Values CatLog read from this paper
Increased Turnover at Limiting O2 Concentrations by the Thr(387) → Ala Variant of HIF-Prolyl Hydroxylase PHD2
PMID 25857330doi:10.1021/bi501540cOpen in Browse
The paper itself is not on this site: read it at the publisher. This page lists only the values CatLog read from it.
CatLog read 10 records (29 values) from this paper: HIF prolyl-4-hydroxylase 2 (PHD2) from Homo sapiens.
Read from the paper by an AI model and checked against the paper by a second, separate AI run; code converted the units. Values are in CatLog's units; each record opens in Browse with the line the paper prints and the checks.
| Enzyme | Organism | Substrate | kcat (s⁻¹) | Km (mM) | kcat/Km (mM⁻¹ s⁻¹) | Conditions | Open record |
|---|---|---|---|---|---|---|---|
| HIF prolyl-4-hydroxylase 2 (PHD2) | Homo sapiens | 2-oxoglutarate | 0.038 | 9 × 10⁻⁴ | 45 | pH 7, 37 °C | Open record: HIF prolyl-4-hydroxylase 2 (PHD2), 2-oxoglutarate |
| HIF prolyl-4-hydroxylase 2 (PHD2) | Homo sapiens | CODD peptide DLDLEALAPYIPADDDFQL (HIF-1α 556-574 with M561A/M568A) | 0.032 | 8 × 10⁻⁴ | 40 | pH 7, 37 °C | Open record: HIF prolyl-4-hydroxylase 2 (PHD2), CODD peptide DLDLEALAPYIPADDDFQL (HIF-1α 556-574 with M561A/M568A) |
| HIF prolyl-4-hydroxylase 2 (PHD2) | Homo sapiens | dioxygen | 0.13 | 0.53 | 0.25 | pH 7, 37 °C | Open record: HIF prolyl-4-hydroxylase 2 (PHD2), dioxygen |
| HIF prolyl-4-hydroxylase 2 (PHD2)variant T387A | Homo sapiens | 2-oxoglutarate | 0.548 | 0.012 | 45 | pH 7, 37 °C | Open record: HIF prolyl-4-hydroxylase 2 (PHD2) variant T387A, 2-oxoglutarate |
| HIF prolyl-4-hydroxylase 2 (PHD2)variant T387A | Homo sapiens | CODD peptide DLDLEALAPYIPADDDFQL (HIF-1α 556-574 with M561A/M568A)Table 2 | 0.73 | 0.0041 | 180 | pH 7, 37 °C | Open record: HIF prolyl-4-hydroxylase 2 (PHD2) variant T387A, CODD peptide DLDLEALAPYIPADDDFQL (HIF-1α 556-574 with M561A/M568A) |
| HIF prolyl-4-hydroxylase 2 (PHD2)variant T387A | Homo sapiens | CODD peptide DLDLEALAPYIPADDDFQL (HIF-1α 556-574 with M561A/M568A)in the text | 0.55 | — | 220 | pH 7, 37 °C | Open record: HIF prolyl-4-hydroxylase 2 (PHD2) variant T387A, CODD peptide DLDLEALAPYIPADDDFQL (HIF-1α 556-574 with M561A/M568A) |
| HIF prolyl-4-hydroxylase 2 (PHD2)variant T387A | Homo sapiens | dioxygen | 0.48 | 0.1 | 5 | pH 7, 37 °C | Open record: HIF prolyl-4-hydroxylase 2 (PHD2) variant T387A, dioxygen |
| HIF prolyl-4-hydroxylase 2 (PHD2)variant T387N | Homo sapiens | 2-oxoglutarate | 0.017 | 7 × 10⁻⁴ | 25 | pH 7, 37 °C | Open record: HIF prolyl-4-hydroxylase 2 (PHD2) variant T387N, 2-oxoglutarate |
| HIF prolyl-4-hydroxylase 2 (PHD2)variant T387N | Homo sapiens | CODD peptide DLDLEALAPYIPADDDFQL (HIF-1α 556-574 with M561A/M568A) | 0.015 | 0.0014 | 12 | pH 7, 37 °C | Open record: HIF prolyl-4-hydroxylase 2 (PHD2) variant T387N, CODD peptide DLDLEALAPYIPADDDFQL (HIF-1α 556-574 with M561A/M568A) |
| HIF prolyl-4-hydroxylase 2 (PHD2)variant T387N | Homo sapiens | dioxygen | 0.063 | 0.76 | 0.083 | pH 7, 37 °C | Open record: HIF prolyl-4-hydroxylase 2 (PHD2) variant T387N, dioxygen |