CatLogenzyme kinetics catalog

Values CatLog read from this paper

The participation of human hepatic P450 isoforms, flavin-containing monooxygenases and aldehyde oxidase in the biotransformation of the insecticide fenthion

PMID 18845175doi:10.1016/j.taap.2008.09.004Open in Browse

The paper itself is not on this site: read it at the publisher. This page lists only the values CatLog read from it.

CatLog read 29 records (41 values) from this paper: CYP2C19, CYP1A2, CYP2B6 and 7 more from Homo sapiens.

Read from the paper by an AI model and checked against the paper by a second, separate AI run; code converted the units. Values are in CatLog's units; each record opens in Browse with the line the paper prints and the checks.

EC 1.2.3.1, EC 1.2.3.8, EC 1.2.3.9, EC 1.6.3.1, EC 1.14.13.8, EC 1.14.13.32, EC 1.14.13.148, EC 1.14.14.1, EC 1.14.14.51, EC 1.14.14.52, EC 1.14.14.53, EC 1.14.14.55, EC 1.14.14.56, EC 1.14.14.73, EC 1.14.14.75, EC 4.2.1.152

EnzymeOrganismSubstratekcat (s⁻¹)Km (mM)kcat/Km (mM⁻¹ s⁻¹)Conditions
aldehyde oxidaseHomo sapiensbenzaldehyde(HLC_1)—0.0025—Open
aldehyde oxidaseHomo sapiensbenzaldehyde(HLC_2)—0.0044—Open
CYP1A1Homo sapiensfenthionFEN 0.5-100 µM added in 12 µL methanol; cosubstrate NADPH—0.008—pH 7.4, 37 °COpen
CYP1A1Homo sapiensfenthion2 mM glucose-6-phosphate; 2 mM MgCl2; 2-4 U/ml G6PDH0.115—15pH 7.4, 37 °COpen
CYP1A2Homo sapiensfenthionFEN 0.5-100 µM added in 12 µL methanol; cosubstrate NADPH—0.0016—pH 7.4, 37 °COpen
CYP1A2Homo sapiensfenthionFEN 0.5-100 µM added in 12 µL methanol; cosubstrate NADPH—0.0022—pH 7.4, 37 °COpen
CYP1A2Homo sapiensfenthion2 mM glucose-6-phosphate; 2 mM MgCl2; 2-4 U/ml G6PDH0.063—32pH 7.4, 37 °COpen
CYP1A2Homo sapiensfenthion2 mM glucose-6-phosphate; 2 mM MgCl2; 2-4 U/ml G6PDH0.065—30pH 7.4, 37 °COpen
CYP2B6Homo sapiensfenthionFEN 0.5-100 µM added in 12 µL methanol; cosubstrate NADPH—0.0027—pH 7.4, 37 °COpen
CYP2B6Homo sapiensfenthionFEN 0.5-100 µM added in 12 µL methanol; cosubstrate NADPH—0.01—pH 7.4, 37 °COpen
CYP2B6Homo sapiensfenthion2 mM glucose-6-phosphate; 2 mM MgCl2; 2-4 U/ml G6PDH0.333—123pH 7.4, 37 °COpen
CYP2B6Homo sapiensfenthion2 mM glucose-6-phosphate; 2 mM MgCl2; 2-4 U/ml G6PDH0.033—3.5pH 7.4, 37 °COpen
CYP2C19Homo sapiensfenthionFEN 0.5-100 µM added in 12 µL methanol; cosubstrate NADPH—0.0024—pH 7.4, 37 °COpen
CYP2C19Homo sapiensfenthionFEN 0.5-100 µM added in 12 µL methanol; cosubstrate NADPH—0.0044—pH 7.4, 37 °COpen
CYP2C19Homo sapiensfenthion2 mM glucose-6-phosphate; 2 mM MgCl2; 2-4 U/ml G6PDH0.0217—8.8pH 7.4, 37 °COpen
CYP2C19Homo sapiensfenthion2 mM glucose-6-phosphate; 2 mM MgCl2; 2-4 U/ml G6PDH0.127—28pH 7.4, 37 °COpen
CYP2C19Homo sapiensfenthion sulfoxideFEN-sulfoxide 1.5-25 µM; 37 °C with shaking—0.018—pH 7.4, 37 °COpen
CYP2C19Homo sapiensfenthion sulfoxide2 mM glucose-6-phosphate; 2 mM MgCl2; 2-4 U/ml G6PDH0.013—0.67pH 7.4, 37 °COpen
CYP2C9Homo sapiensfenthionFEN 0.5-100 µM added in 12 µL methanol; cosubstrate NADPH—0.012—pH 7.4, 37 °COpen
CYP2C9Homo sapiensfenthionFEN 0.5-100 µM added in 12 µL methanol; cosubstrate NADPH—0.006—pH 7.4, 37 °COpen
CYP2C9Homo sapiensfenthion2 mM glucose-6-phosphate; 2 mM MgCl2; 2-4 U/ml G6PDH0.023—2pH 7.4, 37 °COpen
CYP2C9Homo sapiensfenthion2 mM glucose-6-phosphate; 2 mM MgCl2; 2-4 U/ml G6PDH0.027—4.2pH 7.4, 37 °COpen
CYP3A4Homo sapiensfenthionFEN 0.5-100 µM added in 12 µL methanol; cosubstrate NADPH—0.089—pH 7.4, 37 °COpen
CYP3A4Homo sapiensfenthionFEN 0.5-100 µM added in 12 µL methanol; cosubstrate NADPH—0.131—pH 7.4, 37 °COpen
CYP3A4Homo sapiensfenthion2 mM glucose-6-phosphate; 2 mM MgCl2; 2-4 U/ml G6PDH0.028—0.33pH 7.4, 37 °COpen
CYP3A4Homo sapiensfenthion2 mM glucose-6-phosphate; 2 mM MgCl2; 2-4 U/ml G6PDH0.1—0.83pH 7.4, 37 °COpen
FMO1Homo sapiensfenthion—0.0027—pH 7.4, 37 °COpen
FMO3Homo sapiensfenthion—0.039—pH 7.4, 37 °COpen
FMO5Homo sapiensfenthion—0.249—pH 7.4, 37 °COpen