EC 1.14.13.148: trimethylamine monooxygenase
OxidoreductasesOpen in Browse
CatLog read 71 records for EC 1.14.13.148 from 5 papers, for 3 organisms. Names in these papers: flavin-containing monooxygenase 3 (FMO3), trimethylamine monooxygenase (Tmm7211), flavin-containing monooxygenase 3 (hFMO3), FMO1 and 5 more.
Read from the paper by an AI model and checked against the paper by a second, separate AI run; code converted the units.
CatLog also holds 52 records for EC 1.14.13.148 that are not yet re-read: from its earlier version, built from the enzyme databases and partly checked against the papers. All records for EC 1.14.13.148 in Browse.
Papers
| Paper | Organisms | Records |
|---|---|---|
| N- and S-oxygenation activity of truncated human flavin-containing monooxygenase 3 and its common polymorphic variants | Homo sapiens | 40 |
| Structural and Mechanistic Insights Into Dimethylsulfoxide Formation Through Dimethylsulfide Oxidation | Pelagibacter sp. HTCC7211 | 13 |
| Flavin-Containing Monooxygenase 3 Polymorphic Variants Significantly Affect Clearance of Tamoxifen and Clomiphene | Homo sapiens | 12 |
| Metabolism of the anti-tuberculosis drug ethionamide by mouse and human FMO1, FMO2 and FMO3 and mouse and human lung microsomes | Homo sapiens, Mus musculus | 4 |
| The participation of human hepatic P450 isoforms, flavin-containing monooxygenases and aldehyde oxidase in the biotransformation of the insecticide fenthion | Homo sapiens | 2 |
Records
| Enzyme | Organism | Substrate | kcat (s⁻¹) | Km (mM) | kcat/Km (mM⁻¹ s⁻¹) | Conditions | Paper | Open record |
|---|---|---|---|---|---|---|---|---|
| flavin-containing monooxygenase 3 (FMO3) | Homo sapiens | benzydamineTable 2 | 0.052 | 0.052 | 1.0 calc. | pH 7.4, 37 °C | PMID 33152328 | Open record: flavin-containing monooxygenase 3 (FMO3), benzydamine |
| flavin-containing monooxygenase 3 (FMO3) | Homo sapiens | benzydamineC-terminally truncated FMO3 (tr-FMO3); Table 2 | 0.0752 | 0.053 | 1.4 calc. | pH 7.4, 37 °C | PMID 33152328 | Open record: flavin-containing monooxygenase 3 (FMO3), benzydamine |
| flavin-containing monooxygenase 3 (FMO3) | Homo sapiens | benzydamineTable 5 | — | — | 1 | pH 7.4, 37 °C | PMID 33152328 | Open record: flavin-containing monooxygenase 3 (FMO3), benzydamine |
| flavin-containing monooxygenase 3 (FMO3) | Homo sapiens | benzydamineC-terminally truncated FMO3 (tr-FMO3); Table 5 | — | — | 1.5 | pH 7.4, 37 °C | PMID 33152328 | Open record: flavin-containing monooxygenase 3 (FMO3), benzydamine |
| flavin-containing monooxygenase 3 (FMO3) | Homo sapiens | sulindac sulfideTable 4 | 0.0093 | 0.0156 | 0.60 calc. | pH 7.4, 37 °C | PMID 33152328 | Open record: flavin-containing monooxygenase 3 (FMO3), sulindac sulfide |
| flavin-containing monooxygenase 3 (FMO3) | Homo sapiens | sulindac sulfideC-terminally truncated FMO3 (tr-FMO3); Table 4 | 0.0267 | 0.0127 | 2.10 calc. | pH 7.4, 37 °C | PMID 33152328 | Open record: flavin-containing monooxygenase 3 (FMO3), sulindac sulfide |
| flavin-containing monooxygenase 3 (FMO3) | Homo sapiens | sulindac sulfideTable 5 | — | — | 0.67 | pH 7.4, 37 °C | PMID 33152328 | Open record: flavin-containing monooxygenase 3 (FMO3), sulindac sulfide |
| flavin-containing monooxygenase 3 (FMO3) | Homo sapiens | sulindac sulfideC-terminally truncated FMO3 (tr-FMO3); Table 5 | — | — | 2.2 | pH 7.4, 37 °C | PMID 33152328 | Open record: flavin-containing monooxygenase 3 (FMO3), sulindac sulfide |
| flavin-containing monooxygenase 3 (FMO3) | Homo sapiens | tamoxifenTable 3 | 0.0272 | 0.0056 | 4.8 calc. | pH 7.4, 37 °C | PMID 33152328 | Open record: flavin-containing monooxygenase 3 (FMO3), tamoxifen |
| flavin-containing monooxygenase 3 (FMO3) | Homo sapiens | tamoxifenTable 5 | — | — | 4.8 | pH 7.4, 37 °C | PMID 33152328 | Open record: flavin-containing monooxygenase 3 (FMO3), tamoxifen |
| flavin-containing monooxygenase 3 (FMO3)variant E158K | Homo sapiens | benzydamineTable 2 | 0.0182 | 0.0593 | 0.306 calc. | pH 7.4, 37 °C | PMID 33152328 | Open record: flavin-containing monooxygenase 3 (FMO3) variant E158K, benzydamine |
| flavin-containing monooxygenase 3 (FMO3)variant E158K | Homo sapiens | benzydamineC-terminally truncated FMO3 (tr-FMO3); Table 2 | 0.0292 | 0.0659 | 0.443 calc. | pH 7.4, 37 °C | PMID 33152328 | Open record: flavin-containing monooxygenase 3 (FMO3) variant E158K, benzydamine |
| flavin-containing monooxygenase 3 (FMO3)variant E158K | Homo sapiens | benzydamineTable 5 | — | — | 0.33 | pH 7.4, 37 °C | PMID 33152328 | Open record: flavin-containing monooxygenase 3 (FMO3) variant E158K, benzydamine |
| flavin-containing monooxygenase 3 (FMO3)variant E158K | Homo sapiens | benzydamineC-terminally truncated FMO3 (tr-FMO3); Table 5 | — | — | 0.5 | pH 7.4, 37 °C | PMID 33152328 | Open record: flavin-containing monooxygenase 3 (FMO3) variant E158K, benzydamine |
| flavin-containing monooxygenase 3 (FMO3)variant E158K | Homo sapiens | sulindac sulfideTable 4 | 0.0042 | 0.0151 | 0.28 calc. | pH 7.4, 37 °C | PMID 33152328 | Open record: flavin-containing monooxygenase 3 (FMO3) variant E158K, sulindac sulfide |
| flavin-containing monooxygenase 3 (FMO3)variant E158K | Homo sapiens | sulindac sulfideC-terminally truncated FMO3 (tr-FMO3); Table 4 | 0.0115 | 0.0163 | 0.710 calc. | pH 7.4, 37 °C | PMID 33152328 | Open record: flavin-containing monooxygenase 3 (FMO3) variant E158K, sulindac sulfide |
| flavin-containing monooxygenase 3 (FMO3)variant E158K | Homo sapiens | sulindac sulfideTable 5 | — | — | 0.33 | pH 7.4, 37 °C | PMID 33152328 | Open record: flavin-containing monooxygenase 3 (FMO3) variant E158K, sulindac sulfide |
| flavin-containing monooxygenase 3 (FMO3)variant E158K | Homo sapiens | sulindac sulfideC-terminally truncated FMO3 (tr-FMO3); Table 5 | — | — | 0.67 | pH 7.4, 37 °C | PMID 33152328 | Open record: flavin-containing monooxygenase 3 (FMO3) variant E158K, sulindac sulfide |
| flavin-containing monooxygenase 3 (FMO3)variant E158K | Homo sapiens | tamoxifenTable 3 | 0.0113 | 0.00134 | 8.50 calc. | pH 7.4, 37 °C | PMID 33152328 | Open record: flavin-containing monooxygenase 3 (FMO3) variant E158K, tamoxifen |
| flavin-containing monooxygenase 3 (FMO3)variant E158K | Homo sapiens | tamoxifenTable 5 | — | — | 8.5 | pH 7.4, 37 °C | PMID 33152328 | Open record: flavin-containing monooxygenase 3 (FMO3) variant E158K, tamoxifen |
| flavin-containing monooxygenase 3 (FMO3)variant E308G | Homo sapiens | benzydamineTable 2 | 0.0033 | 0.0345 | 0.097 calc. | pH 7.4, 37 °C | PMID 33152328 | Open record: flavin-containing monooxygenase 3 (FMO3) variant E308G, benzydamine |
| flavin-containing monooxygenase 3 (FMO3)variant E308G | Homo sapiens | benzydamineC-terminally truncated FMO3 (tr-FMO3); Table 2 | 0.0078 | 0.0397 | 0.20 calc. | pH 7.4, 37 °C | PMID 33152328 | Open record: flavin-containing monooxygenase 3 (FMO3) variant E308G, benzydamine |
| flavin-containing monooxygenase 3 (FMO3)variant E308G | Homo sapiens | benzydamineTable 5 | — | — | 0.1 | pH 7.4, 37 °C | PMID 33152328 | Open record: flavin-containing monooxygenase 3 (FMO3) variant E308G, benzydamine |
| flavin-containing monooxygenase 3 (FMO3)variant E308G | Homo sapiens | benzydamineC-terminally truncated FMO3 (tr-FMO3); Table 5 | — | — | 0.2 | pH 7.4, 37 °C | PMID 33152328 | Open record: flavin-containing monooxygenase 3 (FMO3) variant E308G, benzydamine |
| flavin-containing monooxygenase 3 (FMO3)variant E308G | Homo sapiens | sulindac sulfideTable 4 | 0.0062 | 0.0101 | 0.61 calc. | pH 7.4, 37 °C | PMID 33152328 | Open record: flavin-containing monooxygenase 3 (FMO3) variant E308G, sulindac sulfide |
| flavin-containing monooxygenase 3 (FMO3)variant E308G | Homo sapiens | sulindac sulfideC-terminally truncated FMO3 (tr-FMO3); Table 4 | 0.0148 | 0.0103 | 1.40 calc. | pH 7.4, 37 °C | PMID 33152328 | Open record: flavin-containing monooxygenase 3 (FMO3) variant E308G, sulindac sulfide |
| flavin-containing monooxygenase 3 (FMO3)variant E308G | Homo sapiens | sulindac sulfideTable 5 | — | — | 0.67 | pH 7.4, 37 °C | PMID 33152328 | Open record: flavin-containing monooxygenase 3 (FMO3) variant E308G, sulindac sulfide |
| flavin-containing monooxygenase 3 (FMO3)variant E308G | Homo sapiens | sulindac sulfideC-terminally truncated FMO3 (tr-FMO3); Table 5 | — | — | 1.5 | pH 7.4, 37 °C | PMID 33152328 | Open record: flavin-containing monooxygenase 3 (FMO3) variant E308G, sulindac sulfide |
| flavin-containing monooxygenase 3 (FMO3)variant E308G | Homo sapiens | tamoxifenTable 3 | 0.0102 | 0.0029 | 3.5 calc. | pH 7.4, 37 °C | PMID 33152328 | Open record: flavin-containing monooxygenase 3 (FMO3) variant E308G, tamoxifen |
| flavin-containing monooxygenase 3 (FMO3)variant E308G | Homo sapiens | tamoxifenTable 5 | — | — | 3.5 | pH 7.4, 37 °C | PMID 33152328 | Open record: flavin-containing monooxygenase 3 (FMO3) variant E308G, tamoxifen |
| flavin-containing monooxygenase 3 (FMO3)variant V257M | Homo sapiens | benzydamineTable 2 | 0.0505 | 0.0373 | 1.35 calc. | pH 7.4, 37 °C | PMID 33152328 | Open record: flavin-containing monooxygenase 3 (FMO3) variant V257M, benzydamine |
| flavin-containing monooxygenase 3 (FMO3)variant V257M | Homo sapiens | benzydamineC-terminally truncated FMO3 (tr-FMO3); Table 2 | 0.0583 | 0.038 | 1.5 calc. | pH 7.4, 37 °C | PMID 33152328 | Open record: flavin-containing monooxygenase 3 (FMO3) variant V257M, benzydamine |
| flavin-containing monooxygenase 3 (FMO3)variant V257M | Homo sapiens | benzydamineTable 5 | — | — | 1.3 | pH 7.4, 37 °C | PMID 33152328 | Open record: flavin-containing monooxygenase 3 (FMO3) variant V257M, benzydamine |
| flavin-containing monooxygenase 3 (FMO3)variant V257M | Homo sapiens | benzydamineC-terminally truncated FMO3 (tr-FMO3); Table 5 | — | — | 1.5 | pH 7.4, 37 °C | PMID 33152328 | Open record: flavin-containing monooxygenase 3 (FMO3) variant V257M, benzydamine |
| flavin-containing monooxygenase 3 (FMO3)variant V257M | Homo sapiens | sulindac sulfideTable 4 | 0.0068 | 0.0143 | 0.48 calc. | pH 7.4, 37 °C | PMID 33152328 | Open record: flavin-containing monooxygenase 3 (FMO3) variant V257M, sulindac sulfide |
| flavin-containing monooxygenase 3 (FMO3)variant V257M | Homo sapiens | sulindac sulfideC-terminally truncated FMO3 (tr-FMO3); Table 4 | 0.0183 | 0.0103 | 1.78 calc. | pH 7.4, 37 °C | PMID 33152328 | Open record: flavin-containing monooxygenase 3 (FMO3) variant V257M, sulindac sulfide |
| flavin-containing monooxygenase 3 (FMO3)variant V257M | Homo sapiens | sulindac sulfideTable 5 | — | — | 0.5 | pH 7.4, 37 °C | PMID 33152328 | Open record: flavin-containing monooxygenase 3 (FMO3) variant V257M, sulindac sulfide |
| flavin-containing monooxygenase 3 (FMO3)variant V257M | Homo sapiens | sulindac sulfideC-terminally truncated FMO3 (tr-FMO3); Table 5 | — | — | 1.8 | pH 7.4, 37 °C | PMID 33152328 | Open record: flavin-containing monooxygenase 3 (FMO3) variant V257M, sulindac sulfide |
| flavin-containing monooxygenase 3 (FMO3)variant V257M | Homo sapiens | tamoxifenTable 3 | 0.0142 | 0.0071 | 2.0 calc. | pH 7.4, 37 °C | PMID 33152328 | Open record: flavin-containing monooxygenase 3 (FMO3) variant V257M, tamoxifen |
| flavin-containing monooxygenase 3 (FMO3)variant V257M | Homo sapiens | tamoxifenTable 5 | — | — | 2 | pH 7.4, 37 °C | PMID 33152328 | Open record: flavin-containing monooxygenase 3 (FMO3) variant V257M, tamoxifen |
| flavin-containing monooxygenase 3 (hFMO3) | Homo sapiens | Clomiphene | 0.0012 | 0.0183 | 0.067 | pH 7.4, 37 °C | PMID 29959872 | Open record: flavin-containing monooxygenase 3 (hFMO3), Clomiphene |
| flavin-containing monooxygenase 3 (hFMO3) | Homo sapiens | GSK5182 | 0.037 | 0.00982 | 3.7 | pH 7.4, 37 °C | PMID 29959872 | Open record: flavin-containing monooxygenase 3 (hFMO3), GSK5182 |
| flavin-containing monooxygenase 3 (hFMO3) | Homo sapiens | Tamoxifen | 0.0188 | 0.0064 | 3 | pH 7.4, 37 °C | PMID 29959872 | Open record: flavin-containing monooxygenase 3 (hFMO3), Tamoxifen |
| flavin-containing monooxygenase 3 (hFMO3)variant E158K | Homo sapiens | Clomiphene | 0.001 | 0.02046 | 0.05 | pH 7.4, 37 °C | PMID 29959872 | Open record: flavin-containing monooxygenase 3 (hFMO3) variant E158K, Clomiphene |
| flavin-containing monooxygenase 3 (hFMO3)variant E158K | Homo sapiens | GSK5182 | 0.0193 | 0.00457 | 4.2 | pH 7.4, 37 °C | PMID 29959872 | Open record: flavin-containing monooxygenase 3 (hFMO3) variant E158K, GSK5182 |
| flavin-containing monooxygenase 3 (hFMO3)variant E158K | Homo sapiens | Tamoxifen | 0.0075 | 0.00156 | 4.8 | pH 7.4, 37 °C | PMID 29959872 | Open record: flavin-containing monooxygenase 3 (hFMO3) variant E158K, Tamoxifen |
| flavin-containing monooxygenase 3 (hFMO3)variant E308G | Homo sapiens | Clomiphene | 0.0042 | 0.0444 | 0.1 | pH 7.4, 37 °C | PMID 29959872 | Open record: flavin-containing monooxygenase 3 (hFMO3) variant E308G, Clomiphene |
| flavin-containing monooxygenase 3 (hFMO3)variant E308G | Homo sapiens | GSK5182 | 0.02 | 0.00587 | 3.3 | pH 7.4, 37 °C | PMID 29959872 | Open record: flavin-containing monooxygenase 3 (hFMO3) variant E308G, GSK5182 |
| flavin-containing monooxygenase 3 (hFMO3)variant E308G | Homo sapiens | Tamoxifen | 0.0063 | 0.0025 | 2.5 | pH 7.4, 37 °C | PMID 29959872 | Open record: flavin-containing monooxygenase 3 (hFMO3) variant E308G, Tamoxifen |
| flavin-containing monooxygenase 3 (hFMO3)variant V257M | Homo sapiens | Clomiphene | 0.005 | 0.0332 | 0.15 | pH 7.4, 37 °C | PMID 29959872 | Open record: flavin-containing monooxygenase 3 (hFMO3) variant V257M, Clomiphene |
| flavin-containing monooxygenase 3 (hFMO3)variant V257M | Homo sapiens | GSK5182 | 0.0948 | 0.0285 | 3.2 | pH 7.4, 37 °C | PMID 29959872 | Open record: flavin-containing monooxygenase 3 (hFMO3) variant V257M, GSK5182 |
| flavin-containing monooxygenase 3 (hFMO3)variant V257M | Homo sapiens | Tamoxifen | 0.01 | 0.0081 | 1.2 | pH 7.4, 37 °C | PMID 29959872 | Open record: flavin-containing monooxygenase 3 (hFMO3) variant V257M, Tamoxifen |
| FMO1 | Homo sapiens | fenthion | — | 0.0027 | — | pH 7.4, 37 °C | PMID 18845175 | Open record: FMO1, fenthion |
| FMO3 | Homo sapiens | fenthion | — | 0.039 | — | pH 7.4, 37 °C | PMID 18845175 | Open record: FMO3, fenthion |
| hFMO1 | Homo sapiens | ethionamide | 1.498 | 0.105 | 14.3 | pH 9.5, 37 °C | PMID 18930751 | Open record: hFMO1, ethionamide |
| hFMO3 | Homo sapiens | ethionamide | 0.973 | 0.336 | 2.8 | pH 9.5, 37 °C | PMID 18930751 | Open record: hFMO3, ethionamide |
| mFmo1 | Mus musculus | ethionamide | 4.52 | 0.104 | 43.7 | pH 9.5, 37 °C | PMID 18930751 | Open record: mFmo1, ethionamide |
| mFmo3 | Mus musculus | ethionamide | 1.01 | 0.114 | 8.8 | pH 9.5, 37 °C | PMID 18930751 | Open record: mFmo3, ethionamide |
| trimethylamine monooxygenase (Tmm7211) | Pelagibacter sp. HTCC7211 | dimethylamine | 0.298 | 0.1814 | 1.645 | pH 7 | PMID 34630359 | Open record: trimethylamine monooxygenase (Tmm7211), dimethylamine |
| trimethylamine monooxygenase (Tmm7211) | Pelagibacter sp. HTCC7211 | dimethylsulfide | 0.075 | 0.2505 | 0.3 | pH 7 | PMID 34630359 | Open record: trimethylamine monooxygenase (Tmm7211), dimethylsulfide |
| trimethylamine monooxygenase (Tmm7211) | Pelagibacter sp. HTCC7211 | Methimazole | 0.087 | 0.1162 | 0.747 | pH 7 | PMID 34630359 | Open record: trimethylamine monooxygenase (Tmm7211), Methimazole |
| trimethylamine monooxygenase (Tmm7211) | Pelagibacter sp. HTCC7211 | NADPH | 0.075 | 0.0128 | 5.9 calc. | pH 7 | PMID 34630359 | Open record: trimethylamine monooxygenase (Tmm7211), NADPH |
| trimethylamine monooxygenase (Tmm7211) | Pelagibacter sp. HTCC7211 | trimethylamine | 0.373 | 0.139 | 2.687 | pH 7 | PMID 34630359 | Open record: trimethylamine monooxygenase (Tmm7211), trimethylamine |
| trimethylamine monooxygenase (Tmm7211)variant D314A | Pelagibacter sp. HTCC7211 | NADPH | 0.035 | 0.032 | 1.1 calc. | pH 7 | PMID 34630359 | Open record: trimethylamine monooxygenase (Tmm7211) variant D314A, NADPH |
| trimethylamine monooxygenase (Tmm7211)variant D314E | Pelagibacter sp. HTCC7211 | NADPH | 0.087 | 0.0097 | 8.9 calc. | pH 7 | PMID 34630359 | Open record: trimethylamine monooxygenase (Tmm7211) variant D314E, NADPH |
| trimethylamine monooxygenase (Tmm7211)variant H227A | Pelagibacter sp. HTCC7211 | NADPH | 0.042 | 0.0412 | 1.0 calc. | pH 7 | PMID 34630359 | Open record: trimethylamine monooxygenase (Tmm7211) variant H227A, NADPH |
| trimethylamine monooxygenase (Tmm7211)variant N288A | Pelagibacter sp. HTCC7211 | NADPH | 0.022 | 0.0611 | 0.35 calc. | pH 7 | PMID 34630359 | Open record: trimethylamine monooxygenase (Tmm7211) variant N288A, NADPH |
| trimethylamine monooxygenase (Tmm7211)variant N72A | Pelagibacter sp. HTCC7211 | NADPH | 0.032 | 0.0341 | 0.93 calc. | pH 7 | PMID 34630359 | Open record: trimethylamine monooxygenase (Tmm7211) variant N72A, NADPH |
| trimethylamine monooxygenase (Tmm7211)variant R226A | Pelagibacter sp. HTCC7211 | NADPH | 0.015 | 0.1018 | 0.15 calc. | pH 7 | PMID 34630359 | Open record: trimethylamine monooxygenase (Tmm7211) variant R226A, NADPH |
| trimethylamine monooxygenase (Tmm7211)variant R409A | Pelagibacter sp. HTCC7211 | NADPH | 0.045 | 0.0449 | 1.0 calc. | pH 7 | PMID 34630359 | Open record: trimethylamine monooxygenase (Tmm7211) variant R409A, NADPH |
| trimethylamine monooxygenase (Tmm7211)variant S203A | Pelagibacter sp. HTCC7211 | NADPH | 0.017 | 0.1348 | 0.12 calc. | pH 7 | PMID 34630359 | Open record: trimethylamine monooxygenase (Tmm7211) variant S203A, NADPH |