Values CatLog read from this paper
Enzymatic Activities of CYP3A4 Allelic Variants on Quinine 3-Hydroxylation In Vitro
PMID 31214030doi:10.3389/fphar.2019.00591Open in Browse
The paper itself is not on this site: read it at the publisher. This page lists only the values CatLog read from it.
CatLog read 28 records (84 values) from this paper: CYP3A4*10 (D174H), CYP3A4*11 (T363M), CYP3A4*12 (L373F) and 25 more from Homo sapiens.
Read from the paper by an AI model and checked against the paper by a second, separate AI run; code converted the units. Values are in CatLog's units; each record opens in Browse with the line the paper prints and the checks.
EC 1.14.14.1, EC 1.14.14.55, EC 1.14.14.56, EC 1.14.14.73
| Enzyme | Organism | Substrate | kcat (s⁻¹) | Km (mM) | kcat/Km (mM⁻¹ s⁻¹) | Conditions | Open record |
|---|---|---|---|---|---|---|---|
| CYP3A4*10 (D174H) | Homo sapiens | quinine | 0.035 | 0.041 | 0.862 | pH 7.4, 37 °C | Open record: CYP3A4*10 (D174H), quinine |
| CYP3A4*11 (T363M) | Homo sapiens | quinine | 0.242 | 0.091 | 2.665 | pH 7.4, 37 °C | Open record: CYP3A4*11 (T363M), quinine |
| CYP3A4*12 (L373F) | Homo sapiens | quinine | 0.02 | 0.216 | 0.093 | pH 7.4, 37 °C | Open record: CYP3A4*12 (L373F), quinine |
| CYP3A4*13 (P416L) | Homo sapiens | quinine | 0.013 | 0.06 | 0.21 | pH 7.4, 37 °C | Open record: CYP3A4*13 (P416L), quinine |
| CYP3A4*14 (L15P) | Homo sapiens | quinine | 0.032 | 0.038 | 0.828 | pH 7.4, 37 °C | Open record: CYP3A4*14 (L15P), quinine |
| CYP3A4*15 (R162Q) | Homo sapiens | quinine | 0.075 | 0.016 | 4.753 | pH 7.4, 37 °C | Open record: CYP3A4*15 (R162Q), quinine |
| CYP3A4*16 (T185S) | Homo sapiens | quinine | 0.027 | 0.029 | 0.958 | pH 7.4, 37 °C | Open record: CYP3A4*16 (T185S), quinine |
| CYP3A4*17 (F189S) | Homo sapiens | quinine | 0.017 | 0.328 | 0.052 | pH 7.4, 37 °C | Open record: CYP3A4*17 (F189S), quinine |
| CYP3A4*18 (L293P) | Homo sapiens | quinine | 0.028 | 0.045 | 0.638 | pH 7.4, 37 °C | Open record: CYP3A4*18 (L293P), quinine |
| CYP3A4*19 (P467S) | Homo sapiens | quinine | 0.053 | 0.034 | 1.558 | pH 7.4, 37 °C | Open record: CYP3A4*19 (P467S), quinine |
| CYP3A4*1A | Homo sapiens | quinine | 0.058 | 0.016 | 3.625 | pH 7.4, 37 °C | Open record: CYP3A4*1A, quinine |
| CYP3A4*2 (S222P) | Homo sapiens | quinine | 0.172 | 0.321 | 0.535 | pH 7.4, 37 °C | Open record: CYP3A4*2 (S222P), quinine |
| CYP3A4*20 (488 frameshift) | Homo sapiens | quinine | 0.032 | 0.227 | 0.138 | pH 7.4, 37 °C | Open record: CYP3A4*20 (488 frameshift), quinine |
| CYP3A4*21 (Y319C) | Homo sapiens | quinine | 0.027 | 0.303 | 0.088 | pH 7.4, 37 °C | Open record: CYP3A4*21 (Y319C), quinine |
| CYP3A4*23 (R162W) | Homo sapiens | quinine | 0.038 | 0.029 | 1.298 | pH 7.4, 37 °C | Open record: CYP3A4*23 (R162W), quinine |
| CYP3A4*24 (Q200H) | Homo sapiens | quinine | 0.037 | 0.043 | 0.838 | pH 7.4, 37 °C | Open record: CYP3A4*24 (Q200H), quinine |
| CYP3A4*28 (L22V) | Homo sapiens | quinine | 0.04 | 0.011 | 3.628 | pH 7.4, 37 °C | Open record: CYP3A4*28 (L22V), quinine |
| CYP3A4*29 (F113I) | Homo sapiens | quinine | 0.137 | 0.012 | 11.47 | pH 7.4, 37 °C | Open record: CYP3A4*29 (F113I), quinine |
| CYP3A4*3 (M445T) | Homo sapiens | quinine | 0.042 | 0.051 | 0.82 | pH 7.4, 37 °C | Open record: CYP3A4*3 (M445T), quinine |
| CYP3A4*31 (H324Q) | Homo sapiens | quinine | 0.035 | 0.018 | 2.165 | pH 7.4, 37 °C | Open record: CYP3A4*31 (H324Q), quinine |
| CYP3A4*32 (I335T) | Homo sapiens | quinine | 0.067 | 0.025 | 2.725 | pH 7.4, 37 °C | Open record: CYP3A4*32 (I335T), quinine |
| CYP3A4*33 (A370S) | Homo sapiens | quinine | 0.023 | 0.018 | 1.27 | pH 7.4, 37 °C | Open record: CYP3A4*33 (A370S), quinine |
| CYP3A4*34 (I427V) | Homo sapiens | quinine | 0.048 | 0.012 | 4.33 | pH 7.4, 37 °C | Open record: CYP3A4*34 (I427V), quinine |
| CYP3A4*4 (I118V) | Homo sapiens | quinine | 0.095 | 0.094 | 1.08 | pH 7.4, 37 °C | Open record: CYP3A4*4 (I118V), quinine |
| CYP3A4*5 (P218R) | Homo sapiens | quinine | 0.048 | 0.129 | 0.378 | pH 7.4, 37 °C | Open record: CYP3A4*5 (P218R), quinine |
| CYP3A4*7 (G56D) | Homo sapiens | quinine | 0.027 | 0.059 | 0.443 | pH 7.4, 37 °C | Open record: CYP3A4*7 (G56D), quinine |
| CYP3A4*8 (R130Q) | Homo sapiens | quinine | 0.03 | 0.324 | 0.093 | pH 7.4, 37 °C | Open record: CYP3A4*8 (R130Q), quinine |
| CYP3A4*9 (V170I) | Homo sapiens | quinine | 0.04 | 0.059 | 0.682 | pH 7.4, 37 °C | Open record: CYP3A4*9 (V170I), quinine |