Values CatLog read from this paper
Single amino acid mutations, but not common polymorphisms, decrease the activity of CYP1B1 against (-)benzo[a]pyrene-7R-trans-7,8-dihydrodiol
PMID 12807732doi:10.1093/carcin/bgg088Open in Browse
The paper itself is not on this site: read it at the publisher. This page lists only the values CatLog read from it.
CatLog read 22 records (66 values) from this paper: CYP1B1 GSVN, CYP1B1 RALN, CYP1B1 RALS and 13 more from Homo sapiens.
Read from the paper by an AI model and checked against the paper by a second, separate AI run; code converted the units. Values are in CatLog's units; each record opens in Browse with the line the paper prints and the checks.
| Enzyme | Organism | Substrate | kcat (s⁻¹) | Km (mM) | kcat/Km (mM⁻¹ s⁻¹) | Conditions | Open record |
|---|---|---|---|---|---|---|---|
| CYP1B1 GALN | Homo sapiens | (-)-benzo[a]pyrene-7R-trans-7,8-dihydrodiol | 0.0128 | 0.00129 | 9.8 | pH 7.5, 37 °C | Open record: CYP1B1 GALN, (-)-benzo[a]pyrene-7R-trans-7,8-dihydrodiol |
| CYP1B1 GALS | Homo sapiens | (-)-benzo[a]pyrene-7R-trans-7,8-dihydrodiol | 0.0093 | 0.00132 | 7 | pH 7.5, 37 °C | Open record: CYP1B1 GALS, (-)-benzo[a]pyrene-7R-trans-7,8-dihydrodiol |
| CYP1B1 GAVN | Homo sapiens | (-)-benzo[a]pyrene-7R-trans-7,8-dihydrodiol | 0.0113 | 8.6 × 10⁻⁴ | 13.2 | pH 7.5, 37 °C | Open record: CYP1B1 GAVN, (-)-benzo[a]pyrene-7R-trans-7,8-dihydrodiol |
| CYP1B1 GAVS | Homo sapiens | (-)-benzo[a]pyrene-7R-trans-7,8-dihydrodiol | 0.0088 | 0.00125 | 7 | pH 7.5, 37 °C | Open record: CYP1B1 GAVS, (-)-benzo[a]pyrene-7R-trans-7,8-dihydrodiol |
| CYP1B1 GSLN | Homo sapiens | (-)-benzo[a]pyrene-7R-trans-7,8-dihydrodiol | 0.0107 | 0.00171 | 6.2 | pH 7.5, 37 °C | Open record: CYP1B1 GSLN, (-)-benzo[a]pyrene-7R-trans-7,8-dihydrodiol |
| CYP1B1 GSLS | Homo sapiens | (-)-benzo[a]pyrene-7R-trans-7,8-dihydrodiol | 0.014 | 0.00208 | 6.7 | pH 7.5, 37 °C | Open record: CYP1B1 GSLS, (-)-benzo[a]pyrene-7R-trans-7,8-dihydrodiol |
| CYP1B1 GSVN | Homo sapiens | (-)-benzo[a]pyrene-7R-trans-7,8-dihydrodiolmicrosomes pooled from at least two preparations | 0.012 | 0.0029 | 4.3 | pH 7.5, 37 °C | Open record: CYP1B1 GSVN, (-)-benzo[a]pyrene-7R-trans-7,8-dihydrodiol |
| CYP1B1 GSVN | Homo sapiens | (-)-benzo[a]pyrene-7R-trans-7,8-dihydrodiol | 0.0105 | 0.00279 | 4 | pH 7.5, 37 °C | Open record: CYP1B1 GSVN, (-)-benzo[a]pyrene-7R-trans-7,8-dihydrodiol |
| CYP1B1 GSVS | Homo sapiens | (-)-benzo[a]pyrene-7R-trans-7,8-dihydrodiol | 0.0167 | 0.00256 | 6.5 | pH 7.5, 37 °C | Open record: CYP1B1 GSVS, (-)-benzo[a]pyrene-7R-trans-7,8-dihydrodiol |
| CYP1B1 RALN | Homo sapiens | (-)-benzo[a]pyrene-7R-trans-7,8-dihydrodiolmicrosomes pooled from at least two preparations | 0.017 | 0.00184 | 9.2 | pH 7.5, 37 °C | Open record: CYP1B1 RALN, (-)-benzo[a]pyrene-7R-trans-7,8-dihydrodiol |
| CYP1B1 RALN | Homo sapiens | (-)-benzo[a]pyrene-7R-trans-7,8-dihydrodiol | 0.0127 | 0.00179 | 7 | pH 7.5, 37 °C | Open record: CYP1B1 RALN, (-)-benzo[a]pyrene-7R-trans-7,8-dihydrodiol |
| CYP1B1 RALS | Homo sapiens | (-)-benzo[a]pyrene-7R-trans-7,8-dihydrodiolmicrosomes pooled from at least two preparations | 0.0073 | 7.6 × 10⁻⁴ | 9.7 | pH 7.5, 37 °C | Open record: CYP1B1 RALS, (-)-benzo[a]pyrene-7R-trans-7,8-dihydrodiol |
| CYP1B1 RALS | Homo sapiens | (-)-benzo[a]pyrene-7R-trans-7,8-dihydrodiol | 0.008 | 0.00132 | 6.7 | pH 7.5, 37 °C | Open record: CYP1B1 RALS, (-)-benzo[a]pyrene-7R-trans-7,8-dihydrodiol |
| CYP1B1 RAVN | Homo sapiens | (-)-benzo[a]pyrene-7R-trans-7,8-dihydrodiolmicrosomes pooled from at least two preparations | 0.019 | 0.00467 | 4 | pH 7.5, 37 °C | Open record: CYP1B1 RAVN, (-)-benzo[a]pyrene-7R-trans-7,8-dihydrodiol |
| CYP1B1 RAVN | Homo sapiens | (-)-benzo[a]pyrene-7R-trans-7,8-dihydrodiol | 0.0142 | 0.00279 | 5.5 | pH 7.5, 37 °C | Open record: CYP1B1 RAVN, (-)-benzo[a]pyrene-7R-trans-7,8-dihydrodiol |
| CYP1B1 RAVS | Homo sapiens | (-)-benzo[a]pyrene-7R-trans-7,8-dihydrodiolmicrosomes pooled from at least two preparations | 0.0225 | 0.00108 | 20.8 | pH 7.5, 37 °C | Open record: CYP1B1 RAVS, (-)-benzo[a]pyrene-7R-trans-7,8-dihydrodiol |
| CYP1B1 RAVS | Homo sapiens | (-)-benzo[a]pyrene-7R-trans-7,8-dihydrodiol | 0.0147 | 0.00138 | 11.3 | pH 7.5, 37 °C | Open record: CYP1B1 RAVS, (-)-benzo[a]pyrene-7R-trans-7,8-dihydrodiol |
| CYP1B1 RSLN | Homo sapiens | (-)-benzo[a]pyrene-7R-trans-7,8-dihydrodiol | 0.0115 | 0.00173 | 6.7 | pH 7.5, 37 °C | Open record: CYP1B1 RSLN, (-)-benzo[a]pyrene-7R-trans-7,8-dihydrodiol |
| CYP1B1 RSLS | Homo sapiens | (-)-benzo[a]pyrene-7R-trans-7,8-dihydrodiol | 0.013 | 0.00194 | 6.7 | pH 7.5, 37 °C | Open record: CYP1B1 RSLS, (-)-benzo[a]pyrene-7R-trans-7,8-dihydrodiol |
| CYP1B1 RSVN | Homo sapiens | (-)-benzo[a]pyrene-7R-trans-7,8-dihydrodiolmicrosomes pooled from at least two preparations | 0.0157 | 7.6 × 10⁻⁴ | 20.5 | pH 7.5, 37 °C | Open record: CYP1B1 RSVN, (-)-benzo[a]pyrene-7R-trans-7,8-dihydrodiol |
| CYP1B1 RSVN | Homo sapiens | (-)-benzo[a]pyrene-7R-trans-7,8-dihydrodiol | 0.012 | 0.00171 | 8.3 | pH 7.5, 37 °C | Open record: CYP1B1 RSVN, (-)-benzo[a]pyrene-7R-trans-7,8-dihydrodiol |
| CYP1B1 RSVS | Homo sapiens | (-)-benzo[a]pyrene-7R-trans-7,8-dihydrodiol | 0.011 | 0.00104 | 10.7 | pH 7.5, 37 °C | Open record: CYP1B1 RSVS, (-)-benzo[a]pyrene-7R-trans-7,8-dihydrodiol |