Values CatLog read from this paper
Retinoic acid biosynthesis catalyzed by retinal dehydrogenases relies on a rate-limiting conformational transition associated with substrate recognition
PMID 23220587doi:10.1016/j.cbi.2012.11.019Open in Browse
The paper itself is not on this site: read it at the publisher. This page lists only the values CatLog read from it.
CatLog read 11 records (22 values) from this paper: ALDH1A1 (RALDH1, retinal dehydrogenase), ALDH1A2 (RALDH2, retinal dehydrogenase) from Homo sapiens, Rattus norvegicus.
Read from the paper by an AI model and checked against the paper by a second, separate AI run; code converted the units. Values are in CatLog's units; each record opens in Browse with the line the paper prints and the checks. CatLog calculated the 11 kcat/Km values marked “calc.” from kcat and Km; no printed kcat/Km was read for those records.
EC 1.2.1.3, EC 1.2.1.19, EC 1.2.1.28, EC 1.2.1.36
| Enzyme | Organism | Substrate | kcat (s⁻¹) | Km (mM) | kcat/Km (mM⁻¹ s⁻¹) | Conditions | Open record |
|---|---|---|---|---|---|---|---|
| ALDH1A1 (RALDH1, retinal dehydrogenase) | Homo sapiens | all-trans-retinal | 0.07 | 0.0081 | 8.6 calc. | pH 8.5, 25 °C | Open record: ALDH1A1 (RALDH1, retinal dehydrogenase), all-trans-retinal |
| ALDH1A1 (RALDH1, retinal dehydrogenase) | Homo sapiens | Decanal | 1 | 0.01 | 100 calc. | pH 8.5, 25 °C | Open record: ALDH1A1 (RALDH1, retinal dehydrogenase), Decanal |
| ALDH1A1 (RALDH1, retinal dehydrogenase)variant K127A | Homo sapiens | all-trans-retinal | 0.03 | 0.0086 | 3.5 calc. | pH 8.5, 25 °C | Open record: ALDH1A1 (RALDH1, retinal dehydrogenase) variant K127A, all-trans-retinal |
| ALDH1A1 (RALDH1, retinal dehydrogenase)variant N120A | Homo sapiens | all-trans-retinal | 0.03 | 0.011 | 2.7 calc. | pH 8.5, 25 °C | Open record: ALDH1A1 (RALDH1, retinal dehydrogenase) variant N120A, all-trans-retinal |
| ALDH1A1 (RALDH1, retinal dehydrogenase)variant Y296A | Homo sapiens | all-trans-retinal | 0.017 | 0.0089 | 1.9 calc. | pH 8.5, 25 °C | Open record: ALDH1A1 (RALDH1, retinal dehydrogenase) variant Y296A, all-trans-retinal |
| ALDH1A1 (RALDH1, retinal dehydrogenase)variant Y296V | Homo sapiens | all-trans-retinal | 0.008 | 0.015 | 0.53 calc. | pH 8.5, 25 °C | Open record: ALDH1A1 (RALDH1, retinal dehydrogenase) variant Y296V, all-trans-retinal |
| ALDH1A2 (RALDH2, retinal dehydrogenase) | Rattus norvegicus | 3,7-dimethyl-2,6-octadienal (mixture of cis and trans isomers, neral and geranial) | 0.1 | 0.0029 | 34 calc. | pH 8.5, 25 °C | Open record: ALDH1A2 (RALDH2, retinal dehydrogenase), 3,7-dimethyl-2,6-octadienal (mixture of cis and trans isomers, neral and geranial) |
| ALDH1A2 (RALDH2, retinal dehydrogenase) | Rattus norvegicus | all-trans-retinal | 0.1 | 0.002 | 50 calc. | pH 8.5, 25 °C | Open record: ALDH1A2 (RALDH2, retinal dehydrogenase), all-trans-retinal |
| ALDH1A2 (RALDH2, retinal dehydrogenase) | Rattus norvegicus | Decanal | 2.2 | 0.0064 | 340 calc. | pH 8.5, 25 °C | Open record: ALDH1A2 (RALDH2, retinal dehydrogenase), Decanal |
| ALDH1A2 (RALDH2, retinal dehydrogenase) | Rattus norvegicus | Hexanal | 2 | 0.023 | 87 calc. | pH 8.5, 25 °C | Open record: ALDH1A2 (RALDH2, retinal dehydrogenase), Hexanal |
| ALDH1A2 (RALDH2, retinal dehydrogenase) | Rattus norvegicus | trans,trans-2,4-decadienal | 0.15 | 0.0063 | 24 calc. | pH 8.5, 25 °C | Open record: ALDH1A2 (RALDH2, retinal dehydrogenase), trans,trans-2,4-decadienal |