Values CatLog read from this paper
Role of the Carboxylate in Enzyme-Catalyzed Decarboxylation of Orotidine 5'-Monophosphate: Transition State Stabilization Dominates Over Ground State Destabilization
PMID 31365243doi:10.1021/jacs.9b04823Open in Browse
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CatLog read 7 records (19 values) from this paper: orotidine 5'-monophosphate decarboxylase (ScOMPDC) from Saccharomyces cerevisiae.
Read from the paper by an AI model and checked against the paper by a second, separate AI run; code converted the units. Values are in CatLog's units; each record opens in Browse with the line the paper prints and the checks.
| Enzyme | Organism | Substrate | kcat (s⁻¹) | Km (mM) | kcat/Km (mM⁻¹ s⁻¹) | Conditions | Open record |
|---|---|---|---|---|---|---|---|
| orotidine 5'-monophosphate decarboxylase (ScOMPDC)variant Q215A | Saccharomyces cerevisiae | 5-fluorouridine 5'-monophosphatepD 7.1 (in D2O; pD = meter reading + 0.4) | 2.7 × 10⁻⁴ | 2 | 1.3 × 10⁻⁴ | 25 °C | Open record: orotidine 5'-monophosphate decarboxylase (ScOMPDC) variant Q215A, 5-fluorouridine 5'-monophosphate |
| orotidine 5'-monophosphate decarboxylase (ScOMPDC)variant Q215A | Saccharomyces cerevisiae | 5-fluorouridine 5'-monophosphatepD 7.4 (in D2O; pD = meter reading + 0.4); 50 mM MOPS buffer | 3.6 × 10⁻⁴ | 0.7 | 5.1 × 10⁻⁴ | 25 °C | Open record: orotidine 5'-monophosphate decarboxylase (ScOMPDC) variant Q215A, 5-fluorouridine 5'-monophosphate |
| orotidine 5'-monophosphate decarboxylase (ScOMPDC)variant Q215A | Saccharomyces cerevisiae | 5-fluorouridine 5'-monophosphatepD 7.7 (in D2O; pD = meter reading + 0.4); 50 mM MOPS buffer | 4.1 × 10⁻⁴ | 0.38 | 0.00108 | 25 °C | Open record: orotidine 5'-monophosphate decarboxylase (ScOMPDC) variant Q215A, 5-fluorouridine 5'-monophosphate |
| orotidine 5'-monophosphate decarboxylase (ScOMPDC)variant Q215A | Saccharomyces cerevisiae | 5-fluorouridine 5'-monophosphatepD 8.1 (in D2O; pD = meter reading + 0.4) | 4.3 × 10⁻⁴ | 0.42 | 0.00102 | 25 °C | Open record: orotidine 5'-monophosphate decarboxylase (ScOMPDC) variant Q215A, 5-fluorouridine 5'-monophosphate |
| orotidine 5'-monophosphate decarboxylase (ScOMPDC)variant Q215A | Saccharomyces cerevisiae | 5-fluorouridine 5'-monophosphatepD 9.3 (in D2O; pD = meter reading + 0.4) | 3 × 10⁻⁴ | 0.54 | 5.6 × 10⁻⁴ | 25 °C | Open record: orotidine 5'-monophosphate decarboxylase (ScOMPDC) variant Q215A, 5-fluorouridine 5'-monophosphate |
| orotidine 5'-monophosphate decarboxylase (ScOMPDC)variant Q215A/Y217F | Saccharomyces cerevisiae | 5-fluorouridine 5'-monophosphate | — | — | 3.9 × 10⁻⁶ | 25 °C | Open record: orotidine 5'-monophosphate decarboxylase (ScOMPDC) variant Q215A/Y217F, 5-fluorouridine 5'-monophosphate |
| orotidine 5'-monophosphate decarboxylase (ScOMPDC)variant Y217F | Saccharomyces cerevisiae | 5-fluorouridine 5'-monophosphate | 0.0023 | 5.8 | 4 × 10⁻⁴ | 25 °C | Open record: orotidine 5'-monophosphate decarboxylase (ScOMPDC) variant Y217F, 5-fluorouridine 5'-monophosphate |