CatLogenzyme kinetics catalog

EC 1.2.1.36: retinal dehydrogenase

OxidoreductasesOpen in Browse

CatLog read 79 records for EC 1.2.1.36 from 8 papers, for 5 organisms. Names in these papers: aldehyde dehydrogenase, mitochondrial (ALDH2), retinal dehydrogenase type II (RalDH(II)), ALDH2 (mitochondrial aldehyde dehydrogenase), retinaldehyde dehydrogenase 3 (RALDH3, ALDH1A3) and 6 more.

Read from the paper by an AI model and checked against the paper by a second, separate AI run; code converted the units.

CatLog also holds 47 records for EC 1.2.1.36 that are not yet re-read: from its earlier version, built from the enzyme databases and partly checked against the papers. All records for EC 1.2.1.36 in Browse.

Papers

PaperOrganismsRecords
Involvement of glutamate 399 and lysine 192 in the mechanism of human liver mitochondrial aldehyde dehydrogenaseHomo sapiens16
Cloning of a cDNA encoding an aldehyde dehydrogenase and its expression in Escherichia coli. Recognition of retinal as substrateRattus norvegicus (rat)12
Retinoic acid biosynthesis catalyzed by retinal dehydrogenases relies on a rate-limiting conformational transition associated with substrate recognitionHomo sapiens, Rattus norvegicus11
Catalytic contribution of threonine 244 in human ALDH2Homo sapiens10
Characterization of retinaldehyde dehydrogenase 3Mus musculus9
Molecular cloning and baculovirus expression of the rabbit corneal aldehyde dehydrogenase (ALDH1A1) cDNAHomo sapiens, Oryctolagus cuniculus8
Molecular cloning and oxidative modification of human lens ALDH1A1: implication in impaired detoxification of lipid aldehydesHomo sapiens7
Crystal structure of human aldehyde dehydrogenase 1A3 complexed with NAD+ and retinoic acidHomo sapiens6

Records

EnzymeOrganismSubstratekcat (s⁻¹)Km (mM)kcat/Km (mM⁻¹ s⁻¹)ConditionsPaper
aldehyde dehydrogenase 1A1 (human lens ALDH1A1)Homo sapiens4-hydroxynonenal—0.0048—pH 7PMID 19296407Open
aldehyde dehydrogenase 1A1 (human lens ALDH1A1)Homo sapiensacetaldehyde—0.2382—pH 8PMID 19296407Open
aldehyde dehydrogenase 1A1 (human lens ALDH1A1)Homo sapiensbenzaldehyde—0.1432—pH 8PMID 19296407Open
aldehyde dehydrogenase 1A1 (human lens ALDH1A1)Homo sapiensmalondialdehyde—0.0035—pH 8PMID 19296407Open
aldehyde dehydrogenase 1A1 (human lens ALDH1A1)Homo sapiensnicotinamide adenine dinucleotide (oxidized)—0.0594—pH 8PMID 19296407Open
aldehyde dehydrogenase 1A1 (human lens ALDH1A1)Homo sapienspropionaldehyde—0.1214—pH 8PMID 19296407Open
aldehyde dehydrogenase 1A1 (human lens ALDH1A1)Homo sapienstrans-2-heptenal—0.1771—pH 8PMID 19296407Open
aldehyde dehydrogenase 1A3 (ALDH1A3)Homo sapiensacetaldehyde20 mM Tris HCl; 500 µM NAD+ fixed; Michaelis-Menten fit—2.4—pH 8, 25 °CPMID 27759097Open
aldehyde dehydrogenase 1A3 (ALDH1A3)Homo sapiensacetaldehyde20 mM Tris-HCl pH 8.0; 2.6 µM enzyme; fixed NAD+ at 500 µM0.12.40.041pH 8, 25 °CPMID 27759097Open
aldehyde dehydrogenase 1A3 (ALDH1A3)Homo sapiensall-trans-retinal20 mM Tris HCl; 500 µM NAD+ fixed; retinal in DMSO1.60.0093170 calc.pH 8, 25 °CPMID 27759097Open
aldehyde dehydrogenase 1A3 (ALDH1A3)Homo sapiensall-trans-retinal20 mM Tris-HCl pH 8.0; 2.6 µM enzyme; fixed NAD+ at 500 µM1.60.00931.7 × 10³pH 8, 25 °CPMID 27759097Open
aldehyde dehydrogenase 1A3 (ALDH1A3)Homo sapiensnicotinamide adenine dinucleotide (oxidized)fixed acetaldehyde at 20 mM; cosubstrate acetaldehyde0.10.07751.3pH 8, 25 °CPMID 27759097Open
aldehyde dehydrogenase 1A3 (ALDH1A3)Homo sapiensnicotinamide adenine dinucleotide (oxidized)fixed all-trans retinal at 100 µM20.00484.2 × 10³pH 8, 25 °CPMID 27759097Open
aldehyde dehydrogenase, mitochondrial (ALDH2)Homo sapiensnicotinamide adenine dinucleotide (oxidized)—0.027—pH 7.4PMID 9228057Open
aldehyde dehydrogenase, mitochondrial (ALDH2)Homo sapienspropanalTable I3.25 × 10⁻⁴6.3 × 10³ calc.pH 7.4PMID 9228057Open
aldehyde dehydrogenase, mitochondrial (ALDH2)Homo sapienspropanalin the text——6.3 × 10³pH 7.4PMID 9228057Open
aldehyde dehydrogenase, mitochondrial (ALDH2)variant E399DHomo sapiensnicotinamide adenine dinucleotide (oxidized)—0.078—pH 7.4PMID 9228057Open
aldehyde dehydrogenase, mitochondrial (ALDH2)variant E399DHomo sapienspropanal1.64 × 10⁻⁴4.0 × 10³ calc.pH 7.4PMID 9228057Open
aldehyde dehydrogenase, mitochondrial (ALDH2)variant E399HHomo sapiensnicotinamide adenine dinucleotide (oxidized)—0.21—pH 7.4PMID 9228057Open
aldehyde dehydrogenase, mitochondrial (ALDH2)variant E399HHomo sapienspropanalTable I0.166 × 10⁻⁴270 calc.pH 7.4PMID 9228057Open
aldehyde dehydrogenase, mitochondrial (ALDH2)variant E399HHomo sapienspropanalin the text——270pH 7.4PMID 9228057Open
aldehyde dehydrogenase, mitochondrial (ALDH2)variant E399KHomo sapiensnicotinamide adenine dinucleotide (oxidized)—0.34—pH 7.4PMID 9228057Open
aldehyde dehydrogenase, mitochondrial (ALDH2)variant E399KHomo sapienspropanal0.0179 × 10⁻⁴19 calc.pH 7.4PMID 9228057Open
aldehyde dehydrogenase, mitochondrial (ALDH2)variant E399QHomo sapiensnicotinamide adenine dinucleotide (oxidized)—0.12—pH 7.4PMID 9228057Open
aldehyde dehydrogenase, mitochondrial (ALDH2)variant E399QHomo sapienspropanal0.333 × 10⁻⁴1.1 × 10³ calc.pH 7.4PMID 9228057Open
aldehyde dehydrogenase, mitochondrial (ALDH2)variant K192EHomo sapiensnicotinamide adenine dinucleotide (oxidized)—0.048—pH 7.4PMID 9228057Open
aldehyde dehydrogenase, mitochondrial (ALDH2)variant K192EHomo sapienspropanal0.0554 × 10⁻⁴140 calc.pH 7.4PMID 9228057Open
aldehyde dehydrogenase, mitochondrial (ALDH2)variant K192QHomo sapiensnicotinamide adenine dinucleotide (oxidized)—3.6—pH 7.4PMID 9228057Open
aldehyde dehydrogenase, mitochondrial (ALDH2)variant K192QHomo sapienspropanal0.580.0035170 calc.pH 7.4PMID 9228057Open
ALDH1A1 (RALDH1, retinal dehydrogenase)Homo sapiensall-trans-retinal0.070.00818.6 calc.pH 8.5, 25 °CPMID 23220587Open
ALDH1A1 (RALDH1, retinal dehydrogenase)Homo sapiensDecanal10.01100 calc.pH 8.5, 25 °CPMID 23220587Open
ALDH1A1 (RALDH1, retinal dehydrogenase)variant K127AHomo sapiensall-trans-retinal0.030.00863.5 calc.pH 8.5, 25 °CPMID 23220587Open
ALDH1A1 (RALDH1, retinal dehydrogenase)variant N120AHomo sapiensall-trans-retinal0.030.0112.7 calc.pH 8.5, 25 °CPMID 23220587Open
ALDH1A1 (RALDH1, retinal dehydrogenase)variant Y296AHomo sapiensall-trans-retinal0.0170.00891.9 calc.pH 8.5, 25 °CPMID 23220587Open
ALDH1A1 (RALDH1, retinal dehydrogenase)variant Y296VHomo sapiensall-trans-retinal0.0080.0150.53 calc.pH 8.5, 25 °CPMID 23220587Open
ALDH1A2 (RALDH2, retinal dehydrogenase)Rattus norvegicus3,7-dimethyl-2,6-octadienal (mixture of cis and trans isomers, neral and geranial)0.10.002934 calc.pH 8.5, 25 °CPMID 23220587Open
ALDH1A2 (RALDH2, retinal dehydrogenase)Rattus norvegicusall-trans-retinal0.10.00250 calc.pH 8.5, 25 °CPMID 23220587Open
ALDH1A2 (RALDH2, retinal dehydrogenase)Rattus norvegicusDecanal2.20.0064340 calc.pH 8.5, 25 °CPMID 23220587Open
ALDH1A2 (RALDH2, retinal dehydrogenase)Rattus norvegicusHexanal20.02387 calc.pH 8.5, 25 °CPMID 23220587Open
ALDH1A2 (RALDH2, retinal dehydrogenase)Rattus norvegicustrans,trans-2,4-decadienal0.150.006324 calc.pH 8.5, 25 °CPMID 23220587Open
ALDH2 (mitochondrial aldehyde dehydrogenase)Homo sapienschloroacetaldehyde7.70.039200pH 7.4PMID 23295226Open
ALDH2 (mitochondrial aldehyde dehydrogenase)Homo sapiensNAD+—0.048158pH 7.4PMID 23295226Open
ALDH2 (mitochondrial aldehyde dehydrogenase)variant T244AHomo sapienschloroacetaldehyde40.313.2pH 7.4PMID 23295226Open
ALDH2 (mitochondrial aldehyde dehydrogenase)variant T244AHomo sapiensNAD+—2.11.8pH 7.4PMID 23295226Open
ALDH2 (mitochondrial aldehyde dehydrogenase)variant T244GHomo sapienschloroacetaldehyde0.630.05212.2pH 7.4PMID 23295226Open
ALDH2 (mitochondrial aldehyde dehydrogenase)variant T244GHomo sapiensNAD+—0.193.3pH 7.4PMID 23295226Open
ALDH2 (mitochondrial aldehyde dehydrogenase)variant T244SHomo sapienschloroacetaldehyde0.470.01333pH 7.4PMID 23295226Open
ALDH2 (mitochondrial aldehyde dehydrogenase)variant T244SHomo sapiensNAD+—0.0945pH 7.4PMID 23295226Open
ALDH2 (mitochondrial aldehyde dehydrogenase)variant T244VHomo sapienschloroacetaldehyde2.50.465.5pH 7.4PMID 23295226Open
ALDH2 (mitochondrial aldehyde dehydrogenase)variant T244VHomo sapiensNAD+—0.396.5pH 7.4PMID 23295226Open
human aldehyde dehydrogenase ALDH1A1Homo sapiens4-hydroxynonenal—0.0179—pH 8, 25 °CPMID 12941160Open
human aldehyde dehydrogenase ALDH1A1Homo sapiensHexanal—0.0134—pH 8, 25 °CPMID 12941160Open
human aldehyde dehydrogenase ALDH1A1Homo sapiensmalondialdehyde—0.1144—pH 8, 25 °CPMID 12941160Open
human aldehyde dehydrogenase ALDH1A1Homo sapiensPropionaldehyde—0.1372—pH 8, 25 °CPMID 12941160Open
rabbit corneal aldehyde dehydrogenase ALDH1A1Oryctolagus cuniculus4-hydroxynonenal—0.0021—pH 8, 25 °CPMID 12941160Open
rabbit corneal aldehyde dehydrogenase ALDH1A1Oryctolagus cuniculusHexanal—0.0035—pH 8, 25 °CPMID 12941160Open
rabbit corneal aldehyde dehydrogenase ALDH1A1Oryctolagus cuniculusmalondialdehyde—0.014—pH 8, 25 °CPMID 12941160Open
rabbit corneal aldehyde dehydrogenase ALDH1A1Oryctolagus cuniculusPropionaldehyde—0.0662—pH 8, 25 °CPMID 12941160Open
retinal dehydrogenase type II (RalDH(II))Rattus norvegicus (rat)acetaldehyde—0.645—pH 8.5, 25 °CPMID 8663198Open
retinal dehydrogenase type II (RalDH(II))Rattus norvegicus (rat)all-trans-retinal—7 × 10⁻⁴—pH 8.5, 37 °CPMID 8663198Open
retinal dehydrogenase type II (RalDH(II))Rattus norvegicus (rat)all-trans-retinal—4 × 10⁻⁴—pH 8.5, 25 °CPMID 8663198Open
retinal dehydrogenase type II (RalDH(II))Rattus norvegicus (rat)all-trans-retinal—0.001—pH 8.5PMID 8663198Open
retinal dehydrogenase type II (RalDH(II))Rattus norvegicus (rat)all-trans-retinal bound to cellular retinol-binding protein type I—2 × 10⁻⁴—pH 8.5, 37 °CPMID 8663198Open
retinal dehydrogenase type II (RalDH(II))Rattus norvegicus (rat)benzaldehyde—0.305—pH 8.5, 25 °CPMID 8663198Open
retinal dehydrogenase type II (RalDH(II))Rattus norvegicus (rat)decanal—0.003—pH 8.5, 25 °CPMID 8663198Open
retinal dehydrogenase type II (RalDH(II))Rattus norvegicus (rat)hexanal—0.028—pH 8.5, 25 °CPMID 8663198Open
retinal dehydrogenase type II (RalDH(II))Rattus norvegicus (rat)nicotinamide adenine dinucleotide (oxidized, NAD+)—0.07—pH 8.5, 37 °CPMID 8663198Open
retinal dehydrogenase type II (RalDH(II))Rattus norvegicus (rat)nicotinamide adenine dinucleotide phosphate (oxidized, NADP+)—0.4—pH 8.5, 37 °CPMID 8663198Open
retinal dehydrogenase type II (RalDH(II))Rattus norvegicus (rat)octanal—0.005—pH 8.5, 25 °CPMID 8663198Open
retinal dehydrogenase type II (RalDH(II))Rattus norvegicus (rat)propanal—0.061—pH 8.5, 25 °CPMID 8663198Open
retinaldehyde dehydrogenase 3 (RALDH3, ALDH1A3)Mus musculusall-trans-retinal3.92 × 10⁻⁴1.95 × 10⁴pH 8.5, 37 °CPMID 16241904Open
retinaldehyde dehydrogenase 3 (RALDH3, ALDH1A3)Mus musculusbenzaldehyde0.20.1031.9pH 8.5, 37 °CPMID 16241904Open
retinaldehyde dehydrogenase 3 (RALDH3, ALDH1A3)Mus musculusdecanal0.40.006561.5pH 8.5, 37 °CPMID 16241904Open
retinaldehyde dehydrogenase 3 (RALDH3, ALDH1A3)Mus musculushexanal0.30.022114pH 8.5, 37 °CPMID 16241904Open
retinaldehyde dehydrogenase 3 (RALDH3, ALDH1A3)Mus musculusNAD+3.30.0528100pH 8.5, 37 °CPMID 16241904Open
retinaldehyde dehydrogenase 3 (RALDH3, ALDH1A3)Mus musculusoctanal4.87 × 10⁻⁴6.9 × 10³pH 8.5, 37 °CPMID 16241904Open
retinaldehyde dehydrogenase 3 (RALDH3, ALDH1A3)variant F471LMus musculusall-trans-retinal132 × 10⁻⁴5.2 × 10⁴pH 8.5, 37 °CPMID 16241904Open
retinaldehyde dehydrogenase 3 (RALDH3, ALDH1A3)variant F471LMus musculusNAD+3.10.0431100pH 8.5, 37 °CPMID 16241904Open
retinaldehyde dehydrogenase 3 (RALDH3, ALDH1A3)variant F471LMus musculusoctanal5.49 × 10⁻⁴6 × 10³pH 8.5, 37 °CPMID 16241904Open