CatLogenzyme kinetics catalog

EC 4.2.1.152: hydroperoxy icosatetraenoate dehydratase

LyasesOpen in Browse

CatLog read 92 records for EC 4.2.1.152 from 8 papers, for 3 organisms. Names in these papers: cytochrome P450 1A2, CYP1A1, CYP1A2, CYP1B1 Arg48,Ala119,Leu432,Asn453 and 21 more.

Read from the paper by an AI model and checked against the paper by a second, separate AI run; code converted the units.

CatLog also holds 19 records for EC 4.2.1.152 that are not yet re-read: from its earlier version, built from the enzyme databases and partly checked against the papers. All records for EC 4.2.1.152 in Browse.

Papers

PaperOrganismsRecords
Functional characterization of four allelic variants of human cytochrome P450 1A2Homo sapiens24
Single amino acid mutations, but not common polymorphisms, decrease the activity of CYP1B1 against (-)benzo[a]pyrene-7R-trans-7,8-dihydrodiolHomo sapiens22
Catalytic properties of polymorphic human cytochrome P450 1B1 variantsHomo sapiens20
Metabolism of retinoids and arachidonic acid by human and mouse cytochrome P450 1b1Homo sapiens, Mus musculus10
Oxidation of 5-methoxy-N,N-diisopropyltryptamine in rat liver microsomes and recombinant cytochrome P450 enzymesHomo sapiens, Rattus norvegicus7
The participation of human hepatic P450 isoforms, flavin-containing monooxygenases and aldehyde oxidase in the biotransformation of the insecticide fenthionHomo sapiens6
Functional characterization of single nucleotide polymorphisms with amino acid substitution in CYP1A2, CYP2A6, and CYP2B6 found in the Japanese populationHomo sapiens2
Key residues controlling phenacetin metabolism by human cytochrome P450 2A enzymesHomo sapiens1

Records

EnzymeOrganismSubstratekcat (s⁻¹)Km (mM)kcat/Km (mM⁻¹ s⁻¹)ConditionsPaper
CYP1A1Homo sapiens5-methoxy-N,N-diisopropyltryptamine0.00550.002672.2pH 7.4, 37 °CPMID 17980859Open
CYP1A1Homo sapiens5-methoxy-N,N-diisopropyltryptamine0.01720.004244.2pH 7.4, 37 °CPMID 17980859Open
CYP1A1Homo sapiens5-methoxy-N,N-diisopropyltryptamine0.1780.0025770.2pH 7.4, 37 °CPMID 17980859Open
CYP1A1Homo sapiensarachidonic acid0.19330.03415.67pH 7.5, 37 °CPMID 15258110Open
CYP1A1Homo sapiensfenthionFEN 0.5-100 µM added in 12 µL methanol; cosubstrate NADPH—0.008—pH 7.4, 37 °CPMID 18845175Open
CYP1A1Homo sapiensfenthion2 mM glucose-6-phosphate; 2 mM MgCl2; 2-4 U/ml G6PDH0.115—15pH 7.4, 37 °CPMID 18845175Open
CYP1A1Rattus norvegicus5-methoxy-N,N-diisopropyltryptamine0.03370.01013.3pH 7.4, 37 °CPMID 17980859Open
CYP1A1Rattus norvegicus5-methoxy-N,N-diisopropyltryptamine0.0070.007981pH 7.4, 37 °CPMID 17980859Open
CYP1A1Rattus norvegicus5-methoxy-N,N-diisopropyltryptamine0.4530.0096547pH 7.4, 37 °CPMID 17980859Open
CYP1A2Homo sapiens7-ethoxyresorufin—9.23 × 10⁻⁴—pH 7.4PMID 15681899Open
CYP1A2Homo sapiensarachidonic acid0.12330.09521.295pH 7.5, 37 °CPMID 15258110Open
CYP1A2Homo sapiensfenthionFEN 0.5-100 µM added in 12 µL methanol; cosubstrate NADPH—0.0016—pH 7.4, 37 °CPMID 18845175Open
CYP1A2Homo sapiensfenthionFEN 0.5-100 µM added in 12 µL methanol; cosubstrate NADPH—0.0022—pH 7.4, 37 °CPMID 18845175Open
CYP1A2Homo sapiensfenthion2 mM glucose-6-phosphate; 2 mM MgCl2; 2-4 U/ml G6PDH0.063—32pH 7.4, 37 °CPMID 18845175Open
CYP1A2Homo sapiensfenthion2 mM glucose-6-phosphate; 2 mM MgCl2; 2-4 U/ml G6PDH0.065—30pH 7.4, 37 °CPMID 18845175Open
CYP1A2Homo sapiensN-(4-ethoxyphenyl)acetamide0.16130.02736pH 7.4, 37 °CPMID 18779312Open
CYP1A2variant Q478HHomo sapiens7-ethoxyresorufin—8.11 × 10⁻⁴—pH 7.4PMID 15681899Open
CYP1A2Rattus norvegicus5-methoxy-N,N-diisopropyltryptamine0.4270.05368.2pH 7.4, 37 °CPMID 17980859Open
CYP1B1Homo sapiens7,12-dimethylbenz(a)anthracene0.04770.21280.223pH 7.4, 37 °CPMID 15258110Open
CYP1B1Homo sapiensall-trans-retinal0.01280.00851.513pH 7.4, 37 °CPMID 15258110Open
CYP1B1Homo sapiensall-trans-retinol0.00250.01850.138pH 7.4, 37 °CPMID 15258110Open
CYP1B1Homo sapiensarachidonic acid0.0080.02980.275pH 7.5, 37 °CPMID 15258110Open
Cyp1b1Mus musculus7,12-dimethylbenz(a)anthracene0.1380.13890.993pH 7.4, 37 °CPMID 15258110Open
Cyp1b1Mus musculusall-trans-retinal0.00870.15390.057pH 7.4, 37 °CPMID 15258110Open
Cyp1b1Mus musculusall-trans-retinol0.0040.39220.01pH 7.4, 37 °CPMID 15258110Open
Cyp1b1Mus musculusarachidonic acid0.00220.50.005pH 7.5, 37 °CPMID 15258110Open
CYP1B1 Arg48,Ala119,Leu432,Asn453Homo sapiens17beta-estradiolproduct measured: 4-hydroxyestradiol0.01520.00513.0 calc.pH 7.4PMID 10426814Open
CYP1B1 Arg48,Ala119,Leu432,Asn453Homo sapiens17beta-estradiolproduct measured: 2-hydroxyestradiol0.0070.00691.0 calc.pH 7.4PMID 10426814Open
CYP1B1 Arg48,Ala119,Leu432,Asn453Homo sapiensprogesterone6β-hydroxyprogesterone0.010.0250.40 calc.PMID 10426814Open
CYP1B1 Arg48,Ala119,Leu432,Asn453Homo sapiensprogesterone16α-hydroxyprogesterone0.0380.0231.7 calc.PMID 10426814Open
CYP1B1 Arg48,Ala119,Leu432,Asn453Homo sapienstestosterone0.0370.0172.2 calc.PMID 10426814Open
CYP1B1 Arg48,Ala119,Val432,Asn453Homo sapiens17beta-estradiolproduct measured: 4-hydroxyestradiol0.02420.00534.6 calc.pH 7.4PMID 10426814Open
CYP1B1 Arg48,Ala119,Val432,Asn453Homo sapiens17beta-estradiolproduct measured: 2-hydroxyestradiol0.00770.00571.3 calc.pH 7.4PMID 10426814Open
CYP1B1 Arg48,Ala119,Val432,Asn453Homo sapiensprogesterone6β-hydroxyprogesterone0.0570.1670.34 calc.PMID 10426814Open
CYP1B1 Arg48,Ala119,Val432,Asn453Homo sapiensprogesterone16α-hydroxyprogesterone0.1380.1540.900 calc.PMID 10426814Open
CYP1B1 Arg48,Ala119,Val432,Asn453Homo sapienstestosterone0.0180.0480.38 calc.PMID 10426814Open
CYP1B1 Arg48,Ser119,Leu432,Asn453Homo sapiens17beta-estradiolproduct measured: 4-hydroxyestradiol0.01920.00523.7 calc.pH 7.4PMID 10426814Open
CYP1B1 Arg48,Ser119,Leu432,Asn453Homo sapiens17beta-estradiolproduct measured: 2-hydroxyestradiol0.01020.00841.2 calc.pH 7.4PMID 10426814Open
CYP1B1 Arg48,Ser119,Leu432,Asn453Homo sapiensprogesterone6β-hydroxyprogesterone0.0230.0740.32 calc.PMID 10426814Open
CYP1B1 Arg48,Ser119,Leu432,Asn453Homo sapiensprogesterone16α-hydroxyprogesterone0.0680.0461.5 calc.PMID 10426814Open
CYP1B1 Arg48,Ser119,Leu432,Asn453Homo sapienstestosterone0.0420.0261.6 calc.PMID 10426814Open
CYP1B1 Arg48,Ser119,Val432,Asn453Homo sapiens17beta-estradiolproduct measured: 4-hydroxyestradiol0.01830.00257.3 calc.pH 7.4PMID 10426814Open
CYP1B1 Arg48,Ser119,Val432,Asn453Homo sapiens17beta-estradiolproduct measured: 2-hydroxyestradiol0.00559 × 10⁻⁴6.1 calc.pH 7.4PMID 10426814Open
CYP1B1 Arg48,Ser119,Val432,Asn453Homo sapiensprogesterone6β-hydroxyprogesterone0.040.1090.37 calc.PMID 10426814Open
CYP1B1 Arg48,Ser119,Val432,Asn453Homo sapiensprogesterone16α-hydroxyprogesterone0.090.0751.2 calc.PMID 10426814Open
CYP1B1 Arg48,Ser119,Val432,Asn453Homo sapienstestosterone0.0250.0540.46 calc.PMID 10426814Open
CYP1B1 GALNHomo sapiens(-)-benzo[a]pyrene-7R-trans-7,8-dihydrodiol0.01280.001299.8pH 7.5, 37 °CPMID 12807732Open
CYP1B1 GALSHomo sapiens(-)-benzo[a]pyrene-7R-trans-7,8-dihydrodiol0.00930.001327pH 7.5, 37 °CPMID 12807732Open
CYP1B1 GAVNHomo sapiens(-)-benzo[a]pyrene-7R-trans-7,8-dihydrodiol0.01138.6 × 10⁻⁴13.2pH 7.5, 37 °CPMID 12807732Open
CYP1B1 GAVSHomo sapiens(-)-benzo[a]pyrene-7R-trans-7,8-dihydrodiol0.00880.001257pH 7.5, 37 °CPMID 12807732Open
CYP1B1 GSLNHomo sapiens(-)-benzo[a]pyrene-7R-trans-7,8-dihydrodiol0.01070.001716.2pH 7.5, 37 °CPMID 12807732Open
CYP1B1 GSLSHomo sapiens(-)-benzo[a]pyrene-7R-trans-7,8-dihydrodiol0.0140.002086.7pH 7.5, 37 °CPMID 12807732Open
CYP1B1 GSVNHomo sapiens(-)-benzo[a]pyrene-7R-trans-7,8-dihydrodiolmicrosomes pooled from at least two preparations0.0120.00294.3pH 7.5, 37 °CPMID 12807732Open
CYP1B1 GSVNHomo sapiens(-)-benzo[a]pyrene-7R-trans-7,8-dihydrodiol0.01050.002794pH 7.5, 37 °CPMID 12807732Open
CYP1B1 GSVSHomo sapiens(-)-benzo[a]pyrene-7R-trans-7,8-dihydrodiol0.01670.002566.5pH 7.5, 37 °CPMID 12807732Open
CYP1B1 RALNHomo sapiens(-)-benzo[a]pyrene-7R-trans-7,8-dihydrodiolmicrosomes pooled from at least two preparations0.0170.001849.2pH 7.5, 37 °CPMID 12807732Open
CYP1B1 RALNHomo sapiens(-)-benzo[a]pyrene-7R-trans-7,8-dihydrodiol0.01270.001797pH 7.5, 37 °CPMID 12807732Open
CYP1B1 RALSHomo sapiens(-)-benzo[a]pyrene-7R-trans-7,8-dihydrodiolmicrosomes pooled from at least two preparations0.00737.6 × 10⁻⁴9.7pH 7.5, 37 °CPMID 12807732Open
CYP1B1 RALSHomo sapiens(-)-benzo[a]pyrene-7R-trans-7,8-dihydrodiol0.0080.001326.7pH 7.5, 37 °CPMID 12807732Open
CYP1B1 RAVNHomo sapiens(-)-benzo[a]pyrene-7R-trans-7,8-dihydrodiolmicrosomes pooled from at least two preparations0.0190.004674pH 7.5, 37 °CPMID 12807732Open
CYP1B1 RAVNHomo sapiens(-)-benzo[a]pyrene-7R-trans-7,8-dihydrodiol0.01420.002795.5pH 7.5, 37 °CPMID 12807732Open
CYP1B1 RAVSHomo sapiens(-)-benzo[a]pyrene-7R-trans-7,8-dihydrodiolmicrosomes pooled from at least two preparations0.02250.0010820.8pH 7.5, 37 °CPMID 12807732Open
CYP1B1 RAVSHomo sapiens(-)-benzo[a]pyrene-7R-trans-7,8-dihydrodiol0.01470.0013811.3pH 7.5, 37 °CPMID 12807732Open
CYP1B1 RSLNHomo sapiens(-)-benzo[a]pyrene-7R-trans-7,8-dihydrodiol0.01150.001736.7pH 7.5, 37 °CPMID 12807732Open
CYP1B1 RSLSHomo sapiens(-)-benzo[a]pyrene-7R-trans-7,8-dihydrodiol0.0130.001946.7pH 7.5, 37 °CPMID 12807732Open
CYP1B1 RSVNHomo sapiens(-)-benzo[a]pyrene-7R-trans-7,8-dihydrodiolmicrosomes pooled from at least two preparations0.01577.6 × 10⁻⁴20.5pH 7.5, 37 °CPMID 12807732Open
CYP1B1 RSVNHomo sapiens(-)-benzo[a]pyrene-7R-trans-7,8-dihydrodiol0.0120.001718.3pH 7.5, 37 °CPMID 12807732Open
CYP1B1 RSVSHomo sapiens(-)-benzo[a]pyrene-7R-trans-7,8-dihydrodiol0.0110.0010410.7pH 7.5, 37 °CPMID 12807732Open
cytochrome P450 1A2Homo sapiens2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine0.180.0712.6 calc.pH 7.4, 37 °CPMID 14725854Open
cytochrome P450 1A2Homo sapiens2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline0.090.0273.3 calc.pH 7.4, 37 °CPMID 14725854Open
cytochrome P450 1A2Homo sapiens2-amino-3-methylimidazo[4,5-f]quinoline0.0970.0214.6 calc.pH 7.4, 37 °CPMID 14725854Open
cytochrome P450 1A2Homo sapiens2-amino-6-methyldipyrido[1,2-a :3^′,2^′-d]imidazole0.0830.00421 calc.pH 7.4, 37 °CPMID 14725854Open
cytochrome P450 1A2Homo sapiensMeIQ0.050.0261.9 calc.pH 7.4, 37 °CPMID 14725854Open
cytochrome P450 1A2Homo sapiensphenacetin0.0250.0251.0 calc.pH 7.4PMID 14725854Open
cytochrome P450 1A2variant C406YHomo sapiens2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine0.430.0666.6 calc.pH 7.4, 37 °CPMID 14725854Open
cytochrome P450 1A2variant C406YHomo sapiens2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline0.1270.026.3 calc.pH 7.4, 37 °CPMID 14725854Open
cytochrome P450 1A2variant C406YHomo sapiens2-amino-3-methylimidazo[4,5-f]quinoline0.1380.0226.3 calc.pH 7.4, 37 °CPMID 14725854Open
cytochrome P450 1A2variant C406YHomo sapiens2-amino-6-methyldipyrido[1,2-a :3^′,2^′-d]imidazole0.220.01120 calc.pH 7.4, 37 °CPMID 14725854Open
cytochrome P450 1A2variant C406YHomo sapiensMeIQ0.0750.0145.4 calc.pH 7.4, 37 °CPMID 14725854Open
cytochrome P450 1A2variant C406YHomo sapiensphenacetin0.020.0620.32 calc.pH 7.4PMID 14725854Open
cytochrome P450 1A2variant D348NHomo sapiens2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine0.480.0627.8 calc.pH 7.4, 37 °CPMID 14725854Open
cytochrome P450 1A2variant D348NHomo sapiens2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline0.150.0334.5 calc.pH 7.4, 37 °CPMID 14725854Open
cytochrome P450 1A2variant D348NHomo sapiens2-amino-3-methylimidazo[4,5-f]quinoline0.1930.0277.2 calc.pH 7.4, 37 °CPMID 14725854Open
cytochrome P450 1A2variant D348NHomo sapiens2-amino-6-methyldipyrido[1,2-a :3^′,2^′-d]imidazole0.220.01317 calc.pH 7.4, 37 °CPMID 14725854Open
cytochrome P450 1A2variant D348NHomo sapiensMeIQ0.0680.0174.0 calc.pH 7.4, 37 °CPMID 14725854Open
cytochrome P450 1A2variant D348NHomo sapiensphenacetin0.0150.0180.83 calc.pH 7.4PMID 14725854Open
cytochrome P450 1A2variant I386FHomo sapiens2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine0.330.3410.98 calc.pH 7.4, 37 °CPMID 14725854Open
cytochrome P450 1A2variant I386FHomo sapiens2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline0.30.0466.5 calc.pH 7.4, 37 °CPMID 14725854Open
cytochrome P450 1A2variant I386FHomo sapiens2-amino-3-methylimidazo[4,5-f]quinoline0.0480.0371.3 calc.pH 7.4, 37 °CPMID 14725854Open
cytochrome P450 1A2variant I386FHomo sapiens2-amino-6-methyldipyrido[1,2-a :3^′,2^′-d]imidazole0.230.01615 calc.pH 7.4, 37 °CPMID 14725854Open
cytochrome P450 1A2variant I386FHomo sapiensMeIQ0.0130.00453.0 calc.pH 7.4, 37 °CPMID 14725854Open
cytochrome P450 1A2variant I386FHomo sapiensphenacetin0.0430.320.14 calc.pH 7.4PMID 14725854Open