CatLogenzyme kinetics catalog

Values CatLog read from this paper

Oxidation of 5-methoxy-N,N-diisopropyltryptamine in rat liver microsomes and recombinant cytochrome P450 enzymes

PMID 17980859doi:10.1016/j.bcp.2007.09.019Open in Browse

The paper itself is not on this site: read it at the publisher. This page lists only the values CatLog read from it.

CatLog read 24 records (52 values) from this paper: CYP1A1, cytochrome P450 (rat liver microsomal 5-MeO-DIPT O-demethylase), cytochrome P450 (rat liver microsomal 5-MeO-DIPT N-deisopropylase) and 7 more from Rattus norvegicus, Homo sapiens.

Read from the paper by an AI model and checked against the paper by a second, separate AI run; code converted the units. Values are in CatLog's units; each record opens in Browse with the line the paper prints and the checks.

EC 1.14.14.1, EC 4.2.1.152

EnzymeOrganismSubstratekcat (s⁻¹)Km (mM)kcat/Km (mM⁻¹ s⁻¹)Conditions
CYP1A1Homo sapiens5-methoxy-N,N-diisopropyltryptamine0.00550.002672.2pH 7.4, 37 °COpen
CYP1A1Homo sapiens5-methoxy-N,N-diisopropyltryptamine0.01720.004244.2pH 7.4, 37 °COpen
CYP1A1Homo sapiens5-methoxy-N,N-diisopropyltryptamine0.1780.0025770.2pH 7.4, 37 °COpen
CYP1A1Rattus norvegicus5-methoxy-N,N-diisopropyltryptamine0.03370.01013.3pH 7.4, 37 °COpen
CYP1A1Rattus norvegicus5-methoxy-N,N-diisopropyltryptamine0.0070.007981pH 7.4, 37 °COpen
CYP1A1Rattus norvegicus5-methoxy-N,N-diisopropyltryptamine0.4530.0096547pH 7.4, 37 °COpen
CYP1A2Rattus norvegicus5-methoxy-N,N-diisopropyltryptamine0.4270.05368.2pH 7.4, 37 °COpen
CYP2C11Rattus norvegicus5-methoxy-N,N-diisopropyltryptamine2.550.455.8pH 7.4, 37 °COpen
CYP2C6Rattus norvegicus5-methoxy-N,N-diisopropyltryptamine5-OH-DIPT formation (aromatic ring O-demethylation)0.11380.1241pH 7.4, 37 °COpen
CYP2C6Rattus norvegicus5-methoxy-N,N-diisopropyltryptamine5-MeO-IPT formation (side-chain N-deisopropylation)0.3470.1612.3pH 7.4, 37 °COpen
CYP2D1Rattus norvegicus5-methoxy-N,N-diisopropyltryptamine5-OH-DIPT formation (aromatic ring O-demethylation)0.0030.06880.05pH 7.4, 37 °COpen
CYP2D1Rattus norvegicus5-methoxy-N,N-diisopropyltryptamine5-MeO-IPT formation (side-chain N-deisopropylation)0.01270.05960.22pH 7.4, 37 °COpen
CYP2D2Rattus norvegicus5-methoxy-N,N-diisopropyltryptamine0.1689 × 10⁻⁵1.87 × 10³pH 7.4, 37 °COpen
CYP3A2Rattus norvegicus5-methoxy-N,N-diisopropyltryptamine0.2250.420.5pH 7.4, 37 °COpen
cytochrome P450 (rat liver microsomal 5-MeO-DIPT 6-hydroxylase)Rattus norvegicus5-methoxy-N,N-diisopropyltryptamine—0.0146—pH 7.4, 37 °COpen
cytochrome P450 (rat liver microsomal 5-MeO-DIPT N-deisopropylase)Rattus norvegicus5-methoxy-N,N-diisopropyltryptamineuntreated male Wistar rats—0.445—pH 7.4, 37 °COpen
cytochrome P450 (rat liver microsomal 5-MeO-DIPT N-deisopropylase)Rattus norvegicus5-methoxy-N,N-diisopropyltryptamine—0.288—pH 7.4, 37 °COpen
cytochrome P450 (rat liver microsomal 5-MeO-DIPT N-deisopropylase)Rattus norvegicus5-methoxy-N,N-diisopropyltryptamineuntreated female Wistar rats—0.403—pH 7.4, 37 °COpen
cytochrome P450 (rat liver microsomal 5-MeO-DIPT O-demethylase)Rattus norvegicus5-methoxy-N,N-diisopropyltryptamineuntreated male Wistar rats—1.3 × 10⁻⁴—pH 7.4, 37 °COpen
cytochrome P450 (rat liver microsomal 5-MeO-DIPT O-demethylase)Rattus norvegicus5-methoxy-N,N-diisopropyltryptamineuntreated male Wistar rats—0.273—pH 7.4, 37 °COpen
cytochrome P450 (rat liver microsomal 5-MeO-DIPT O-demethylase)Rattus norvegicus5-methoxy-N,N-diisopropyltryptamine—1.3 × 10⁻⁴—pH 7.4, 37 °COpen
cytochrome P450 (rat liver microsomal 5-MeO-DIPT O-demethylase)Rattus norvegicus5-methoxy-N,N-diisopropyltryptamine—0.0708—pH 7.4, 37 °COpen
cytochrome P450 (rat liver microsomal 5-MeO-DIPT O-demethylase)Rattus norvegicus5-methoxy-N,N-diisopropyltryptamineuntreated female Wistar rats—2.1 × 10⁻⁴—pH 7.4, 37 °COpen
cytochrome P450 (rat liver microsomal 5-MeO-DIPT O-demethylase)Rattus norvegicus5-methoxy-N,N-diisopropyltryptamineuntreated female Wistar rats—0.23—pH 7.4, 37 °COpen