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Biochemical characterization of the phosphatase domain of the tumor suppressor PH domain leucine-rich repeat protein phosphatase

PMID 24892992doi:10.1021/bi500428jOpen in Browse

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CatLog read 12 records (26 values) from this paper: PHLPP2 (PH domain leucine-rich repeat protein phosphatase 2) phosphatase domain, PHLPP1 (PH domain leucine-rich repeat protein phosphatase 1) phosphatase domain, PHLPP1 (PH domain leucine-rich repeat protein phosphatase 1) from Homo sapiens.

Read from the paper by an AI model and checked against the paper by a second, separate AI run; code converted the units. Values are in CatLog's units; each record opens in Browse with the line the paper prints and the checks.

EC 3.1.3.16

Records read from this paper
EnzymeOrganismSubstratekcat (s⁻¹)Km (mM)kcat/Km (mM⁻¹ s⁻¹)ConditionsOpen record
PHLPP1 (PH domain leucine-rich repeat protein phosphatase 1)Homo sapiensp-nitrophenyl phosphate—1.5—pH 7.5Open record: PHLPP1 (PH domain leucine-rich repeat protein phosphatase 1), p-nitrophenyl phosphate
PHLPP1 (PH domain leucine-rich repeat protein phosphatase 1) phosphatase domainHomo sapiensp-nitrophenyl phosphateGST-tagged phosphatase (PP2C) domain; GST tag not removed0.00182.19 × 10⁻⁴pH 7.5Open record: PHLPP1 (PH domain leucine-rich repeat protein phosphatase 1) phosphatase domain, p-nitrophenyl phosphate
PHLPP1 (PH domain leucine-rich repeat protein phosphatase 1) phosphatase domainHomo sapiensp-nitrophenyl phosphate—1.5—pH 7.5Open record: PHLPP1 (PH domain leucine-rich repeat protein phosphatase 1) phosphatase domain, p-nitrophenyl phosphate
PHLPP1 (PH domain leucine-rich repeat protein phosphatase 1) phosphatase domainHomo sapiensp-nitrophenyl phosphate0.0022——Open record: PHLPP1 (PH domain leucine-rich repeat protein phosphatase 1) phosphatase domain, p-nitrophenyl phosphate
PHLPP1 (PH domain leucine-rich repeat protein phosphatase 1) phosphatase domainHomo sapiensp-nitrophenyl phosphate——2.94 × 10⁻⁵Open record: PHLPP1 (PH domain leucine-rich repeat protein phosphatase 1) phosphatase domain, p-nitrophenyl phosphate
PHLPP2 (PH domain leucine-rich repeat protein phosphatase 2) phosphatase domainHomo sapiensHFPQF(pS)YSAS, serine-phosphorylated Akt hydrophobic-motif peptideGST-tagged phosphatase (PP2C) domain; GST tag not removed1.10.1398pH 7.5Open record: PHLPP2 (PH domain leucine-rich repeat protein phosphatase 2) phosphatase domain, HFPQF(pS)YSAS, serine-phosphorylated Akt hydrophobic-motif peptide
PHLPP2 (PH domain leucine-rich repeat protein phosphatase 2) phosphatase domainHomo sapiensHFPQF(pS)YSAS, serine-phosphorylated Akt hydrophobic-motif peptideresidue range not stated0.90.040522pH 7.5Open record: PHLPP2 (PH domain leucine-rich repeat protein phosphatase 2) phosphatase domain, HFPQF(pS)YSAS, serine-phosphorylated Akt hydrophobic-motif peptide
PHLPP2 (PH domain leucine-rich repeat protein phosphatase 2) phosphatase domainHomo sapiensp-nitrophenyl phosphateGST-tagged phosphatase (PP2C) domain; GST tag not removed0.00181.80.001pH 7.5Open record: PHLPP2 (PH domain leucine-rich repeat protein phosphatase 2) phosphatase domain, p-nitrophenyl phosphate
PHLPP2 (PH domain leucine-rich repeat protein phosphatase 2) phosphatase domainHomo sapiensp-nitrophenyl phosphateresidue range not stated0.371.30.285pH 7.5Open record: PHLPP2 (PH domain leucine-rich repeat protein phosphatase 2) phosphatase domain, p-nitrophenyl phosphate
PHLPP2 (PH domain leucine-rich repeat protein phosphatase 2) phosphatase domainHomo sapiensp-nitrophenyl phosphate——2.017 × 10⁻⁵Open record: PHLPP2 (PH domain leucine-rich repeat protein phosphatase 2) phosphatase domain, p-nitrophenyl phosphate
PHLPP2 (PH domain leucine-rich repeat protein phosphatase 2) phosphatase domainHomo sapiensRRA(pT)VA, threonine-phosphorylated peptide Arg-Arg-Ala-pThr-Val-AlaGST-tagged phosphatase (PP2C) domain; GST tag not removed0.150.0642.3pH 7.5Open record: PHLPP2 (PH domain leucine-rich repeat protein phosphatase 2) phosphatase domain, RRA(pT)VA, threonine-phosphorylated peptide Arg-Arg-Ala-pThr-Val-Ala
PHLPP2 (PH domain leucine-rich repeat protein phosphatase 2) phosphatase domainHomo sapiensRRA(pT)VA, threonine-phosphorylated peptide Arg-Arg-Ala-pThr-Val-Alaresidue range not stated1.10.06318pH 7.5Open record: PHLPP2 (PH domain leucine-rich repeat protein phosphatase 2) phosphatase domain, RRA(pT)VA, threonine-phosphorylated peptide Arg-Arg-Ala-pThr-Val-Ala