Values CatLog read from this paper
Engineering neprilysin activity and specificity to create a novel therapeutic for Alzheimer's disease
PMID 25089527doi:10.1371/journal.pone.0104001Open in Browse
The paper itself is not on this site: read it at the publisher. This page lists only the values CatLog read from it.
CatLog read 46 records (138 values) from this paper: neprilysin (neutral endopeptidase, NEP) from Homo sapiens.
Read from the paper by an AI model and checked against the paper by a second, separate AI run; code converted the units. Values are in CatLog's units; each record opens in Browse with the line the paper prints and the checks.
| Enzyme | Organism | Substrate | kcat (s⁻¹) | Km (mM) | kcat/Km (mM⁻¹ s⁻¹) | Conditions | Open record |
|---|---|---|---|---|---|---|---|
| neprilysin (neutral endopeptidase, NEP) | Homo sapiens | amyloid beta 1-40 | 0.83 | 0.104 | 8 | pH 7.4, 37 °C | Open record: neprilysin (neutral endopeptidase, NEP), amyloid beta 1-40 |
| neprilysin (neutral endopeptidase, NEP) | Homo sapiens | Angiotensin | 8.2 | 0.0086 | 970 | pH 7.4, 37 °C | Open record: neprilysin (neutral endopeptidase, NEP), Angiotensin |
| neprilysin (neutral endopeptidase, NEP) | Homo sapiens | Arg-vasopressin | 2.8 | 0.0062 | 450 | pH 7.4, 37 °C | Open record: neprilysin (neutral endopeptidase, NEP), Arg-vasopressin |
| neprilysin (neutral endopeptidase, NEP) | Homo sapiens | atrial natriuretic peptide | 7.1 | 0.0084 | 910 | pH 7.4, 37 °C | Open record: neprilysin (neutral endopeptidase, NEP), atrial natriuretic peptide |
| neprilysin (neutral endopeptidase, NEP) | Homo sapiens | Bradykinin | 16 | 0.032 | 480 | pH 7.4, 37 °C | Open record: neprilysin (neutral endopeptidase, NEP), Bradykinin |
| neprilysin (neutral endopeptidase, NEP) | Homo sapiens | Endothelin-1 | 0.68 | 0.053 | 13 | 37 °C | Open record: neprilysin (neutral endopeptidase, NEP), Endothelin-1 |
| neprilysin (neutral endopeptidase, NEP) | Homo sapiens | gastrin-releasing peptide | 26 | 0.15 | 170 | pH 7.4, 37 °C | Open record: neprilysin (neutral endopeptidase, NEP), gastrin-releasing peptide |
| neprilysin (neutral endopeptidase, NEP) | Homo sapiens | Glucagon | 4.5 | 0.025 | 180 | pH 7.4, 37 °C | Open record: neprilysin (neutral endopeptidase, NEP), Glucagon |
| neprilysin (neutral endopeptidase, NEP) | Homo sapiens | glucagon-like peptide-1 | 3.3 | 0.024 | 140 | pH 7.4, 37 °C | Open record: neprilysin (neutral endopeptidase, NEP), glucagon-like peptide-1 |
| neprilysin (neutral endopeptidase, NEP) | Homo sapiens | Neurokinin A | 17 | 0.0093 | 1.7 × 10³ | pH 7.4, 37 °C | Open record: neprilysin (neutral endopeptidase, NEP), Neurokinin A |
| neprilysin (neutral endopeptidase, NEP) | Homo sapiens | Neurokinin B | 20 | 0.022 | 920 | pH 7.4, 37 °C | Open record: neprilysin (neutral endopeptidase, NEP), Neurokinin B |
| neprilysin (neutral endopeptidase, NEP) | Homo sapiens | Neurotensin | 13 | 0.016 | 820 | pH 7.4, 37 °C | Open record: neprilysin (neutral endopeptidase, NEP), Neurotensin |
| neprilysin (neutral endopeptidase, NEP) | Homo sapiens | Nociceptin | 11 | 0.02 | 570 | pH 7.4, 37 °C | Open record: neprilysin (neutral endopeptidase, NEP), Nociceptin |
| neprilysin (neutral endopeptidase, NEP) | Homo sapiens | Somatostatin 14 | 32 | 0.0074 | 4.4 × 10³ | pH 7.4, 37 °C | Open record: neprilysin (neutral endopeptidase, NEP), Somatostatin 14 |
| neprilysin (neutral endopeptidase, NEP) | Homo sapiens | Somatostatin 28 | 9.1 | 0.031 | 160 | pH 7.4, 37 °C | Open record: neprilysin (neutral endopeptidase, NEP), Somatostatin 28 |
| neprilysin (neutral endopeptidase, NEP) | Homo sapiens | Substance P | 18 | 0.016 | 1.1 × 10³ | pH 7.4, 37 °C | Open record: neprilysin (neutral endopeptidase, NEP), Substance P |
| neprilysin (neutral endopeptidase, NEP) | Homo sapiens | α-endorphin | 8.9 | 0.024 | 390 | pH 7.4, 37 °C | Open record: neprilysin (neutral endopeptidase, NEP), α-endorphin |
| neprilysin (neutral endopeptidase, NEP) | Homo sapiens | γ-endorphin | 4.8 | 0.013 | 380 | pH 7.4, 37 °C | Open record: neprilysin (neutral endopeptidase, NEP), γ-endorphin |
| neprilysin (neutral endopeptidase, NEP)variant G399V | Homo sapiens | amyloid beta 1-40 | 2.7 | 0.055 | 49 | pH 7.4, 37 °C | Open record: neprilysin (neutral endopeptidase, NEP) variant G399V, amyloid beta 1-40 |
| neprilysin (neutral endopeptidase, NEP)variant G399V | Homo sapiens | Angiotensin | 0.73 | 0.0036 | 210 | pH 7.4, 37 °C | Open record: neprilysin (neutral endopeptidase, NEP) variant G399V, Angiotensin |
| neprilysin (neutral endopeptidase, NEP)variant G399V | Homo sapiens | Bradykinin | 0.15 | 0.079 | 1.9 | pH 7.4, 37 °C | Open record: neprilysin (neutral endopeptidase, NEP) variant G399V, Bradykinin |
| neprilysin (neutral endopeptidase, NEP)variant G399V | Homo sapiens | Glucagon | 2.9 | 0.02 | 150 | pH 7.4, 37 °C | Open record: neprilysin (neutral endopeptidase, NEP) variant G399V, Glucagon |
| neprilysin (neutral endopeptidase, NEP)variant G399V | Homo sapiens | Neurotensin | 1.1 | 0.012 | 100 | pH 7.4, 37 °C | Open record: neprilysin (neutral endopeptidase, NEP) variant G399V, Neurotensin |
| neprilysin (neutral endopeptidase, NEP)variant G399V/G714K | Homo sapiens | amyloid beta 1-40 | 2.1 | 0.014 | 150 | pH 7.4, 37 °C | Open record: neprilysin (neutral endopeptidase, NEP) variant G399V/G714K, amyloid beta 1-40 |
| neprilysin (neutral endopeptidase, NEP)variant G399V/G714K | Homo sapiens | Angiotensin | 0.14 | 0.013 | 11 | pH 7.4, 37 °C | Open record: neprilysin (neutral endopeptidase, NEP) variant G399V/G714K, Angiotensin |
| neprilysin (neutral endopeptidase, NEP)variant G399V/G714K | Homo sapiens | Arg-vasopressin | 0.017 | 0.022 | 0.9 | pH 7.4, 37 °C | Open record: neprilysin (neutral endopeptidase, NEP) variant G399V/G714K, Arg-vasopressin |
| neprilysin (neutral endopeptidase, NEP)variant G399V/G714K | Homo sapiens | atrial natriuretic peptide | 0.56 | 0.033 | 17 | pH 7.4, 37 °C | Open record: neprilysin (neutral endopeptidase, NEP) variant G399V/G714K, atrial natriuretic peptide |
| neprilysin (neutral endopeptidase, NEP)variant G399V/G714K | Homo sapiens | Bradykinin | 0.0055 | 0.037 | 0.15 | pH 7.4, 37 °C | Open record: neprilysin (neutral endopeptidase, NEP) variant G399V/G714K, Bradykinin |
| neprilysin (neutral endopeptidase, NEP)variant G399V/G714K | Homo sapiens | Endothelin-1 | 0.059 | 0.057 | 1 | 37 °C | Open record: neprilysin (neutral endopeptidase, NEP) variant G399V/G714K, Endothelin-1 |
| neprilysin (neutral endopeptidase, NEP)variant G399V/G714K | Homo sapiens | gastrin-releasing peptide | 0.39 | 0.12 | 3.3 | pH 7.4, 37 °C | Open record: neprilysin (neutral endopeptidase, NEP) variant G399V/G714K, gastrin-releasing peptide |
| neprilysin (neutral endopeptidase, NEP)variant G399V/G714K | Homo sapiens | Glucagon | 1.2 | 0.03 | 46 | pH 7.4, 37 °C | Open record: neprilysin (neutral endopeptidase, NEP) variant G399V/G714K, Glucagon |
| neprilysin (neutral endopeptidase, NEP)variant G399V/G714K | Homo sapiens | glucagon-like peptide-1 | 0.89 | 0.023 | 40 | pH 7.4, 37 °C | Open record: neprilysin (neutral endopeptidase, NEP) variant G399V/G714K, glucagon-like peptide-1 |
| neprilysin (neutral endopeptidase, NEP)variant G399V/G714K | Homo sapiens | Neurokinin A | 1.1 | 0.034 | 34 | pH 7.4, 37 °C | Open record: neprilysin (neutral endopeptidase, NEP) variant G399V/G714K, Neurokinin A |
| neprilysin (neutral endopeptidase, NEP)variant G399V/G714K | Homo sapiens | Neurokinin B | 0.42 | 0.022 | 19 | pH 7.4, 37 °C | Open record: neprilysin (neutral endopeptidase, NEP) variant G399V/G714K, Neurokinin B |
| neprilysin (neutral endopeptidase, NEP)variant G399V/G714K | Homo sapiens | Neurotensin | 0.039 | 0.016 | 2.6 | pH 7.4, 37 °C | Open record: neprilysin (neutral endopeptidase, NEP) variant G399V/G714K, Neurotensin |
| neprilysin (neutral endopeptidase, NEP)variant G399V/G714K | Homo sapiens | Nociceptin | 14 | 0.063 | 220 | pH 7.4, 37 °C | Open record: neprilysin (neutral endopeptidase, NEP) variant G399V/G714K, Nociceptin |
| neprilysin (neutral endopeptidase, NEP)variant G399V/G714K | Homo sapiens | Somatostatin 14 | 9.1 | 0.032 | 300 | pH 7.4, 37 °C | Open record: neprilysin (neutral endopeptidase, NEP) variant G399V/G714K, Somatostatin 14 |
| neprilysin (neutral endopeptidase, NEP)variant G399V/G714K | Homo sapiens | Somatostatin 28 | 0.086 | 0.047 | 1.8 | pH 7.4, 37 °C | Open record: neprilysin (neutral endopeptidase, NEP) variant G399V/G714K, Somatostatin 28 |
| neprilysin (neutral endopeptidase, NEP)variant G399V/G714K | Homo sapiens | Substance P | 12 | 0.092 | 130 | pH 7.4, 37 °C | Open record: neprilysin (neutral endopeptidase, NEP) variant G399V/G714K, Substance P |
| neprilysin (neutral endopeptidase, NEP)variant G399V/G714K | Homo sapiens | α-endorphin | 0.089 | 0.0065 | 15 | pH 7.4, 37 °C | Open record: neprilysin (neutral endopeptidase, NEP) variant G399V/G714K, α-endorphin |
| neprilysin (neutral endopeptidase, NEP)variant G399V/G714K | Homo sapiens | γ-endorphin | 0.16 | 0.0044 | 38 | pH 7.4, 37 °C | Open record: neprilysin (neutral endopeptidase, NEP) variant G399V/G714K, γ-endorphin |
| neprilysin (neutral endopeptidase, NEP)variant G714K | Homo sapiens | amyloid beta 1-40 | 1.9 | 0.042 | 45 | pH 7.4, 37 °C | Open record: neprilysin (neutral endopeptidase, NEP) variant G714K, amyloid beta 1-40 |
| neprilysin (neutral endopeptidase, NEP)variant G714K | Homo sapiens | Angiotensin | 12 | 0.018 | 670 | pH 7.4, 37 °C | Open record: neprilysin (neutral endopeptidase, NEP) variant G714K, Angiotensin |
| neprilysin (neutral endopeptidase, NEP)variant G714K | Homo sapiens | Bradykinin | 7.4 | 0.12 | 64 | pH 7.4, 37 °C | Open record: neprilysin (neutral endopeptidase, NEP) variant G714K, Bradykinin |
| neprilysin (neutral endopeptidase, NEP)variant G714K | Homo sapiens | Glucagon | 5.2 | 0.042 | 120 | pH 7.4, 37 °C | Open record: neprilysin (neutral endopeptidase, NEP) variant G714K, Glucagon |
| neprilysin (neutral endopeptidase, NEP)variant G714K | Homo sapiens | Neurotensin | 8.6 | 0.01 | 840 | pH 7.4, 37 °C | Open record: neprilysin (neutral endopeptidase, NEP) variant G714K, Neurotensin |