CatLogenzyme kinetics catalog

EC 1.14.14.1: unspecific monooxygenase

OxidoreductasesOpen in Browse

CatLog read 320 records for EC 1.14.14.1 from 24 papers, for 11 organisms. Names in these papers: cytochrome P450 1A2, cytochrome P450 3A4, CYP102A2, CYP102A3 and 92 more.

Read from the paper by an AI model and checked against the paper by a second, separate AI run; code converted the units.

CatLog also holds 111 records for EC 1.14.14.1 that are not yet re-read: from its earlier version, built from the enzyme databases and partly checked against the papers. All records for EC 1.14.14.1 in Browse.

Papers

PaperOrganismsRecords
Expression, purification, and characterization of Bacillus subtilis cytochromes P450 CYP102A2 and CYP102A3: flavocytochrome homologues of P450 BM3 from Bacillus megateriumBacillus subtilis30
Enzymatic Activities of CYP3A4 Allelic Variants on Quinine 3-Hydroxylation In VitroHomo sapiens28
Ordered chimerogenesis applied to CYP2B P450 enzymescanine (dog)26
Functional characterization of four allelic variants of human cytochrome P450 1A2Homo sapiens24
Single amino acid mutations, but not common polymorphisms, decrease the activity of CYP1B1 against (-)benzo[a]pyrene-7R-trans-7,8-dihydrodiolHomo sapiens22
Cytochrome P450 3A4-catalyzed testosterone 6beta-hydroxylation stereochemistry, kinetic deuterium isotope effects, and rate-limiting stepsHomo sapiens21
Catalytic properties of polymorphic human cytochrome P450 1B1 variantsHomo sapiens20
The participation of human hepatic P450 isoforms, flavin-containing monooxygenases and aldehyde oxidase in the biotransformation of the insecticide fenthionHomo sapiens20
Oxidation of 5-methoxy-N,N-diisopropyltryptamine in rat liver microsomes and recombinant cytochrome P450 enzymesHomo sapiens, Rattus norvegicus14
Preparative use of isolated CYP102 monooxygenases -- a critical appraisalBacillus megaterium13
Identification of rat and human cytochrome p450 isoforms and a rat serum esterase that metabolize the pyrethroid insecticides deltamethrin and esfenvalerateHomo sapiens, Rattus norvegicus11
Purification and characterization of recombinant human neutrophil leukotriene B4 omega-hydroxylase (cytochrome P450 4F3)Homo sapiens11
Structural determination of the substrate specificities and regioselectivities of the rat and human fatty acid omega-hydroxylasesHomo sapiens, Rattus norvegicus10
Metabolism of retinoids and arachidonic acid by human and mouse cytochrome P450 1b1Homo sapiens, Mus musculus10
Cloning, expression and characterisation of CYP102A7, a self-sufficient P450 monooxygenase from Bacillus licheniformisBacillus licheniformis9
Role of cytochrome P450 enzymes in fimasartan metabolism in vitroHomo sapiens9
Sulfaphenazole derivatives as tools for comparing cytochrome P450 2C5 and human cytochromes P450 2Cs: identification of a new high affinity substrate common to those enzymesHomo sapiens, Oryctolagus cuniculus8
High-level expression of full-length human CYP2E1 in Escherichia coli: Comparison of full-length human CYP2E1 to truncated counterpart shows enhanced association with redox partnersHomo sapiens8
Key residues controlling phenacetin metabolism by human cytochrome P450 2A enzymesHomo sapiens7
Cytochrome P450 2E polymorphism in feline liverCanis lupus familiaris, Felis catus and 1 more5
Differential redox and electron-transfer properties of purified yeast, plant and human NADPH-cytochrome P-450 reductases highly modulate cytochrome P-450 activitiesOryctolagus cuniculus5
Cloning, expression and characterization of a fast self-sufficient P450: CYP102A5 from Bacillus cereusBacillus cereus, Bacillus megaterium and 1 more4
Characterization of rat and human CYP2J enzymes as Vitamin D 25-hydroxylasesRattus norvegicus3
Functional characterization of single nucleotide polymorphisms with amino acid substitution in CYP1A2, CYP2A6, and CYP2B6 found in the Japanese populationHomo sapiens2

Records

EnzymeOrganismSubstratekcat (s⁻¹)Km (mM)kcat/Km (mM⁻¹ s⁻¹)ConditionsPaper
chimeric CYP2B (Chim A, CYP2B6 segment in CYP2B11 framework)chimera A—7-ethoxy-4-trifluoromethylcoumarin—0.0104—pH 7.4PMID 27015760Open
chimeric CYP2B (Chim A, CYP2B6 segment in CYP2B11 framework)chimera A—cyclophosphamide—0.1—pH 7.4, 30 °CPMID 27015760Open
chimeric CYP2B (Chim B, CYP2B6 segment in CYP2B11 framework)chimera B—7-ethoxy-4-trifluoromethylcoumarin—0.0221—pH 7.4PMID 27015760Open
chimeric CYP2B (Chim B, CYP2B6 segment in CYP2B11 framework)chimera B—cyclophosphamide—0.53—pH 7.4, 30 °CPMID 27015760Open
chimeric CYP2B (Chim E, CYP2B6 segment in CYP2B11 framework)chimera E—7-ethoxy-4-trifluoromethylcoumarin—0.0092—pH 7.4PMID 27015760Open
chimeric CYP2B (Chim E, CYP2B6 segment in CYP2B11 framework)chimera E—cyclophosphamide—0.16—pH 7.4, 30 °CPMID 27015760Open
chimeric CYP2B (Chim F, CYP2B6 segment in CYP2B11 framework)chimera F—7-ethoxy-4-trifluoromethylcoumarin—0.0043—pH 7.4PMID 27015760Open
chimeric CYP2B (Chim F, CYP2B6 segment in CYP2B11 framework)chimera F—cyclophosphamide—0.14—pH 7.4, 30 °CPMID 27015760Open
chimeric CYP2B (Chim G, CYP2B6 segment in CYP2B11 framework)chimera G—7-ethoxy-4-trifluoromethylcoumarin—0.0058—pH 7.4PMID 27015760Open
chimeric CYP2B (Chim G, CYP2B6 segment in CYP2B11 framework)chimera G—cyclophosphamide—1.29—pH 7.4, 30 °CPMID 27015760Open
chimeric CYP2B (Chim H, CYP2B6 segment in CYP2B11 framework)chimera H—7-ethoxy-4-trifluoromethylcoumarin—0.0203—pH 7.4PMID 27015760Open
chimeric CYP2B (Chim H, CYP2B6 segment in CYP2B11 framework)chimera H—cyclophosphamide—0.35—pH 7.4, 30 °CPMID 27015760Open
chimeric CYP2B (Chim J, CYP2B6 segment in CYP2B11 framework)chimera J—7-ethoxy-4-trifluoromethylcoumarin—0.0122—pH 7.4PMID 27015760Open
chimeric CYP2B (Chim J, CYP2B6 segment in CYP2B11 framework)chimera J—cyclophosphamide—0.1—pH 7.4, 30 °CPMID 27015760Open
chimeric CYP2B (Chim K, CYP2B6 segment in CYP2B11 framework)chimera K—7-ethoxy-4-trifluoromethylcoumarin—0.016—pH 7.4PMID 27015760Open
chimeric CYP2B (Chim K, CYP2B6 segment in CYP2B11 framework)chimera K—cyclophosphamide—0.07—pH 7.4, 30 °CPMID 27015760Open
chimeric CYP2B (Chim M, CYP2B6 segment in CYP2B11 framework)chimera M—7-ethoxy-4-trifluoromethylcoumarin—0.0267—pH 7.4PMID 27015760Open
chimeric CYP2B (Chim M, CYP2B6 segment in CYP2B11 framework)chimera M—cyclophosphamide—0.33—pH 7.4, 30 °CPMID 27015760Open
chimeric CYP2B (Chim N, CYP2B6 segment in CYP2B11 framework)chimera N—7-ethoxy-4-trifluoromethylcoumarin—0.0041—pH 7.4PMID 27015760Open
chimeric CYP2B (Chim N, CYP2B6 segment in CYP2B11 framework)chimera N—cyclophosphamide—0.09—pH 7.4, 30 °CPMID 27015760Open
chimeric CYP2B (Chim O, CYP2B6 segment in CYP2B11 framework)chimera O—7-ethoxy-4-trifluoromethylcoumarin—0.0024—pH 7.4PMID 27015760Open
chimeric CYP2B (Chim O, CYP2B6 segment in CYP2B11 framework)chimera O—cyclophosphamide—0.02—pH 7.4, 30 °CPMID 27015760Open
CYP102A1Bacillus megateriumLinoleic acid68.35——pH 7.4PMID 17945181Open
CYP102A1 (P450 BM-3)variant A74G/F87V/L188QBacillus megateriumNADH46.81.4332.8 calc.PMID 16716428Open
CYP102A1 (P450 BM-3)variant A74G/F87V/L188QBacillus megateriumNADPH132.20.00255.3 × 10⁴ calc.PMID 16716428Open
CYP102A1 (P450 BM-3)variant A74G/F87V/L188Q/R966DBacillus megateriumNADH320.3397 calc.PMID 16716428Open
CYP102A1 (P450 BM-3)variant A74G/F87V/L188Q/R966DBacillus megateriumNADPH1830.131.4 × 10³ calc.PMID 16716428Open
CYP102A1 (P450 BM-3)variant A74G/F87V/L188Q/R966MBacillus megateriumNADH37.80.5470 calc.PMID 16716428Open
CYP102A1 (P450 BM-3)variant A74G/F87V/L188Q/R966MBacillus megateriumNADPH362.80.057.3 × 10³ calc.PMID 16716428Open
CYP102A1 (P450 BM-3)variant A74G/F87V/L188Q/S965DBacillus megateriumNADH70.0041.8 × 10³ calc.PMID 16716428Open
CYP102A1 (P450 BM-3)variant A74G/F87V/L188Q/S965DBacillus megateriumNADPH5.70.02280 calc.PMID 16716428Open
CYP102A1 (P450 BM-3)variant A74G/F87V/L188Q/W1046ABacillus megateriumNADH105.20.025.3 × 10³ calc.PMID 16716428Open
CYP102A1 (P450 BM-3)variant A74G/F87V/L188Q/W1046ABacillus megateriumNADPH6.50.0023.2 × 10³ calc.PMID 16716428Open
CYP102A1 (P450 BM-3)variant A74G/F87V/L188Q/W1046SBacillus megateriumNADH1560.011.6 × 10⁴ calc.PMID 16716428Open
CYP102A1 (P450 BM-3)variant A74G/F87V/L188Q/W1046SBacillus megateriumNADPH9.80.0024.9 × 10³ calc.PMID 16716428Open
CYP102A1 (P450 BM-3)variant A74G/F87V/L188Q/W1046S/R966DBacillus megateriumNADH7500.017.5 × 10⁴ calc.PMID 16716428Open
CYP102A2Bacillus subtilis12-methylmyristic acid70.25——pH 7.4, 30 °CPMID 15122913Open
CYP102A2Bacillus subtilis13-methylmyristic acid64.42——pH 7.4, 30 °CPMID 15122913Open
CYP102A2Bacillus subtilis14-methylpentadecanoic acid79.8——pH 7.4, 30 °CPMID 15122913Open
CYP102A2Bacillus subtilis15-methylpalmitic acid101.80.05681.79 × 10³ calc.pH 7.4, 30 °CPMID 15122913Open
CYP102A2Bacillus subtilisarachidonic acid101.3——pH 7.4, 30 °CPMID 15122913Open
CYP102A2Bacillus subtiliscytochrome c1900.00692.8 × 10⁴ calc.pH 7.4, 30 °CPMID 15122913Open
CYP102A2Bacillus subtilisferricyanide635.80.15344145 calc.pH 7.4, 30 °CPMID 15122913Open
CYP102A2Bacillus subtilislauric acid26.92——pH 7.4, 30 °CPMID 15122913Open
CYP102A2Bacillus subtilislinoleic acid87.17——pH 7.4, 30 °CPMID 15122913Open
CYP102A2Bacillus subtilisLinoleic acid78——pH 7.4PMID 17945181Open
CYP102A2Bacillus subtilisNADH30.817.91.72 calc.pH 7.4, 30 °CPMID 15122913Open
CYP102A2Bacillus subtilispalmitic acid3.33——pH 7.4, 30 °CPMID 15122913Open
CYP102A2Bacillus subtilisphytanic acid90.50.15600 calc.pH 7.4, 30 °CPMID 15122913Open
CYP102A2Bacillus subtilisreduced nicotinamide adenine dinucleotide phosphate192.70.00365.4 × 10⁴ calc.pH 7.4, 30 °CPMID 15122913Open
CYP102A2Bacillus subtilisstearic acid7.170.0388185 calc.pH 7.4, 30 °CPMID 15122913Open
CYP102A2Bacillus subtilistetradecanoic acid0.68——pH 7.4, 30 °CPMID 15122913Open
CYP102A3Bacillus subtilis12-methylmyristic acid34.25——pH 7.4, 30 °CPMID 15122913Open
CYP102A3Bacillus subtilis13-methylmyristic acid36——pH 7.4, 30 °CPMID 15122913Open
CYP102A3Bacillus subtilis14-methylpentadecanoic acid34.92——pH 7.4, 30 °CPMID 15122913Open
CYP102A3Bacillus subtilis15-methylpalmitic acid64.080.0683938 calc.pH 7.4, 30 °CPMID 15122913Open
CYP102A3Bacillus subtilisarachidonic acid28.20.079360 calc.pH 7.4, 30 °CPMID 15122913Open
CYP102A3Bacillus subtiliscytochrome c58.70.01095.38 × 10³ calc.pH 7.4, 30 °CPMID 15122913Open
CYP102A3Bacillus subtilisferricyanide617.50.2852.17 × 10³ calc.pH 7.4, 30 °CPMID 15122913Open
CYP102A3Bacillus subtilislauric acid1.730.16510.5 calc.pH 7.4, 30 °CPMID 15122913Open
CYP102A3Bacillus subtilislinoleic acid18.5——pH 7.4, 30 °CPMID 15122913Open
CYP102A3Bacillus subtilisNADH1.592.430.654 calc.pH 7.4, 30 °CPMID 15122913Open
CYP102A3Bacillus subtilispalmitic acid11.270.33733.4 calc.pH 7.4, 30 °CPMID 15122913Open
CYP102A3Bacillus subtilisphytanic acid13.230.0287461 calc.pH 7.4, 30 °CPMID 15122913Open
CYP102A3Bacillus subtilisreduced nicotinamide adenine dinucleotide phosphate58.80.00511.2 × 10⁴ calc.pH 7.4, 30 °CPMID 15122913Open
CYP102A3Bacillus subtilisstearic acid6.230.068591.0 calc.pH 7.4, 30 °CPMID 15122913Open
CYP102A3Bacillus subtilistetradecanoic acid9.270.54217.1 calc.pH 7.4, 30 °CPMID 15122913Open
CYP102A5Bacillus cereusLinoleic acid112.2——pH 7.4PMID 17945181Open
CYP102A5Bacillus cereusPalmitic acid9.80.2343 calc.pH 7.4PMID 17945181Open
CYP102A7Bacillus licheniformis12-Methyl-tetradecanoic acid13.870.01291.07 × 10³ calc.pH 7.5PMID 18483737Open
CYP102A7Bacillus licheniformis13-Methyl-tetradecanoic acid21.070.01651.28 × 10³ calc.pH 7.5PMID 18483737Open
CYP102A7Bacillus licheniformiscytochrome c122.40.00413.0 × 10⁴ calc.pH 7.5PMID 18483737Open
CYP102A7Bacillus licheniformisDodecanoic acid27.730.102272 calc.pH 7.5PMID 18483737Open
CYP102A7Bacillus licheniformisHexadecanoic acid25.650.0386665 calc.pH 7.5PMID 18483737Open
CYP102A7Bacillus licheniformisLinoleic acid29.30.0551532 calc.pH 7.5PMID 18483737Open
CYP102A7Bacillus licheniformisPalmitoleic acid22.820.01651.38 × 10³ calc.pH 7.5PMID 18483737Open
CYP102A7Bacillus licheniformisStearic acid16.180.01181.37 × 10³ calc.pH 7.5PMID 18483737Open
CYP102A7Bacillus licheniformisTetradecanoic acid59.820.05091.18 × 10³ calc.pH 7.5PMID 18483737Open
CYP1A1Homo sapiens5-methoxy-N,N-diisopropyltryptamine0.00550.002672.2pH 7.4, 37 °CPMID 17980859Open
CYP1A1Homo sapiens5-methoxy-N,N-diisopropyltryptamine0.01720.004244.2pH 7.4, 37 °CPMID 17980859Open
CYP1A1Homo sapiens5-methoxy-N,N-diisopropyltryptamine0.1780.0025770.2pH 7.4, 37 °CPMID 17980859Open
CYP1A1Homo sapiensarachidonic acid0.19330.03415.67pH 7.5, 37 °CPMID 15258110Open
CYP1A1Homo sapiensfenthionFEN 0.5-100 µM added in 12 µL methanol; cosubstrate NADPH—0.008—pH 7.4, 37 °CPMID 18845175Open
CYP1A1Homo sapiensfenthion2 mM glucose-6-phosphate; 2 mM MgCl2; 2-4 U/ml G6PDH0.115—15pH 7.4, 37 °CPMID 18845175Open
CYP1A1Rattus norvegicus5-methoxy-N,N-diisopropyltryptamine0.03370.01013.3pH 7.4, 37 °CPMID 17980859Open
CYP1A1Rattus norvegicus5-methoxy-N,N-diisopropyltryptamine0.0070.007981pH 7.4, 37 °CPMID 17980859Open
CYP1A1Rattus norvegicus5-methoxy-N,N-diisopropyltryptamine0.4530.0096547pH 7.4, 37 °CPMID 17980859Open
CYP1A2Homo sapiens7-ethoxyresorufin—9.23 × 10⁻⁴—pH 7.4PMID 15681899Open
CYP1A2Homo sapiensarachidonic acid0.12330.09521.295pH 7.5, 37 °CPMID 15258110Open
CYP1A2Homo sapiensfenthionFEN 0.5-100 µM added in 12 µL methanol; cosubstrate NADPH—0.0016—pH 7.4, 37 °CPMID 18845175Open
CYP1A2Homo sapiensfenthionFEN 0.5-100 µM added in 12 µL methanol; cosubstrate NADPH—0.0022—pH 7.4, 37 °CPMID 18845175Open
CYP1A2Homo sapiensfenthion2 mM glucose-6-phosphate; 2 mM MgCl2; 2-4 U/ml G6PDH0.063—32pH 7.4, 37 °CPMID 18845175Open
CYP1A2Homo sapiensfenthion2 mM glucose-6-phosphate; 2 mM MgCl2; 2-4 U/ml G6PDH0.065—30pH 7.4, 37 °CPMID 18845175Open
CYP1A2Homo sapiensN-(4-ethoxyphenyl)acetamide0.16130.02736pH 7.4, 37 °CPMID 18779312Open
CYP1A2variant Q478HHomo sapiens7-ethoxyresorufin—8.11 × 10⁻⁴—pH 7.4PMID 15681899Open
CYP1A2Rattus norvegicus5-methoxy-N,N-diisopropyltryptamine0.4270.05368.2pH 7.4, 37 °CPMID 17980859Open
CYP1B1Homo sapiens7,12-dimethylbenz(a)anthracene0.04770.21280.223pH 7.4, 37 °CPMID 15258110Open
CYP1B1Homo sapiensall-trans-retinal0.01280.00851.513pH 7.4, 37 °CPMID 15258110Open
CYP1B1Homo sapiensall-trans-retinol0.00250.01850.138pH 7.4, 37 °CPMID 15258110Open
CYP1B1Homo sapiensarachidonic acid0.0080.02980.275pH 7.5, 37 °CPMID 15258110Open
Cyp1b1Mus musculus7,12-dimethylbenz(a)anthracene0.1380.13890.993pH 7.4, 37 °CPMID 15258110Open
Cyp1b1Mus musculusall-trans-retinal0.00870.15390.057pH 7.4, 37 °CPMID 15258110Open
Cyp1b1Mus musculusall-trans-retinol0.0040.39220.01pH 7.4, 37 °CPMID 15258110Open
Cyp1b1Mus musculusarachidonic acid0.00220.50.005pH 7.5, 37 °CPMID 15258110Open
CYP1B1 Arg48,Ala119,Leu432,Asn453Homo sapiens17beta-estradiolproduct measured: 4-hydroxyestradiol0.01520.00513.0 calc.pH 7.4PMID 10426814Open
CYP1B1 Arg48,Ala119,Leu432,Asn453Homo sapiens17beta-estradiolproduct measured: 2-hydroxyestradiol0.0070.00691.0 calc.pH 7.4PMID 10426814Open
CYP1B1 Arg48,Ala119,Leu432,Asn453Homo sapiensprogesterone6β-hydroxyprogesterone0.010.0250.40 calc.PMID 10426814Open
CYP1B1 Arg48,Ala119,Leu432,Asn453Homo sapiensprogesterone16α-hydroxyprogesterone0.0380.0231.7 calc.PMID 10426814Open
CYP1B1 Arg48,Ala119,Leu432,Asn453Homo sapienstestosterone0.0370.0172.2 calc.PMID 10426814Open
CYP1B1 Arg48,Ala119,Val432,Asn453Homo sapiens17beta-estradiolproduct measured: 4-hydroxyestradiol0.02420.00534.6 calc.pH 7.4PMID 10426814Open
CYP1B1 Arg48,Ala119,Val432,Asn453Homo sapiens17beta-estradiolproduct measured: 2-hydroxyestradiol0.00770.00571.3 calc.pH 7.4PMID 10426814Open
CYP1B1 Arg48,Ala119,Val432,Asn453Homo sapiensprogesterone6β-hydroxyprogesterone0.0570.1670.34 calc.PMID 10426814Open
CYP1B1 Arg48,Ala119,Val432,Asn453Homo sapiensprogesterone16α-hydroxyprogesterone0.1380.1540.900 calc.PMID 10426814Open
CYP1B1 Arg48,Ala119,Val432,Asn453Homo sapienstestosterone0.0180.0480.38 calc.PMID 10426814Open
CYP1B1 Arg48,Ser119,Leu432,Asn453Homo sapiens17beta-estradiolproduct measured: 4-hydroxyestradiol0.01920.00523.7 calc.pH 7.4PMID 10426814Open
CYP1B1 Arg48,Ser119,Leu432,Asn453Homo sapiens17beta-estradiolproduct measured: 2-hydroxyestradiol0.01020.00841.2 calc.pH 7.4PMID 10426814Open
CYP1B1 Arg48,Ser119,Leu432,Asn453Homo sapiensprogesterone6β-hydroxyprogesterone0.0230.0740.32 calc.PMID 10426814Open
CYP1B1 Arg48,Ser119,Leu432,Asn453Homo sapiensprogesterone16α-hydroxyprogesterone0.0680.0461.5 calc.PMID 10426814Open
CYP1B1 Arg48,Ser119,Leu432,Asn453Homo sapienstestosterone0.0420.0261.6 calc.PMID 10426814Open
CYP1B1 Arg48,Ser119,Val432,Asn453Homo sapiens17beta-estradiolproduct measured: 4-hydroxyestradiol0.01830.00257.3 calc.pH 7.4PMID 10426814Open
CYP1B1 Arg48,Ser119,Val432,Asn453Homo sapiens17beta-estradiolproduct measured: 2-hydroxyestradiol0.00559 × 10⁻⁴6.1 calc.pH 7.4PMID 10426814Open
CYP1B1 Arg48,Ser119,Val432,Asn453Homo sapiensprogesterone6β-hydroxyprogesterone0.040.1090.37 calc.PMID 10426814Open
CYP1B1 Arg48,Ser119,Val432,Asn453Homo sapiensprogesterone16α-hydroxyprogesterone0.090.0751.2 calc.PMID 10426814Open
CYP1B1 Arg48,Ser119,Val432,Asn453Homo sapienstestosterone0.0250.0540.46 calc.PMID 10426814Open
CYP1B1 GALNHomo sapiens(-)-benzo[a]pyrene-7R-trans-7,8-dihydrodiol0.01280.001299.8pH 7.5, 37 °CPMID 12807732Open
CYP1B1 GALSHomo sapiens(-)-benzo[a]pyrene-7R-trans-7,8-dihydrodiol0.00930.001327pH 7.5, 37 °CPMID 12807732Open
CYP1B1 GAVNHomo sapiens(-)-benzo[a]pyrene-7R-trans-7,8-dihydrodiol0.01138.6 × 10⁻⁴13.2pH 7.5, 37 °CPMID 12807732Open
CYP1B1 GAVSHomo sapiens(-)-benzo[a]pyrene-7R-trans-7,8-dihydrodiol0.00880.001257pH 7.5, 37 °CPMID 12807732Open
CYP1B1 GSLNHomo sapiens(-)-benzo[a]pyrene-7R-trans-7,8-dihydrodiol0.01070.001716.2pH 7.5, 37 °CPMID 12807732Open
CYP1B1 GSLSHomo sapiens(-)-benzo[a]pyrene-7R-trans-7,8-dihydrodiol0.0140.002086.7pH 7.5, 37 °CPMID 12807732Open
CYP1B1 GSVNHomo sapiens(-)-benzo[a]pyrene-7R-trans-7,8-dihydrodiolmicrosomes pooled from at least two preparations0.0120.00294.3pH 7.5, 37 °CPMID 12807732Open
CYP1B1 GSVNHomo sapiens(-)-benzo[a]pyrene-7R-trans-7,8-dihydrodiol0.01050.002794pH 7.5, 37 °CPMID 12807732Open
CYP1B1 GSVSHomo sapiens(-)-benzo[a]pyrene-7R-trans-7,8-dihydrodiol0.01670.002566.5pH 7.5, 37 °CPMID 12807732Open
CYP1B1 RALNHomo sapiens(-)-benzo[a]pyrene-7R-trans-7,8-dihydrodiolmicrosomes pooled from at least two preparations0.0170.001849.2pH 7.5, 37 °CPMID 12807732Open
CYP1B1 RALNHomo sapiens(-)-benzo[a]pyrene-7R-trans-7,8-dihydrodiol0.01270.001797pH 7.5, 37 °CPMID 12807732Open
CYP1B1 RALSHomo sapiens(-)-benzo[a]pyrene-7R-trans-7,8-dihydrodiolmicrosomes pooled from at least two preparations0.00737.6 × 10⁻⁴9.7pH 7.5, 37 °CPMID 12807732Open
CYP1B1 RALSHomo sapiens(-)-benzo[a]pyrene-7R-trans-7,8-dihydrodiol0.0080.001326.7pH 7.5, 37 °CPMID 12807732Open
CYP1B1 RAVNHomo sapiens(-)-benzo[a]pyrene-7R-trans-7,8-dihydrodiolmicrosomes pooled from at least two preparations0.0190.004674pH 7.5, 37 °CPMID 12807732Open
CYP1B1 RAVNHomo sapiens(-)-benzo[a]pyrene-7R-trans-7,8-dihydrodiol0.01420.002795.5pH 7.5, 37 °CPMID 12807732Open
CYP1B1 RAVSHomo sapiens(-)-benzo[a]pyrene-7R-trans-7,8-dihydrodiolmicrosomes pooled from at least two preparations0.02250.0010820.8pH 7.5, 37 °CPMID 12807732Open
CYP1B1 RAVSHomo sapiens(-)-benzo[a]pyrene-7R-trans-7,8-dihydrodiol0.01470.0013811.3pH 7.5, 37 °CPMID 12807732Open
CYP1B1 RSLNHomo sapiens(-)-benzo[a]pyrene-7R-trans-7,8-dihydrodiol0.01150.001736.7pH 7.5, 37 °CPMID 12807732Open
CYP1B1 RSLSHomo sapiens(-)-benzo[a]pyrene-7R-trans-7,8-dihydrodiol0.0130.001946.7pH 7.5, 37 °CPMID 12807732Open
CYP1B1 RSVNHomo sapiens(-)-benzo[a]pyrene-7R-trans-7,8-dihydrodiolmicrosomes pooled from at least two preparations0.01577.6 × 10⁻⁴20.5pH 7.5, 37 °CPMID 12807732Open
CYP1B1 RSVNHomo sapiens(-)-benzo[a]pyrene-7R-trans-7,8-dihydrodiol0.0120.001718.3pH 7.5, 37 °CPMID 12807732Open
CYP1B1 RSVSHomo sapiens(-)-benzo[a]pyrene-7R-trans-7,8-dihydrodiol0.0110.0010410.7pH 7.5, 37 °CPMID 12807732Open
CYP2A13Homo sapiensN-(4-ethoxyphenyl)acetamide0.06370.01076pH 7.4, 37 °CPMID 18779312Open
CYP2A13variant A117VHomo sapiensN-(4-ethoxyphenyl)acetamide0.490.047810.3pH 7.4, 37 °CPMID 18779312Open
CYP2A13variant A213SHomo sapiensN-(4-ethoxyphenyl)acetamide0.03570.02061.7pH 7.4, 37 °CPMID 18779312Open
CYP2A13variant H372RHomo sapiensN-(4-ethoxyphenyl)acetamide0.03180.00486.7pH 7.4, 37 °CPMID 18779312Open
CYP2A13variant L366IHomo sapiensN-(4-ethoxyphenyl)acetamide0.2280.03636.3pH 7.4, 37 °CPMID 18779312Open
CYP2A13variant M365VHomo sapiensN-(4-ethoxyphenyl)acetamide0.01550.02040.83pH 7.4, 37 °CPMID 18779312Open
CYP2B11canine (dog)7-ethoxy-4-trifluoromethylcoumarin—0.0082—pH 7.4PMID 27015760Open
CYP2B11canine (dog)7-ethoxy-4-trifluoromethylcoumarin0.28——pH 7.4PMID 27015760Open
CYP2B11canine (dog)cyclophosphamide—0.08—pH 7.4, 30 °CPMID 27015760Open
CYP2B11canine (dog)cyclophosphamide0.92——pH 7.4, 30 °CPMID 27015760Open
CYP2C11Rattus norvegicus(alphaS)-cyano-3-phenoxybenzyl (1R, 3R)-cis-3-(2,2-dibromovinyl)-2,2-dimethylcyclopropane carboxylate3.430.0319108 calc.pH 7.4, 37 °CPMID 17576809Open
CYP2C11Rattus norvegicus(alphaS)-cyano-3-phenoxybenzyl 2-(4-chlorophenyl)-3-methylbutyrate3.6570.0335109 calc.pH 7.4, 37 °CPMID 17576809Open
CYP2C11Rattus norvegicus5-methoxy-N,N-diisopropyltryptamine2.550.455.8pH 7.4, 37 °CPMID 17980859Open
CYP2C18Homo sapiens4-methyl-N-methyl-N-(2-phenyl-2H-pyrazol-3-yl)-benzenesulfonamide0.670.005130pH 7.4, 28 °CPMID 12767217Open
CYP2C19Homo sapiens(alphaS)-cyano-3-phenoxybenzyl (1R, 3R)-cis-3-(2,2-dibromovinyl)-2,2-dimethylcyclopropane carboxylate1.0270.009110 calc.pH 7.4, 37 °CPMID 17576809Open
CYP2C19Homo sapiens(alphaS)-cyano-3-phenoxybenzyl 2-(4-chlorophenyl)-3-methylbutyrate1.0730.0041260 calc.pH 7.4, 37 °CPMID 17576809Open
CYP2C19Homo sapiens4-methyl-N-methyl-N-(2-phenyl-2H-pyrazol-3-yl)-benzenesulfonamide0.270.00833pH 7.4, 28 °CPMID 12767217Open
CYP2C19Homo sapiensfenthionFEN 0.5-100 µM added in 12 µL methanol; cosubstrate NADPH—0.0024—pH 7.4, 37 °CPMID 18845175Open
CYP2C19Homo sapiensfenthionFEN 0.5-100 µM added in 12 µL methanol; cosubstrate NADPH—0.0044—pH 7.4, 37 °CPMID 18845175Open
CYP2C19Homo sapiensfenthion2 mM glucose-6-phosphate; 2 mM MgCl2; 2-4 U/ml G6PDH0.0217—8.8pH 7.4, 37 °CPMID 18845175Open
CYP2C19Homo sapiensfenthion2 mM glucose-6-phosphate; 2 mM MgCl2; 2-4 U/ml G6PDH0.127—28pH 7.4, 37 °CPMID 18845175Open
CYP2C19Homo sapiensfenthion sulfoxideFEN-sulfoxide 1.5-25 µM; 37 °C with shaking—0.018—pH 7.4, 37 °CPMID 18845175Open
CYP2C19Homo sapiensfenthion sulfoxide2 mM glucose-6-phosphate; 2 mM MgCl2; 2-4 U/ml G6PDH0.013—0.67pH 7.4, 37 °CPMID 18845175Open
CYP2C5variant CYP2C5/3LVdHOryctolagus cuniculus4-methyl-N-methyl-N-(2-phenyl-2H-pyrazol-3-yl)-benzenesulfonamide0.670.0167pH 7.6, 37 °CPMID 12767217Open
CYP2C5variant CYP2C5dHOryctolagus cuniculus4-methyl-N-methyl-N-(2-phenyl-2H-pyrazol-3-yl)-benzenesulfonamide1.50.013120pH 7.6, 37 °CPMID 12767217Open
CYP2C5variant CYP2C5dHOryctolagus cuniculusprogesteronein the text0.2——pH 7.6, 37 °CPMID 12767217Open
CYP2C5variant CYP2C5dHOryctolagus cuniculusprogesteroneTable 1—0.004—pH 7.6, 37 °CPMID 12767217Open
CYP2C6Rattus norvegicus(alphaS)-cyano-3-phenoxybenzyl (1R, 3R)-cis-3-(2,2-dibromovinyl)-2,2-dimethylcyclopropane carboxylate2.50.0216120 calc.pH 7.4, 37 °CPMID 17576809Open
CYP2C6Rattus norvegicus(alphaS)-cyano-3-phenoxybenzyl 2-(4-chlorophenyl)-3-methylbutyrate2.6370.038269.0 calc.pH 7.4, 37 °CPMID 17576809Open
CYP2C6Rattus norvegicus5-methoxy-N,N-diisopropyltryptamine5-OH-DIPT formation (aromatic ring O-demethylation)0.11380.1241pH 7.4, 37 °CPMID 17980859Open
CYP2C6Rattus norvegicus5-methoxy-N,N-diisopropyltryptamine5-MeO-IPT formation (side-chain N-deisopropylation)0.3470.1612.3pH 7.4, 37 °CPMID 17980859Open
CYP2C8Homo sapiens(alphaS)-cyano-3-phenoxybenzyl (1R, 3R)-cis-3-(2,2-dibromovinyl)-2,2-dimethylcyclopropane carboxylate0.7120.010269.8 calc.pH 7.4, 37 °CPMID 17576809Open
CYP2C8Homo sapiens(alphaS)-cyano-3-phenoxybenzyl 2-(4-chlorophenyl)-3-methylbutyrate0.9870.019151.7 calc.pH 7.4, 37 °CPMID 17576809Open
CYP2C8Homo sapiens4-methyl-N-methyl-N-(2-phenyl-2H-pyrazol-3-yl)-benzenesulfonamide0.0670.041.7pH 7.4, 28 °CPMID 12767217Open
CYP2C9Homo sapiens2-n-butyl-5-dimethylaminothiocarbonylmethyl-6-methyl-3-{[2-(1H-tetrazole-5-yl)biphenyl-4-yl]methyl}pyrimidine-4(3H)-oneformation of FMS S-oxide0.0780.0223.5pH 7.4, 37 °CPMID 29596975Open
CYP2C9Homo sapiens2-n-butyl-5-dimethylaminothiocarbonylmethyl-6-methyl-3-{[2-(1H-tetrazole-5-yl)biphenyl-4-yl]methyl}pyrimidine-4(3H)-oneformation of 1-OH butyl FMS0.0980.7710.127pH 7.4, 37 °CPMID 29596975Open
CYP2C9Homo sapiens2-n-butyl-5-dimethylaminothiocarbonylmethyl-6-methyl-3-{[2-(1H-tetrazole-5-yl)biphenyl-4-yl]methyl}pyrimidine-4(3H)-oneformation of 2-OH or 3-OH butyl FMS0.00830.01220.68pH 7.4, 37 °CPMID 29596975Open
CYP2C9Homo sapiens2-n-butyl-5-dimethylaminothiocarbonylmethyl-6-methyl-3-{[2-(1H-tetrazole-5-yl)biphenyl-4-yl]methyl}pyrimidine-4(3H)-oneformation of 4-OH butyl FMS0.0140.02410.58pH 7.4, 37 °CPMID 29596975Open
CYP2C9Homo sapiens4-methyl-N-methyl-N-(2-phenyl-2H-pyrazol-3-yl)-benzenesulfonamide0.580.01250pH 7.4, 28 °CPMID 12767217Open
CYP2C9Homo sapiensfenthionFEN 0.5-100 µM added in 12 µL methanol; cosubstrate NADPH—0.012—pH 7.4, 37 °CPMID 18845175Open
CYP2C9Homo sapiensfenthionFEN 0.5-100 µM added in 12 µL methanol; cosubstrate NADPH—0.006—pH 7.4, 37 °CPMID 18845175Open
CYP2C9Homo sapiensfenthion2 mM glucose-6-phosphate; 2 mM MgCl2; 2-4 U/ml G6PDH0.023—2pH 7.4, 37 °CPMID 18845175Open
CYP2C9Homo sapiensfenthion2 mM glucose-6-phosphate; 2 mM MgCl2; 2-4 U/ml G6PDH0.027—4.2pH 7.4, 37 °CPMID 18845175Open
CYP2C9*1Homo sapiens(alphaS)-cyano-3-phenoxybenzyl 2-(4-chlorophenyl)-3-methylbutyrate1.330.024354.7 calc.pH 7.4, 37 °CPMID 17576809Open
CYP2D1Rattus norvegicus5-methoxy-N,N-diisopropyltryptamine5-OH-DIPT formation (aromatic ring O-demethylation)0.0030.06880.05pH 7.4, 37 °CPMID 17980859Open
CYP2D1Rattus norvegicus5-methoxy-N,N-diisopropyltryptamine5-MeO-IPT formation (side-chain N-deisopropylation)0.01270.05960.22pH 7.4, 37 °CPMID 17980859Open
CYP2D2Rattus norvegicus5-methoxy-N,N-diisopropyltryptamine0.1689 × 10⁻⁵1.87 × 10³pH 7.4, 37 °CPMID 17980859Open
CYP2E1Homo sapiens4-nitrophenolreconstituted in DLPC (30 µg/mL) with 0.5 µM POR; no cyt b50.0350.1490.23pH 7.4, 37 °CPMID 42398471Open
CYP2E1Homo sapiens4-nitrophenol0.150.1191.27pH 7.4, 37 °CPMID 42398471Open
CYP2E1Homo sapiens4-nitrophenolreconstituted in DLPC (30 µg/mL) with 0.5 µM POR; no cyt b50.0180.4710.038pH 7.4, 37 °CPMID 42398471Open
CYP2E1Homo sapiens4-nitrophenolN-terminally truncated hCYP2E1dH (His-tagged)0.060.1560.38pH 7.4, 37 °CPMID 42398471Open
CYP2E1Homo sapienschlorzoxazonereconstituted in DLPC (30 µg/mL) with 0.5 µM POR; no cyt b50.0370.2760.133pH 7.4, 37 °CPMID 42398471Open
CYP2E1Homo sapienschlorzoxazone0.20.0842.3pH 7.4, 37 °CPMID 42398471Open
CYP2E1Homo sapienschlorzoxazonereconstituted in DLPC (30 µg/mL) with 0.5 µM POR; no cyt b50.0150.2470.06pH 7.4, 37 °CPMID 42398471Open
CYP2E1Homo sapienschlorzoxazoneN-terminally truncated hCYP2E1dH (His-tagged)0.0470.0540.87pH 7.4, 37 °CPMID 42398471Open
CYP2J3Rattus norvegicus1α-hydroxyvitamin D30.37——pH 7.7, 37 °CPMID 16842832Open
CYP2J3Rattus norvegicusvitamin D_20.0143——pH 7.7, 37 °CPMID 16842832Open
CYP2J3Rattus norvegicusvitamin D_30.023——pH 7.7, 37 °CPMID 16842832Open
CYP3A2Rattus norvegicus(alphaS)-cyano-3-phenoxybenzyl (1R, 3R)-cis-3-(2,2-dibromovinyl)-2,2-dimethylcyclopropane carboxylate0.4320.006467 calc.pH 7.4, 37 °CPMID 17576809Open
CYP3A2Rattus norvegicus(alphaS)-cyano-3-phenoxybenzyl 2-(4-chlorophenyl)-3-methylbutyrate0.6580.0043150 calc.pH 7.4, 37 °CPMID 17576809Open
CYP3A2Rattus norvegicus5-methoxy-N,N-diisopropyltryptamine0.2250.420.5pH 7.4, 37 °CPMID 17980859Open
CYP3A4Homo sapiens2-n-butyl-5-dimethylaminothiocarbonylmethyl-6-methyl-3-{[2-(1H-tetrazole-5-yl)biphenyl-4-yl]methyl}pyrimidine-4(3H)-oneformation of FMS S-oxide0.1850.03285.7pH 7.4, 37 °CPMID 29596975Open
CYP3A4Homo sapiens2-n-butyl-5-dimethylaminothiocarbonylmethyl-6-methyl-3-{[2-(1H-tetrazole-5-yl)biphenyl-4-yl]methyl}pyrimidine-4(3H)-oneformation of BR-A-5570.0350.04510.8pH 7.4, 37 °CPMID 29596975Open
CYP3A4Homo sapiens2-n-butyl-5-dimethylaminothiocarbonylmethyl-6-methyl-3-{[2-(1H-tetrazole-5-yl)biphenyl-4-yl]methyl}pyrimidine-4(3H)-oneformation of BR-A-5350.0060.07460.08pH 7.4, 37 °CPMID 29596975Open
CYP3A4Homo sapiensfenthionFEN 0.5-100 µM added in 12 µL methanol; cosubstrate NADPH—0.089—pH 7.4, 37 °CPMID 18845175Open
CYP3A4Homo sapiensfenthionFEN 0.5-100 µM added in 12 µL methanol; cosubstrate NADPH—0.131—pH 7.4, 37 °CPMID 18845175Open
CYP3A4Homo sapiensfenthion2 mM glucose-6-phosphate; 2 mM MgCl2; 2-4 U/ml G6PDH0.028—0.33pH 7.4, 37 °CPMID 18845175Open
CYP3A4Homo sapiensfenthion2 mM glucose-6-phosphate; 2 mM MgCl2; 2-4 U/ml G6PDH0.1—0.83pH 7.4, 37 °CPMID 18845175Open
CYP3A4*10 (D174H)Homo sapiensquinine0.0350.0410.862pH 7.4, 37 °CPMID 31214030Open
CYP3A4*11 (T363M)Homo sapiensquinine0.2420.0912.665pH 7.4, 37 °CPMID 31214030Open
CYP3A4*12 (L373F)Homo sapiensquinine0.020.2160.093pH 7.4, 37 °CPMID 31214030Open
CYP3A4*13 (P416L)Homo sapiensquinine0.0130.060.21pH 7.4, 37 °CPMID 31214030Open
CYP3A4*14 (L15P)Homo sapiensquinine0.0320.0380.828pH 7.4, 37 °CPMID 31214030Open
CYP3A4*15 (R162Q)Homo sapiensquinine0.0750.0164.753pH 7.4, 37 °CPMID 31214030Open
CYP3A4*16 (T185S)Homo sapiensquinine0.0270.0290.958pH 7.4, 37 °CPMID 31214030Open
CYP3A4*17 (F189S)Homo sapiensquinine0.0170.3280.052pH 7.4, 37 °CPMID 31214030Open
CYP3A4*18 (L293P)Homo sapiensquinine0.0280.0450.638pH 7.4, 37 °CPMID 31214030Open
CYP3A4*19 (P467S)Homo sapiensquinine0.0530.0341.558pH 7.4, 37 °CPMID 31214030Open
CYP3A4*1AHomo sapiensquinine0.0580.0163.625pH 7.4, 37 °CPMID 31214030Open
CYP3A4*2 (S222P)Homo sapiensquinine0.1720.3210.535pH 7.4, 37 °CPMID 31214030Open
CYP3A4*20 (488 frameshift)Homo sapiensquinine0.0320.2270.138pH 7.4, 37 °CPMID 31214030Open
CYP3A4*21 (Y319C)Homo sapiensquinine0.0270.3030.088pH 7.4, 37 °CPMID 31214030Open
CYP3A4*23 (R162W)Homo sapiensquinine0.0380.0291.298pH 7.4, 37 °CPMID 31214030Open
CYP3A4*24 (Q200H)Homo sapiensquinine0.0370.0430.838pH 7.4, 37 °CPMID 31214030Open
CYP3A4*28 (L22V)Homo sapiensquinine0.040.0113.628pH 7.4, 37 °CPMID 31214030Open
CYP3A4*29 (F113I)Homo sapiensquinine0.1370.01211.47pH 7.4, 37 °CPMID 31214030Open
CYP3A4*3 (M445T)Homo sapiensquinine0.0420.0510.82pH 7.4, 37 °CPMID 31214030Open
CYP3A4*31 (H324Q)Homo sapiensquinine0.0350.0182.165pH 7.4, 37 °CPMID 31214030Open
CYP3A4*32 (I335T)Homo sapiensquinine0.0670.0252.725pH 7.4, 37 °CPMID 31214030Open
CYP3A4*33 (A370S)Homo sapiensquinine0.0230.0181.27pH 7.4, 37 °CPMID 31214030Open
CYP3A4*34 (I427V)Homo sapiensquinine0.0480.0124.33pH 7.4, 37 °CPMID 31214030Open
CYP3A4*4 (I118V)Homo sapiensquinine0.0950.0941.08pH 7.4, 37 °CPMID 31214030Open
CYP3A4*5 (P218R)Homo sapiensquinine0.0480.1290.378pH 7.4, 37 °CPMID 31214030Open
CYP3A4*7 (G56D)Homo sapiensquinine0.0270.0590.443pH 7.4, 37 °CPMID 31214030Open
CYP3A4*8 (R130Q)Homo sapiensquinine0.030.3240.093pH 7.4, 37 °CPMID 31214030Open
CYP3A4*9 (V170I)Homo sapiensquinine0.040.0590.682pH 7.4, 37 °CPMID 31214030Open
CYP3A5Homo sapiens2-n-butyl-5-dimethylaminothiocarbonylmethyl-6-methyl-3-{[2-(1H-tetrazole-5-yl)biphenyl-4-yl]methyl}pyrimidine-4(3H)-oneformation of FMS S-oxide0.1430.04613.2pH 7.4, 37 °CPMID 29596975Open
CYP3A5Homo sapiens2-n-butyl-5-dimethylaminothiocarbonylmethyl-6-methyl-3-{[2-(1H-tetrazole-5-yl)biphenyl-4-yl]methyl}pyrimidine-4(3H)-oneformation of BR-A-5570.0470.1930.25pH 7.4, 37 °CPMID 29596975Open
CYP4A11Homo sapiensarachidonic acid0.0067——pH 7.4, 37 °CPMID 10620324Open
CYP4A11Homo sapiensdodecanoic acid0.7——pH 7.4, 37 °CPMID 10620324Open
CYP4A11Homo sapienshexadecanoic acid0.17——pH 7.4, 37 °CPMID 10620324Open
CYP4A11Homo sapiensoleic acid0.0067——pH 7.4, 37 °CPMID 10620324Open
CYP4A11Homo sapienstetradecanoic acid0.83——pH 7.4, 37 °CPMID 10620324Open
CYP4A8Rattus norvegicusarachidonic acid0.017——pH 7.4, 37 °CPMID 10620324Open
CYP4A8Rattus norvegicusdodecanoic acid3.8——pH 7.4, 37 °CPMID 10620324Open
CYP4A8Rattus norvegicushexadecanoic acid0.025——pH 7.4, 37 °CPMID 10620324Open
CYP4A8Rattus norvegicusoleic acid0.023——pH 7.4, 37 °CPMID 10620324Open
CYP4A8Rattus norvegicustetradecanoic acid0.1——pH 7.4, 37 °CPMID 10620324Open
cytochrome P-450 2B4 (CYP2B4)Oryctolagus cuniculus7-ethoxycoumarinArabidopsis ATR1 CPR0.047——pH 7.5, 30 °CPMID 9990323Open
cytochrome P-450 2B4 (CYP2B4)Oryctolagus cuniculus7-ethoxycoumarinArabidopsis ATR2 CPR0.017——pH 7.5, 30 °CPMID 9990323Open
cytochrome P-450 2B4 (CYP2B4)Oryctolagus cuniculus7-ethoxycoumarinyeast SCR1 CPR0.11——pH 7.5, 30 °CPMID 9990323Open
cytochrome P-450 2B4 (CYP2B4)Oryctolagus cuniculus7-ethoxycoumarin0.03——pH 7.5, 30 °CPMID 9990323Open
cytochrome P-450 2B4 (CYP2B4)Oryctolagus cuniculus7-ethoxycoumarinhuman HSR1 CPR without cytochrome b50.0067——pH 7.5, 30 °CPMID 9990323Open
cytochrome P450 1A2Homo sapiens2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine0.180.0712.6 calc.pH 7.4, 37 °CPMID 14725854Open
cytochrome P450 1A2Homo sapiens2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline0.090.0273.3 calc.pH 7.4, 37 °CPMID 14725854Open
cytochrome P450 1A2Homo sapiens2-amino-3-methylimidazo[4,5-f]quinoline0.0970.0214.6 calc.pH 7.4, 37 °CPMID 14725854Open
cytochrome P450 1A2Homo sapiens2-amino-6-methyldipyrido[1,2-a :3^′,2^′-d]imidazole0.0830.00421 calc.pH 7.4, 37 °CPMID 14725854Open
cytochrome P450 1A2Homo sapiensMeIQ0.050.0261.9 calc.pH 7.4, 37 °CPMID 14725854Open
cytochrome P450 1A2Homo sapiensphenacetin0.0250.0251.0 calc.pH 7.4PMID 14725854Open
cytochrome P450 1A2variant C406YHomo sapiens2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine0.430.0666.6 calc.pH 7.4, 37 °CPMID 14725854Open
cytochrome P450 1A2variant C406YHomo sapiens2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline0.1270.026.3 calc.pH 7.4, 37 °CPMID 14725854Open
cytochrome P450 1A2variant C406YHomo sapiens2-amino-3-methylimidazo[4,5-f]quinoline0.1380.0226.3 calc.pH 7.4, 37 °CPMID 14725854Open
cytochrome P450 1A2variant C406YHomo sapiens2-amino-6-methyldipyrido[1,2-a :3^′,2^′-d]imidazole0.220.01120 calc.pH 7.4, 37 °CPMID 14725854Open
cytochrome P450 1A2variant C406YHomo sapiensMeIQ0.0750.0145.4 calc.pH 7.4, 37 °CPMID 14725854Open
cytochrome P450 1A2variant C406YHomo sapiensphenacetin0.020.0620.32 calc.pH 7.4PMID 14725854Open
cytochrome P450 1A2variant D348NHomo sapiens2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine0.480.0627.8 calc.pH 7.4, 37 °CPMID 14725854Open
cytochrome P450 1A2variant D348NHomo sapiens2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline0.150.0334.5 calc.pH 7.4, 37 °CPMID 14725854Open
cytochrome P450 1A2variant D348NHomo sapiens2-amino-3-methylimidazo[4,5-f]quinoline0.1930.0277.2 calc.pH 7.4, 37 °CPMID 14725854Open
cytochrome P450 1A2variant D348NHomo sapiens2-amino-6-methyldipyrido[1,2-a :3^′,2^′-d]imidazole0.220.01317 calc.pH 7.4, 37 °CPMID 14725854Open
cytochrome P450 1A2variant D348NHomo sapiensMeIQ0.0680.0174.0 calc.pH 7.4, 37 °CPMID 14725854Open
cytochrome P450 1A2variant D348NHomo sapiensphenacetin0.0150.0180.83 calc.pH 7.4PMID 14725854Open
cytochrome P450 1A2variant I386FHomo sapiens2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine0.330.3410.98 calc.pH 7.4, 37 °CPMID 14725854Open
cytochrome P450 1A2variant I386FHomo sapiens2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline0.30.0466.5 calc.pH 7.4, 37 °CPMID 14725854Open
cytochrome P450 1A2variant I386FHomo sapiens2-amino-3-methylimidazo[4,5-f]quinoline0.0480.0371.3 calc.pH 7.4, 37 °CPMID 14725854Open
cytochrome P450 1A2variant I386FHomo sapiens2-amino-6-methyldipyrido[1,2-a :3^′,2^′-d]imidazole0.230.01615 calc.pH 7.4, 37 °CPMID 14725854Open
cytochrome P450 1A2variant I386FHomo sapiensMeIQ0.0130.00453.0 calc.pH 7.4, 37 °CPMID 14725854Open
cytochrome P450 1A2variant I386FHomo sapiensphenacetin0.0430.320.14 calc.pH 7.4PMID 14725854Open
cytochrome P450 2E, CYP2E-aFelis catuschlorzoxazone0.14670.650.23 calc.pH 7.4, 37 °CPMID 16168565Open
cytochrome P450 2E, CYP2E-bFelis catuschlorzoxazone0.08050.880.091 calc.pH 7.4, 37 °CPMID 16168565Open
cytochrome P450 2E, CYP2E-cFelis catuschlorzoxazone0.05331.10.049 calc.pH 7.4, 37 °CPMID 16168565Open
cytochrome P450 2E1 (CYP2E1)Canis lupus familiarischlorzoxazone0.09880.950.10 calc.pH 7.4, 37 °CPMID 16168565Open
cytochrome P450 2E1 (CYP2E1)Homo sapienschlorzoxazone0.31451.070.294 calc.pH 7.4, 37 °CPMID 16168565Open
cytochrome P450 3A4Homo sapiens(2,2,4,6,6-2H5)testosteroneBaculosomes (4 pmol P450 3A4); 4 pmol P450; Table I0.88——pH 7.4, 37 °CPMID 15772082Open
cytochrome P450 3A4Homo sapiens(2,2,4,6,6-2H5)testosteroneBaculosomes (4 pmol P450 3A4); 4 pmol P450; Table I0.033——pH 7.4, 37 °CPMID 15772082Open
cytochrome P450 3A4Homo sapiens(2,2,4,6,6-2H5)testosteroneBaculosomes (4 pmol P450 3A4); 4 pmol P450; Table I0.237——pH 7.4, 37 °CPMID 15772082Open
cytochrome P450 3A4Homo sapiens(2,2,4,6,6-2H5)testosteroneBaculosomes (4 pmol P450 3A4); 4 pmol P450; Table I0.227——pH 7.4, 37 °CPMID 15772082Open
cytochrome P450 3A4Homo sapiens(2,2,4,6,6-2H5)testosterone30 pmol P450; Table II0.202——pH 7.4, 37 °CPMID 15772082Open
cytochrome P450 3A4Homo sapiens(6,6-2H2)testosterone4-200 µM testosterone; 4 pmol P450; Table I0.42——pH 7.4, 37 °CPMID 15772082Open
cytochrome P450 3A4Homo sapiens(6,6-2H2)testosterone4-200 µM testosterone; 4 pmol P450; Table I0.2——pH 7.4, 37 °CPMID 15772082Open
cytochrome P450 3A4Homo sapiens(6,6-2H2)testosterone4-200 µM testosterone; 4 pmol P450; Table I0.107——pH 7.4, 37 °CPMID 15772082Open
cytochrome P450 3A4Homo sapiens(6,6-2H2)testosterone4-200 µM testosterone; 4 pmol P450; Table I0.115——pH 7.4, 37 °CPMID 15772082Open
cytochrome P450 3A4Homo sapiens(6,6-2H2)testosterone4-200 µM testosterone; 30 pmol P450; Table II0.143——pH 7.4, 37 °CPMID 15772082Open
cytochrome P450 3A4Homo sapiens(6,6-2H2)testosterone4-200 µM testosterone; Table II0.115——pH 7.4, 37 °CPMID 15772082Open
cytochrome P450 3A4Homo sapiens(6,6-2H2)testosteroneTable II0.178——pH 7.4, 37 °CPMID 15772082Open
cytochrome P450 3A4Homo sapiens7-(benzyloxy)quinoline0.05330.0143.8 calc.pH 7.4, 37 °CPMID 15772082Open
cytochrome P450 3A4Homo sapiensd2-benzyloxyquinoline0.020.02150.93 calc.pH 7.4, 37 °CPMID 15772082Open
cytochrome P450 3A4Homo sapienstestosterone4-200 µM testosterone; 4 pmol P450; Table I1.3——pH 7.4, 37 °CPMID 15772082Open
cytochrome P450 3A4Homo sapienstestosterone4-200 µM testosterone; 4 pmol P450; Table I0.23——pH 7.4, 37 °CPMID 15772082Open
cytochrome P450 3A4Homo sapienstestosterone4-200 µM testosterone; 4 pmol P450; Table I0.118——pH 7.4, 37 °CPMID 15772082Open
cytochrome P450 3A4Homo sapienstestosterone4-200 µM testosterone; 4 pmol P450; Table I0.118——pH 7.4, 37 °CPMID 15772082Open
cytochrome P450 3A4Homo sapienstestosterone4-200 µM testosterone; 30 pmol P450; Table II0.255——pH 7.4, 37 °CPMID 15772082Open
cytochrome P450 3A4Homo sapienstestosterone4-200 µM testosterone; Table II0.165——pH 7.4, 37 °CPMID 15772082Open
cytochrome P450 3A4Homo sapienstestosteroneTable II0.242——pH 7.4, 37 °CPMID 15772082Open
leukotriene B4 omega-hydroxylase (cytochrome P450 4F3)Homo sapiens(5(R,S),6E,8Z,11Z,14Z)-5-hydroxyeicosatetraenoic acid0.360.025714PMID 9675028Open
leukotriene B4 omega-hydroxylase (cytochrome P450 4F3)Homo sapiens(5(R,S),6E,8Z,11Z,14Z,17Z)-5-hydroxyeicosapentaenoic acid1.5850.049532PMID 9675028Open
leukotriene B4 omega-hydroxylase (cytochrome P450 4F3)Homo sapiens(5S,6E,8E,10E,12R,14Z)-5,12-dihydroxyeicosatetraenoic acid0.4980.09615.2PMID 9675028Open
leukotriene B4 omega-hydroxylase (cytochrome P450 4F3)Homo sapiens(5Z,8Z,10E,12(R,S),14Z)-12-hydroxyeicosatetraenoic acid0.720.040917.7PMID 9675028Open
leukotriene B4 omega-hydroxylase (cytochrome P450 4F3)Homo sapiens12-hydroxy-oleate0.3170.022813.8PMID 9675028Open
leukotriene B4 omega-hydroxylase (cytochrome P450 4F3)Homo sapiens12-hydroxystearate0.9080.014264PMID 9675028Open
leukotriene B4 omega-hydroxylase (cytochrome P450 4F3)Homo sapiens20-hydroxy-leukotriene B41.1120.0065172PMID 9675028Open
leukotriene B4 omega-hydroxylase (cytochrome P450 4F3)Homo sapiensleukotriene B420 mM Hepes buffer with 340 mM sucrose; 1 mM EDTA; 1 mM DTT0.5676.4 × 10⁻⁴885pH 7.5, 37 °CPMID 9675028Open
leukotriene B4 omega-hydroxylase (cytochrome P450 4F3)Homo sapiensleukotriene B4recombinant; in yeast microsomal fraction (not purified)—7 × 10⁻⁴—pH 7.5, 37 °CPMID 9675028Open
leukotriene B4 omega-hydroxylase (cytochrome P450 4F3)Homo sapienslipoxin A40.250.2541PMID 9675028Open
leukotriene B4 omega-hydroxylase (cytochrome P450 4F3)Homo sapienslipoxin B40.6420.017935.8PMID 9675028Open