CatLogenzyme kinetics catalog

EC 1.14.14.56: 1,8-cineole 2-exo-monooxygenase

OxidoreductasesOpen in Browse

CatLog read 56 records for EC 1.14.14.56 from 4 papers, for 1 organism. Names in these papers: cytochrome P450 3A4, CYP3A4, CYP3A4*10 (D174H), CYP3A4*11 (T363M) and 26 more.

Read from the paper by an AI model and checked against the paper by a second, separate AI run; code converted the units.

CatLog also holds 3 records for EC 1.14.14.56 that are not yet re-read: from its earlier version, built from the enzyme databases and partly checked against the papers. All records for EC 1.14.14.56 in Browse.

Papers

PaperOrganismsRecords
Enzymatic Activities of CYP3A4 Allelic Variants on Quinine 3-Hydroxylation In VitroHomo sapiens28
Cytochrome P450 3A4-catalyzed testosterone 6beta-hydroxylation stereochemistry, kinetic deuterium isotope effects, and rate-limiting stepsHomo sapiens21
The participation of human hepatic P450 isoforms, flavin-containing monooxygenases and aldehyde oxidase in the biotransformation of the insecticide fenthionHomo sapiens4
Role of cytochrome P450 enzymes in fimasartan metabolism in vitroHomo sapiens3

Records

EnzymeOrganismSubstratekcat (s⁻¹)Km (mM)kcat/Km (mM⁻¹ s⁻¹)ConditionsPaper
CYP3A4Homo sapiens2-n-butyl-5-dimethylaminothiocarbonylmethyl-6-methyl-3-{[2-(1H-tetrazole-5-yl)biphenyl-4-yl]methyl}pyrimidine-4(3H)-oneformation of FMS S-oxide0.1850.03285.7pH 7.4, 37 °CPMID 29596975Open
CYP3A4Homo sapiens2-n-butyl-5-dimethylaminothiocarbonylmethyl-6-methyl-3-{[2-(1H-tetrazole-5-yl)biphenyl-4-yl]methyl}pyrimidine-4(3H)-oneformation of BR-A-5570.0350.04510.8pH 7.4, 37 °CPMID 29596975Open
CYP3A4Homo sapiens2-n-butyl-5-dimethylaminothiocarbonylmethyl-6-methyl-3-{[2-(1H-tetrazole-5-yl)biphenyl-4-yl]methyl}pyrimidine-4(3H)-oneformation of BR-A-5350.0060.07460.08pH 7.4, 37 °CPMID 29596975Open
CYP3A4Homo sapiensfenthionFEN 0.5-100 µM added in 12 µL methanol; cosubstrate NADPH—0.089—pH 7.4, 37 °CPMID 18845175Open
CYP3A4Homo sapiensfenthionFEN 0.5-100 µM added in 12 µL methanol; cosubstrate NADPH—0.131—pH 7.4, 37 °CPMID 18845175Open
CYP3A4Homo sapiensfenthion2 mM glucose-6-phosphate; 2 mM MgCl2; 2-4 U/ml G6PDH0.028—0.33pH 7.4, 37 °CPMID 18845175Open
CYP3A4Homo sapiensfenthion2 mM glucose-6-phosphate; 2 mM MgCl2; 2-4 U/ml G6PDH0.1—0.83pH 7.4, 37 °CPMID 18845175Open
CYP3A4*10 (D174H)Homo sapiensquinine0.0350.0410.862pH 7.4, 37 °CPMID 31214030Open
CYP3A4*11 (T363M)Homo sapiensquinine0.2420.0912.665pH 7.4, 37 °CPMID 31214030Open
CYP3A4*12 (L373F)Homo sapiensquinine0.020.2160.093pH 7.4, 37 °CPMID 31214030Open
CYP3A4*13 (P416L)Homo sapiensquinine0.0130.060.21pH 7.4, 37 °CPMID 31214030Open
CYP3A4*14 (L15P)Homo sapiensquinine0.0320.0380.828pH 7.4, 37 °CPMID 31214030Open
CYP3A4*15 (R162Q)Homo sapiensquinine0.0750.0164.753pH 7.4, 37 °CPMID 31214030Open
CYP3A4*16 (T185S)Homo sapiensquinine0.0270.0290.958pH 7.4, 37 °CPMID 31214030Open
CYP3A4*17 (F189S)Homo sapiensquinine0.0170.3280.052pH 7.4, 37 °CPMID 31214030Open
CYP3A4*18 (L293P)Homo sapiensquinine0.0280.0450.638pH 7.4, 37 °CPMID 31214030Open
CYP3A4*19 (P467S)Homo sapiensquinine0.0530.0341.558pH 7.4, 37 °CPMID 31214030Open
CYP3A4*1AHomo sapiensquinine0.0580.0163.625pH 7.4, 37 °CPMID 31214030Open
CYP3A4*2 (S222P)Homo sapiensquinine0.1720.3210.535pH 7.4, 37 °CPMID 31214030Open
CYP3A4*20 (488 frameshift)Homo sapiensquinine0.0320.2270.138pH 7.4, 37 °CPMID 31214030Open
CYP3A4*21 (Y319C)Homo sapiensquinine0.0270.3030.088pH 7.4, 37 °CPMID 31214030Open
CYP3A4*23 (R162W)Homo sapiensquinine0.0380.0291.298pH 7.4, 37 °CPMID 31214030Open
CYP3A4*24 (Q200H)Homo sapiensquinine0.0370.0430.838pH 7.4, 37 °CPMID 31214030Open
CYP3A4*28 (L22V)Homo sapiensquinine0.040.0113.628pH 7.4, 37 °CPMID 31214030Open
CYP3A4*29 (F113I)Homo sapiensquinine0.1370.01211.47pH 7.4, 37 °CPMID 31214030Open
CYP3A4*3 (M445T)Homo sapiensquinine0.0420.0510.82pH 7.4, 37 °CPMID 31214030Open
CYP3A4*31 (H324Q)Homo sapiensquinine0.0350.0182.165pH 7.4, 37 °CPMID 31214030Open
CYP3A4*32 (I335T)Homo sapiensquinine0.0670.0252.725pH 7.4, 37 °CPMID 31214030Open
CYP3A4*33 (A370S)Homo sapiensquinine0.0230.0181.27pH 7.4, 37 °CPMID 31214030Open
CYP3A4*34 (I427V)Homo sapiensquinine0.0480.0124.33pH 7.4, 37 °CPMID 31214030Open
CYP3A4*4 (I118V)Homo sapiensquinine0.0950.0941.08pH 7.4, 37 °CPMID 31214030Open
CYP3A4*5 (P218R)Homo sapiensquinine0.0480.1290.378pH 7.4, 37 °CPMID 31214030Open
CYP3A4*7 (G56D)Homo sapiensquinine0.0270.0590.443pH 7.4, 37 °CPMID 31214030Open
CYP3A4*8 (R130Q)Homo sapiensquinine0.030.3240.093pH 7.4, 37 °CPMID 31214030Open
CYP3A4*9 (V170I)Homo sapiensquinine0.040.0590.682pH 7.4, 37 °CPMID 31214030Open
cytochrome P450 3A4Homo sapiens(2,2,4,6,6-2H5)testosteroneBaculosomes (4 pmol P450 3A4); 4 pmol P450; Table I0.88——pH 7.4, 37 °CPMID 15772082Open
cytochrome P450 3A4Homo sapiens(2,2,4,6,6-2H5)testosteroneBaculosomes (4 pmol P450 3A4); 4 pmol P450; Table I0.033——pH 7.4, 37 °CPMID 15772082Open
cytochrome P450 3A4Homo sapiens(2,2,4,6,6-2H5)testosteroneBaculosomes (4 pmol P450 3A4); 4 pmol P450; Table I0.237——pH 7.4, 37 °CPMID 15772082Open
cytochrome P450 3A4Homo sapiens(2,2,4,6,6-2H5)testosteroneBaculosomes (4 pmol P450 3A4); 4 pmol P450; Table I0.227——pH 7.4, 37 °CPMID 15772082Open
cytochrome P450 3A4Homo sapiens(2,2,4,6,6-2H5)testosterone30 pmol P450; Table II0.202——pH 7.4, 37 °CPMID 15772082Open
cytochrome P450 3A4Homo sapiens(6,6-2H2)testosterone4-200 µM testosterone; 4 pmol P450; Table I0.42——pH 7.4, 37 °CPMID 15772082Open
cytochrome P450 3A4Homo sapiens(6,6-2H2)testosterone4-200 µM testosterone; 4 pmol P450; Table I0.2——pH 7.4, 37 °CPMID 15772082Open
cytochrome P450 3A4Homo sapiens(6,6-2H2)testosterone4-200 µM testosterone; 4 pmol P450; Table I0.107——pH 7.4, 37 °CPMID 15772082Open
cytochrome P450 3A4Homo sapiens(6,6-2H2)testosterone4-200 µM testosterone; 4 pmol P450; Table I0.115——pH 7.4, 37 °CPMID 15772082Open
cytochrome P450 3A4Homo sapiens(6,6-2H2)testosterone4-200 µM testosterone; 30 pmol P450; Table II0.143——pH 7.4, 37 °CPMID 15772082Open
cytochrome P450 3A4Homo sapiens(6,6-2H2)testosterone4-200 µM testosterone; Table II0.115——pH 7.4, 37 °CPMID 15772082Open
cytochrome P450 3A4Homo sapiens(6,6-2H2)testosteroneTable II0.178——pH 7.4, 37 °CPMID 15772082Open
cytochrome P450 3A4Homo sapiens7-(benzyloxy)quinoline0.05330.0143.8 calc.pH 7.4, 37 °CPMID 15772082Open
cytochrome P450 3A4Homo sapiensd2-benzyloxyquinoline0.020.02150.93 calc.pH 7.4, 37 °CPMID 15772082Open
cytochrome P450 3A4Homo sapienstestosterone4-200 µM testosterone; 4 pmol P450; Table I1.3——pH 7.4, 37 °CPMID 15772082Open
cytochrome P450 3A4Homo sapienstestosterone4-200 µM testosterone; 4 pmol P450; Table I0.23——pH 7.4, 37 °CPMID 15772082Open
cytochrome P450 3A4Homo sapienstestosterone4-200 µM testosterone; 4 pmol P450; Table I0.118——pH 7.4, 37 °CPMID 15772082Open
cytochrome P450 3A4Homo sapienstestosterone4-200 µM testosterone; 4 pmol P450; Table I0.118——pH 7.4, 37 °CPMID 15772082Open
cytochrome P450 3A4Homo sapienstestosterone4-200 µM testosterone; 30 pmol P450; Table II0.255——pH 7.4, 37 °CPMID 15772082Open
cytochrome P450 3A4Homo sapienstestosterone4-200 µM testosterone; Table II0.165——pH 7.4, 37 °CPMID 15772082Open
cytochrome P450 3A4Homo sapienstestosteroneTable II0.242——pH 7.4, 37 °CPMID 15772082Open