EC 1.14.13.8: flavin-containing monooxygenase

OxidoreductasesOpen in Browse

CatLog read 166 records for EC 1.14.13.8 from 11 papers, for 5 organisms. Names in these papers: flavin-containing monooxygenase 3 (FMO3), FAD-containing monooxygenase, FMO3 (flavin-containing monooxygenase 3), flavin-containing monooxygenase 3 (hFMO3) and 12 more.

Read from the paper by an AI model and checked against the paper by a second, separate AI run; code converted the units.

CatLog also holds 45 records for EC 1.14.13.8 that are not yet re-read: from its earlier version, built from the enzyme databases and partly checked against the papers. All records for EC 1.14.13.8 in Browse.

Papers

Papers with records for EC 1.14.13.8
Paper	Organisms	Records
Functional characterization of genetic variants of human FMO3 associated with trimethylaminuria	Homo sapiens	42
N- and S-oxygenation activity of truncated human flavin-containing monooxygenase 3 and its common polymorphic variants	Homo sapiens	40
The oxidation of hydrazine derivatives catalyzed by the purified liver microsomal FAD-containing monooxygenase	Sus scrofa	18
Identification and functional analysis of common human flavin-containing monooxygenase 3 genetic variants	Homo sapiens	14
Flavin-Containing Monooxygenase 3 Polymorphic Variants Significantly Affect Clearance of Tamoxifen and Clomiphene	Homo sapiens	12
Tryptophan-47 in the active site of Methylophaga sp. strain SK1 flavin-monooxygenase is important for hydride transfer	Methylophaga sp. strain SK1	10
Structure-Based Redesign of a Self-Sufficient Flavin-Containing Monooxygenase towards Indigo Production	Methylophaga sp.	10
Human flavin-containing monooxygenase 2.1 catalyzes oxygenation of the antitubercular drugs thiacetazone and ethionamide	Homo sapiens	6
Characterization of sulfoxygenation and structural implications of human flavin-containing monooxygenase isoform 2 (FMO2.1) variants S195L and N413K	Homo sapiens	6
Metabolism of the anti-tuberculosis drug ethionamide by mouse and human FMO1, FMO2 and FMO3 and mouse and human lung microsomes	Homo sapiens, Mus musculus	5
The participation of human hepatic P450 isoforms, flavin-containing monooxygenases and aldehyde oxidase in the biotransformation of the insecticide fenthion	Homo sapiens	3

Records

Records for EC 1.14.13.8 read from the paper
Enzyme	Organism	Substrate	k_cat (s⁻¹)	K_m (mM)	k_cat/K_m (mM⁻¹ s⁻¹)	Conditions	Paper	Open record
FAD-containing monooxygenase	Sus scrofa	1,1-dimethylhydrazine	—	0.43	—	pH 8.2, 37 °C	PMID 7217078	Open record: FAD-containing monooxygenase, 1,1-dimethylhydrazine
FAD-containing monooxygenase	Sus scrofa	1,2-dimethylhydrazine	—	12	—	pH 8.2, 37 °C	PMID 7217078	Open record: FAD-containing monooxygenase, 1,2-dimethylhydrazine
FAD-containing monooxygenase	Sus scrofa	1,2-Dimethylphenylhydrazine	—	0.38	—	pH 8.2, 37 °C	PMID 7217078	Open record: FAD-containing monooxygenase, 1,2-Dimethylphenylhydrazine
FAD-containing monooxygenase	Sus scrofa	1-aminopiperidine	—	0.03	—	pH 8.2, 37 °C	PMID 7217078	Open record: FAD-containing monooxygenase, 1-aminopiperidine
FAD-containing monooxygenase	Sus scrofa	1-aminopyrrolidine	—	0.1	—	pH 8.2, 37 °C	PMID 7217078	Open record: FAD-containing monooxygenase, 1-aminopyrrolidine
FAD-containing monooxygenase	Sus scrofa	1-methyl-1-phenylhydrazine	—	0.08	—	pH 8.2, 37 °C	PMID 7217078	Open record: FAD-containing monooxygenase, 1-methyl-1-phenylhydrazine
FAD-containing monooxygenase	Sus scrofa	1-methyl-2-benzylhydrazine	—	2	—	pH 8.2, 37 °C	PMID 7217078	Open record: FAD-containing monooxygenase, 1-methyl-2-benzylhydrazine
FAD-containing monooxygenase	Sus scrofa	benzylhydrazine	—	7	—	pH 8.2, 37 °C	PMID 7217078	Open record: FAD-containing monooxygenase, benzylhydrazine
FAD-containing monooxygenase	Sus scrofa	butylhydrazine	—	6.9	—	pH 8.2, 37 °C	PMID 7217078	Open record: FAD-containing monooxygenase, butylhydrazine
FAD-containing monooxygenase	Sus scrofa	ethylhydrazine	—	40	—	pH 8.2, 37 °C	PMID 7217078	Open record: FAD-containing monooxygenase, ethylhydrazine
FAD-containing monooxygenase	Sus scrofa	isopropylhydrazine	—	8.3	—	pH 8.2, 37 °C	PMID 7217078	Open record: FAD-containing monooxygenase, isopropylhydrazine
FAD-containing monooxygenase	Sus scrofa	methylhydrazine	—	35	—	pH 8.2, 37 °C	PMID 7217078	Open record: FAD-containing monooxygenase, methylhydrazine
FAD-containing monooxygenase	Sus scrofa	N,N-dimethylaniline	—	0.02	—	pH 8.2, 37 °C	PMID 7217078	Open record: FAD-containing monooxygenase, N,N-dimethylaniline
FAD-containing monooxygenase	Sus scrofa	N-Aminohomopiperidine	—	0.17	—	pH 8.2, 37 °C	PMID 7217078	Open record: FAD-containing monooxygenase, N-Aminohomopiperidine
FAD-containing monooxygenase	Sus scrofa	N-isopropyl-alpha-(2-methylhydrazino)-p-toluamide hydrochloride	—	5.7	—	pH 8.2, 37 °C	PMID 7217078	Open record: FAD-containing monooxygenase, N-isopropyl-alpha-(2-methylhydrazino)-p-toluamide hydrochloride
FAD-containing monooxygenase	Sus scrofa	n-propylhydrazine	—	15	—	pH 8.2, 37 °C	PMID 7217078	Open record: FAD-containing monooxygenase, n-propylhydrazine
FAD-containing monooxygenase	Sus scrofa	phenylhydrazine	—	3	—	pH 8.2, 37 °C	PMID 7217078	Open record: FAD-containing monooxygenase, phenylhydrazine
FAD-containing monooxygenase	Sus scrofa	β-Ethylphenylhydrazine	—	3.3	—	pH 8.2, 37 °C	PMID 7217078	Open record: FAD-containing monooxygenase, β-Ethylphenylhydrazine
flavin-containing monooxygenase (FMO)	Methylophaga sp. strain SK1	Methimazole	2.7	0.163	16	pH 8.5, 25 °C	PMID 23357278	Open record: flavin-containing monooxygenase (FMO), Methimazole
flavin-containing monooxygenase (FMO)	Methylophaga sp. strain SK1	NADPHcosubstrate trimethylamine (20 μM, saturating)	7.3	0.0041	1.8 × 10³	pH 8.5, 25 °C	PMID 23357278	Open record: flavin-containing monooxygenase (FMO), NADPH
flavin-containing monooxygenase (FMO)	Methylophaga sp. strain SK1	NADPHoxidase activity in the absence of second substrate	0.08	—	—	pH 8.5, 25 °C	PMID 23357278	Open record: flavin-containing monooxygenase (FMO), NADPH
flavin-containing monooxygenase (FMO)	Methylophaga sp. strain SK1	Oxygen	7.7	0.019	410	pH 8.5, 25 °C	PMID 23357278	Open record: flavin-containing monooxygenase (FMO), Oxygen
flavin-containing monooxygenase (FMO)	Methylophaga sp. strain SK1	Trimethylamine	6.1	0.0026	2.3 × 10³	pH 8.5, 25 °C	PMID 23357278	Open record: flavin-containing monooxygenase (FMO), Trimethylamine
flavin-containing monooxygenase (FMO)variant W47F	Methylophaga sp. strain SK1	Methimazole	0.67	0.037	18	pH 8.5, 25 °C	PMID 23357278	Open record: flavin-containing monooxygenase (FMO) variant W47F, Methimazole
flavin-containing monooxygenase (FMO)variant W47F	Methylophaga sp. strain SK1	NADPHcosubstrate trimethylamine (20 μM, saturating)	0.92	0.0043	210	pH 8.5, 25 °C	PMID 23357278	Open record: flavin-containing monooxygenase (FMO) variant W47F, NADPH
flavin-containing monooxygenase (FMO)variant W47F	Methylophaga sp. strain SK1	NADPHoxidase activity in the absence of second substrate	0.17	—	—	pH 8.5, 25 °C	PMID 23357278	Open record: flavin-containing monooxygenase (FMO) variant W47F, NADPH
flavin-containing monooxygenase (FMO)variant W47F	Methylophaga sp. strain SK1	Oxygen	2.7	0.042	60	pH 8.5, 25 °C	PMID 23357278	Open record: flavin-containing monooxygenase (FMO) variant W47F, Oxygen
flavin-containing monooxygenase (FMO)variant W47F	Methylophaga sp. strain SK1	Trimethylamine	1.25	0.0015	800	pH 8.5, 25 °C	PMID 23357278	Open record: flavin-containing monooxygenase (FMO) variant W47F, Trimethylamine
flavin-containing monooxygenase (mFMO)variant M15L/S23A (*mFMO; labelled WT in Table 2)	Methylophaga sp.	indole	0.85	0.4	2.1 calc.		PMID 31817552	Open record: flavin-containing monooxygenase (mFMO) variant M15L/S23A (*mFMO; labelled WT in Table 2), indole
flavin-containing monooxygenase (mFMO)variant M15L/S23A/C78A (C78A)	Methylophaga sp.	indole	0.79	0.4	2.0 calc.		PMID 31817552	Open record: flavin-containing monooxygenase (mFMO) variant M15L/S23A/C78A (C78A), indole
flavin-containing monooxygenase (mFMO)variant M15L/S23A/C78I (C78I)	Methylophaga sp.	indole	1.28	0.8	1.6 calc.		PMID 31817552	Open record: flavin-containing monooxygenase (mFMO) variant M15L/S23A/C78I (C78I), indole
flavin-containing monooxygenase (mFMO)variant M15L/S23A/C78I/Y207W/W319A (C78I/Y207W/W319A)	Methylophaga sp.	indole	0.93	0.8	1.2 calc.		PMID 31817552	Open record: flavin-containing monooxygenase (mFMO) variant M15L/S23A/C78I/Y207W/W319A (C78I/Y207W/W319A), indole
flavin-containing monooxygenase (mFMO)variant M15L/S23A/C78L (C78L)	Methylophaga sp.	indole	0.7	0.8	0.88 calc.		PMID 31817552	Open record: flavin-containing monooxygenase (mFMO) variant M15L/S23A/C78L (C78L), indole
flavin-containing monooxygenase (mFMO)variant M15L/S23A/C78V (C78V)	Methylophaga sp.	indole	1.04	0.7	1.5 calc.		PMID 31817552	Open record: flavin-containing monooxygenase (mFMO) variant M15L/S23A/C78V (C78V), indole
flavin-containing monooxygenase (mFMO)variant M15L/S23A/W319A (W319A)	Methylophaga sp.	indole	0.42	0.9	0.47 calc.		PMID 31817552	Open record: flavin-containing monooxygenase (mFMO) variant M15L/S23A/W319A (W319A), indole
flavin-containing monooxygenase (mFMO)variant M15L/S23A/W319F (W319F)	Methylophaga sp.	indole	0.64	0.4	1.6 calc.		PMID 31817552	Open record: flavin-containing monooxygenase (mFMO) variant M15L/S23A/W319F (W319F), indole
flavin-containing monooxygenase (mFMO)variant M15L/S23A/Y207W (Y207W)	Methylophaga sp.	indole	0.31	0.1	3.1 calc.		PMID 31817552	Open record: flavin-containing monooxygenase (mFMO) variant M15L/S23A/Y207W (Y207W), indole
flavin-containing monooxygenase (mFMO)variant M15L/S23A/Y207W/W319A (Y207W/W319A)	Methylophaga sp.	indole	0.8	0.8	1.0 calc.		PMID 31817552	Open record: flavin-containing monooxygenase (mFMO) variant M15L/S23A/Y207W/W319A (Y207W/W319A), indole
flavin-containing monooxygenase 3 (FMO3)	Homo sapiens	benzydaminekcat per FAD	0.43	—	—	pH 7.4, 37 °C	PMID 17531949	Open record: flavin-containing monooxygenase 3 (FMO3), benzydamine
flavin-containing monooxygenase 3 (FMO3)	Homo sapiens	benzydamineapparent Km	—	0.043	—	pH 7.4, 37 °C	PMID 17531949	Open record: flavin-containing monooxygenase 3 (FMO3), benzydamine
flavin-containing monooxygenase 3 (FMO3)	Homo sapiens	benzydamineTable 2	0.052	0.052	1.0 calc.	pH 7.4, 37 °C	PMID 33152328	Open record: flavin-containing monooxygenase 3 (FMO3), benzydamine
flavin-containing monooxygenase 3 (FMO3)	Homo sapiens	benzydamineC-terminally truncated FMO3 (tr-FMO3); Table 2	0.0752	0.053	1.4 calc.	pH 7.4, 37 °C	PMID 33152328	Open record: flavin-containing monooxygenase 3 (FMO3), benzydamine
flavin-containing monooxygenase 3 (FMO3)	Homo sapiens	benzydamineTable 5	—	—	1	pH 7.4, 37 °C	PMID 33152328	Open record: flavin-containing monooxygenase 3 (FMO3), benzydamine
flavin-containing monooxygenase 3 (FMO3)	Homo sapiens	benzydamineC-terminally truncated FMO3 (tr-FMO3); Table 5	—	—	1.5	pH 7.4, 37 °C	PMID 33152328	Open record: flavin-containing monooxygenase 3 (FMO3), benzydamine
flavin-containing monooxygenase 3 (FMO3)	Homo sapiens	methyl 4-methylphenyl sulfidekcat per FAD	0.23	—	—	pH 7.4, 37 °C	PMID 17531949	Open record: flavin-containing monooxygenase 3 (FMO3), methyl 4-methylphenyl sulfide
flavin-containing monooxygenase 3 (FMO3)	Homo sapiens	methyl 4-methylphenyl sulfideapparent Km	—	0.248	—	pH 7.4, 37 °C	PMID 17531949	Open record: flavin-containing monooxygenase 3 (FMO3), methyl 4-methylphenyl sulfide
flavin-containing monooxygenase 3 (FMO3)	Homo sapiens	sulindac sulfideTable 4	0.0093	0.0156	0.60 calc.	pH 7.4, 37 °C	PMID 33152328	Open record: flavin-containing monooxygenase 3 (FMO3), sulindac sulfide
flavin-containing monooxygenase 3 (FMO3)	Homo sapiens	sulindac sulfideC-terminally truncated FMO3 (tr-FMO3); Table 4	0.0267	0.0127	2.10 calc.	pH 7.4, 37 °C	PMID 33152328	Open record: flavin-containing monooxygenase 3 (FMO3), sulindac sulfide
flavin-containing monooxygenase 3 (FMO3)	Homo sapiens	sulindac sulfideTable 5	—	—	0.67	pH 7.4, 37 °C	PMID 33152328	Open record: flavin-containing monooxygenase 3 (FMO3), sulindac sulfide
flavin-containing monooxygenase 3 (FMO3)	Homo sapiens	sulindac sulfideC-terminally truncated FMO3 (tr-FMO3); Table 5	—	—	2.2	pH 7.4, 37 °C	PMID 33152328	Open record: flavin-containing monooxygenase 3 (FMO3), sulindac sulfide
flavin-containing monooxygenase 3 (FMO3)	Homo sapiens	tamoxifenTable 3	0.0272	0.0056	4.8 calc.	pH 7.4, 37 °C	PMID 33152328	Open record: flavin-containing monooxygenase 3 (FMO3), tamoxifen
flavin-containing monooxygenase 3 (FMO3)	Homo sapiens	tamoxifenTable 5	—	—	4.8	pH 7.4, 37 °C	PMID 33152328	Open record: flavin-containing monooxygenase 3 (FMO3), tamoxifen
flavin-containing monooxygenase 3 (FMO3)	Homo sapiens	trimethylaminekcat per FAD	0.38	—	—	pH 7.4, 37 °C	PMID 17531949	Open record: flavin-containing monooxygenase 3 (FMO3), trimethylamine
flavin-containing monooxygenase 3 (FMO3)	Homo sapiens	trimethylamineapparent Km	—	0.031	—	pH 7.4, 37 °C	PMID 17531949	Open record: flavin-containing monooxygenase 3 (FMO3), trimethylamine
flavin-containing monooxygenase 3 (FMO3)variant E158K	Homo sapiens	benzydaminekcat per FAD	0.48	—	—	pH 7.4, 37 °C	PMID 17531949	Open record: flavin-containing monooxygenase 3 (FMO3) variant E158K, benzydamine
flavin-containing monooxygenase 3 (FMO3)variant E158K	Homo sapiens	benzydamineapparent Km	—	0.033	—	pH 7.4, 37 °C	PMID 17531949	Open record: flavin-containing monooxygenase 3 (FMO3) variant E158K, benzydamine
flavin-containing monooxygenase 3 (FMO3)variant E158K	Homo sapiens	benzydamineTable 2	0.0182	0.0593	0.306 calc.	pH 7.4, 37 °C	PMID 33152328	Open record: flavin-containing monooxygenase 3 (FMO3) variant E158K, benzydamine
flavin-containing monooxygenase 3 (FMO3)variant E158K	Homo sapiens	benzydamineC-terminally truncated FMO3 (tr-FMO3); Table 2	0.0292	0.0659	0.443 calc.	pH 7.4, 37 °C	PMID 33152328	Open record: flavin-containing monooxygenase 3 (FMO3) variant E158K, benzydamine
flavin-containing monooxygenase 3 (FMO3)variant E158K	Homo sapiens	benzydamineTable 5	—	—	0.33	pH 7.4, 37 °C	PMID 33152328	Open record: flavin-containing monooxygenase 3 (FMO3) variant E158K, benzydamine
flavin-containing monooxygenase 3 (FMO3)variant E158K	Homo sapiens	benzydamineC-terminally truncated FMO3 (tr-FMO3); Table 5	—	—	0.5	pH 7.4, 37 °C	PMID 33152328	Open record: flavin-containing monooxygenase 3 (FMO3) variant E158K, benzydamine
flavin-containing monooxygenase 3 (FMO3)variant E158K	Homo sapiens	methyl 4-methylphenyl sulfidekcat per FAD	0.3	—	—	pH 7.4, 37 °C	PMID 17531949	Open record: flavin-containing monooxygenase 3 (FMO3) variant E158K, methyl 4-methylphenyl sulfide
flavin-containing monooxygenase 3 (FMO3)variant E158K	Homo sapiens	methyl 4-methylphenyl sulfideapparent Km	—	0.181	—	pH 7.4, 37 °C	PMID 17531949	Open record: flavin-containing monooxygenase 3 (FMO3) variant E158K, methyl 4-methylphenyl sulfide
flavin-containing monooxygenase 3 (FMO3)variant E158K	Homo sapiens	sulindac sulfideTable 4	0.0042	0.0151	0.28 calc.	pH 7.4, 37 °C	PMID 33152328	Open record: flavin-containing monooxygenase 3 (FMO3) variant E158K, sulindac sulfide
flavin-containing monooxygenase 3 (FMO3)variant E158K	Homo sapiens	sulindac sulfideC-terminally truncated FMO3 (tr-FMO3); Table 4	0.0115	0.0163	0.710 calc.	pH 7.4, 37 °C	PMID 33152328	Open record: flavin-containing monooxygenase 3 (FMO3) variant E158K, sulindac sulfide
flavin-containing monooxygenase 3 (FMO3)variant E158K	Homo sapiens	sulindac sulfideTable 5	—	—	0.33	pH 7.4, 37 °C	PMID 33152328	Open record: flavin-containing monooxygenase 3 (FMO3) variant E158K, sulindac sulfide
flavin-containing monooxygenase 3 (FMO3)variant E158K	Homo sapiens	sulindac sulfideC-terminally truncated FMO3 (tr-FMO3); Table 5	—	—	0.67	pH 7.4, 37 °C	PMID 33152328	Open record: flavin-containing monooxygenase 3 (FMO3) variant E158K, sulindac sulfide
flavin-containing monooxygenase 3 (FMO3)variant E158K	Homo sapiens	tamoxifenTable 3	0.0113	0.00134	8.50 calc.	pH 7.4, 37 °C	PMID 33152328	Open record: flavin-containing monooxygenase 3 (FMO3) variant E158K, tamoxifen
flavin-containing monooxygenase 3 (FMO3)variant E158K	Homo sapiens	tamoxifenTable 5	—	—	8.5	pH 7.4, 37 °C	PMID 33152328	Open record: flavin-containing monooxygenase 3 (FMO3) variant E158K, tamoxifen
flavin-containing monooxygenase 3 (FMO3)variant E158K	Homo sapiens	trimethylaminekcat per FAD	0.45	—	—	pH 7.4, 37 °C	PMID 17531949	Open record: flavin-containing monooxygenase 3 (FMO3) variant E158K, trimethylamine
flavin-containing monooxygenase 3 (FMO3)variant E158K	Homo sapiens	trimethylamineapparent Km	—	0.027	—	pH 7.4, 37 °C	PMID 17531949	Open record: flavin-containing monooxygenase 3 (FMO3) variant E158K, trimethylamine
flavin-containing monooxygenase 3 (FMO3)variant E158K/E308G	Homo sapiens	benzydaminekcat per FAD	0.6	—	—	pH 7.4, 37 °C	PMID 17531949	Open record: flavin-containing monooxygenase 3 (FMO3) variant E158K/E308G, benzydamine
flavin-containing monooxygenase 3 (FMO3)variant E158K/E308G	Homo sapiens	benzydamineapparent Km	—	0.047	—	pH 7.4, 37 °C	PMID 17531949	Open record: flavin-containing monooxygenase 3 (FMO3) variant E158K/E308G, benzydamine
flavin-containing monooxygenase 3 (FMO3)variant E158K/E308G	Homo sapiens	methyl 4-methylphenyl sulfidekcat per FAD	0.2	—	—	pH 7.4, 37 °C	PMID 17531949	Open record: flavin-containing monooxygenase 3 (FMO3) variant E158K/E308G, methyl 4-methylphenyl sulfide
flavin-containing monooxygenase 3 (FMO3)variant E158K/E308G	Homo sapiens	methyl 4-methylphenyl sulfideapparent Km	—	0.301	—	pH 7.4, 37 °C	PMID 17531949	Open record: flavin-containing monooxygenase 3 (FMO3) variant E158K/E308G, methyl 4-methylphenyl sulfide
flavin-containing monooxygenase 3 (FMO3)variant E158K/E308G	Homo sapiens	trimethylaminekcat per FAD	0.5	—	—	pH 7.4, 37 °C	PMID 17531949	Open record: flavin-containing monooxygenase 3 (FMO3) variant E158K/E308G, trimethylamine
flavin-containing monooxygenase 3 (FMO3)variant E158K/E308G	Homo sapiens	trimethylamineapparent Km	—	0.022	—	pH 7.4, 37 °C	PMID 17531949	Open record: flavin-containing monooxygenase 3 (FMO3) variant E158K/E308G, trimethylamine
flavin-containing monooxygenase 3 (FMO3)variant E308G	Homo sapiens	benzydaminekcat per FAD	0.55	—	—	pH 7.4, 37 °C	PMID 17531949	Open record: flavin-containing monooxygenase 3 (FMO3) variant E308G, benzydamine
flavin-containing monooxygenase 3 (FMO3)variant E308G	Homo sapiens	benzydamineapparent Km	—	0.039	—	pH 7.4, 37 °C	PMID 17531949	Open record: flavin-containing monooxygenase 3 (FMO3) variant E308G, benzydamine
flavin-containing monooxygenase 3 (FMO3)variant E308G	Homo sapiens	benzydamineTable 2	0.0033	0.0345	0.097 calc.	pH 7.4, 37 °C	PMID 33152328	Open record: flavin-containing monooxygenase 3 (FMO3) variant E308G, benzydamine
flavin-containing monooxygenase 3 (FMO3)variant E308G	Homo sapiens	benzydamineC-terminally truncated FMO3 (tr-FMO3); Table 2	0.0078	0.0397	0.20 calc.	pH 7.4, 37 °C	PMID 33152328	Open record: flavin-containing monooxygenase 3 (FMO3) variant E308G, benzydamine
flavin-containing monooxygenase 3 (FMO3)variant E308G	Homo sapiens	benzydamineTable 5	—	—	0.1	pH 7.4, 37 °C	PMID 33152328	Open record: flavin-containing monooxygenase 3 (FMO3) variant E308G, benzydamine
flavin-containing monooxygenase 3 (FMO3)variant E308G	Homo sapiens	benzydamineC-terminally truncated FMO3 (tr-FMO3); Table 5	—	—	0.2	pH 7.4, 37 °C	PMID 33152328	Open record: flavin-containing monooxygenase 3 (FMO3) variant E308G, benzydamine
flavin-containing monooxygenase 3 (FMO3)variant E308G	Homo sapiens	methyl 4-methylphenyl sulfidekcat per FAD	0.3	—	—	pH 7.4, 37 °C	PMID 17531949	Open record: flavin-containing monooxygenase 3 (FMO3) variant E308G, methyl 4-methylphenyl sulfide
flavin-containing monooxygenase 3 (FMO3)variant E308G	Homo sapiens	methyl 4-methylphenyl sulfideapparent Km	—	0.219	—	pH 7.4, 37 °C	PMID 17531949	Open record: flavin-containing monooxygenase 3 (FMO3) variant E308G, methyl 4-methylphenyl sulfide
flavin-containing monooxygenase 3 (FMO3)variant E308G	Homo sapiens	sulindac sulfideTable 4	0.0062	0.0101	0.61 calc.	pH 7.4, 37 °C	PMID 33152328	Open record: flavin-containing monooxygenase 3 (FMO3) variant E308G, sulindac sulfide
flavin-containing monooxygenase 3 (FMO3)variant E308G	Homo sapiens	sulindac sulfideC-terminally truncated FMO3 (tr-FMO3); Table 4	0.0148	0.0103	1.40 calc.	pH 7.4, 37 °C	PMID 33152328	Open record: flavin-containing monooxygenase 3 (FMO3) variant E308G, sulindac sulfide
flavin-containing monooxygenase 3 (FMO3)variant E308G	Homo sapiens	sulindac sulfideTable 5	—	—	0.67	pH 7.4, 37 °C	PMID 33152328	Open record: flavin-containing monooxygenase 3 (FMO3) variant E308G, sulindac sulfide
flavin-containing monooxygenase 3 (FMO3)variant E308G	Homo sapiens	sulindac sulfideC-terminally truncated FMO3 (tr-FMO3); Table 5	—	—	1.5	pH 7.4, 37 °C	PMID 33152328	Open record: flavin-containing monooxygenase 3 (FMO3) variant E308G, sulindac sulfide
flavin-containing monooxygenase 3 (FMO3)variant E308G	Homo sapiens	tamoxifenTable 3	0.0102	0.0029	3.5 calc.	pH 7.4, 37 °C	PMID 33152328	Open record: flavin-containing monooxygenase 3 (FMO3) variant E308G, tamoxifen
flavin-containing monooxygenase 3 (FMO3)variant E308G	Homo sapiens	tamoxifenTable 5	—	—	3.5	pH 7.4, 37 °C	PMID 33152328	Open record: flavin-containing monooxygenase 3 (FMO3) variant E308G, tamoxifen
flavin-containing monooxygenase 3 (FMO3)variant E308G	Homo sapiens	trimethylaminekcat per FAD	0.3	—	—	pH 7.4, 37 °C	PMID 17531949	Open record: flavin-containing monooxygenase 3 (FMO3) variant E308G, trimethylamine
flavin-containing monooxygenase 3 (FMO3)variant E308G	Homo sapiens	trimethylamineapparent Km	—	0.029	—	pH 7.4, 37 °C	PMID 17531949	Open record: flavin-containing monooxygenase 3 (FMO3) variant E308G, trimethylamine
flavin-containing monooxygenase 3 (FMO3)variant N61S	Homo sapiens	benzydaminekcat per FAD	0.045	—	—	pH 7.4, 37 °C	PMID 17531949	Open record: flavin-containing monooxygenase 3 (FMO3) variant N61S, benzydamine
flavin-containing monooxygenase 3 (FMO3)variant N61S	Homo sapiens	benzydamineapparent Km	—	0.335	—	pH 7.4, 37 °C	PMID 17531949	Open record: flavin-containing monooxygenase 3 (FMO3) variant N61S, benzydamine
flavin-containing monooxygenase 3 (FMO3)variant N61S	Homo sapiens	methyl 4-methylphenyl sulfidekcat per FAD	0.018	—	—	pH 7.4, 37 °C	PMID 17531949	Open record: flavin-containing monooxygenase 3 (FMO3) variant N61S, methyl 4-methylphenyl sulfide
flavin-containing monooxygenase 3 (FMO3)variant N61S	Homo sapiens	methyl 4-methylphenyl sulfideapparent Km	—	0.264	—	pH 7.4, 37 °C	PMID 17531949	Open record: flavin-containing monooxygenase 3 (FMO3) variant N61S, methyl 4-methylphenyl sulfide
flavin-containing monooxygenase 3 (FMO3)variant N61S	Homo sapiens	trimethylaminekcat per FAD	0.092	—	—	pH 7.4, 37 °C	PMID 17531949	Open record: flavin-containing monooxygenase 3 (FMO3) variant N61S, trimethylamine
flavin-containing monooxygenase 3 (FMO3)variant N61S	Homo sapiens	trimethylamineapparent Km	—	0.205	—	pH 7.4, 37 °C	PMID 17531949	Open record: flavin-containing monooxygenase 3 (FMO3) variant N61S, trimethylamine
flavin-containing monooxygenase 3 (FMO3)variant P153L	Homo sapiens	benzydaminekcat per FAD	0.057	—	—	pH 7.4, 37 °C	PMID 17531949	Open record: flavin-containing monooxygenase 3 (FMO3) variant P153L, benzydamine
flavin-containing monooxygenase 3 (FMO3)variant P153L	Homo sapiens	benzydamineapparent Km	—	0.073	—	pH 7.4, 37 °C	PMID 17531949	Open record: flavin-containing monooxygenase 3 (FMO3) variant P153L, benzydamine
flavin-containing monooxygenase 3 (FMO3)variant P153L	Homo sapiens	methyl 4-methylphenyl sulfidekcat per FAD	0.15	—	—	pH 7.4, 37 °C	PMID 17531949	Open record: flavin-containing monooxygenase 3 (FMO3) variant P153L, methyl 4-methylphenyl sulfide
flavin-containing monooxygenase 3 (FMO3)variant P153L	Homo sapiens	methyl 4-methylphenyl sulfideapparent Km	—	0.242	—	pH 7.4, 37 °C	PMID 17531949	Open record: flavin-containing monooxygenase 3 (FMO3) variant P153L, methyl 4-methylphenyl sulfide
flavin-containing monooxygenase 3 (FMO3)variant P153L	Homo sapiens	trimethylaminekcat per FAD	0.033	—	—	pH 7.4, 37 °C	PMID 17531949	Open record: flavin-containing monooxygenase 3 (FMO3) variant P153L, trimethylamine
flavin-containing monooxygenase 3 (FMO3)variant P153L	Homo sapiens	trimethylamineapparent Km	—	0.03	—	pH 7.4, 37 °C	PMID 17531949	Open record: flavin-containing monooxygenase 3 (FMO3) variant P153L, trimethylamine
flavin-containing monooxygenase 3 (FMO3)variant V257M	Homo sapiens	benzydaminekcat per FAD	0.43	—	—	pH 7.4, 37 °C	PMID 17531949	Open record: flavin-containing monooxygenase 3 (FMO3) variant V257M, benzydamine
flavin-containing monooxygenase 3 (FMO3)variant V257M	Homo sapiens	benzydamineapparent Km	—	0.121	—	pH 7.4, 37 °C	PMID 17531949	Open record: flavin-containing monooxygenase 3 (FMO3) variant V257M, benzydamine
flavin-containing monooxygenase 3 (FMO3)variant V257M	Homo sapiens	benzydamineTable 2	0.0505	0.0373	1.35 calc.	pH 7.4, 37 °C	PMID 33152328	Open record: flavin-containing monooxygenase 3 (FMO3) variant V257M, benzydamine
flavin-containing monooxygenase 3 (FMO3)variant V257M	Homo sapiens	benzydamineC-terminally truncated FMO3 (tr-FMO3); Table 2	0.0583	0.038	1.5 calc.	pH 7.4, 37 °C	PMID 33152328	Open record: flavin-containing monooxygenase 3 (FMO3) variant V257M, benzydamine
flavin-containing monooxygenase 3 (FMO3)variant V257M	Homo sapiens	benzydamineTable 5	—	—	1.3	pH 7.4, 37 °C	PMID 33152328	Open record: flavin-containing monooxygenase 3 (FMO3) variant V257M, benzydamine
flavin-containing monooxygenase 3 (FMO3)variant V257M	Homo sapiens	benzydamineC-terminally truncated FMO3 (tr-FMO3); Table 5	—	—	1.5	pH 7.4, 37 °C	PMID 33152328	Open record: flavin-containing monooxygenase 3 (FMO3) variant V257M, benzydamine
flavin-containing monooxygenase 3 (FMO3)variant V257M	Homo sapiens	methyl 4-methylphenyl sulfidekcat per FAD	0.083	—	—	pH 7.4, 37 °C	PMID 17531949	Open record: flavin-containing monooxygenase 3 (FMO3) variant V257M, methyl 4-methylphenyl sulfide
flavin-containing monooxygenase 3 (FMO3)variant V257M	Homo sapiens	methyl 4-methylphenyl sulfideapparent Km	—	0.207	—	pH 7.4, 37 °C	PMID 17531949	Open record: flavin-containing monooxygenase 3 (FMO3) variant V257M, methyl 4-methylphenyl sulfide
flavin-containing monooxygenase 3 (FMO3)variant V257M	Homo sapiens	sulindac sulfideTable 4	0.0068	0.0143	0.48 calc.	pH 7.4, 37 °C	PMID 33152328	Open record: flavin-containing monooxygenase 3 (FMO3) variant V257M, sulindac sulfide
flavin-containing monooxygenase 3 (FMO3)variant V257M	Homo sapiens	sulindac sulfideC-terminally truncated FMO3 (tr-FMO3); Table 4	0.0183	0.0103	1.78 calc.	pH 7.4, 37 °C	PMID 33152328	Open record: flavin-containing monooxygenase 3 (FMO3) variant V257M, sulindac sulfide
flavin-containing monooxygenase 3 (FMO3)variant V257M	Homo sapiens	sulindac sulfideTable 5	—	—	0.5	pH 7.4, 37 °C	PMID 33152328	Open record: flavin-containing monooxygenase 3 (FMO3) variant V257M, sulindac sulfide
flavin-containing monooxygenase 3 (FMO3)variant V257M	Homo sapiens	sulindac sulfideC-terminally truncated FMO3 (tr-FMO3); Table 5	—	—	1.8	pH 7.4, 37 °C	PMID 33152328	Open record: flavin-containing monooxygenase 3 (FMO3) variant V257M, sulindac sulfide
flavin-containing monooxygenase 3 (FMO3)variant V257M	Homo sapiens	tamoxifenTable 3	0.0142	0.0071	2.0 calc.	pH 7.4, 37 °C	PMID 33152328	Open record: flavin-containing monooxygenase 3 (FMO3) variant V257M, tamoxifen
flavin-containing monooxygenase 3 (FMO3)variant V257M	Homo sapiens	tamoxifenTable 5	—	—	2	pH 7.4, 37 °C	PMID 33152328	Open record: flavin-containing monooxygenase 3 (FMO3) variant V257M, tamoxifen
flavin-containing monooxygenase 3 (FMO3)variant V257M	Homo sapiens	trimethylaminekcat per FAD	0.55	—	—	pH 7.4, 37 °C	PMID 17531949	Open record: flavin-containing monooxygenase 3 (FMO3) variant V257M, trimethylamine
flavin-containing monooxygenase 3 (FMO3)variant V257M	Homo sapiens	trimethylamineapparent Km	—	0.027	—	pH 7.4, 37 °C	PMID 17531949	Open record: flavin-containing monooxygenase 3 (FMO3) variant V257M, trimethylamine
flavin-containing monooxygenase 3 (hFMO3)	Homo sapiens	Clomiphene	0.0012	0.0183	0.067	pH 7.4, 37 °C	PMID 29959872	Open record: flavin-containing monooxygenase 3 (hFMO3), Clomiphene
flavin-containing monooxygenase 3 (hFMO3)	Homo sapiens	GSK5182	0.037	0.00982	3.7	pH 7.4, 37 °C	PMID 29959872	Open record: flavin-containing monooxygenase 3 (hFMO3), GSK5182
flavin-containing monooxygenase 3 (hFMO3)	Homo sapiens	Tamoxifen	0.0188	0.0064	3	pH 7.4, 37 °C	PMID 29959872	Open record: flavin-containing monooxygenase 3 (hFMO3), Tamoxifen
flavin-containing monooxygenase 3 (hFMO3)variant E158K	Homo sapiens	Clomiphene	0.001	0.02046	0.05	pH 7.4, 37 °C	PMID 29959872	Open record: flavin-containing monooxygenase 3 (hFMO3) variant E158K, Clomiphene
flavin-containing monooxygenase 3 (hFMO3)variant E158K	Homo sapiens	GSK5182	0.0193	0.00457	4.2	pH 7.4, 37 °C	PMID 29959872	Open record: flavin-containing monooxygenase 3 (hFMO3) variant E158K, GSK5182
flavin-containing monooxygenase 3 (hFMO3)variant E158K	Homo sapiens	Tamoxifen	0.0075	0.00156	4.8	pH 7.4, 37 °C	PMID 29959872	Open record: flavin-containing monooxygenase 3 (hFMO3) variant E158K, Tamoxifen
flavin-containing monooxygenase 3 (hFMO3)variant E308G	Homo sapiens	Clomiphene	0.0042	0.0444	0.1	pH 7.4, 37 °C	PMID 29959872	Open record: flavin-containing monooxygenase 3 (hFMO3) variant E308G, Clomiphene
flavin-containing monooxygenase 3 (hFMO3)variant E308G	Homo sapiens	GSK5182	0.02	0.00587	3.3	pH 7.4, 37 °C	PMID 29959872	Open record: flavin-containing monooxygenase 3 (hFMO3) variant E308G, GSK5182
flavin-containing monooxygenase 3 (hFMO3)variant E308G	Homo sapiens	Tamoxifen	0.0063	0.0025	2.5	pH 7.4, 37 °C	PMID 29959872	Open record: flavin-containing monooxygenase 3 (hFMO3) variant E308G, Tamoxifen
flavin-containing monooxygenase 3 (hFMO3)variant V257M	Homo sapiens	Clomiphene	0.005	0.0332	0.15	pH 7.4, 37 °C	PMID 29959872	Open record: flavin-containing monooxygenase 3 (hFMO3) variant V257M, Clomiphene
flavin-containing monooxygenase 3 (hFMO3)variant V257M	Homo sapiens	GSK5182	0.0948	0.0285	3.2	pH 7.4, 37 °C	PMID 29959872	Open record: flavin-containing monooxygenase 3 (hFMO3) variant V257M, GSK5182
flavin-containing monooxygenase 3 (hFMO3)variant V257M	Homo sapiens	Tamoxifen	0.01	0.0081	1.2	pH 7.4, 37 °C	PMID 29959872	Open record: flavin-containing monooxygenase 3 (hFMO3) variant V257M, Tamoxifen
flavin-containing monooxygenase isoform 2 (FMO2.1)	Homo sapiens	methyl p-tolyl sulfide	0.705	0.0135	55	pH 9, 37 °C	PMID 19420133	Open record: flavin-containing monooxygenase isoform 2 (FMO2.1), methyl p-tolyl sulfide
flavin-containing monooxygenase isoform 2 (FMO2.1)	Homo sapiens	NADPH	0.393	0.0115	113	pH 9, 37 °C	PMID 19420133	Open record: flavin-containing monooxygenase isoform 2 (FMO2.1), NADPH
flavin-containing monooxygenase isoform 2 (FMO2.1)variant N413K	Homo sapiens	methyl p-tolyl sulfide	1.185	0.0048	248	pH 9, 37 °C	PMID 19420133	Open record: flavin-containing monooxygenase isoform 2 (FMO2.1) variant N413K, methyl p-tolyl sulfide
flavin-containing monooxygenase isoform 2 (FMO2.1)variant N413K	Homo sapiens	NADPH	1.573	0.0068	240	pH 9, 37 °C	PMID 19420133	Open record: flavin-containing monooxygenase isoform 2 (FMO2.1) variant N413K, NADPH
flavin-containing monooxygenase isoform 2 (FMO2.1)variant S195L	Homo sapiens	methyl p-tolyl sulfide	0.167	0.005	37	pH 9, 37 °C	PMID 19420133	Open record: flavin-containing monooxygenase isoform 2 (FMO2.1) variant S195L, methyl p-tolyl sulfide
flavin-containing monooxygenase isoform 2 (FMO2.1)variant S195L	Homo sapiens	NADPH	0.253	0.132	2.3	pH 9, 37 °C	PMID 19420133	Open record: flavin-containing monooxygenase isoform 2 (FMO2.1) variant S195L, NADPH
FMO1	Homo sapiens	4′-formylacetanilide thiosemicarbazone	0.0847	0.0063	13.23	pH 8.5, 37 °C	PMID 18948378	Open record: FMO1, 4′-formylacetanilide thiosemicarbazone
FMO1	Homo sapiens	fenthion	—	0.0027	—	pH 7.4, 37 °C	PMID 18845175	Open record: FMO1, fenthion
FMO1	Homo sapiens	methimazole	0.0378	0.00808	4.685	pH 8.5	PMID 18948378	Open record: FMO1, methimazole
FMO2.1	Homo sapiens	4′-formylacetanilide thiosemicarbazone	1.335	0.0058	237.6	pH 9.5, 37 °C	PMID 18948378	Open record: FMO2.1, 4′-formylacetanilide thiosemicarbazone
FMO2.1	Homo sapiens	methimazole	0.525	0.5757	0.913	pH 9.5	PMID 18948378	Open record: FMO2.1, methimazole
FMO3	Homo sapiens	4′-formylacetanilide thiosemicarbazone	0.0228	0.00701	3.27	pH 8.5, 37 °C	PMID 18948378	Open record: FMO3, 4′-formylacetanilide thiosemicarbazone
FMO3	Homo sapiens	fenthion	—	0.039	—	pH 7.4, 37 °C	PMID 18845175	Open record: FMO3, fenthion
FMO3	Homo sapiens	methimazole	0.0433	0.0293	1.495	pH 8.5	PMID 18948378	Open record: FMO3, methimazole
FMO3 (flavin-containing monooxygenase 3)	Homo sapiens	ethylenethiourea	0.605	0.0557	10.8	pH 8.5	PMID 17050781	Open record: FMO3 (flavin-containing monooxygenase 3), ethylenethiourea
FMO3 (flavin-containing monooxygenase 3)	Homo sapiens	methimazole	2.063	0.0718	28.7	pH 8.5	PMID 17050781	Open record: FMO3 (flavin-containing monooxygenase 3), methimazole
FMO3 (flavin-containing monooxygenase 3)	Homo sapiens	sulindac	0.78	0.1501	5.2	pH 8.5	PMID 17050781	Open record: FMO3 (flavin-containing monooxygenase 3), sulindac
FMO3 (flavin-containing monooxygenase 3)	Homo sapiens	trimethylamine	0.562	0.0209	26.8	pH 8.5	PMID 17050781	Open record: FMO3 (flavin-containing monooxygenase 3), trimethylamine
FMO3 (flavin-containing monooxygenase 3)variant E24D	Homo sapiens	ethylenethiourea	0.835	0.0761	11	pH 8.5	PMID 17050781	Open record: FMO3 (flavin-containing monooxygenase 3) variant E24D, ethylenethiourea
FMO3 (flavin-containing monooxygenase 3)variant E24D	Homo sapiens	methimazole	3.663	0.0854	42.8	pH 8.5	PMID 17050781	Open record: FMO3 (flavin-containing monooxygenase 3) variant E24D, methimazole
FMO3 (flavin-containing monooxygenase 3)variant E24D	Homo sapiens	sulindac	0.727	0.1208	6	pH 8.5	PMID 17050781	Open record: FMO3 (flavin-containing monooxygenase 3) variant E24D, sulindac
FMO3 (flavin-containing monooxygenase 3)variant E24D	Homo sapiens	trimethylamine	1.082	0.0228	47.5	pH 8.5	PMID 17050781	Open record: FMO3 (flavin-containing monooxygenase 3) variant E24D, trimethylamine
FMO3 (flavin-containing monooxygenase 3)variant K416N	Homo sapiens	ethylenethiourea	0.703	0.0502	14	pH 8.5	PMID 17050781	Open record: FMO3 (flavin-containing monooxygenase 3) variant K416N, ethylenethiourea
FMO3 (flavin-containing monooxygenase 3)variant K416N	Homo sapiens	methimazole	0.78	0.0773	10.2	pH 8.5	PMID 17050781	Open record: FMO3 (flavin-containing monooxygenase 3) variant K416N, methimazole
FMO3 (flavin-containing monooxygenase 3)variant K416N	Homo sapiens	sulindac	1.14	0.0665	17.2	pH 8.5	PMID 17050781	Open record: FMO3 (flavin-containing monooxygenase 3) variant K416N, sulindac
FMO3 (flavin-containing monooxygenase 3)variant K416N	Homo sapiens	trimethylamine	0.85	0.0373	22.8	pH 8.5	PMID 17050781	Open record: FMO3 (flavin-containing monooxygenase 3) variant K416N, trimethylamine
FMO3 (flavin-containing monooxygenase 3)variant N61K	Homo sapiens	methimazole	0.072	0.1233	0.67	pH 8.5	PMID 17050781	Open record: FMO3 (flavin-containing monooxygenase 3) variant N61K, methimazole
FMO3 (flavin-containing monooxygenase 3)variant N61K	Homo sapiens	sulindac	0.048	0.2071	0.17	pH 8.5	PMID 17050781	Open record: FMO3 (flavin-containing monooxygenase 3) variant N61K, sulindac
FMO5	Homo sapiens	fenthion	—	0.249	—	pH 7.4, 37 °C	PMID 18845175	Open record: FMO5, fenthion
hFMO1	Homo sapiens	ethionamide	1.498	0.105	14.3	pH 9.5, 37 °C	PMID 18930751	Open record: hFMO1, ethionamide
hFMO2	Homo sapiens	ethionamide	0.805	0.261	3.2	pH 9.5, 37 °C	PMID 18930751	Open record: hFMO2, ethionamide
hFMO3	Homo sapiens	ethionamide	0.973	0.336	2.8	pH 9.5, 37 °C	PMID 18930751	Open record: hFMO3, ethionamide
mFmo1	Mus musculus	ethionamide	4.52	0.104	43.7	pH 9.5, 37 °C	PMID 18930751	Open record: mFmo1, ethionamide
mFmo3	Mus musculus	ethionamide	1.01	0.114	8.8	pH 9.5, 37 °C	PMID 18930751	Open record: mFmo3, ethionamide