotidine 5'-monophosphate |
| orotidine 5'-monophosphate decarboxylase (MtOMPDC)variant R160A/Y206F | Methanothermobacter thermautotrophicus | 5-fluoro-1-(beta-D-erythrofuranosyl)orotic acid | — | — | 3.2 × 10⁻⁵ | pH 7.1, 25 °C | Open record: orotidine 5'-monophosphate decarboxylase (MtOMPDC) variant R160A/Y206F, 5-fluoro-1-(beta-D-erythrofuranosyl)orotic acid |
| orotidine 5'-monophosphate decarboxylase (MtOMPDC)variant R160A/Y206F | Methanothermobacter thermautotrophicus | orotidine 5'-monophosphate | 1.1 | 0.13 | 8.5 | pH 7.1, 25 °C | Open record: orotidine 5'-monophosphate decarboxylase (MtOMPDC) variant R160A/Y206F, orotidine 5'-monophosphate |
| orotidine 5'-monophosphate decarboxylase (MtOMPDC)variant R203A | Methanothermobacter thermautotrophicus | 1-(beta-D-erythrofuranosyl)orotic acid | — | — | 5.5 × 10⁻⁶ | pH 7.1, 25 °C | Open record: orotidine 5'-monophosphate decarboxylase (MtOMPDC) variant R203A, 1-(beta-D-erythrofuranosyl)orotic acid |
| orotidine 5'-monophosphate decarboxylase (MtOMPDC)variant R203A | Methanothermobacter thermautotrophicus | 5-fluoro-1-(beta-D-erythrofuranosyl)orotic acid | — | — | 0.0047 | pH 7.1, 25 °C | Open record: orotidine 5'-monophosphate decarboxylase (MtOMPDC) variant R203A, 5-fluoro-1-(beta-D-erythrofuranosyl)orotic acid |
| orotidine 5'-monophosphate decarboxylase (MtOMPDC)variant R203A | Methanothermobacter thermautotrophicus | orotidine 5'-monophosphate | 1.5 | 0.98 | 1.5 | pH 7.1, 25 °C | Open record: orotidine 5'-monophosphate decarboxylase (MtOMPDC) variant R203A, orotidine 5'-monophosphate |
| orotidine 5'-monophosphate decarboxylase (MtOMPDC)variant T159V | Methanothermobacter thermautotrophicus | 1-(beta-D-erythrofuranosyl)orotic acid | — | — | 4 × 10⁻⁷ | pH 7.1, 25 °C | Open record: orotidine 5'-monophosphate decarboxylase (MtOMPDC) variant T159V, 1-(beta-D-erythrofuranosyl)orotic acid |
| orotidine 5'-monophosphate decarboxylase (MtOMPDC)variant T159V | Methanothermobacter thermautotrophicus | 5-fluoro-1-(beta-D-erythrofuranosyl)orotic acid | — | — | 8.3 × 10⁻⁵ | pH 7.1, 25 °C | Open record: orotidine 5'-monophosphate decarboxylase (MtOMPDC) variant T159V, 5-fluoro-1-(beta-D-erythrofuranosyl)orotic acid |
| orotidine 5'-monophosphate decarboxylase (MtOMPDC)variant T159V | Methanothermobacter thermautotrophicus | orotidine 5'-monophosphate | 2.3 | 0.033 | 70 | pH 7.1, 25 °C | Open record: orotidine 5'-monophosphate decarboxylase (MtOMPDC) variant T159V, orotidine 5'-monophosphate |
| orotidine 5'-monophosphate decarboxylase (MtOMPDC)variant T159V/R203A | Methanothermobacter thermautotrophicus | 1-(beta-D-erythrofuranosyl)orotic acid | — | — | 2 × 10⁻⁷ | pH 7.1, 25 °C | Open record: orotidine 5'-monophosphate decarboxylase (MtOMPDC) variant T159V/R203A, 1-(beta-D-erythrofuranosyl)orotic acid |
| orotidine 5'-monophosphate decarboxylase (MtOMPDC)variant T159V/R203A | Methanothermobacter thermautotrophicus | orotidine 5'-monophosphate | — | — | 0.0099 | pH 7.1, 25 °C | Open record: orotidine 5'-monophosphate decarboxylase (MtOMPDC) variant T159V/R203A, orotidine 5'-monophosphate |
| orotidine 5'-monophosphate decarboxylase (MtOMPDC)variant T159V/V182A | Methanothermobacter thermautotrophicus | 5-fluoro-1-(beta-D-erythrofuranosyl)orotic acid | — | — | 3.4 × 10⁻⁵ | pH 7.1, 25 °C | Open record: orotidine 5'-monophosphate decarboxylase (MtOMPDC) variant T159V/V182A, 5-fluoro-1-(beta-D-erythrofuranosyl)orotic acid |
| orotidine 5'-monophosphate decarboxylase (MtOMPDC)variant T159V/V182A | Methanothermobacter thermautotrophicus | orotidine 5'-monophosphate | 0.56 | 0.7 | 0.8 | pH 7.1, 25 °C | Open record: orotidine 5'-monophosphate decarboxylase (MtOMPDC) variant T159V/V182A, orotidine 5'-monophosphate |
| orotidine 5'-monophosphate decarboxylase (MtOMPDC)variant T159V/V182A/Y206F | Methanothermobacter thermautotrophicus | 5-fluoro-1-(beta-D-erythrofuranosyl)orotic acid | — | — | 1.7 × 10⁻⁵ | pH 7.1, 25 °C | Open record: orotidine 5'-monophosphate decarboxylase (MtOMPDC) variant T159V/V182A/Y206F, 5-fluoro-1-(beta-D-erythrofuranosyl)orotic acid |
| orotidine 5'-monophosphate decarboxylase (MtOMPDC)variant T159V/V182A/Y206F | Methanothermobacter thermautotrophicus | orotidine 5'-monophosphate | 0.24 | 1.9 | 0.13 | pH 7.1, 25 °C | Open record: orotidine 5'-monophosphate decarboxylase (MtOMPDC) variant T159V/V182A/Y206F, orotidine 5'-monophosphate |
| orotidine 5'-monophosphate decarboxylase (MtOMPDC)variant T159V/Y206F | Methanothermobacter thermautotrophicus | 5-fluoro-1-(beta-D-erythrofuranosyl)orotic acid | — | — | 3.5 × 10⁻⁵ | pH 7.1, 25 °C | Open record: orotidine 5'-monophosphate decarboxylase (MtOMPDC) variant T159V/Y206F, 5-fluoro-1-(beta-D-erythrofuranosyl)orotic acid |
| orotidine 5'-monophosphate decarboxylase (MtOMPDC)variant T159V/Y206F | Methanothermobacter thermautotrophicus | orotidine 5'-monophosphate | 1.1 | 0.3 | 3.7 | pH 7.1, 25 °C | Open record: orotidine 5'-monophosphate decarboxylase (MtOMPDC) variant T159V/Y206F, orotidine 5'-monophosphate |
| orotidine 5'-monophosphate decarboxylase (MtOMPDC)variant V182A | Methanothermobacter thermautotrophicus | 1-(beta-D-erythrofuranosyl)orotic acid | — | — | 1.4 × 10⁻⁶ | pH 7.1, 25 °C | Open record: orotidine 5'-monophosphate decarboxylase (MtOMPDC) variant V182A, 1-(beta-D-erythrofuranosyl)orotic acid |
| orotidine 5'-monophosphate decarboxylase (MtOMPDC)variant V182A | Methanothermobacter thermautotrophicus | 5-fluoro-1-(beta-D-erythrofuranosyl)orotic acid | — | — | 6.3 × 10⁻⁴ | pH 7.1, 25 °C | Open record: orotidine 5'-monophosphate decarboxylase (MtOMPDC) variant V182A, 5-fluoro-1-(beta-D-erythrofuranosyl)orotic acid |
| orotidine 5'-monophosphate decarboxylase (MtOMPDC)variant V182A | Methanothermobacter thermautotrophicus | orotidine 5'-monophosphate | 3 | 0.024 | 130 | pH 7.1, 25 °C | Open record: orotidine 5'-monophosphate decarboxylase (MtOMPDC) variant V182A, orotidine 5'-monophosphate |
| orotidine 5'-monophosphate decarboxylase (MtOMPDC)variant V182A/R203A | Methanothermobacter thermautotrophicus | 1-(beta-D-erythrofuranosyl)orotic acid | — | — | 1.3 × 10⁻⁶ | pH 7.1, 25 °C | Open record: orotidine 5'-monophosphate decarboxylase (MtOMPDC) variant V182A/R203A, 1-(beta-D-erythrofuranosyl)orotic acid |
| orotidine 5'-monophosphate decarboxylase (MtOMPDC)variant V182A/R203A | Methanothermobacter thermautotrophicus | orotidine 5'-monophosphate | — | — | 0.032 | pH 7.1, 25 °C | Open record: orotidine 5'-monophosphate decarboxylase (MtOMPDC) variant V182A/R203A, orotidine 5'-monophosphate |
| orotidine 5'-monophosphate decarboxylase (MtOMPDC)variant V182A/Y206F | Methanothermobacter thermautotrophicus | 5-fluoro-1-(beta-D-erythrofuranosyl)orotic acid | — | — | 3 × 10⁻⁴ | pH 7.1, 25 °C | Open record: orotidine 5'-monophosphate decarboxylase (MtOMPDC) variant V182A/Y206F, 5-fluoro-1-(beta-D-erythrofuranosyl)orotic acid |
| orotidine 5'-monophosphate decarboxylase (MtOMPDC)variant V182A/Y206F | Methanothermobacter thermautotrophicus | orotidine 5'-monophosphate | 1.5 | 0.1 | 15 | pH 7.1, 25 °C | Open record: orotidine 5'-monophosphate decarboxylase (MtOMPDC) variant V182A/Y206F, orotidine 5'-monophosphate |
| orotidine 5'-monophosphate decarboxylase (MtOMPDC)variant Y206F | Methanothermobacter thermautotrophicus | 1-(beta-D-erythrofuranosyl)orotic acid | — | — | 6 × 10⁻⁶ | pH 7.1, 25 °C | Open record: orotidine 5'-monophosphate decarboxylase (MtOMPDC) variant Y206F, 1-(beta-D-erythrofuranosyl)orotic acid |
| orotidine 5'-monophosphate decarboxylase (MtOMPDC)variant Y206F | Methanothermobacter thermautotrophicus | 5-fluoro-1-(beta-D-erythrofuranosyl)orotic acid | — | — | 0.0022 | pH 7.1, 25 °C | Open record: orotidine 5'-monophosphate decarboxylase (MtOMPDC) variant Y206F, 5-fluoro-1-(beta-D-erythrofuranosyl)orotic acid |
| orotidine 5'-monophosphate decarboxylase (MtOMPDC)variant Y206F | Methanothermobacter thermautotrophicus | orotidine 5'-monophosphate | 4.1 | 0.0055 | 750 | pH 7.1, 25 °C | Open record: orotidine 5'-monophosphate decarboxylase (MtOMPDC) variant Y206F, orotidine 5'-monophosphate |