Values CatLog read from this paper
Role of cytochrome P450 enzymes in fimasartan metabolism in vitro
PMID 29596975doi:10.1016/j.fct.2018.03.036Open in Browse
The paper itself is not on this site: read it at the publisher. This page lists only the values CatLog read from it.
CatLog read 9 records (27 values) from this paper: CYP2C9, CYP3A4, CYP3A5 from Homo sapiens.
Read from the paper by an AI model and checked against the paper by a second, separate AI run; code converted the units. Values are in CatLog's units; each record opens in Browse with the line the paper prints and the checks.
EC 1.14.14.1, EC 1.14.14.51, EC 1.14.14.52, EC 1.14.14.53, EC 1.14.14.55, EC 1.14.14.56, EC 1.14.14.73
| Enzyme | Organism | Substrate | kcat (s⁻¹) | Km (mM) | kcat/Km (mM⁻¹ s⁻¹) | Conditions | Open record |
|---|---|---|---|---|---|---|---|
| CYP2C9 | Homo sapiens | 2-n-butyl-5-dimethylaminothiocarbonylmethyl-6-methyl-3-{[2-(1H-tetrazole-5-yl)biphenyl-4-yl]methyl}pyrimidine-4(3H)-oneformation of FMS S-oxide | 0.078 | 0.022 | 3.5 | pH 7.4, 37 °C | Open record: CYP2C9, 2-n-butyl-5-dimethylaminothiocarbonylmethyl-6-methyl-3-{[2-(1H-tetrazole-5-yl)biphenyl-4-yl]methyl}pyrimidine-4(3H)-one |
| CYP2C9 | Homo sapiens | 2-n-butyl-5-dimethylaminothiocarbonylmethyl-6-methyl-3-{[2-(1H-tetrazole-5-yl)biphenyl-4-yl]methyl}pyrimidine-4(3H)-oneformation of 1-OH butyl FMS | 0.098 | 0.771 | 0.127 | pH 7.4, 37 °C | Open record: CYP2C9, 2-n-butyl-5-dimethylaminothiocarbonylmethyl-6-methyl-3-{[2-(1H-tetrazole-5-yl)biphenyl-4-yl]methyl}pyrimidine-4(3H)-one |
| CYP2C9 | Homo sapiens | 2-n-butyl-5-dimethylaminothiocarbonylmethyl-6-methyl-3-{[2-(1H-tetrazole-5-yl)biphenyl-4-yl]methyl}pyrimidine-4(3H)-oneformation of 2-OH or 3-OH butyl FMS | 0.0083 | 0.0122 | 0.68 | pH 7.4, 37 °C | Open record: CYP2C9, 2-n-butyl-5-dimethylaminothiocarbonylmethyl-6-methyl-3-{[2-(1H-tetrazole-5-yl)biphenyl-4-yl]methyl}pyrimidine-4(3H)-one |
| CYP2C9 | Homo sapiens | 2-n-butyl-5-dimethylaminothiocarbonylmethyl-6-methyl-3-{[2-(1H-tetrazole-5-yl)biphenyl-4-yl]methyl}pyrimidine-4(3H)-oneformation of 4-OH butyl FMS | 0.014 | 0.0241 | 0.58 | pH 7.4, 37 °C | Open record: CYP2C9, 2-n-butyl-5-dimethylaminothiocarbonylmethyl-6-methyl-3-{[2-(1H-tetrazole-5-yl)biphenyl-4-yl]methyl}pyrimidine-4(3H)-one |
| CYP3A4 | Homo sapiens | 2-n-butyl-5-dimethylaminothiocarbonylmethyl-6-methyl-3-{[2-(1H-tetrazole-5-yl)biphenyl-4-yl]methyl}pyrimidine-4(3H)-oneformation of FMS S-oxide | 0.185 | 0.0328 | 5.7 | pH 7.4, 37 °C | Open record: CYP3A4, 2-n-butyl-5-dimethylaminothiocarbonylmethyl-6-methyl-3-{[2-(1H-tetrazole-5-yl)biphenyl-4-yl]methyl}pyrimidine-4(3H)-one |
| CYP3A4 | Homo sapiens | 2-n-butyl-5-dimethylaminothiocarbonylmethyl-6-methyl-3-{[2-(1H-tetrazole-5-yl)biphenyl-4-yl]methyl}pyrimidine-4(3H)-oneformation of BR-A-557 | 0.035 | 0.0451 | 0.8 | pH 7.4, 37 °C | Open record: CYP3A4, 2-n-butyl-5-dimethylaminothiocarbonylmethyl-6-methyl-3-{[2-(1H-tetrazole-5-yl)biphenyl-4-yl]methyl}pyrimidine-4(3H)-one |
| CYP3A4 | Homo sapiens | 2-n-butyl-5-dimethylaminothiocarbonylmethyl-6-methyl-3-{[2-(1H-tetrazole-5-yl)biphenyl-4-yl]methyl}pyrimidine-4(3H)-oneformation of BR-A-535 | 0.006 | 0.0746 | 0.08 | pH 7.4, 37 °C | Open record: CYP3A4, 2-n-butyl-5-dimethylaminothiocarbonylmethyl-6-methyl-3-{[2-(1H-tetrazole-5-yl)biphenyl-4-yl]methyl}pyrimidine-4(3H)-one |
| CYP3A5 | Homo sapiens | 2-n-butyl-5-dimethylaminothiocarbonylmethyl-6-methyl-3-{[2-(1H-tetrazole-5-yl)biphenyl-4-yl]methyl}pyrimidine-4(3H)-oneformation of FMS S-oxide | 0.143 | 0.0461 | 3.2 | pH 7.4, 37 °C | Open record: CYP3A5, 2-n-butyl-5-dimethylaminothiocarbonylmethyl-6-methyl-3-{[2-(1H-tetrazole-5-yl)biphenyl-4-yl]methyl}pyrimidine-4(3H)-one |
| CYP3A5 | Homo sapiens | 2-n-butyl-5-dimethylaminothiocarbonylmethyl-6-methyl-3-{[2-(1H-tetrazole-5-yl)biphenyl-4-yl]methyl}pyrimidine-4(3H)-oneformation of BR-A-557 | 0.047 | 0.193 | 0.25 | pH 7.4, 37 °C | Open record: CYP3A5, 2-n-butyl-5-dimethylaminothiocarbonylmethyl-6-methyl-3-{[2-(1H-tetrazole-5-yl)biphenyl-4-yl]methyl}pyrimidine-4(3H)-one |