CatLogenzyme kinetics catalog

Values CatLog read from this paper

Ordered chimerogenesis applied to CYP2B P450 enzymes

PMID 27015760doi:10.1016/j.bbagen.2016.03.028Open in Browse

The paper itself is not on this site: read it at the publisher. This page lists only the values CatLog read from it.

CatLog read 30 records (30 values) from this paper: CYP2B11, CYP2B6, chimeric CYP2B (Chim A, CYP2B6 segment in CYP2B11 framework) and 10 more from canine (dog), Homo sapiens.

Read from the paper by an AI model and checked against the paper by a second, separate AI run; code converted the units. Values are in CatLog's units; each record opens in Browse with the line the paper prints and the checks.

EC 1.14.14.1

EnzymeOrganismSubstratekcat (s⁻¹)Km (mM)kcat/Km (mM⁻¹ s⁻¹)Conditions
chimeric CYP2B (Chim A, CYP2B6 segment in CYP2B11 framework)chimera A—7-ethoxy-4-trifluoromethylcoumarin—0.0104—pH 7.4Open
chimeric CYP2B (Chim A, CYP2B6 segment in CYP2B11 framework)chimera A—cyclophosphamide—0.1—pH 7.4, 30 °COpen
chimeric CYP2B (Chim B, CYP2B6 segment in CYP2B11 framework)chimera B—7-ethoxy-4-trifluoromethylcoumarin—0.0221—pH 7.4Open
chimeric CYP2B (Chim B, CYP2B6 segment in CYP2B11 framework)chimera B—cyclophosphamide—0.53—pH 7.4, 30 °COpen
chimeric CYP2B (Chim E, CYP2B6 segment in CYP2B11 framework)chimera E—7-ethoxy-4-trifluoromethylcoumarin—0.0092—pH 7.4Open
chimeric CYP2B (Chim E, CYP2B6 segment in CYP2B11 framework)chimera E—cyclophosphamide—0.16—pH 7.4, 30 °COpen
chimeric CYP2B (Chim F, CYP2B6 segment in CYP2B11 framework)chimera F—7-ethoxy-4-trifluoromethylcoumarin—0.0043—pH 7.4Open
chimeric CYP2B (Chim F, CYP2B6 segment in CYP2B11 framework)chimera F—cyclophosphamide—0.14—pH 7.4, 30 °COpen
chimeric CYP2B (Chim G, CYP2B6 segment in CYP2B11 framework)chimera G—7-ethoxy-4-trifluoromethylcoumarin—0.0058—pH 7.4Open
chimeric CYP2B (Chim G, CYP2B6 segment in CYP2B11 framework)chimera G—cyclophosphamide—1.29—pH 7.4, 30 °COpen
chimeric CYP2B (Chim H, CYP2B6 segment in CYP2B11 framework)chimera H—7-ethoxy-4-trifluoromethylcoumarin—0.0203—pH 7.4Open
chimeric CYP2B (Chim H, CYP2B6 segment in CYP2B11 framework)chimera H—cyclophosphamide—0.35—pH 7.4, 30 °COpen
chimeric CYP2B (Chim J, CYP2B6 segment in CYP2B11 framework)chimera J—7-ethoxy-4-trifluoromethylcoumarin—0.0122—pH 7.4Open
chimeric CYP2B (Chim J, CYP2B6 segment in CYP2B11 framework)chimera J—cyclophosphamide—0.1—pH 7.4, 30 °COpen
chimeric CYP2B (Chim K, CYP2B6 segment in CYP2B11 framework)chimera K—7-ethoxy-4-trifluoromethylcoumarin—0.016—pH 7.4Open
chimeric CYP2B (Chim K, CYP2B6 segment in CYP2B11 framework)chimera K—cyclophosphamide—0.07—pH 7.4, 30 °COpen
chimeric CYP2B (Chim M, CYP2B6 segment in CYP2B11 framework)chimera M—7-ethoxy-4-trifluoromethylcoumarin—0.0267—pH 7.4Open
chimeric CYP2B (Chim M, CYP2B6 segment in CYP2B11 framework)chimera M—cyclophosphamide—0.33—pH 7.4, 30 °COpen
chimeric CYP2B (Chim N, CYP2B6 segment in CYP2B11 framework)chimera N—7-ethoxy-4-trifluoromethylcoumarin—0.0041—pH 7.4Open
chimeric CYP2B (Chim N, CYP2B6 segment in CYP2B11 framework)chimera N—cyclophosphamide—0.09—pH 7.4, 30 °COpen
chimeric CYP2B (Chim O, CYP2B6 segment in CYP2B11 framework)chimera O—7-ethoxy-4-trifluoromethylcoumarin—0.0024—pH 7.4Open
chimeric CYP2B (Chim O, CYP2B6 segment in CYP2B11 framework)chimera O—cyclophosphamide—0.02—pH 7.4, 30 °COpen
CYP2B11canine (dog)7-ethoxy-4-trifluoromethylcoumarin—0.0082—pH 7.4Open
CYP2B11canine (dog)7-ethoxy-4-trifluoromethylcoumarin0.28——pH 7.4Open
CYP2B11canine (dog)cyclophosphamide—0.08—pH 7.4, 30 °COpen
CYP2B11canine (dog)cyclophosphamide0.92——pH 7.4, 30 °COpen
CYP2B6Homo sapiens7-ethoxy-4-trifluoromethylcoumarin—0.0035—pH 7.4Open
CYP2B6Homo sapiens7-ethoxy-4-trifluoromethylcoumarin0.28——pH 7.4Open
CYP2B6Homo sapienscyclophosphamide—4.03—pH 7.4, 30 °COpen
CYP2B6Homo sapienscyclophosphamide0.6——pH 7.4, 30 °COpen