CatLogenzyme kinetics catalog

EC 1.14.11.29: hypoxia-inducible factor-proline dioxygenase

OxidoreductasesOpen in Browse

CatLog read 46 records for EC 1.14.11.29 from 3 papers, for 1 organism. Names in these papers: HIF-P4H-3 (HIF prolyl 4-hydroxylase isoenzyme 3), HIF-P4H-2 (HIF prolyl 4-hydroxylase isoenzyme 2), HIF prolyl-4-hydroxylase 2 (PHD2).

Read from the paper by an AI model and checked against the paper by a second, separate AI run; code converted the units.

CatLog also holds 12 records for EC 1.14.11.29 that are not yet re-read: from its earlier version, built from the enzyme databases and partly checked against the papers. All records for EC 1.14.11.29 in Browse.

Papers

PaperOrganismsRecords
Characterization of the human prolyl 4-hydroxylases that modify the hypoxia-inducible factorHomo sapiens34
Increased Turnover at Limiting O2 Concentrations by the Thr(387) → Ala Variant of HIF-Prolyl Hydroxylase PHD2Homo sapiens10
Substrate preference of the HIF-prolyl hydroxylase-2 (PHD2) and substrate-induced conformational changeHomo sapiens2

Records

EnzymeOrganismSubstratekcat (s⁻¹)Km (mM)kcat/Km (mM⁻¹ s⁻¹)ConditionsPaper
HIF prolyl-4-hydroxylase 2 (PHD2)Homo sapiens2-oxoglutarate0.0389 × 10⁻⁴45pH 7, 37 °CPMID 25857330Open
HIF prolyl-4-hydroxylase 2 (PHD2)Homo sapiensCODD peptide DLDLEALAPYIPADDDFQL (HIF-1α 556-574 with M561A/M568A)0.0328 × 10⁻⁴40pH 7, 37 °CPMID 25857330Open
HIF prolyl-4-hydroxylase 2 (PHD2)Homo sapiensdioxygen0.130.530.25pH 7, 37 °CPMID 25857330Open
HIF prolyl-4-hydroxylase 2 (PHD2)Homo sapiensHIF-1α N-terminal oxygen degradation domain peptide HIF-1α(395-414) F413Y, DALTLLAPAAGDTIISLDYGno added NaCl0.01020.0140.67pH 7, 37 °CPMID 23787140Open
HIF prolyl-4-hydroxylase 2 (PHD2)Homo sapiensHIF-1α N-terminal oxygen degradation domain peptide HIF-1α(395-414) F413Y, DALTLLAPAAGDTIISLDYG100 mM NaCl0.01030.0110.83pH 7, 37 °CPMID 23787140Open
HIF prolyl-4-hydroxylase 2 (PHD2)variant T387AHomo sapiens2-oxoglutarate0.5480.01245pH 7, 37 °CPMID 25857330Open
HIF prolyl-4-hydroxylase 2 (PHD2)variant T387AHomo sapiensCODD peptide DLDLEALAPYIPADDDFQL (HIF-1α 556-574 with M561A/M568A)Table 20.730.0041180pH 7, 37 °CPMID 25857330Open
HIF prolyl-4-hydroxylase 2 (PHD2)variant T387AHomo sapiensCODD peptide DLDLEALAPYIPADDDFQL (HIF-1α 556-574 with M561A/M568A)in the text0.55—220pH 7, 37 °CPMID 25857330Open
HIF prolyl-4-hydroxylase 2 (PHD2)variant T387AHomo sapiensdioxygen0.480.15pH 7, 37 °CPMID 25857330Open
HIF prolyl-4-hydroxylase 2 (PHD2)variant T387NHomo sapiens2-oxoglutarate0.0177 × 10⁻⁴25pH 7, 37 °CPMID 25857330Open
HIF prolyl-4-hydroxylase 2 (PHD2)variant T387NHomo sapiensCODD peptide DLDLEALAPYIPADDDFQL (HIF-1α 556-574 with M561A/M568A)0.0150.001412pH 7, 37 °CPMID 25857330Open
HIF prolyl-4-hydroxylase 2 (PHD2)variant T387NHomo sapiensdioxygen0.0630.760.083pH 7, 37 °CPMID 25857330Open
HIF-P4H-2 (HIF prolyl 4-hydroxylase isoenzyme 2)Homo sapiens2-oxoglutarate—0.06—pH 7.8, 37 °CPMID 12788921Open
HIF-P4H-2 (HIF prolyl 4-hydroxylase isoenzyme 2)Homo sapiensascorbate—0.18—pH 7.8, 37 °CPMID 12788921Open
HIF-P4H-2 (HIF prolyl 4-hydroxylase isoenzyme 2)Homo sapiensDALDLEMLAPYISMDDDFQL—0.015—pH 7.8, 37 °CPMID 12788921Open
HIF-P4H-2 (HIF prolyl 4-hydroxylase isoenzyme 2)Homo sapiensDALTLLAPAAGDTIISLFG—0.13—pH 7.8, 37 °CPMID 12788921Open
HIF-P4H-2 (HIF prolyl 4-hydroxylase isoenzyme 2)Homo sapiensDLDLEMLAPAIPMDDDFQL—0.01—pH 7.8, 37 °CPMID 12788921Open
HIF-P4H-2 (HIF prolyl 4-hydroxylase isoenzyme 2)Homo sapiensDLDLEMLAPGIPMDDDFQL—0.02—pH 7.8, 37 °CPMID 12788921Open
HIF-P4H-2 (HIF prolyl 4-hydroxylase isoenzyme 2)Homo sapiensDLDLEMLAPYIPMD—0.1—pH 7.8, 37 °CPMID 12788921Open
HIF-P4H-2 (HIF prolyl 4-hydroxylase isoenzyme 2)Homo sapiensDLDLEMLAPYIPMDD—0.06—pH 7.8, 37 °CPMID 12788921Open
HIF-P4H-2 (HIF prolyl 4-hydroxylase isoenzyme 2)Homo sapiensDLDLEMLAPYIPMDDDF—0.05—pH 7.8, 37 °CPMID 12788921Open
HIF-P4H-2 (HIF prolyl 4-hydroxylase isoenzyme 2)Homo sapiensDLDLEMLAPYIPMDDDFQL—0.007—pH 7.8, 37 °CPMID 12788921Open
HIF-P4H-2 (HIF prolyl 4-hydroxylase isoenzyme 2)Homo sapiensDLDLEMLAPYIPMDDDFQLRSFDQ—0.006—pH 7.8, 37 °CPMID 12788921Open
HIF-P4H-2 (HIF prolyl 4-hydroxylase isoenzyme 2)Homo sapiensDLEMLAPYIPMDDDFQL—0.007—pH 7.8, 37 °CPMID 12788921Open
HIF-P4H-2 (HIF prolyl 4-hydroxylase isoenzyme 2)Homo sapiensELDLETLAPYIPMDGEDFQ—0.03—pH 7.8, 37 °CPMID 12788921Open
HIF-P4H-2 (HIF prolyl 4-hydroxylase isoenzyme 2)Homo sapiensEMLAPYIPMDDDFQL—0.035—pH 7.8, 37 °CPMID 12788921Open
HIF-P4H-2 (HIF prolyl 4-hydroxylase isoenzyme 2)Homo sapiensEPEELAQLAPTPGDAIISLD—0.06—pH 7.8, 37 °CPMID 12788921Open
HIF-P4H-2 (HIF prolyl 4-hydroxylase isoenzyme 2)Homo sapiensO2—0.25—pH 7.8, 37 °CPMID 12788921Open
HIF-P4H-3 (HIF prolyl 4-hydroxylase isoenzyme 3)Homo sapiens2-oxoglutarate—0.055—pH 7.8, 37 °CPMID 12788921Open
HIF-P4H-3 (HIF prolyl 4-hydroxylase isoenzyme 3)Homo sapiensascorbate—0.14—pH 7.8, 37 °CPMID 12788921Open
HIF-P4H-3 (HIF prolyl 4-hydroxylase isoenzyme 3)Homo sapiensDALDLEMLAPYISMDDDFQL—0.006—pH 7.8, 37 °CPMID 12788921Open
HIF-P4H-3 (HIF prolyl 4-hydroxylase isoenzyme 3)Homo sapiensDLDLEMLAPAIPMDDDFQL—0.01—pH 7.8, 37 °CPMID 12788921Open
HIF-P4H-3 (HIF prolyl 4-hydroxylase isoenzyme 3)Homo sapiensDLDLEMLAPGIPMDDDFQL—0.02—pH 7.8, 37 °CPMID 12788921Open
HIF-P4H-3 (HIF prolyl 4-hydroxylase isoenzyme 3)Homo sapiensDLDLEMLAPYIPMD—0.03—pH 7.8, 37 °CPMID 12788921Open
HIF-P4H-3 (HIF prolyl 4-hydroxylase isoenzyme 3)Homo sapiensDLDLEMLAPYIPMDD—0.009—pH 7.8, 37 °CPMID 12788921Open
HIF-P4H-3 (HIF prolyl 4-hydroxylase isoenzyme 3)Homo sapiensDLDLEMLAPYIPMDDDF—0.007—pH 7.8, 37 °CPMID 12788921Open
HIF-P4H-3 (HIF prolyl 4-hydroxylase isoenzyme 3)Homo sapiensDLDLEMLAPYIPMDDDFQL—0.007—pH 7.8, 37 °CPMID 12788921Open
HIF-P4H-3 (HIF prolyl 4-hydroxylase isoenzyme 3)Homo sapiensDLDLEMLAPYIPMDDDFQLRSFDQ—0.006—pH 7.8, 37 °CPMID 12788921Open
HIF-P4H-3 (HIF prolyl 4-hydroxylase isoenzyme 3)Homo sapiensDLEMLAPYIPMDDDFQL—0.007—pH 7.8, 37 °CPMID 12788921Open
HIF-P4H-3 (HIF prolyl 4-hydroxylase isoenzyme 3)Homo sapiensEEPDLSCLAPFVDTYDMMQM—0.07—pH 7.8, 37 °CPMID 12788921Open
HIF-P4H-3 (HIF prolyl 4-hydroxylase isoenzyme 3)Homo sapiensELDLETLAPYIPMDGEDFQ—0.011—pH 7.8, 37 °CPMID 12788921Open
HIF-P4H-3 (HIF prolyl 4-hydroxylase isoenzyme 3)Homo sapiensEMLAPYIPMDD—0.05—pH 7.8, 37 °CPMID 12788921Open
HIF-P4H-3 (HIF prolyl 4-hydroxylase isoenzyme 3)Homo sapiensEMLAPYIPMDDDFQL—0.007—pH 7.8, 37 °CPMID 12788921Open
HIF-P4H-3 (HIF prolyl 4-hydroxylase isoenzyme 3)Homo sapiensEPEELAQLAPTPGDAIISLD—0.1—pH 7.8, 37 °CPMID 12788921Open
HIF-P4H-3 (HIF prolyl 4-hydroxylase isoenzyme 3)Homo sapiensLAPYIPMDDDFQL—0.015—pH 7.8, 37 °CPMID 12788921Open
HIF-P4H-3 (HIF prolyl 4-hydroxylase isoenzyme 3)Homo sapiensO2—0.23—pH 7.8, 37 °CPMID 12788921Open