EC 4.1.1.23: orotidine-5'-phosphate decarboxylase

LyasesOpen in Browse

CatLog read 107 records for EC 4.1.1.23 from 9 papers, for 4 organisms. Names in these papers: orotidine 5'-monophosphate decarboxylase (MtOMPDC), orotidine 5'-monophosphate decarboxylase (ScOMPDC), orotidine 5'-monophosphate decarboxylase, orotidine 5'-monophosphate decarboxylase (OMPDC) and 2 more.

Read from the paper by an AI model and checked against the paper by a second, separate AI run; code converted the units.

CatLog also holds 42 records for EC 4.1.1.23 that are not yet re-read: from its earlier version, built from the enzyme databases and partly checked against the papers. All records for EC 4.1.1.23 in Browse.

Papers

Papers with records for EC 4.1.1.23
Paper	Organisms	Records
Conformational changes in orotidine 5'-monophosphate decarboxylase: a structure-based explanation for how the 5'-phosphate group activates the enzyme	Methanothermobacter thermautotrophicus	41
Mechanism of the orotidine 5'-monophosphate decarboxylase-catalyzed reaction: importance of residues in the orotate binding site	Methanothermobacter thermoautotrophicus	15
Enzyme architecture: deconstruction of the enzyme-activating phosphodianion interactions of orotidine 5'-monophosphate decarboxylase	Saccharomyces cerevisiae	10
Orotidine 5'-Monophosphate Decarboxylase: The Operation of Active Site Chains Within and Across Protein Subunits	Saccharomyces cerevisiae	10
Rate and Equilibrium Constants for an Enzyme Conformational Change during Catalysis by Orotidine 5'-Monophosphate Decarboxylase	Saccharomyces cerevisiae	9
Role of a guanidinium cation-phosphodianion pair in stabilizing the vinyl carbanion intermediate of orotidine 5'-phosphate decarboxylase-catalyzed reactions	Saccharomyces cerevisiae	7
Role of the Carboxylate in Enzyme-Catalyzed Decarboxylation of Orotidine 5'-Monophosphate: Transition State Stabilization Dominates Over Ground State Destabilization	Saccharomyces cerevisiae	7
Role of enzyme-ribofuranosyl contacts in the ground state and transition state for orotidine 5'-phosphate decarboxylase: a role for substrate destabilization?	Saccharomyces cerevisiae	5
Dissecting a charged network at the active site of orotidine-5'-phosphate decarboxylase	yeast	3

Records

Records for EC 4.1.1.23 read from the paper
Enzyme	Organism	Substrate	k_cat (s⁻¹)	K_m (mM)	k_cat/K_m (mM⁻¹ s⁻¹)	Conditions	Paper	Open record
orotidine 5'-monophosphate decarboxylasevariant Q215A/R235A	Saccharomyces cerevisiae	orotidine 5'-monophosphateionic strength I = 0.105 (NaCl)	0.02	1.4	0.014	pH 7.1, 25 °C	PMID 24958125	Open record: orotidine 5'-monophosphate decarboxylase variant Q215A/R235A, orotidine 5'-monophosphate
orotidine 5'-monophosphate decarboxylasevariant Q215A/R235A	Saccharomyces cerevisiae	orotidine 5'-monophosphateionic strength I = 0.05 (NaCl)	0.019	0.35	0.054	pH 7.1, 25 °C	PMID 24958125	Open record: orotidine 5'-monophosphate decarboxylase variant Q215A/R235A, orotidine 5'-monophosphate
orotidine 5'-monophosphate decarboxylasevariant Q215A/Y217F	Saccharomyces cerevisiae	orotidine 5'-monophosphateionic strength I = 0.105 (NaCl)	4.8	1.4	3.4	pH 7.1, 25 °C	PMID 24958125	Open record: orotidine 5'-monophosphate decarboxylase variant Q215A/Y217F, orotidine 5'-monophosphate
orotidine 5'-monophosphate decarboxylasevariant Q215A/Y217F	Saccharomyces cerevisiae	orotidine 5'-monophosphateionic strength I = 0.05 (NaCl)	5	0.29	17	pH 7.1, 25 °C	PMID 24958125	Open record: orotidine 5'-monophosphate decarboxylase variant Q215A/Y217F, orotidine 5'-monophosphate
orotidine 5'-monophosphate decarboxylasevariant Q215A/Y217F/R235A	Saccharomyces cerevisiae	orotidine 5'-monophosphateionic strength I = 0.105 (NaCl)	4.8 × 10⁻⁴	12.9	3.7 × 10⁻⁵	pH 7.1, 25 °C	PMID 24958125	Open record: orotidine 5'-monophosphate decarboxylase variant Q215A/Y217F/R235A, orotidine 5'-monophosphate
orotidine 5'-monophosphate decarboxylasevariant Q215A/Y217F/R235A	Saccharomyces cerevisiae	orotidine 5'-monophosphateionic strength I = 0.05 (NaCl)	4.8 × 10⁻⁴	2.2	2.2 × 10⁻⁴	pH 7.1, 25 °C	PMID 24958125	Open record: orotidine 5'-monophosphate decarboxylase variant Q215A/Y217F/R235A, orotidine 5'-monophosphate
orotidine 5'-monophosphate decarboxylasevariant Y217F	Saccharomyces cerevisiae	orotidine 5'-monophosphate	20	0.11	180	pH 7.1, 25 °C	PMID 24958125	Open record: orotidine 5'-monophosphate decarboxylase variant Y217F, orotidine 5'-monophosphate
orotidine 5'-monophosphate decarboxylasevariant Y217F/R235A	Saccharomyces cerevisiae	orotidine 5'-monophosphateionic strength I = 0.105 (NaCl)	0.11	27.1	0.0041	pH 7.1, 25 °C	PMID 24958125	Open record: orotidine 5'-monophosphate decarboxylase variant Y217F/R235A, orotidine 5'-monophosphate
orotidine 5'-monophosphate decarboxylasevariant Y217F/R235A	Saccharomyces cerevisiae	orotidine 5'-monophosphateionic strength I = 0.075 (NaCl)	0.11	12.9	0.0085	pH 7.1, 25 °C	PMID 24958125	Open record: orotidine 5'-monophosphate decarboxylase variant Y217F/R235A, orotidine 5'-monophosphate
orotidine 5'-monophosphate decarboxylasevariant Y217F/R235A	Saccharomyces cerevisiae	orotidine 5'-monophosphateionic strength I = 0.05 (NaCl)	0.11	6.1	0.018	pH 7.1, 25 °C	PMID 24958125	Open record: orotidine 5'-monophosphate decarboxylase variant Y217F/R235A, orotidine 5'-monophosphate
orotidine 5'-monophosphate decarboxylase (MtOMPDC)	Methanothermobacter thermautotrophicus	1-(beta-D-erythrofuranosyl)orotic acid	—	—	1.24 × 10⁻⁵	pH 7.1, 25 °C	PMID 23030629	Open record: orotidine 5'-monophosphate decarboxylase (MtOMPDC), 1-(beta-D-erythrofuranosyl)orotic acid
orotidine 5'-monophosphate decarboxylase (MtOMPDC)	Methanothermobacter thermautotrophicus	5-fluoro-1-(beta-D-erythrofuranosyl)orotic acid	—	—	0.0048	pH 7.1, 25 °C	PMID 23030629	Open record: orotidine 5'-monophosphate decarboxylase (MtOMPDC), 5-fluoro-1-(beta-D-erythrofuranosyl)orotic acid
orotidine 5'-monophosphate decarboxylase (MtOMPDC)	Methanothermobacter thermautotrophicus	orotidine 5'-monophosphate	5.3	0.0018	2.9 × 10³	pH 7.1, 25 °C	PMID 23030629	Open record: orotidine 5'-monophosphate decarboxylase (MtOMPDC), orotidine 5'-monophosphate
orotidine 5'-monophosphate decarboxylase (MtOMPDC)variant Q185A	Methanothermobacter thermautotrophicus	1-(beta-D-erythrofuranosyl)orotic acid	—	—	2 × 10⁻⁶	pH 7.1, 25 °C	PMID 23030629	Open record: orotidine 5'-monophosphate decarboxylase (MtOMPDC) variant Q185A, 1-(beta-D-erythrofuranosyl)orotic acid
orotidine 5'-monophosphate decarboxylase (MtOMPDC)variant Q185A	Methanothermobacter thermautotrophicus	5-fluoro-1-(beta-D-erythrofuranosyl)orotic acid	—	—	9.2 × 10⁻⁴	pH 7.1, 25 °C	PMID 23030629	Open record: orotidine 5'-monophosphate decarboxylase (MtOMPDC) variant Q185A, 5-fluoro-1-(beta-D-erythrofuranosyl)orotic acid
orotidine 5'-monophosphate decarboxylase (MtOMPDC)variant Q185A	Methanothermobacter thermautotrophicus	orotidine 5'-monophosphate	1.4	0.11	13	pH 7.1, 25 °C	PMID 23030629	Open record: orotidine 5'-monophosphate decarboxylase (MtOMPDC) variant Q185A, orotidine 5'-monophosphate
orotidine 5'-monophosphate decarboxylase (MtOMPDC)variant Q185A/R203A	Methanothermobacter thermautotrophicus	1-(beta-D-erythrofuranosyl)orotic acid	—	—	3.2 × 10⁻⁶	pH 7.1, 25 °C	PMID 23030629	Open record: orotidine 5'-monophosphate decarboxylase (MtOMPDC) variant Q185A/R203A, 1-(beta-D-erythrofuranosyl)orotic acid
orotidine 5'-monophosphate decarboxylase (MtOMPDC)variant Q185A/R203A	Methanothermobacter thermautotrophicus	orotidine 5'-monophosphate	—	—	0.0096	pH 7.1, 25 °C	PMID 23030629	Open record: orotidine 5'-monophosphate decarboxylase (MtOMPDC) variant Q185A/R203A, orotidine 5'-monophosphate
orotidine 5'-monophosphate decarboxylase (MtOMPDC)variant R160A	Methanothermobacter thermautotrophicus	1-(beta-D-erythrofuranosyl)orotic acid	—	—	2 × 10⁻⁷	pH 7.1, 25 °C	PMID 23030629	Open record: orotidine 5'-monophosphate decarboxylase (MtOMPDC) variant R160A, 1-(beta-D-erythrofuranosyl)orotic acid
orotidine 5'-monophosphate decarboxylase (MtOMPDC)variant R160A	Methanothermobacter thermautotrophicus	5-fluoro-1-(beta-D-erythrofuranosyl)orotic acid	—	—	2.1 × 10⁻⁴	pH 7.1, 25 °C	PMID 23030629	Open record: orotidine 5'-monophosphate decarboxylase (MtOMPDC) variant R160A, 5-fluoro-1-(beta-D-erythrofuranosyl)orotic acid
orotidine 5'-monophosphate decarboxylase (MtOMPDC)variant R160A	Methanothermobacter thermautotrophicus	orotidine 5'-monophosphate	2	0.03	67	pH 7.1, 25 °C	PMID 23030629	Open record: orotidine 5'-monophosphate decarboxylase (MtOMPDC) variant R160A, orotidine 5'-monophosphate
orotidine 5'-monophosphate decarboxylase (MtOMPDC)variant R160A/R203A	Methanothermobacter thermautotrophicus	1-(beta-D-erythrofuranosyl)orotic acid	—	—	2 × 10⁻⁷	pH 7.1, 25 °C	PMID 23030629	Open record: orotidine 5'-monophosphate decarboxylase (MtOMPDC) variant R160A/R203A, 1-(beta-D-erythrofuranosyl)orotic acid
orotidine 5'-monophosphate decarboxylase (MtOMPDC)variant R160A/R203A	Methanothermobacter thermautotrophicus	orotidine 5'-monophosphate	—	—	0.016	pH 7.1, 25 °C	PMID 23030629	Open record: orotidine 5'-monophosphate decarboxylase (MtOMPDC) variant R160A/R203A, orotidine 5'-monophosphate
orotidine 5'-monophosphate decarboxylase (MtOMPDC)variant R160A/V182A	Methanothermobacter thermautotrophicus	5-fluoro-1-(beta-D-erythrofuranosyl)orotic acid	—	—	2.5 × 10⁻⁵	pH 7.1, 25 °C	PMID 23030629	Open record: orotidine 5'-monophosphate decarboxylase (MtOMPDC) variant R160A/V182A, 5-fluoro-1-(beta-D-erythrofuranosyl)orotic acid
orotidine 5'-monophosphate decarboxylase (MtOMPDC)variant R160A/V182A	Methanothermobacter thermautotrophicus	orotidine 5'-monophosphate	1	0.6	1.7	pH 7.1, 25 °C	PMID 23030629	Open record: orotidine 5'-monophosphate decarboxylase (MtOMPDC) variant R160A/V182A, orotidine 5'-monophosphate
orotidine 5'-monophosphate decarboxylase (MtOMPDC)variant R160A/Y206F	Methanothermobacter thermautotrophicus	5-fluoro-1-(beta-D-erythrofuranosyl)orotic acid	—	—	3.2 × 10⁻⁵	pH 7.1, 25 °C	PMID 23030629	Open record: orotidine 5'-monophosphate decarboxylase (MtOMPDC) variant R160A/Y206F, 5-fluoro-1-(beta-D-erythrofuranosyl)orotic acid
orotidine 5'-monophosphate decarboxylase (MtOMPDC)variant R160A/Y206F	Methanothermobacter thermautotrophicus	orotidine 5'-monophosphate	1.1	0.13	8.5	pH 7.1, 25 °C	PMID 23030629	Open record: orotidine 5'-monophosphate decarboxylase (MtOMPDC) variant R160A/Y206F, orotidine 5'-monophosphate
orotidine 5'-monophosphate decarboxylase (MtOMPDC)variant R203A	Methanothermobacter thermautotrophicus	1-(beta-D-erythrofuranosyl)orotic acid	—	—	5.5 × 10⁻⁶	pH 7.1, 25 °C	PMID 23030629	Open record: orotidine 5'-monophosphate decarboxylase (MtOMPDC) variant R203A, 1-(beta-D-erythrofuranosyl)orotic acid
orotidine 5'-monophosphate decarboxylase (MtOMPDC)variant R203A	Methanothermobacter thermautotrophicus	5-fluoro-1-(beta-D-erythrofuranosyl)orotic acid	—	—	0.0047	pH 7.1, 25 °C	PMID 23030629	Open record: orotidine 5'-monophosphate decarboxylase (MtOMPDC) variant R203A, 5-fluoro-1-(beta-D-erythrofuranosyl)orotic acid
orotidine 5'-monophosphate decarboxylase (MtOMPDC)variant R203A	Methanothermobacter thermautotrophicus	orotidine 5'-monophosphate	1.5	0.98	1.5	pH 7.1, 25 °C	PMID 23030629	Open record: orotidine 5'-monophosphate decarboxylase (MtOMPDC) variant R203A, orotidine 5'-monophosphate
orotidine 5'-monophosphate decarboxylase (MtOMPDC)variant T159V	Methanothermobacter thermautotrophicus	1-(beta-D-erythrofuranosyl)orotic acid	—	—	4 × 10⁻⁷	pH 7.1, 25 °C	PMID 23030629	Open record: orotidine 5'-monophosphate decarboxylase (MtOMPDC) variant T159V, 1-(beta-D-erythrofuranosyl)orotic acid
orotidine 5'-monophosphate decarboxylase (MtOMPDC)variant T159V	Methanothermobacter thermautotrophicus	5-fluoro-1-(beta-D-erythrofuranosyl)orotic acid	—	—	8.3 × 10⁻⁵	pH 7.1, 25 °C	PMID 23030629	Open record: orotidine 5'-monophosphate decarboxylase (MtOMPDC) variant T159V, 5-fluoro-1-(beta-D-erythrofuranosyl)orotic acid
orotidine 5'-monophosphate decarboxylase (MtOMPDC)variant T159V	Methanothermobacter thermautotrophicus	orotidine 5'-monophosphate	2.3	0.033	70	pH 7.1, 25 °C	PMID 23030629	Open record: orotidine 5'-monophosphate decarboxylase (MtOMPDC) variant T159V, orotidine 5'-monophosphate
orotidine 5'-monophosphate decarboxylase (MtOMPDC)variant T159V/R203A	Methanothermobacter thermautotrophicus	1-(beta-D-erythrofuranosyl)orotic acid	—	—	2 × 10⁻⁷	pH 7.1, 25 °C	PMID 23030629	Open record: orotidine 5'-monophosphate decarboxylase (MtOMPDC) variant T159V/R203A, 1-(beta-D-erythrofuranosyl)orotic acid
orotidine 5'-monophosphate decarboxylase (MtOMPDC)variant T159V/R203A	Methanothermobacter thermautotrophicus	orotidine 5'-monophosphate	—	—	0.0099	pH 7.1, 25 °C	PMID 23030629	Open record: orotidine 5'-monophosphate decarboxylase (MtOMPDC) variant T159V/R203A, orotidine 5'-monophosphate
orotidine 5'-monophosphate decarboxylase (MtOMPDC)variant T159V/V182A	Methanothermobacter thermautotrophicus	5-fluoro-1-(beta-D-erythrofuranosyl)orotic acid	—	—	3.4 × 10⁻⁵	pH 7.1, 25 °C	PMID 23030629	Open record: orotidine 5'-monophosphate decarboxylase (MtOMPDC) variant T159V/V182A, 5-fluoro-1-(beta-D-erythrofuranosyl)orotic acid
orotidine 5'-monophosphate decarboxylase (MtOMPDC)variant T159V/V182A	Methanothermobacter thermautotrophicus	orotidine 5'-monophosphate	0.56	0.7	0.8	pH 7.1, 25 °C	PMID 23030629	Open record: orotidine 5'-monophosphate decarboxylase (MtOMPDC) variant T159V/V182A, orotidine 5'-monophosphate
orotidine 5'-monophosphate decarboxylase (MtOMPDC)variant T159V/V182A/Y206F	Methanothermobacter thermautotrophicus	5-fluoro-1-(beta-D-erythrofuranosyl)orotic acid	—	—	1.7 × 10⁻⁵	pH 7.1, 25 °C	PMID 23030629	Open record: orotidine 5'-monophosphate decarboxylase (MtOMPDC) variant T159V/V182A/Y206F, 5-fluoro-1-(beta-D-erythrofuranosyl)orotic acid
orotidine 5'-monophosphate decarboxylase (MtOMPDC)variant T159V/V182A/Y206F	Methanothermobacter thermautotrophicus	orotidine 5'-monophosphate	0.24	1.9	0.13	pH 7.1, 25 °C	PMID 23030629	Open record: orotidine 5'-monophosphate decarboxylase (MtOMPDC) variant T159V/V182A/Y206F, orotidine 5'-monophosphate
orotidine 5'-monophosphate decarboxylase (MtOMPDC)variant T159V/Y206F	Methanothermobacter thermautotrophicus	5-fluoro-1-(beta-D-erythrofuranosyl)orotic acid	—	—	3.5 × 10⁻⁵	pH 7.1, 25 °C	PMID 23030629	Open record: orotidine 5'-monophosphate decarboxylase (MtOMPDC) variant T159V/Y206F, 5-fluoro-1-(beta-D-erythrofuranosyl)orotic acid
orotidine 5'-monophosphate decarboxylase (MtOMPDC)variant T159V/Y206F	Methanothermobacter thermautotrophicus	orotidine 5'-monophosphate	1.1	0.3	3.7	pH 7.1, 25 °C	PMID 23030629	Open record: orotidine 5'-monophosphate decarboxylase (MtOMPDC) variant T159V/Y206F, orotidine 5'-monophosphate
orotidine 5'-monophosphate decarboxylase (MtOMPDC)variant V182A	Methanothermobacter thermautotrophicus	1-(beta-D-erythrofuranosyl)orotic acid	—	—	1.4 × 10⁻⁶	pH 7.1, 25 °C	PMID 23030629	Open record: orotidine 5'-monophosphate decarboxylase (MtOMPDC) variant V182A, 1-(beta-D-erythrofuranosyl)orotic acid
orotidine 5'-monophosphate decarboxylase (MtOMPDC)variant V182A	Methanothermobacter thermautotrophicus	5-fluoro-1-(beta-D-erythrofuranosyl)orotic acid	—	—	6.3 × 10⁻⁴	pH 7.1, 25 °C	PMID 23030629	Open record: orotidine 5'-monophosphate decarboxylase (MtOMPDC) variant V182A, 5-fluoro-1-(beta-D-erythrofuranosyl)orotic acid
orotidine 5'-monophosphate decarboxylase (MtOMPDC)variant V182A	Methanothermobacter thermautotrophicus	orotidine 5'-monophosphate	3	0.024	130	pH 7.1, 25 °C	PMID 23030629	Open record: orotidine 5'-monophosphate decarboxylase (MtOMPDC) variant V182A, orotidine 5'-monophosphate
orotidine 5'-monophosphate decarboxylase (MtOMPDC)variant V182A/R203A	Methanothermobacter thermautotrophicus	1-(beta-D-erythrofuranosyl)orotic acid	—	—	1.3 × 10⁻⁶	pH 7.1, 25 °C	PMID 23030629	Open record: orotidine 5'-monophosphate decarboxylase (MtOMPDC) variant V182A/R203A, 1-(beta-D-erythrofuranosyl)orotic acid
orotidine 5'-monophosphate decarboxylase (MtOMPDC)variant V182A/R203A	Methanothermobacter thermautotrophicus	orotidine 5'-monophosphate	—	—	0.032	pH 7.1, 25 °C	PMID 23030629	Open record: orotidine 5'-monophosphate decarboxylase (MtOMPDC) variant V182A/R203A, orotidine 5'-monophosphate
orotidine 5'-monophosphate decarboxylase (MtOMPDC)variant V182A/Y206F	Methanothermobacter thermautotrophicus	5-fluoro-1-(beta-D-erythrofuranosyl)orotic acid	—	—	3 × 10⁻⁴	pH 7.1, 25 °C	PMID 23030629	Open record: orotidine 5'-monophosphate decarboxylase (MtOMPDC) variant V182A/Y206F, 5-fluoro-1-(beta-D-erythrofuranosyl)orotic acid
orotidine 5'-monophosphate decarboxylase (MtOMPDC)variant V182A/Y206F	Methanothermobacter thermautotrophicus	orotidine 5'-monophosphate	1.5	0.1	15	pH 7.1, 25 °C	PMID 23030629	Open record: orotidine 5'-monophosphate decarboxylase (MtOMPDC) variant V182A/Y206F, orotidine 5'-monophosphate
orotidine 5'-monophosphate decarboxylase (MtOMPDC)variant Y206F	Methanothermobacter thermautotrophicus	1-(beta-D-erythrofuranosyl)orotic acid	—	—	6 × 10⁻⁶	pH 7.1, 25 °C	PMID 23030629	Open record: orotidine 5'-monophosphate decarboxylase (MtOMPDC) variant Y206F, 1-(beta-D-erythrofuranosyl)orotic acid
orotidine 5'-monophosphate decarboxylase (MtOMPDC)variant Y206F	Methanothermobacter thermautotrophicus	5-fluoro-1-(beta-D-erythrofuranosyl)orotic acid	—	—	0.0022	pH 7.1, 25 °C	PMID 23030629	Open record: orotidine 5'-monophosphate decarboxylase (MtOMPDC) variant Y206F, 5-fluoro-1-(beta-D-erythrofuranosyl)orotic acid
orotidine 5'-monophosphate decarboxylase (MtOMPDC)variant Y206F	Methanothermobacter thermautotrophicus	orotidine 5'-monophosphate	4.1	0.0055	750	pH 7.1, 25 °C	PMID 23030629	Open record: orotidine 5'-monophosphate decarboxylase (MtOMPDC) variant Y206F, orotidine 5'-monophosphate
orotidine 5'-monophosphate decarboxylase (MtOMPDC)	Methanothermobacter thermoautotrophicus	orotidine 5'-monophosphateTable 3	4	0.0016	2 × 10³	pH 7.1, 25 °C	PMID 21870810	Open record: orotidine 5'-monophosphate decarboxylase (MtOMPDC), orotidine 5'-monophosphate
orotidine 5'-monophosphate decarboxylase (MtOMPDC)	Methanothermobacter thermoautotrophicus	orotidine 5'-monophosphateTable 4	4.6	0.0021	2.2 × 10³	pH 7.1, 25 °C	PMID 21870810	Open record: orotidine 5'-monophosphate decarboxylase (MtOMPDC), orotidine 5'-monophosphate
orotidine 5'-monophosphate decarboxylase (MtOMPDC)variant D70N	Methanothermobacter thermoautotrophicus	orotidine 5'-monophosphate	0.024	0.006	4	pH 7.1, 25 °C	PMID 21870810	Open record: orotidine 5'-monophosphate decarboxylase (MtOMPDC) variant D70N, orotidine 5'-monophosphate
orotidine 5'-monophosphate decarboxylase (MtOMPDC)variant D70N/I96S	Methanothermobacter thermoautotrophicus	orotidine 5'-monophosphate	6 × 10⁻⁵	—	—	pH 7.1, 25 °C	PMID 21870810	Open record: orotidine 5'-monophosphate decarboxylase (MtOMPDC) variant D70N/I96S, orotidine 5'-monophosphate
orotidine 5'-monophosphate decarboxylase (MtOMPDC)variant D70N/L123S	Methanothermobacter thermoautotrophicus	orotidine 5'-monophosphate	9.3 × 10⁻⁴	—	—	pH 7.1, 25 °C	PMID 21870810	Open record: orotidine 5'-monophosphate decarboxylase (MtOMPDC) variant D70N/L123S, orotidine 5'-monophosphate
orotidine 5'-monophosphate decarboxylase (MtOMPDC)variant D70N/V155S	Methanothermobacter thermoautotrophicus	orotidine 5'-monophosphate	1.8 × 10⁻⁴	—	—	pH 7.1, 25 °C	PMID 21870810	Open record: orotidine 5'-monophosphate decarboxylase (MtOMPDC) variant D70N/V155S, orotidine 5'-monophosphate
orotidine 5'-monophosphate decarboxylase (MtOMPDC)variant I96S	Methanothermobacter thermoautotrophicus	orotidine 5'-monophosphate	0.011	0.001	10	pH 7.1, 25 °C	PMID 21870810	Open record: orotidine 5'-monophosphate decarboxylase (MtOMPDC) variant I96S, orotidine 5'-monophosphate
orotidine 5'-monophosphate decarboxylase (MtOMPDC)variant I96T	Methanothermobacter thermoautotrophicus	orotidine 5'-monophosphate	0.69	0.0023	300	pH 7.1, 25 °C	PMID 21870810	Open record: orotidine 5'-monophosphate decarboxylase (MtOMPDC) variant I96T, orotidine 5'-monophosphate
orotidine 5'-monophosphate decarboxylase (MtOMPDC)variant L123N	Methanothermobacter thermoautotrophicus	orotidine 5'-monophosphate	0.64	0.0035	190	pH 7.1, 25 °C	PMID 21870810	Open record: orotidine 5'-monophosphate decarboxylase (MtOMPDC) variant L123N, orotidine 5'-monophosphate
orotidine 5'-monophosphate decarboxylase (MtOMPDC)variant L123S	Methanothermobacter thermoautotrophicus	orotidine 5'-monophosphate	0.36	0.003	120	pH 7.1, 25 °C	PMID 21870810	Open record: orotidine 5'-monophosphate decarboxylase (MtOMPDC) variant L123S, orotidine 5'-monophosphate
orotidine 5'-monophosphate decarboxylase (MtOMPDC)variant S127A	Methanothermobacter thermoautotrophicus	orotidine 5'-monophosphate	0.035	0.096	0.36	pH 7.1, 25 °C	PMID 21870810	Open record: orotidine 5'-monophosphate decarboxylase (MtOMPDC) variant S127A, orotidine 5'-monophosphate
orotidine 5'-monophosphate decarboxylase (MtOMPDC)variant S127G	Methanothermobacter thermoautotrophicus	orotidine 5'-monophosphate	0.26	0.059	4.3	pH 7.1, 25 °C	PMID 21870810	Open record: orotidine 5'-monophosphate decarboxylase (MtOMPDC) variant S127G, orotidine 5'-monophosphate
orotidine 5'-monophosphate decarboxylase (MtOMPDC)variant S127P	Methanothermobacter thermoautotrophicus	orotidine 5'-monophosphate	—	—	8.8 × 10⁻⁴	pH 7.1, 25 °C	PMID 21870810	Open record: orotidine 5'-monophosphate decarboxylase (MtOMPDC) variant S127P, orotidine 5'-monophosphate
orotidine 5'-monophosphate decarboxylase (MtOMPDC)variant V155D	Methanothermobacter thermoautotrophicus	orotidine 5'-monophosphate	5 × 10⁻⁴	0.0046	0.46	pH 7.1, 25 °C	PMID 21870810	Open record: orotidine 5'-monophosphate decarboxylase (MtOMPDC) variant V155D, orotidine 5'-monophosphate
orotidine 5'-monophosphate decarboxylase (MtOMPDC)variant V155S	Methanothermobacter thermoautotrophicus	orotidine 5'-monophosphate	0.011	0.0047	22	pH 7.1, 25 °C	PMID 21870810	Open record: orotidine 5'-monophosphate decarboxylase (MtOMPDC) variant V155S, orotidine 5'-monophosphate
orotidine 5'-monophosphate decarboxylase (OMPDC)	Saccharomyces cerevisiae	5-fluoroorotidine 5'-monophosphate	95	0.008	1.2 × 10⁴	pH 7.1, 25 °C	PMID 32374983	Open record: orotidine 5'-monophosphate decarboxylase (OMPDC), 5-fluoroorotidine 5'-monophosphate
orotidine 5'-monophosphate decarboxylase (OMPDC)	Saccharomyces cerevisiae	orotidine 5'-monophosphate	15	0.0014	1.1 × 10⁴	pH 7.1, 25 °C	PMID 32374983	Open record: orotidine 5'-monophosphate decarboxylase (OMPDC), orotidine 5'-monophosphate
orotidine 5'-monophosphate decarboxylase (OMPDC)variant D37A	Saccharomyces cerevisiae	5-fluoroorotidine 5'-monophosphate	73	1.1	66	pH 7.1, 25 °C	PMID 32374983	Open record: orotidine 5'-monophosphate decarboxylase (OMPDC) variant D37A, 5-fluoroorotidine 5'-monophosphate
orotidine 5'-monophosphate decarboxylase (OMPDC)variant D37A	Saccharomyces cerevisiae	orotidine 5'-monophosphate	0.5	0.042	12	pH 7.1, 25 °C	PMID 32374983	Open record: orotidine 5'-monophosphate decarboxylase (OMPDC) variant D37A, orotidine 5'-monophosphate
orotidine 5'-monophosphate decarboxylase (OMPDC)variant D37G	Saccharomyces cerevisiae	5-fluoroorotidine 5'-monophosphate	134	0.025	5.4 × 10³	pH 7.1, 25 °C	PMID 32374983	Open record: orotidine 5'-monophosphate decarboxylase (OMPDC) variant D37G, 5-fluoroorotidine 5'-monophosphate
orotidine 5'-monophosphate decarboxylase (OMPDC)variant D37G	Saccharomyces cerevisiae	orotidine 5'-monophosphate	4.2	0.013	320	pH 7.1, 25 °C	PMID 32374983	Open record: orotidine 5'-monophosphate decarboxylase (OMPDC) variant D37G, orotidine 5'-monophosphate
orotidine 5'-monophosphate decarboxylase (OMPDC)variant T100A	Saccharomyces cerevisiae	5-fluoroorotidine 5'-monophosphate	—	—	4.3 × 10³	pH 7.1, 25 °C	PMID 32374983	Open record: orotidine 5'-monophosphate decarboxylase (OMPDC) variant T100A, 5-fluoroorotidine 5'-monophosphate
orotidine 5'-monophosphate decarboxylase (OMPDC)variant T100A	Saccharomyces cerevisiae	orotidine 5'-monophosphate	3.3	0.016	210	pH 7.1, 25 °C	PMID 32374983	Open record: orotidine 5'-monophosphate decarboxylase (OMPDC) variant T100A, orotidine 5'-monophosphate
orotidine 5'-monophosphate decarboxylase (OMPDC)variant T100G	Saccharomyces cerevisiae	5-fluoroorotidine 5'-monophosphate	—	—	7.2	pH 7.1, 25 °C	PMID 32374983	Open record: orotidine 5'-monophosphate decarboxylase (OMPDC) variant T100G, 5-fluoroorotidine 5'-monophosphate
orotidine 5'-monophosphate decarboxylase (OMPDC)variant T100G	Saccharomyces cerevisiae	orotidine 5'-monophosphate	1.1	0.44	2.5	pH 7.1, 25 °C	PMID 32374983	Open record: orotidine 5'-monophosphate decarboxylase (OMPDC) variant T100G, orotidine 5'-monophosphate
orotidine 5'-monophosphate decarboxylase (ScOMPDC)variant Q215A	Saccharomyces cerevisiae	5-fluoroorotidine 5'-monophosphate	190	0.096	2 × 10³	pH 7.1, 25 °C	PMID 26135041	Open record: orotidine 5'-monophosphate decarboxylase (ScOMPDC) variant Q215A, 5-fluoroorotidine 5'-monophosphate
orotidine 5'-monophosphate decarboxylase (ScOMPDC)variant Q215A	Saccharomyces cerevisiae	5-fluorouridine 5'-monophosphatepD 7.1 (in D2O; pD = meter reading + 0.4)	2.7 × 10⁻⁴	2	1.3 × 10⁻⁴	25 °C	PMID 31365243	Open record: orotidine 5'-monophosphate decarboxylase (ScOMPDC) variant Q215A, 5-fluorouridine 5'-monophosphate
orotidine 5'-monophosphate decarboxylase (ScOMPDC)variant Q215A	Saccharomyces cerevisiae	5-fluorouridine 5'-monophosphatepD 7.4 (in D2O; pD = meter reading + 0.4); 50 mM MOPS buffer	3.6 × 10⁻⁴	0.7	5.1 × 10⁻⁴	25 °C	PMID 31365243	Open record: orotidine 5'-monophosphate decarboxylase (ScOMPDC) variant Q215A, 5-fluorouridine 5'-monophosphate
orotidine 5'-monophosphate decarboxylase (ScOMPDC)variant Q215A	Saccharomyces cerevisiae	5-fluorouridine 5'-monophosphatepD 7.7 (in D2O; pD = meter reading + 0.4); 50 mM MOPS buffer	4.1 × 10⁻⁴	0.38	0.00108	25 °C	PMID 31365243	Open record: orotidine 5'-monophosphate decarboxylase (ScOMPDC) variant Q215A, 5-fluorouridine 5'-monophosphate
orotidine 5'-monophosphate decarboxylase (ScOMPDC)variant Q215A	Saccharomyces cerevisiae	5-fluorouridine 5'-monophosphatepD 8.1 (in D2O; pD = meter reading + 0.4)	4.3 × 10⁻⁴	0.42	0.00102	25 °C	PMID 31365243	Open record: orotidine 5'-monophosphate decarboxylase (ScOMPDC) variant Q215A, 5-fluorouridine 5'-monophosphate
orotidine 5'-monophosphate decarboxylase (ScOMPDC)variant Q215A	Saccharomyces cerevisiae	5-fluorouridine 5'-monophosphatepD 9.3 (in D2O; pD = meter reading + 0.4)	3 × 10⁻⁴	0.54	5.6 × 10⁻⁴	25 °C	PMID 31365243	Open record: orotidine 5'-monophosphate decarboxylase (ScOMPDC) variant Q215A, 5-fluorouridine 5'-monophosphate
orotidine 5'-monophosphate decarboxylase (ScOMPDC)variant Q215A/R235A	Saccharomyces cerevisiae	5-fluoroorotidine 5'-monophosphate	4.7	0.65	7.2	pH 7.1, 25 °C	PMID 26135041	Open record: orotidine 5'-monophosphate decarboxylase (ScOMPDC) variant Q215A/R235A, 5-fluoroorotidine 5'-monophosphate
orotidine 5'-monophosphate decarboxylase (ScOMPDC)variant Q215A/Y217F	Saccharomyces cerevisiae	5-fluoroorotidine 5'-monophosphate	49	0.92	53	pH 7.1, 25 °C	PMID 26135041	Open record: orotidine 5'-monophosphate decarboxylase (ScOMPDC) variant Q215A/Y217F, 5-fluoroorotidine 5'-monophosphate
orotidine 5'-monophosphate decarboxylase (ScOMPDC)variant Q215A/Y217F	Saccharomyces cerevisiae	5-fluorouridine 5'-monophosphate	—	—	3.9 × 10⁻⁶	25 °C	PMID 31365243	Open record: orotidine 5'-monophosphate decarboxylase (ScOMPDC) variant Q215A/Y217F, 5-fluorouridine 5'-monophosphate
orotidine 5'-monophosphate decarboxylase (ScOMPDC)variant Q215A/Y217F/R235A	Saccharomyces cerevisiae	5-fluoroorotidine 5'-monophosphate	—	—	0.028	pH 7.1, 25 °C	PMID 26135041	Open record: orotidine 5'-monophosphate decarboxylase (ScOMPDC) variant Q215A/Y217F/R235A, 5-fluoroorotidine 5'-monophosphate
orotidine 5'-monophosphate decarboxylase (ScOMPDC)variant R235A	Saccharomyces cerevisiae	1-(beta-D-erythrofuranosyl) 5-fluoroorotic acid	—	—	0.012	pH 7, 25 °C	PMID 24053466	Open record: orotidine 5'-monophosphate decarboxylase (ScOMPDC) variant R235A, 1-(beta-D-erythrofuranosyl) 5-fluoroorotic acid
orotidine 5'-monophosphate decarboxylase (ScOMPDC)variant R235A	Saccharomyces cerevisiae	5-fluoroorotidine 5'-monophosphate	92	0.58	160	pH 7.1, 25 °C	PMID 24053466	Open record: orotidine 5'-monophosphate decarboxylase (ScOMPDC) variant R235A, 5-fluoroorotidine 5'-monophosphate
orotidine 5'-monophosphate decarboxylase (ScOMPDC)variant R235A	Saccharomyces cerevisiae	5-fluorouridine 5'-monophosphate	9.3 × 10⁻⁶	5	1.9 × 10⁻⁶	25 °C	PMID 24053466	Open record: orotidine 5'-monophosphate decarboxylase (ScOMPDC) variant R235A, 5-fluorouridine 5'-monophosphate
orotidine 5'-monophosphate decarboxylase (ScOMPDC)variant R235A	Saccharomyces cerevisiae	orotidine 5'-monophosphateI = 0.10 (NaCl)	1	1.1	0.91	pH 7.1, 25 °C	PMID 24053466	Open record: orotidine 5'-monophosphate decarboxylase (ScOMPDC) variant R235A, orotidine 5'-monophosphate
orotidine 5'-monophosphate decarboxylase (ScOMPDC)variant R235A	Saccharomyces cerevisiae	orotidine 5'-monophosphateI = 0.050 (NaCl)	0.93	0.23	4	pH 7.1, 25 °C	PMID 24053466	Open record: orotidine 5'-monophosphate decarboxylase (ScOMPDC) variant R235A, orotidine 5'-monophosphate
orotidine 5'-monophosphate decarboxylase (ScOMPDC)variant R235A	Saccharomyces cerevisiae	orotidine 5'-monophosphateI = 0.035 (NaCl)	1.21	0.23	5.3	pH 7.1, 25 °C	PMID 24053466	Open record: orotidine 5'-monophosphate decarboxylase (ScOMPDC) variant R235A, orotidine 5'-monophosphate
orotidine 5'-monophosphate decarboxylase (ScOMPDC)variant R235A	Saccharomyces cerevisiae	orotidine 5'-monophosphateI = 0.020 (NaCl)	1.33	0.16	8.3	pH 7.1, 25 °C	PMID 24053466	Open record: orotidine 5'-monophosphate decarboxylase (ScOMPDC) variant R235A, orotidine 5'-monophosphate
orotidine 5'-monophosphate decarboxylase (ScOMPDC)variant S154A	Saccharomyces cerevisiae	5-fluoroorotidine 5'-monophosphate	16	0.055	290	pH 7.1, 25 °C	PMID 26135041	Open record: orotidine 5'-monophosphate decarboxylase (ScOMPDC) variant S154A, 5-fluoroorotidine 5'-monophosphate
orotidine 5'-monophosphate decarboxylase (ScOMPDC)variant S154A/Q215A	Saccharomyces cerevisiae	5-fluoroorotidine 5'-monophosphate	6.6	0.086	77	pH 7.1, 25 °C	PMID 26135041	Open record: orotidine 5'-monophosphate decarboxylase (ScOMPDC) variant S154A/Q215A, 5-fluoroorotidine 5'-monophosphate
orotidine 5'-monophosphate decarboxylase (ScOMPDC)variant Y217A	Saccharomyces cerevisiae	5-fluoroorotidine 5'-monophosphate	8.2	0.62	13	pH 7.1, 25 °C	PMID 26135041	Open record: orotidine 5'-monophosphate decarboxylase (ScOMPDC) variant Y217A, 5-fluoroorotidine 5'-monophosphate
orotidine 5'-monophosphate decarboxylase (ScOMPDC)variant Y217F	Saccharomyces cerevisiae	5-fluoroorotidine 5'-monophosphate	430	0.42	1.1 × 10³	pH 7.1, 25 °C	PMID 26135041	Open record: orotidine 5'-monophosphate decarboxylase (ScOMPDC) variant Y217F, 5-fluoroorotidine 5'-monophosphate
orotidine 5'-monophosphate decarboxylase (ScOMPDC)variant Y217F	Saccharomyces cerevisiae	5-fluorouridine 5'-monophosphate	0.0023	5.8	4 × 10⁻⁴	25 °C	PMID 31365243	Open record: orotidine 5'-monophosphate decarboxylase (ScOMPDC) variant Y217F, 5-fluorouridine 5'-monophosphate
orotidine 5'-monophosphate decarboxylase (ScOMPDC)variant Y217F/R235A	Saccharomyces cerevisiae	5-fluoroorotidine 5'-monophosphate	—	—	0.82	pH 7.1, 25 °C	PMID 26135041	Open record: orotidine 5'-monophosphate decarboxylase (ScOMPDC) variant Y217F/R235A, 5-fluoroorotidine 5'-monophosphate
orotidine 5′-phosphate decarboxylase (ODCase)	Saccharomyces cerevisiae	2′-deoxyorotidine 5′-phosphate	0.15	0.0054	28	pH 7.2, 25 °C	PMID 11371183	Open record: orotidine 5′-phosphate decarboxylase (ODCase), 2′-deoxyorotidine 5′-phosphate
orotidine 5′-phosphate decarboxylase (ODCase)variant D37A	Saccharomyces cerevisiae	2′-deoxyorotidine 5′-phosphate	0.0017	0.01	0.17	pH 7.2, 25 °C	PMID 11371183	Open record: orotidine 5′-phosphate decarboxylase (ODCase) variant D37A, 2′-deoxyorotidine 5′-phosphate
orotidine 5′-phosphate decarboxylase (ODCase)variant D37A	Saccharomyces cerevisiae	orotidine 5′-phosphate	0.9	0.0042	210	pH 7.2, 25 °C	PMID 11371183	Open record: orotidine 5′-phosphate decarboxylase (ODCase) variant D37A, orotidine 5′-phosphate
orotidine 5′-phosphate decarboxylase (ODCase)variant T100A	Saccharomyces cerevisiae	2′-deoxyorotidine 5′-phosphate	0.16	0.0052	31	pH 7.2, 25 °C	PMID 11371183	Open record: orotidine 5′-phosphate decarboxylase (ODCase) variant T100A, 2′-deoxyorotidine 5′-phosphate
orotidine 5′-phosphate decarboxylase (ODCase)variant T100A	Saccharomyces cerevisiae	orotidine 5′-phosphate	7.2	0.0067	1.1 × 10³	pH 7.2, 25 °C	PMID 11371183	Open record: orotidine 5′-phosphate decarboxylase (ODCase) variant T100A, orotidine 5′-phosphate
orotidine-5′-phosphate decarboxylase (ODCase)	yeast	orotidine 5′-phosphate	44	7 × 10⁻⁴	6.3 × 10⁴	pH 7.2	PMID 11278904	Open record: orotidine-5′-phosphate decarboxylase (ODCase), orotidine 5′-phosphate
orotidine-5′-phosphate decarboxylase (ODCase)variant K59A	yeast	orotidine 5′-phosphate	0.34	0.64	0.53	pH 7.2	PMID 11278904	Open record: orotidine-5′-phosphate decarboxylase (ODCase) variant K59A, orotidine 5′-phosphate
orotidine-5′-phosphate decarboxylase (ODCase)variant Q215A	yeast	orotidine 5′-phosphate	41	0.0025	1.6 × 10⁴	pH 7.2	PMID 11278904	Open record: orotidine-5′-phosphate decarboxylase (ODCase) variant Q215A, orotidine 5′-phosphate