Values CatLog read from this paper
Revisiting the nucleotide and aminoglycoside substrate specificity of the bifunctional aminoglycoside acetyltransferase(6')-Ie/aminoglycoside phosphotransferase(2'')-Ia enzyme
PMID 23115238doi:10.1074/jbc.m112.416453Open in Browse
The paper itself is not on this site: read it at the publisher. This page lists only the values CatLog read from it.
CatLog read 9 records (21 values) from this paper: AAC(6')-Ie/APH(2'')-Ia (bifunctional aminoglycoside acetyltransferase/phosphotransferase; APH(2'')-Ia phosphotransferase activity).
Read from the paper by an AI model and checked against the paper by a second, separate AI run; code converted the units. Values are in CatLog's units; each record opens in Browse with the line the paper prints and the checks.
| Enzyme | Organism | Substrate | kcat (s⁻¹) | Km (mM) | kcat/Km (mM⁻¹ s⁻¹) | Conditions | Open record |
|---|---|---|---|---|---|---|---|
| AAC(6')-Ie/APH(2'')-Ia (bifunctional aminoglycoside acetyltransferase/phosphotransferase; APH(2'')-Ia phosphotransferase activity) | — | Amikacin | 3.7 | 0.033 | 110 | pH 7 | Open record: AAC(6')-Ie/APH(2'')-Ia (bifunctional aminoglycoside acetyltransferase/phosphotransferase; APH(2'')-Ia phosphotransferase activity), Amikacin |
| AAC(6')-Ie/APH(2'')-Ia (bifunctional aminoglycoside acetyltransferase/phosphotransferase; APH(2'')-Ia phosphotransferase activity) | — | Arbekacin | 2.3 | 8 × 10⁻⁴ | 2.9 × 10³ | pH 7 | Open record: AAC(6')-Ie/APH(2'')-Ia (bifunctional aminoglycoside acetyltransferase/phosphotransferase; APH(2'')-Ia phosphotransferase activity), Arbekacin |
| AAC(6')-Ie/APH(2'')-Ia (bifunctional aminoglycoside acetyltransferase/phosphotransferase; APH(2'')-Ia phosphotransferase activity) | — | Dibekacin | 0.15 | 3 × 10⁻⁴ | 500 | pH 7 | Open record: AAC(6')-Ie/APH(2'')-Ia (bifunctional aminoglycoside acetyltransferase/phosphotransferase; APH(2'')-Ia phosphotransferase activity), Dibekacin |
| AAC(6')-Ie/APH(2'')-Ia (bifunctional aminoglycoside acetyltransferase/phosphotransferase; APH(2'')-Ia phosphotransferase activity) | — | Gentamicin C | 3 | 6 × 10⁻⁴ | 5 × 10³ | pH 7 | Open record: AAC(6')-Ie/APH(2'')-Ia (bifunctional aminoglycoside acetyltransferase/phosphotransferase; APH(2'')-Ia phosphotransferase activity), Gentamicin C |
| AAC(6')-Ie/APH(2'')-Ia (bifunctional aminoglycoside acetyltransferase/phosphotransferase; APH(2'')-Ia phosphotransferase activity) | — | Kanamycin A | 0.57 | — | — | pH 7 | Open record: AAC(6')-Ie/APH(2'')-Ia (bifunctional aminoglycoside acetyltransferase/phosphotransferase; APH(2'')-Ia phosphotransferase activity), Kanamycin A |
| AAC(6')-Ie/APH(2'')-Ia (bifunctional aminoglycoside acetyltransferase/phosphotransferase; APH(2'')-Ia phosphotransferase activity) | — | Kanamycin B | 0.12 | — | — | pH 7 | Open record: AAC(6')-Ie/APH(2'')-Ia (bifunctional aminoglycoside acetyltransferase/phosphotransferase; APH(2'')-Ia phosphotransferase activity), Kanamycin B |
| AAC(6')-Ie/APH(2'')-Ia (bifunctional aminoglycoside acetyltransferase/phosphotransferase; APH(2'')-Ia phosphotransferase activity) | — | Netilmicin | 6.5 | 4.1 × 10⁻⁴ | 1.6 × 10⁴ | pH 7 | Open record: AAC(6')-Ie/APH(2'')-Ia (bifunctional aminoglycoside acetyltransferase/phosphotransferase; APH(2'')-Ia phosphotransferase activity), Netilmicin |
| AAC(6')-Ie/APH(2'')-Ia (bifunctional aminoglycoside acetyltransferase/phosphotransferase; APH(2'')-Ia phosphotransferase activity) | — | Sisomicin | 8.1 | 8 × 10⁻⁴ | 1 × 10⁴ | pH 7 | Open record: AAC(6')-Ie/APH(2'')-Ia (bifunctional aminoglycoside acetyltransferase/phosphotransferase; APH(2'')-Ia phosphotransferase activity), Sisomicin |
| AAC(6')-Ie/APH(2'')-Ia (bifunctional aminoglycoside acetyltransferase/phosphotransferase; APH(2'')-Ia phosphotransferase activity) | — | Tobramycin | 0.11 | — | — | pH 7 | Open record: AAC(6')-Ie/APH(2'')-Ia (bifunctional aminoglycoside acetyltransferase/phosphotransferase; APH(2'')-Ia phosphotransferase activity), Tobramycin |