Values CatLog read from this paper

A conserved motif mediates both multimer formation and allosteric activation of phosphoglycerate mutase 5

PMID 25012655doi:10.1074/jbc.m114.565549Open in Browse

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CatLog read 39 records (91 values) from this paper: phosphoglycerate mutase 5 (PGAM5), long isoform PGAM5-L (Ser/Thr protein phosphatase) from Homo sapiens.

Read from the paper by an AI model and checked against the paper by a second, separate AI run; code converted the units. Values are in CatLog's units; each record opens in Browse with the line the paper prints and the checks.

EC 3.1.3.16

Records read from this paper
Enzyme	Organism	Substrate	k_cat (s⁻¹)	K_m (mM)	k_cat/K_m (mM⁻¹ s⁻¹)	Conditions	Open record
phosphoglycerate mutase 5 (PGAM5), long isoform PGAM5-L (Ser/Thr protein phosphatase)	Homo sapiens	AAA(pT)VA phosphopeptide (phosphorylated residue in parentheses)	1.052	0.206	5.2	pH 7.4	Open record: phosphoglycerate mutase 5 (PGAM5), long isoform PGAM5-L (Ser/Thr protein phosphatase), AAA(pT)VA phosphopeptide (phosphorylated residue in parentheses)
phosphoglycerate mutase 5 (PGAM5), long isoform PGAM5-L (Ser/Thr protein phosphatase)	Homo sapiens	AGPAL(pS)PVPPV phosphopeptide (Bcl2 Ser-87 site of the protein; phosphorylated residue in parentheses)	1.307	0.357	3.3	pH 7.4	Open record: phosphoglycerate mutase 5 (PGAM5), long isoform PGAM5-L (Ser/Thr protein phosphatase), AGPAL(pS)PVPPV phosphopeptide (Bcl2 Ser-87 site of the protein; phosphorylated residue in parentheses)
phosphoglycerate mutase 5 (PGAM5), long isoform PGAM5-L (Ser/Thr protein phosphatase)	Homo sapiens	ALSAG(pS)NEYLR phosphopeptide (ASK1 Ser-958 site of the protein; phosphorylated residue in parentheses)	0.652	2.749	0.17	pH 7.4	Open record: phosphoglycerate mutase 5 (PGAM5), long isoform PGAM5-L (Ser/Thr protein phosphatase), ALSAG(pS)NEYLR phosphopeptide (ASK1 Ser-958 site of the protein; phosphorylated residue in parentheses)
phosphoglycerate mutase 5 (PGAM5), long isoform PGAM5-L (Ser/Thr protein phosphatase)	Homo sapiens	ASQEP(pS)PAASA phosphopeptide (Drp1 Ser-548 site of the protein; phosphorylated residue in parentheses)	0.615	0.114	5	pH 7.4	Open record: phosphoglycerate mutase 5 (PGAM5), long isoform PGAM5-L (Ser/Thr protein phosphatase), ASQEP(pS)PAASA phosphopeptide (Drp1 Ser-548 site of the protein; phosphorylated residue in parentheses)
phosphoglycerate mutase 5 (PGAM5), long isoform PGAM5-L (Ser/Thr protein phosphatase)	Homo sapiens	DDA(pT)VA phosphopeptide (phosphorylated residue in parentheses)	1.297	0.072	18	pH 7.4	Open record: phosphoglycerate mutase 5 (PGAM5), long isoform PGAM5-L (Ser/Thr protein phosphatase), DDA(pT)VA phosphopeptide (phosphorylated residue in parentheses)
phosphoglycerate mutase 5 (PGAM5), long isoform PGAM5-L (Ser/Thr protein phosphatase)	Homo sapiens	END(pT)INASL phosphopeptide (phosphorylated residue in parentheses)	1.202	0.113	10.7	pH 7.4	Open record: phosphoglycerate mutase 5 (PGAM5), long isoform PGAM5-L (Ser/Thr protein phosphatase), END(pT)INASL phosphopeptide (phosphorylated residue in parentheses)
phosphoglycerate mutase 5 (PGAM5), long isoform PGAM5-L (Ser/Thr protein phosphatase)	Homo sapiens	ESEME(pT)PSAIN phosphopeptide (Bcl-XL Thr-47 site of the protein; phosphorylated residue in parentheses)	0.385	0.05	8.3	pH 7.4	Open record: phosphoglycerate mutase 5 (PGAM5), long isoform PGAM5-L (Ser/Thr protein phosphatase), ESEME(pT)PSAIN phosphopeptide (Bcl-XL Thr-47 site of the protein; phosphorylated residue in parentheses)
phosphoglycerate mutase 5 (PGAM5), long isoform PGAM5-L (Ser/Thr protein phosphatase)	Homo sapiens	HSAPP(pS)PEEKD phosphopeptide (ASK1 Ser-1033 site of the protein; phosphorylated residue in parentheses)	0.857	0.026	32	pH 7.4	Open record: phosphoglycerate mutase 5 (PGAM5), long isoform PGAM5-L (Ser/Thr protein phosphatase), HSAPP(pS)PEEKD phosphopeptide (ASK1 Ser-1033 site of the protein; phosphorylated residue in parentheses)
phosphoglycerate mutase 5 (PGAM5), long isoform PGAM5-L (Ser/Thr protein phosphatase)	Homo sapiens	NFEDH(pS)APPSP phosphopeptide (ASK1 Ser-1029 site of the protein; phosphorylated residue in parentheses)	1.332	0.023	57	pH 7.4	Open record: phosphoglycerate mutase 5 (PGAM5), long isoform PGAM5-L (Ser/Thr protein phosphatase), NFEDH(pS)APPSP phosphopeptide (ASK1 Ser-1029 site of the protein; phosphorylated residue in parentheses)
phosphoglycerate mutase 5 (PGAM5), long isoform PGAM5-L (Ser/Thr protein phosphatase)	Homo sapiens	NPCTE(pT)FTGTL phosphopeptide (ASK1 Thr-838 site of the protein; phosphorylated residue in parentheses)	1.163	0.065	18	pH 7.4	Open record: phosphoglycerate mutase 5 (PGAM5), long isoform PGAM5-L (Ser/Thr protein phosphatase), NPCTE(pT)FTGTL phosphopeptide (ASK1 Thr-838 site of the protein; phosphorylated residue in parentheses)
phosphoglycerate mutase 5 (PGAM5), long isoform PGAM5-L (Ser/Thr protein phosphatase)	Homo sapiens	PVART(pS)PLQTP phosphopeptide (Bcl2 Ser-70 site of the protein; phosphorylated residue in parentheses)	0.642	0.098	6.7	pH 7.4	Open record: phosphoglycerate mutase 5 (PGAM5), long isoform PGAM5-L (Ser/Thr protein phosphatase), PVART(pS)PLQTP phosphopeptide (Bcl2 Ser-70 site of the protein; phosphorylated residue in parentheses)
phosphoglycerate mutase 5 (PGAM5), long isoform PGAM5-L (Ser/Thr protein phosphatase)	Homo sapiens	RGRGS(pS)VGGGS phosphopeptide (ASK1 Ser-83 site of the protein; phosphorylated residue in parentheses)	0.0255	0.656	0.033	pH 7.4	Open record: phosphoglycerate mutase 5 (PGAM5), long isoform PGAM5-L (Ser/Thr protein phosphatase), RGRGS(pS)VGGGS phosphopeptide (ASK1 Ser-83 site of the protein; phosphorylated residue in parentheses)
phosphoglycerate mutase 5 (PGAM5), long isoform PGAM5-L (Ser/Thr protein phosphatase)	Homo sapiens	RRA(pS)VA phosphopeptide (phosphorylated residue in parentheses)	0.928	1.354	0.67	pH 7.4	Open record: phosphoglycerate mutase 5 (PGAM5), long isoform PGAM5-L (Ser/Thr protein phosphatase), RRA(pS)VA phosphopeptide (phosphorylated residue in parentheses)
phosphoglycerate mutase 5 (PGAM5), long isoform PGAM5-L (Ser/Thr protein phosphatase)	Homo sapiens	RRA(pT)VA phosphopeptide (phosphorylated residue in parentheses)	0.605	1.954	0.33	pH 7.4	Open record: phosphoglycerate mutase 5 (PGAM5), long isoform PGAM5-L (Ser/Thr protein phosphatase), RRA(pT)VA phosphopeptide (phosphorylated residue in parentheses)
phosphoglycerate mutase 5 (PGAM5), long isoform PGAM5-L (Ser/Thr protein phosphatase)	Homo sapiens	SQLHI(pT)PGTAY phosphopeptide (Bcl-XL Thr-115 site of the protein; phosphorylated residue in parentheses)	0.395	0.48	0.83	pH 7.4	Open record: phosphoglycerate mutase 5 (PGAM5), long isoform PGAM5-L (Ser/Thr protein phosphatase), SQLHI(pT)PGTAY phosphopeptide (Bcl-XL Thr-115 site of the protein; phosphorylated residue in parentheses)
phosphoglycerate mutase 5 (PGAM5), long isoform PGAM5-L (Ser/Thr protein phosphatase)	Homo sapiens	VARKL(pS)AREQR phosphopeptide (Drp1 Ser-637 site of the protein; phosphorylated residue in parentheses)	0.862	0.409	2.2	pH 7.4	Open record: phosphoglycerate mutase 5 (PGAM5), long isoform PGAM5-L (Ser/Thr protein phosphatase), VARKL(pS)AREQR phosphopeptide (Drp1 Ser-637 site of the protein; phosphorylated residue in parentheses)
phosphoglycerate mutase 5 (PGAM5), long isoform PGAM5-L (Ser/Thr protein phosphatase)	Homo sapiens	WHLAD(pS)PAVNG phosphopeptide (Bcl-XL Ser-62 site of the protein; phosphorylated residue in parentheses)no WDXNWD peptide added; Table 2	1.027	0.028	37	pH 7.4	Open record: phosphoglycerate mutase 5 (PGAM5), long isoform PGAM5-L (Ser/Thr protein phosphatase), WHLAD(pS)PAVNG phosphopeptide (Bcl-XL Ser-62 site of the protein; phosphorylated residue in parentheses)
phosphoglycerate mutase 5 (PGAM5), long isoform PGAM5-L (Ser/Thr protein phosphatase)	Homo sapiens	WHLAD(pS)PAVNG phosphopeptide (Bcl-XL Ser-62 site of the protein; phosphorylated residue in parentheses)effector peptide: 0 µM WT(52–74) peptide (no peptide)	2.2	0.102	22	pH 7.4	Open record: phosphoglycerate mutase 5 (PGAM5), long isoform PGAM5-L (Ser/Thr protein phosphatase), WHLAD(pS)PAVNG phosphopeptide (Bcl-XL Ser-62 site of the protein; phosphorylated residue in parentheses)
phosphoglycerate mutase 5 (PGAM5), long isoform PGAM5-L (Ser/Thr protein phosphatase)	Homo sapiens	WHLAD(pS)PAVNG phosphopeptide (Bcl-XL Ser-62 site of the protein; phosphorylated residue in parentheses)effector peptide: 40 µM WT(52–74) peptide; Table 3 series	0.55	0.076	6.7	pH 7.4	Open record: phosphoglycerate mutase 5 (PGAM5), long isoform PGAM5-L (Ser/Thr protein phosphatase), WHLAD(pS)PAVNG phosphopeptide (Bcl-XL Ser-62 site of the protein; phosphorylated residue in parentheses)
phosphoglycerate mutase 5 (PGAM5), long isoform PGAM5-L (Ser/Thr protein phosphatase)	Homo sapiens	WHLAD(pS)PAVNG phosphopeptide (Bcl-XL Ser-62 site of the protein; phosphorylated residue in parentheses)effector peptide: 100 µM A4(52–74) peptide; Table 3 series	0.47	0.061	6.7	pH 7.4	Open record: phosphoglycerate mutase 5 (PGAM5), long isoform PGAM5-L (Ser/Thr protein phosphatase), WHLAD(pS)PAVNG phosphopeptide (Bcl-XL Ser-62 site of the protein; phosphorylated residue in parentheses)
phosphoglycerate mutase 5 (PGAM5), long isoform PGAM5-L (Ser/Thr protein phosphatase)	Homo sapiens	WHLAD(pS)PAVNG phosphopeptide (Bcl-XL Ser-62 site of the protein; phosphorylated residue in parentheses)10 nM enzyme; no WDXNWD peptide added; Fig. 2C experiment	—	0.058	—	pH 7.4	Open record: phosphoglycerate mutase 5 (PGAM5), long isoform PGAM5-L (Ser/Thr protein phosphatase), WHLAD(pS)PAVNG phosphopeptide (Bcl-XL Ser-62 site of the protein; phosphorylated residue in parentheses)
phosphoglycerate mutase 5 (PGAM5), long isoform PGAM5-L (Ser/Thr protein phosphatase)	Homo sapiens	WHLAD(pS)PAVNG phosphopeptide (Bcl-XL Ser-62 site of the protein; phosphorylated residue in parentheses)10 nM enzyme; no WDXNWD peptide added; Fig. 2C experiment	—	0.057	—	pH 7.4	Open record: phosphoglycerate mutase 5 (PGAM5), long isoform PGAM5-L (Ser/Thr protein phosphatase), WHLAD(pS)PAVNG phosphopeptide (Bcl-XL Ser-62 site of the protein; phosphorylated residue in parentheses)
phosphoglycerate mutase 5 (PGAM5), long isoform PGAM5-L (Ser/Thr protein phosphatase)	Homo sapiens	WHLAD(pS)PAVNG phosphopeptide (Bcl-XL Ser-62 site of the protein; phosphorylated residue in parentheses)10 nM enzyme; no WDXNWD peptide added; Fig. 3B experiment	—	0.059	—	pH 7.4	Open record: phosphoglycerate mutase 5 (PGAM5), long isoform PGAM5-L (Ser/Thr protein phosphatase), WHLAD(pS)PAVNG phosphopeptide (Bcl-XL Ser-62 site of the protein; phosphorylated residue in parentheses)
phosphoglycerate mutase 5 (PGAM5), long isoform PGAM5-L (Ser/Thr protein phosphatase)	Homo sapiens	WHLAD(pS)PAVNG phosphopeptide (Bcl-XL Ser-62 site of the protein; phosphorylated residue in parentheses)10 nM enzyme; effector peptide: 5 µM WT(52–74) peptide	—	0.114	—	pH 7.4	Open record: phosphoglycerate mutase 5 (PGAM5), long isoform PGAM5-L (Ser/Thr protein phosphatase), WHLAD(pS)PAVNG phosphopeptide (Bcl-XL Ser-62 site of the protein; phosphorylated residue in parentheses)
phosphoglycerate mutase 5 (PGAM5), long isoform PGAM5-L (Ser/Thr protein phosphatase)	Homo sapiens	WHLAD(pS)PAVNG phosphopeptide (Bcl-XL Ser-62 site of the protein; phosphorylated residue in parentheses)10 nM enzyme; effector peptide: 20 µM WT(52–74) peptide	—	0.126	—	pH 7.4	Open record: phosphoglycerate mutase 5 (PGAM5), long isoform PGAM5-L (Ser/Thr protein phosphatase), WHLAD(pS)PAVNG phosphopeptide (Bcl-XL Ser-62 site of the protein; phosphorylated residue in parentheses)
phosphoglycerate mutase 5 (PGAM5), long isoform PGAM5-L (Ser/Thr protein phosphatase)	Homo sapiens	WHLAD(pS)PAVNG phosphopeptide (Bcl-XL Ser-62 site of the protein; phosphorylated residue in parentheses)10 nM enzyme; effector peptide: 30 µM WT(52–74) peptide	—	0.074	—	pH 7.4	Open record: phosphoglycerate mutase 5 (PGAM5), long isoform PGAM5-L (Ser/Thr protein phosphatase), WHLAD(pS)PAVNG phosphopeptide (Bcl-XL Ser-62 site of the protein; phosphorylated residue in parentheses)
phosphoglycerate mutase 5 (PGAM5), long isoform PGAM5-L (Ser/Thr protein phosphatase)	Homo sapiens	WHLAD(pS)PAVNG phosphopeptide (Bcl-XL Ser-62 site of the protein; phosphorylated residue in parentheses)10 nM enzyme; ΔN25-PGAM5: lacking the first 25 residues	—	0.096	—	pH 7.4	Open record: phosphoglycerate mutase 5 (PGAM5), long isoform PGAM5-L (Ser/Thr protein phosphatase), WHLAD(pS)PAVNG phosphopeptide (Bcl-XL Ser-62 site of the protein; phosphorylated residue in parentheses)
phosphoglycerate mutase 5 (PGAM5), long isoform PGAM5-L (Ser/Thr protein phosphatase)	Homo sapiens	WHLAD(pS)PAVNG phosphopeptide (Bcl-XL Ser-62 site of the protein; phosphorylated residue in parentheses)10 nM enzyme; effector peptide: 10 µM A4(52–74) peptide	—	0.056	—	pH 7.4	Open record: phosphoglycerate mutase 5 (PGAM5), long isoform PGAM5-L (Ser/Thr protein phosphatase), WHLAD(pS)PAVNG phosphopeptide (Bcl-XL Ser-62 site of the protein; phosphorylated residue in parentheses)
phosphoglycerate mutase 5 (PGAM5), long isoform PGAM5-L (Ser/Thr protein phosphatase)	Homo sapiens	WHLAD(pS)PAVNG phosphopeptide (Bcl-XL Ser-62 site of the protein; phosphorylated residue in parentheses)10 nM enzyme; effector peptide: 50 µM A4(52–74) peptide	—	0.046	—	pH 7.4	Open record: phosphoglycerate mutase 5 (PGAM5), long isoform PGAM5-L (Ser/Thr protein phosphatase), WHLAD(pS)PAVNG phosphopeptide (Bcl-XL Ser-62 site of the protein; phosphorylated residue in parentheses)
phosphoglycerate mutase 5 (PGAM5), long isoform PGAM5-L (Ser/Thr protein phosphatase)	Homo sapiens	YLRSI(pS)LPVPV phosphopeptide (ASK1 Ser-966 site of the protein; phosphorylated residue in parentheses)	0.483	0.237	2	pH 7.4	Open record: phosphoglycerate mutase 5 (PGAM5), long isoform PGAM5-L (Ser/Thr protein phosphatase), YLRSI(pS)LPVPV phosphopeptide (ASK1 Ser-966 site of the protein; phosphorylated residue in parentheses)
phosphoglycerate mutase 5 (PGAM5), long isoform PGAM5-L (Ser/Thr protein phosphatase)variant W58A/D59A/W62A/D63A	Homo sapiens	NFEDH(pS)APPSP phosphopeptide (ASK1 Ser-1029 site of the protein; phosphorylated residue in parentheses)effector peptide: 0 µM WT(52–74) peptide (no peptide)	0.0128	0.446	0.028	pH 7.4	Open record: phosphoglycerate mutase 5 (PGAM5), long isoform PGAM5-L (Ser/Thr protein phosphatase) variant W58A/D59A/W62A/D63A, NFEDH(pS)APPSP phosphopeptide (ASK1 Ser-1029 site of the protein; phosphorylated residue in parentheses)
phosphoglycerate mutase 5 (PGAM5), long isoform PGAM5-L (Ser/Thr protein phosphatase)variant W58A/D59A/W62A/D63A	Homo sapiens	NFEDH(pS)APPSP phosphopeptide (ASK1 Ser-1029 site of the protein; phosphorylated residue in parentheses)effector peptide: 4 µM WT(52–74) peptide; Table 3 series	0.18	0.818	0.223	pH 7.4	Open record: phosphoglycerate mutase 5 (PGAM5), long isoform PGAM5-L (Ser/Thr protein phosphatase) variant W58A/D59A/W62A/D63A, NFEDH(pS)APPSP phosphopeptide (ASK1 Ser-1029 site of the protein; phosphorylated residue in parentheses)
phosphoglycerate mutase 5 (PGAM5), long isoform PGAM5-L (Ser/Thr protein phosphatase)variant W58A/D59A/W62A/D63A	Homo sapiens	NFEDH(pS)APPSP phosphopeptide (ASK1 Ser-1029 site of the protein; phosphorylated residue in parentheses)effector peptide: 15 µM WT(52–74) peptide; Table 3 series	0.48	0.48	1	pH 7.4	Open record: phosphoglycerate mutase 5 (PGAM5), long isoform PGAM5-L (Ser/Thr protein phosphatase) variant W58A/D59A/W62A/D63A, NFEDH(pS)APPSP phosphopeptide (ASK1 Ser-1029 site of the protein; phosphorylated residue in parentheses)
phosphoglycerate mutase 5 (PGAM5), long isoform PGAM5-L (Ser/Thr protein phosphatase)variant W58A/D59A/W62A/D63A	Homo sapiens	NFEDH(pS)APPSP phosphopeptide (ASK1 Ser-1029 site of the protein; phosphorylated residue in parentheses)effector peptide: 15 µM A4(52–74) peptide; Table 3 series	0.0155	0.721	0.022	pH 7.4	Open record: phosphoglycerate mutase 5 (PGAM5), long isoform PGAM5-L (Ser/Thr protein phosphatase) variant W58A/D59A/W62A/D63A, NFEDH(pS)APPSP phosphopeptide (ASK1 Ser-1029 site of the protein; phosphorylated residue in parentheses)
phosphoglycerate mutase 5 (PGAM5), long isoform PGAM5-L (Ser/Thr protein phosphatase)variant W58A/D59A/W62A/D63A	Homo sapiens	NFEDH(pS)APPSP phosphopeptide (ASK1 Ser-1029 site of the protein; phosphorylated residue in parentheses)500 nM enzyme; no WDXNWD peptide added; Fig. 3C experiment	—	0.167	—	pH 7.4	Open record: phosphoglycerate mutase 5 (PGAM5), long isoform PGAM5-L (Ser/Thr protein phosphatase) variant W58A/D59A/W62A/D63A, NFEDH(pS)APPSP phosphopeptide (ASK1 Ser-1029 site of the protein; phosphorylated residue in parentheses)
phosphoglycerate mutase 5 (PGAM5), long isoform PGAM5-L (Ser/Thr protein phosphatase)variant W58A/D59A/W62A/D63A	Homo sapiens	NFEDH(pS)APPSP phosphopeptide (ASK1 Ser-1029 site of the protein; phosphorylated residue in parentheses)500 nM enzyme; effector peptide: 0.5 µM WT(52–74) peptide	—	0.423	—	pH 7.4	Open record: phosphoglycerate mutase 5 (PGAM5), long isoform PGAM5-L (Ser/Thr protein phosphatase) variant W58A/D59A/W62A/D63A, NFEDH(pS)APPSP phosphopeptide (ASK1 Ser-1029 site of the protein; phosphorylated residue in parentheses)
phosphoglycerate mutase 5 (PGAM5), long isoform PGAM5-L (Ser/Thr protein phosphatase)variant W58A/D59A/W62A/D63A	Homo sapiens	NFEDH(pS)APPSP phosphopeptide (ASK1 Ser-1029 site of the protein; phosphorylated residue in parentheses)500 nM enzyme; effector peptide: 1 µM WT(52–74) peptide	—	0.948	—	pH 7.4	Open record: phosphoglycerate mutase 5 (PGAM5), long isoform PGAM5-L (Ser/Thr protein phosphatase) variant W58A/D59A/W62A/D63A, NFEDH(pS)APPSP phosphopeptide (ASK1 Ser-1029 site of the protein; phosphorylated residue in parentheses)
phosphoglycerate mutase 5 (PGAM5), long isoform PGAM5-L (Ser/Thr protein phosphatase)variant W58A/D59A/W62A/D63A	Homo sapiens	NFEDH(pS)APPSP phosphopeptide (ASK1 Ser-1029 site of the protein; phosphorylated residue in parentheses)500 nM enzyme; effector peptide: 2 µM WT(52–74) peptide	—	0.777	—	pH 7.4	Open record: phosphoglycerate mutase 5 (PGAM5), long isoform PGAM5-L (Ser/Thr protein phosphatase) variant W58A/D59A/W62A/D63A, NFEDH(pS)APPSP phosphopeptide (ASK1 Ser-1029 site of the protein; phosphorylated residue in parentheses)
phosphoglycerate mutase 5 (PGAM5), long isoform PGAM5-L (Ser/Thr protein phosphatase)variant W58A/D59A/W62A/D63A	Homo sapiens	WHLAD(pS)PAVNG phosphopeptide (Bcl-XL Ser-62 site of the protein; phosphorylated residue in parentheses)	0.0073	0.503	0.015	pH 7.4	Open record: phosphoglycerate mutase 5 (PGAM5), long isoform PGAM5-L (Ser/Thr protein phosphatase) variant W58A/D59A/W62A/D63A, WHLAD(pS)PAVNG phosphopeptide (Bcl-XL Ser-62 site of the protein; phosphorylated residue in parentheses)