Values CatLog read from this paper
A novel cofactor-binding mode in bacterial IMP dehydrogenases explains inhibitor selectivity
PMID 25572472doi:10.1074/jbc.m114.619767Open in Browse
The paper itself is not on this site: read it at the publisher. This page lists only the values CatLog read from it.
CatLog read 16 records (24 values) from this paper: IMP dehydrogenase (BaIMPDH), IMP dehydrogenase (CjIMPDH), IMP dehydrogenase (ClpIMPDH) and 1 more from Bacillus anthracis, Campylobacter jejuni, Clostridium perfringens and 1 more.
Read from the paper by an AI model and checked against the paper by a second, separate AI run; code converted the units. Values are in CatLog's units; each record opens in Browse with the line the paper prints and the checks. CatLog calculated the 8 kcat/Km values marked “calc.” from kcat and Km; no printed kcat/Km was read for those records.
| Enzyme | Organism | Substrate | kcat (s⁻¹) | Km (mM) | kcat/Km (mM⁻¹ s⁻¹) | Conditions | Open record |
|---|---|---|---|---|---|---|---|
| IMP dehydrogenase (BaIMPDH) | Bacillus anthracis | inosine 5'-monophosphate | 5.3 | 0.064 | 83 calc. | pH 8, 25 °C | Open record: IMP dehydrogenase (BaIMPDH), inosine 5'-monophosphate |
| IMP dehydrogenase (BaIMPDH) | Bacillus anthracis | NAD+ | — | 0.55 | — | pH 8, 25 °C | Open record: IMP dehydrogenase (BaIMPDH), NAD+ |
| IMP dehydrogenase (BaIMPDH)ΔL (CBS domain deletion) | Bacillus anthracis | inosine 5'-monophosphate | 4.5 | 0.15 | 30 calc. | pH 8, 25 °C | Open record: IMP dehydrogenase (BaIMPDH) ΔL (CBS domain deletion), inosine 5'-monophosphate |
| IMP dehydrogenase (BaIMPDH)ΔL (CBS domain deletion) | Bacillus anthracis | NAD+ | — | 0.46 | — | pH 8, 25 °C | Open record: IMP dehydrogenase (BaIMPDH) ΔL (CBS domain deletion), NAD+ |
| IMP dehydrogenase (BaIMPDH)ΔS (CBS domain deletion) | Bacillus anthracis | inosine 5'-monophosphate | 6.1 | 0.061 | 100 calc. | pH 8, 25 °C | Open record: IMP dehydrogenase (BaIMPDH) ΔS (CBS domain deletion), inosine 5'-monophosphate |
| IMP dehydrogenase (BaIMPDH)ΔS (CBS domain deletion) | Bacillus anthracis | NAD+ | — | 0.56 | — | pH 8, 25 °C | Open record: IMP dehydrogenase (BaIMPDH) ΔS (CBS domain deletion), NAD+ |
| IMP dehydrogenase (CjIMPDH) | Campylobacter jejuni | inosine 5'-monophosphate | 2.2 | 0.055 | 40 calc. | pH 8, 25 °C | Open record: IMP dehydrogenase (CjIMPDH), inosine 5'-monophosphate |
| IMP dehydrogenase (CjIMPDH) | Campylobacter jejuni | NAD+ | — | 0.22 | — | pH 8, 25 °C | Open record: IMP dehydrogenase (CjIMPDH), NAD+ |
| IMP dehydrogenase (CjIMPDH)ΔS (CBS domain deletion) | Campylobacter jejuni | inosine 5'-monophosphate | 1.9 | 0.027 | 70 calc. | pH 8, 25 °C | Open record: IMP dehydrogenase (CjIMPDH) ΔS (CBS domain deletion), inosine 5'-monophosphate |
| IMP dehydrogenase (CjIMPDH)ΔS (CBS domain deletion) | Campylobacter jejuni | NAD+ | — | 0.52 | — | pH 8, 25 °C | Open record: IMP dehydrogenase (CjIMPDH) ΔS (CBS domain deletion), NAD+ |
| IMP dehydrogenase (ClpIMPDH) | Clostridium perfringens | inosine 5'-monophosphate | 2.9 | 0.1 | 29 calc. | pH 8, 25 °C | Open record: IMP dehydrogenase (ClpIMPDH), inosine 5'-monophosphate |
| IMP dehydrogenase (ClpIMPDH) | Clostridium perfringens | NAD+ | — | 0.37 | — | pH 8, 25 °C | Open record: IMP dehydrogenase (ClpIMPDH), NAD+ |
| IMP dehydrogenase (ClpIMPDH)ΔL (CBS domain deletion) | Clostridium perfringens | inosine 5'-monophosphate | 1.8 | 0.049 | 37 calc. | pH 8, 25 °C | Open record: IMP dehydrogenase (ClpIMPDH) ΔL (CBS domain deletion), inosine 5'-monophosphate |
| IMP dehydrogenase (ClpIMPDH)ΔL (CBS domain deletion) | Clostridium perfringens | NAD+ | — | 0.51 | — | pH 8, 25 °C | Open record: IMP dehydrogenase (ClpIMPDH) ΔL (CBS domain deletion), NAD+ |
| IMP dehydrogenase (VcIMPDH)ΔL (CBS domain deletion) | Vibrio cholerae | inosine 5'-monophosphate | 5.2 | 0.087 | 60 calc. | pH 8, 25 °C | Open record: IMP dehydrogenase (VcIMPDH) ΔL (CBS domain deletion), inosine 5'-monophosphate |
| IMP dehydrogenase (VcIMPDH)ΔL (CBS domain deletion) | Vibrio cholerae | NAD+ | — | 1.1 | — | pH 8, 25 °C | Open record: IMP dehydrogenase (VcIMPDH) ΔL (CBS domain deletion), NAD+ |