EC 2.7.1.190: aminoglycoside 2''-phosphotransferase

TransferasesOpen in Browse

CatLog read 62 records for EC 2.7.1.190 from 4 papers, for 2 organisms. Names in these papers: AAC(6')-APH(2″), APH(2'')-If (aminoglycoside 2''-phosphotransferase-If), AAC(6')-Ie/APH(2'')-Ia (bifunctional aminoglycoside acetyltransferase/phosphotransferase; APH(2'')-Ia phosphotransferase activity), aminoglycoside 2''-phosphotransferase IVa (APH(2'')-IVa).

Read from the paper by an AI model and checked against the paper by a second, separate AI run; code converted the units.

CatLog also holds 21 records for EC 2.7.1.190 that are not yet re-read: from its earlier version, built from the enzyme databases and partly checked against the papers. All records for EC 2.7.1.190 in Browse.

Papers

Papers with records for EC 2.7.1.190
Paper	Organisms	Records
Prodigious substrate specificity of AAC(6')-APH(2"), an aminoglycoside antibiotic resistance determinant in enterococci and staphylococci	Enterococcus faecalis	35
Novel aminoglycoside 2''-phosphotransferase identified in a gram-negative pathogen	Campylobacter jejuni	12
Revisiting the nucleotide and aminoglycoside substrate specificity of the bifunctional aminoglycoside acetyltransferase(6')-Ie/aminoglycoside phosphotransferase(2'')-Ia enzyme	—	9
Structural basis for dual nucleotide selectivity of aminoglycoside 2''-phosphotransferase IVa provides insight on determinants of nucleotide specificity of aminoglycoside kinases	—	6

Records

Records for EC 2.7.1.190 read from the paper
Enzyme	Organism	Substrate	k_cat (s⁻¹)	K_m (mM)	k_cat/K_m (mM⁻¹ s⁻¹)	Conditions	Paper	Open record
AAC(6')-APH(2″)	Enterococcus faecalis	acetyl coenzyme A	0.73	0.0059	124	pH 7, 37 °C	PMID 10021417	Open record: AAC(6')-APH(2″), acetyl coenzyme A
AAC(6')-APH(2″)	Enterococcus faecalis	amikacin	—	0.0209	101	pH 7, 37 °C	PMID 10021417	Open record: AAC(6')-APH(2″), amikacin
AAC(6')-APH(2″)	Enterococcus faecalis	amikacin	0.16	0.158	1	pH 8, 36 °C	PMID 10021417	Open record: AAC(6')-APH(2″), amikacin
AAC(6')-APH(2″)	Enterococcus faecalis	ATP	0.17	0.0241	7.1	pH 8, 36 °C	PMID 10021417	Open record: AAC(6')-APH(2″), ATP
AAC(6')-APH(2″)	Enterococcus faecalis	butirosin A	1.27	0.0258	49.2	pH 7, 37 °C	PMID 10021417	Open record: AAC(6')-APH(2″), butirosin A
AAC(6')-APH(2″)	Enterococcus faecalis	butirosin A	0.43	—	37.1	pH 8, 36 °C	PMID 10021417	Open record: AAC(6')-APH(2″), butirosin A
AAC(6')-APH(2″)	Enterococcus faecalis	dibekacin	1.5	0.0024	620 calc.	pH 7, 37 °C	PMID 10021417	Open record: AAC(6')-APH(2″), dibekacin
AAC(6')-APH(2″)	Enterococcus faecalis	dibekacin	0.34	0.0036	94	pH 8, 36 °C	PMID 10021417	Open record: AAC(6')-APH(2″), dibekacin
AAC(6')-APH(2″)	Enterococcus faecalis	fortimicin	0.19	0.0022	86.4	pH 7, 37 °C	PMID 10021417	Open record: AAC(6')-APH(2″), fortimicin
AAC(6')-APH(2″)	Enterococcus faecalis	gentamicin B	0.3	—	273	pH 7, 37 °C	PMID 10021417	Open record: AAC(6')-APH(2″), gentamicin B
AAC(6')-APH(2″)	Enterococcus faecalis	gentamicin B	0.65	0.0389	16.7	pH 8, 36 °C	PMID 10021417	Open record: AAC(6')-APH(2″), gentamicin B
AAC(6')-APH(2″)	Enterococcus faecalis	gentamicin C	0.85	0.0046	185	pH 7, 37 °C	PMID 10021417	Open record: AAC(6')-APH(2″), gentamicin C
AAC(6')-APH(2″)	Enterococcus faecalis	gentamicin C	0.23	0.0034	68	pH 8, 36 °C	PMID 10021417	Open record: AAC(6')-APH(2″), gentamicin C
AAC(6')-APH(2″)	Enterococcus faecalis	isepamicin	1.66	0.0187	88.7	pH 7, 37 °C	PMID 10021417	Open record: AAC(6')-APH(2″), isepamicin
AAC(6')-APH(2″)	Enterococcus faecalis	isepamicin	0.59	0.197	3	pH 8, 36 °C	PMID 10021417	Open record: AAC(6')-APH(2″), isepamicin
AAC(6')-APH(2″)	Enterococcus faecalis	kanamycin A	0.31	0.0014	221	pH 7, 37 °C	PMID 10021417	Open record: AAC(6')-APH(2″), kanamycin A
AAC(6')-APH(2″)	Enterococcus faecalis	kanamycin A	0.41	0.007	58.4	pH 8, 36 °C	PMID 10021417	Open record: AAC(6')-APH(2″), kanamycin A
AAC(6')-APH(2″)	Enterococcus faecalis	kanamycin B	1.3	0.0075	170	pH 7, 37 °C	PMID 10021417	Open record: AAC(6')-APH(2″), kanamycin B
AAC(6')-APH(2″)	Enterococcus faecalis	kanamycin B	1.07	0.0093	115	pH 8, 36 °C	PMID 10021417	Open record: AAC(6')-APH(2″), kanamycin B
AAC(6')-APH(2″)	Enterococcus faecalis	lividomycin A	0.02	0.0101	2	pH 7, 37 °C	PMID 10021417	Open record: AAC(6')-APH(2″), lividomycin A
AAC(6')-APH(2″)	Enterococcus faecalis	lividomycin A	0.22	0.0329	6.7	pH 8, 36 °C	PMID 10021417	Open record: AAC(6')-APH(2″), lividomycin A
AAC(6')-APH(2″)	Enterococcus faecalis	neamine	3	0.0084	360 calc.	pH 7, 37 °C	PMID 10021417	Open record: AAC(6')-APH(2″), neamine
AAC(6')-APH(2″)	Enterococcus faecalis	neamine	0.17	0.0096	18 calc.	pH 8, 36 °C	PMID 10021417	Open record: AAC(6')-APH(2″), neamine
AAC(6')-APH(2″)	Enterococcus faecalis	neomycin B	1.53	0.0042	364	pH 7, 37 °C	PMID 10021417	Open record: AAC(6')-APH(2″), neomycin B
AAC(6')-APH(2″)	Enterococcus faecalis	neomycin B	0.19	0.0019	100 calc.	pH 8, 36 °C	PMID 10021417	Open record: AAC(6')-APH(2″), neomycin B
AAC(6')-APH(2″)	Enterococcus faecalis	netilmicin	0.87	0.0032	272	pH 7, 37 °C	PMID 10021417	Open record: AAC(6')-APH(2″), netilmicin
AAC(6')-APH(2″)	Enterococcus faecalis	netilmicin	0.21	0.0364	5.77	pH 8, 36 °C	PMID 10021417	Open record: AAC(6')-APH(2″), netilmicin
AAC(6')-APH(2″)	Enterococcus faecalis	paromomycin	0.032	0.0175	1.8	pH 7, 37 °C	PMID 10021417	Open record: AAC(6')-APH(2″), paromomycin
AAC(6')-APH(2″)	Enterococcus faecalis	paromomycin	0.49	0.0034	144	pH 8, 36 °C	PMID 10021417	Open record: AAC(6')-APH(2″), paromomycin
AAC(6')-APH(2″)	Enterococcus faecalis	ribostamycin	2.06	0.0061	338	pH 7, 37 °C	PMID 10021417	Open record: AAC(6')-APH(2″), ribostamycin
AAC(6')-APH(2″)	Enterococcus faecalis	ribostamycin	0.25	—	371	pH 8, 36 °C	PMID 10021417	Open record: AAC(6')-APH(2″), ribostamycin
AAC(6')-APH(2″)	Enterococcus faecalis	sisomicin	2.92	0.0065	450	pH 7, 37 °C	PMID 10021417	Open record: AAC(6')-APH(2″), sisomicin
AAC(6')-APH(2″)	Enterococcus faecalis	sisomicin	0.4	0.0122	32.8	pH 8, 36 °C	PMID 10021417	Open record: AAC(6')-APH(2″), sisomicin
AAC(6')-APH(2″)	Enterococcus faecalis	tobramycin	0.68	0.0023	300	pH 7, 37 °C	PMID 10021417	Open record: AAC(6')-APH(2″), tobramycin
AAC(6')-APH(2″)	Enterococcus faecalis	tobramycin	0.33	0.0048	69	pH 8, 36 °C	PMID 10021417	Open record: AAC(6')-APH(2″), tobramycin
AAC(6')-Ie/APH(2'')-Ia (bifunctional aminoglycoside acetyltransferase/phosphotransferase; APH(2'')-Ia phosphotransferase activity)	—	Amikacin	3.7	0.033	110	pH 7	PMID 23115238	Open record: AAC(6')-Ie/APH(2'')-Ia (bifunctional aminoglycoside acetyltransferase/phosphotransferase; APH(2'')-Ia phosphotransferase activity), Amikacin
AAC(6')-Ie/APH(2'')-Ia (bifunctional aminoglycoside acetyltransferase/phosphotransferase; APH(2'')-Ia phosphotransferase activity)	—	Arbekacin	2.3	8 × 10⁻⁴	2.9 × 10³	pH 7	PMID 23115238	Open record: AAC(6')-Ie/APH(2'')-Ia (bifunctional aminoglycoside acetyltransferase/phosphotransferase; APH(2'')-Ia phosphotransferase activity), Arbekacin
AAC(6')-Ie/APH(2'')-Ia (bifunctional aminoglycoside acetyltransferase/phosphotransferase; APH(2'')-Ia phosphotransferase activity)	—	Dibekacin	0.15	3 × 10⁻⁴	500	pH 7	PMID 23115238	Open record: AAC(6')-Ie/APH(2'')-Ia (bifunctional aminoglycoside acetyltransferase/phosphotransferase; APH(2'')-Ia phosphotransferase activity), Dibekacin
AAC(6')-Ie/APH(2'')-Ia (bifunctional aminoglycoside acetyltransferase/phosphotransferase; APH(2'')-Ia phosphotransferase activity)	—	Gentamicin C	3	6 × 10⁻⁴	5 × 10³	pH 7	PMID 23115238	Open record: AAC(6')-Ie/APH(2'')-Ia (bifunctional aminoglycoside acetyltransferase/phosphotransferase; APH(2'')-Ia phosphotransferase activity), Gentamicin C
AAC(6')-Ie/APH(2'')-Ia (bifunctional aminoglycoside acetyltransferase/phosphotransferase; APH(2'')-Ia phosphotransferase activity)	—	Kanamycin A	0.57	—	—	pH 7	PMID 23115238	Open record: AAC(6')-Ie/APH(2'')-Ia (bifunctional aminoglycoside acetyltransferase/phosphotransferase; APH(2'')-Ia phosphotransferase activity), Kanamycin A
AAC(6')-Ie/APH(2'')-Ia (bifunctional aminoglycoside acetyltransferase/phosphotransferase; APH(2'')-Ia phosphotransferase activity)	—	Kanamycin B	0.12	—	—	pH 7	PMID 23115238	Open record: AAC(6')-Ie/APH(2'')-Ia (bifunctional aminoglycoside acetyltransferase/phosphotransferase; APH(2'')-Ia phosphotransferase activity), Kanamycin B
AAC(6')-Ie/APH(2'')-Ia (bifunctional aminoglycoside acetyltransferase/phosphotransferase; APH(2'')-Ia phosphotransferase activity)	—	Netilmicin	6.5	4.1 × 10⁻⁴	1.6 × 10⁴	pH 7	PMID 23115238	Open record: AAC(6')-Ie/APH(2'')-Ia (bifunctional aminoglycoside acetyltransferase/phosphotransferase; APH(2'')-Ia phosphotransferase activity), Netilmicin
AAC(6')-Ie/APH(2'')-Ia (bifunctional aminoglycoside acetyltransferase/phosphotransferase; APH(2'')-Ia phosphotransferase activity)	—	Sisomicin	8.1	8 × 10⁻⁴	1 × 10⁴	pH 7	PMID 23115238	Open record: AAC(6')-Ie/APH(2'')-Ia (bifunctional aminoglycoside acetyltransferase/phosphotransferase; APH(2'')-Ia phosphotransferase activity), Sisomicin
AAC(6')-Ie/APH(2'')-Ia (bifunctional aminoglycoside acetyltransferase/phosphotransferase; APH(2'')-Ia phosphotransferase activity)	—	Tobramycin	0.11	—	—	pH 7	PMID 23115238	Open record: AAC(6')-Ie/APH(2'')-Ia (bifunctional aminoglycoside acetyltransferase/phosphotransferase; APH(2'')-Ia phosphotransferase activity), Tobramycin
aminoglycoside 2''-phosphotransferase IVa (APH(2'')-IVa)	—	adenosine 5'-triphosphate	4.37	0.069	63	pH 7.5, 37 °C	PMID 22371504	Open record: aminoglycoside 2''-phosphotransferase IVa (APH(2'')-IVa), adenosine 5'-triphosphate
aminoglycoside 2''-phosphotransferase IVa (APH(2'')-IVa)	—	guanosine 5'-triphosphate	5.03	0.168	30	pH 7.5, 37 °C	PMID 22371504	Open record: aminoglycoside 2''-phosphotransferase IVa (APH(2'')-IVa), guanosine 5'-triphosphate
aminoglycoside 2''-phosphotransferase IVa (APH(2'')-IVa)variant F95M	—	adenosine 5'-triphosphate	3.06	0.055	55	pH 7.5, 37 °C	PMID 22371504	Open record: aminoglycoside 2''-phosphotransferase IVa (APH(2'')-IVa) variant F95M, adenosine 5'-triphosphate
aminoglycoside 2''-phosphotransferase IVa (APH(2'')-IVa)variant F95M	—	guanosine 5'-triphosphate	4.35	0.156	28	pH 7.5, 37 °C	PMID 22371504	Open record: aminoglycoside 2''-phosphotransferase IVa (APH(2'')-IVa) variant F95M, guanosine 5'-triphosphate
aminoglycoside 2''-phosphotransferase IVa (APH(2'')-IVa)variant F95Y	—	adenosine 5'-triphosphate	1.06	0.072	15	pH 7.5, 37 °C	PMID 22371504	Open record: aminoglycoside 2''-phosphotransferase IVa (APH(2'')-IVa) variant F95Y, adenosine 5'-triphosphate
aminoglycoside 2''-phosphotransferase IVa (APH(2'')-IVa)variant F95Y	—	guanosine 5'-triphosphate	1.15	0.049	23	pH 7.5, 37 °C	PMID 22371504	Open record: aminoglycoside 2''-phosphotransferase IVa (APH(2'')-IVa) variant F95Y, guanosine 5'-triphosphate
APH(2'')-If (aminoglycoside 2''-phosphotransferase-If)	Campylobacter jejuni	adenosine 5'-triphosphate	0.38	2	0.19	pH 7	PMID 23129050	Open record: APH(2'')-If (aminoglycoside 2''-phosphotransferase-If), adenosine 5'-triphosphate
APH(2'')-If (aminoglycoside 2''-phosphotransferase-If)	Campylobacter jejuni	Amikacin	6.5	0.26	25	pH 7	PMID 23129050	Open record: APH(2'')-If (aminoglycoside 2''-phosphotransferase-If), Amikacin
APH(2'')-If (aminoglycoside 2''-phosphotransferase-If)	Campylobacter jejuni	Arbekacin	4.3	0.0062	690	pH 7	PMID 23129050	Open record: APH(2'')-If (aminoglycoside 2''-phosphotransferase-If), Arbekacin
APH(2'')-If (aminoglycoside 2''-phosphotransferase-If)	Campylobacter jejuni	Dibekacin	0.79	0.0012	660	pH 7	PMID 23129050	Open record: APH(2'')-If (aminoglycoside 2''-phosphotransferase-If), Dibekacin
APH(2'')-If (aminoglycoside 2''-phosphotransferase-If)	Campylobacter jejuni	Gentamicin C	8.3	7 × 10⁻⁴	1.2 × 10⁴	pH 7	PMID 23129050	Open record: APH(2'')-If (aminoglycoside 2''-phosphotransferase-If), Gentamicin C
APH(2'')-If (aminoglycoside 2''-phosphotransferase-If)	Campylobacter jejuni	guanosine 5'-triphosphate	0.4	8 × 10⁻⁴	510	pH 7	PMID 23129050	Open record: APH(2'')-If (aminoglycoside 2''-phosphotransferase-If), guanosine 5'-triphosphate
APH(2'')-If (aminoglycoside 2''-phosphotransferase-If)	Campylobacter jejuni	Isepamicin	0.25	0.56	0.45	pH 7	PMID 23129050	Open record: APH(2'')-If (aminoglycoside 2''-phosphotransferase-If), Isepamicin
APH(2'')-If (aminoglycoside 2''-phosphotransferase-If)	Campylobacter jejuni	Kanamycin A	1.7	0.0011	1.5 × 10³	pH 7	PMID 23129050	Open record: APH(2'')-If (aminoglycoside 2''-phosphotransferase-If), Kanamycin A
APH(2'')-If (aminoglycoside 2''-phosphotransferase-If)	Campylobacter jejuni	Kanamycin B	0.38	5.5 × 10⁻⁴	690	pH 7	PMID 23129050	Open record: APH(2'')-If (aminoglycoside 2''-phosphotransferase-If), Kanamycin B
APH(2'')-If (aminoglycoside 2''-phosphotransferase-If)	Campylobacter jejuni	Netilmicin	18	0.01	1.7 × 10³	pH 7	PMID 23129050	Open record: APH(2'')-If (aminoglycoside 2''-phosphotransferase-If), Netilmicin
APH(2'')-If (aminoglycoside 2''-phosphotransferase-If)	Campylobacter jejuni	Sisomicin	17	0.0016	1.1 × 10⁴	pH 7	PMID 23129050	Open record: APH(2'')-If (aminoglycoside 2''-phosphotransferase-If), Sisomicin
APH(2'')-If (aminoglycoside 2''-phosphotransferase-If)	Campylobacter jejuni	Tobramycin	0.48	—	—	pH 7	PMID 23129050	Open record: APH(2'')-If (aminoglycoside 2''-phosphotransferase-If), Tobramycin