CatLogenzyme kinetics catalog

EC 1.14.14.73: albendazole monooxygenase (sulfoxide-forming)

OxidoreductasesOpen in Browse

CatLog read 59 records for EC 1.14.14.73 from 5 papers, for 1 organism. Names in these papers: cytochrome P450 3A4, CYP3A4, CYP2J2, CYP3A4*10 (D174H) and 27 more.

Read from the paper by an AI model and checked against the paper by a second, separate AI run; code converted the units.

Papers

PaperOrganismsRecords
Enzymatic Activities of CYP3A4 Allelic Variants on Quinine 3-Hydroxylation In VitroHomo sapiens28
Cytochrome P450 3A4-catalyzed testosterone 6beta-hydroxylation stereochemistry, kinetic deuterium isotope effects, and rate-limiting stepsHomo sapiens21
The participation of human hepatic P450 isoforms, flavin-containing monooxygenases and aldehyde oxidase in the biotransformation of the insecticide fenthionHomo sapiens4
Characterization of rat and human CYP2J enzymes as Vitamin D 25-hydroxylasesHomo sapiens3
Role of cytochrome P450 enzymes in fimasartan metabolism in vitroHomo sapiens3

Records

EnzymeOrganismSubstratekcat (s⁻¹)Km (mM)kcat/Km (mM⁻¹ s⁻¹)ConditionsPaper
CYP2J2Homo sapiens1α-hydroxyvitamin D30.0370.00448.3 calc.pH 7.7, 37 °CPMID 16842832Open
CYP2J2Homo sapiensvitamin D_20.00270.0021.3 calc.pH 7.7, 37 °CPMID 16842832Open
CYP2J2Homo sapiensvitamin D_30.001450.00770.19 calc.pH 7.7, 37 °CPMID 16842832Open
CYP3A4Homo sapiens2-n-butyl-5-dimethylaminothiocarbonylmethyl-6-methyl-3-{[2-(1H-tetrazole-5-yl)biphenyl-4-yl]methyl}pyrimidine-4(3H)-oneformation of FMS S-oxide0.1850.03285.7pH 7.4, 37 °CPMID 29596975Open
CYP3A4Homo sapiens2-n-butyl-5-dimethylaminothiocarbonylmethyl-6-methyl-3-{[2-(1H-tetrazole-5-yl)biphenyl-4-yl]methyl}pyrimidine-4(3H)-oneformation of BR-A-5570.0350.04510.8pH 7.4, 37 °CPMID 29596975Open
CYP3A4Homo sapiens2-n-butyl-5-dimethylaminothiocarbonylmethyl-6-methyl-3-{[2-(1H-tetrazole-5-yl)biphenyl-4-yl]methyl}pyrimidine-4(3H)-oneformation of BR-A-5350.0060.07460.08pH 7.4, 37 °CPMID 29596975Open
CYP3A4Homo sapiensfenthionFEN 0.5-100 µM added in 12 µL methanol; cosubstrate NADPH—0.089—pH 7.4, 37 °CPMID 18845175Open
CYP3A4Homo sapiensfenthionFEN 0.5-100 µM added in 12 µL methanol; cosubstrate NADPH—0.131—pH 7.4, 37 °CPMID 18845175Open
CYP3A4Homo sapiensfenthion2 mM glucose-6-phosphate; 2 mM MgCl2; 2-4 U/ml G6PDH0.028—0.33pH 7.4, 37 °CPMID 18845175Open
CYP3A4Homo sapiensfenthion2 mM glucose-6-phosphate; 2 mM MgCl2; 2-4 U/ml G6PDH0.1—0.83pH 7.4, 37 °CPMID 18845175Open
CYP3A4*10 (D174H)Homo sapiensquinine0.0350.0410.862pH 7.4, 37 °CPMID 31214030Open
CYP3A4*11 (T363M)Homo sapiensquinine0.2420.0912.665pH 7.4, 37 °CPMID 31214030Open
CYP3A4*12 (L373F)Homo sapiensquinine0.020.2160.093pH 7.4, 37 °CPMID 31214030Open
CYP3A4*13 (P416L)Homo sapiensquinine0.0130.060.21pH 7.4, 37 °CPMID 31214030Open
CYP3A4*14 (L15P)Homo sapiensquinine0.0320.0380.828pH 7.4, 37 °CPMID 31214030Open
CYP3A4*15 (R162Q)Homo sapiensquinine0.0750.0164.753pH 7.4, 37 °CPMID 31214030Open
CYP3A4*16 (T185S)Homo sapiensquinine0.0270.0290.958pH 7.4, 37 °CPMID 31214030Open
CYP3A4*17 (F189S)Homo sapiensquinine0.0170.3280.052pH 7.4, 37 °CPMID 31214030Open
CYP3A4*18 (L293P)Homo sapiensquinine0.0280.0450.638pH 7.4, 37 °CPMID 31214030Open
CYP3A4*19 (P467S)Homo sapiensquinine0.0530.0341.558pH 7.4, 37 °CPMID 31214030Open
CYP3A4*1AHomo sapiensquinine0.0580.0163.625pH 7.4, 37 °CPMID 31214030Open
CYP3A4*2 (S222P)Homo sapiensquinine0.1720.3210.535pH 7.4, 37 °CPMID 31214030Open
CYP3A4*20 (488 frameshift)Homo sapiensquinine0.0320.2270.138pH 7.4, 37 °CPMID 31214030Open
CYP3A4*21 (Y319C)Homo sapiensquinine0.0270.3030.088pH 7.4, 37 °CPMID 31214030Open
CYP3A4*23 (R162W)Homo sapiensquinine0.0380.0291.298pH 7.4, 37 °CPMID 31214030Open
CYP3A4*24 (Q200H)Homo sapiensquinine0.0370.0430.838pH 7.4, 37 °CPMID 31214030Open
CYP3A4*28 (L22V)Homo sapiensquinine0.040.0113.628pH 7.4, 37 °CPMID 31214030Open
CYP3A4*29 (F113I)Homo sapiensquinine0.1370.01211.47pH 7.4, 37 °CPMID 31214030Open
CYP3A4*3 (M445T)Homo sapiensquinine0.0420.0510.82pH 7.4, 37 °CPMID 31214030Open
CYP3A4*31 (H324Q)Homo sapiensquinine0.0350.0182.165pH 7.4, 37 °CPMID 31214030Open
CYP3A4*32 (I335T)Homo sapiensquinine0.0670.0252.725pH 7.4, 37 °CPMID 31214030Open
CYP3A4*33 (A370S)Homo sapiensquinine0.0230.0181.27pH 7.4, 37 °CPMID 31214030Open
CYP3A4*34 (I427V)Homo sapiensquinine0.0480.0124.33pH 7.4, 37 °CPMID 31214030Open
CYP3A4*4 (I118V)Homo sapiensquinine0.0950.0941.08pH 7.4, 37 °CPMID 31214030Open
CYP3A4*5 (P218R)Homo sapiensquinine0.0480.1290.378pH 7.4, 37 °CPMID 31214030Open
CYP3A4*7 (G56D)Homo sapiensquinine0.0270.0590.443pH 7.4, 37 °CPMID 31214030Open
CYP3A4*8 (R130Q)Homo sapiensquinine0.030.3240.093pH 7.4, 37 °CPMID 31214030Open
CYP3A4*9 (V170I)Homo sapiensquinine0.040.0590.682pH 7.4, 37 °CPMID 31214030Open
cytochrome P450 3A4Homo sapiens(2,2,4,6,6-2H5)testosteroneBaculosomes (4 pmol P450 3A4); 4 pmol P450; Table I0.88——pH 7.4, 37 °CPMID 15772082Open
cytochrome P450 3A4Homo sapiens(2,2,4,6,6-2H5)testosteroneBaculosomes (4 pmol P450 3A4); 4 pmol P450; Table I0.033——pH 7.4, 37 °CPMID 15772082Open
cytochrome P450 3A4Homo sapiens(2,2,4,6,6-2H5)testosteroneBaculosomes (4 pmol P450 3A4); 4 pmol P450; Table I0.237——pH 7.4, 37 °CPMID 15772082Open
cytochrome P450 3A4Homo sapiens(2,2,4,6,6-2H5)testosteroneBaculosomes (4 pmol P450 3A4); 4 pmol P450; Table I0.227——pH 7.4, 37 °CPMID 15772082Open
cytochrome P450 3A4Homo sapiens(2,2,4,6,6-2H5)testosterone30 pmol P450; Table II0.202——pH 7.4, 37 °CPMID 15772082Open
cytochrome P450 3A4Homo sapiens(6,6-2H2)testosterone4-200 µM testosterone; 4 pmol P450; Table I0.42——pH 7.4, 37 °CPMID 15772082Open
cytochrome P450 3A4Homo sapiens(6,6-2H2)testosterone4-200 µM testosterone; 4 pmol P450; Table I0.2——pH 7.4, 37 °CPMID 15772082Open
cytochrome P450 3A4Homo sapiens(6,6-2H2)testosterone4-200 µM testosterone; 4 pmol P450; Table I0.107——pH 7.4, 37 °CPMID 15772082Open
cytochrome P450 3A4Homo sapiens(6,6-2H2)testosterone4-200 µM testosterone; 4 pmol P450; Table I0.115——pH 7.4, 37 °CPMID 15772082Open
cytochrome P450 3A4Homo sapiens(6,6-2H2)testosterone4-200 µM testosterone; 30 pmol P450; Table II0.143——pH 7.4, 37 °CPMID 15772082Open
cytochrome P450 3A4Homo sapiens(6,6-2H2)testosterone4-200 µM testosterone; Table II0.115——pH 7.4, 37 °CPMID 15772082Open
cytochrome P450 3A4Homo sapiens(6,6-2H2)testosteroneTable II0.178——pH 7.4, 37 °CPMID 15772082Open
cytochrome P450 3A4Homo sapiens7-(benzyloxy)quinoline0.05330.0143.8 calc.pH 7.4, 37 °CPMID 15772082Open
cytochrome P450 3A4Homo sapiensd2-benzyloxyquinoline0.020.02150.93 calc.pH 7.4, 37 °CPMID 15772082Open
cytochrome P450 3A4Homo sapienstestosterone4-200 µM testosterone; 4 pmol P450; Table I1.3——pH 7.4, 37 °CPMID 15772082Open
cytochrome P450 3A4Homo sapienstestosterone4-200 µM testosterone; 4 pmol P450; Table I0.23——pH 7.4, 37 °CPMID 15772082Open
cytochrome P450 3A4Homo sapienstestosterone4-200 µM testosterone; 4 pmol P450; Table I0.118——pH 7.4, 37 °CPMID 15772082Open
cytochrome P450 3A4Homo sapienstestosterone4-200 µM testosterone; 4 pmol P450; Table I0.118——pH 7.4, 37 °CPMID 15772082Open
cytochrome P450 3A4Homo sapienstestosterone4-200 µM testosterone; 30 pmol P450; Table II0.255——pH 7.4, 37 °CPMID 15772082Open
cytochrome P450 3A4Homo sapienstestosterone4-200 µM testosterone; Table II0.165——pH 7.4, 37 °CPMID 15772082Open
cytochrome P450 3A4Homo sapienstestosteroneTable II0.242——pH 7.4, 37 °CPMID 15772082Open