Values CatLog read from this paper
Leucine 208 in human histamine N-methyltransferase emerges as a hotspot for protein stability rationalizing the role of the L208P variant in intellectual disability
PMID 27769936doi:10.1016/j.bbadis.2016.10.005Open in Browse
The paper itself is not on this site: read it at the publisher. This page lists only the values CatLog read from it.
CatLog read 7 records (11 values) from this paper: histamine N-methyltransferase from Homo sapiens.
Read from the paper by an AI model and checked against the paper by a second, separate AI run; code converted the units. Values are in CatLog's units; each record opens in Browse with the line the paper prints and the checks. CatLog calculated the 4 kcat/Km values marked “calc.” from kcat and Km; no printed kcat/Km was read for those records.
| Enzyme | Organism | Substrate | kcat (s⁻¹) | Km (mM) | kcat/Km (mM⁻¹ s⁻¹) | Conditions | Open record |
|---|---|---|---|---|---|---|---|
| histamine N-methyltransferase | Homo sapiens | histamine | — | 0.0019 | — | pH 8, 25 °C | Open record: histamine N-methyltransferase, histamine |
| histamine N-methyltransferase | Homo sapiens | S-adenosylmethionine | 0.61 | 0.0041 | 150 calc. | pH 8, 25 °C | Open record: histamine N-methyltransferase, S-adenosylmethionine |
| histamine N-methyltransferasevariant L208F | Homo sapiens | histamine | — | 0.0034 | — | pH 8, 25 °C | Open record: histamine N-methyltransferase variant L208F, histamine |
| histamine N-methyltransferasevariant L208F | Homo sapiens | S-adenosylmethionine | 0.11 | 0.0124 | 8.9 calc. | pH 8, 25 °C | Open record: histamine N-methyltransferase variant L208F, S-adenosylmethionine |
| histamine N-methyltransferasevariant L208K | Homo sapiens | S-adenosylmethionine | 0.03 | 0.015 | 2.0 calc. | pH 8, 25 °C | Open record: histamine N-methyltransferase variant L208K, S-adenosylmethionine |
| histamine N-methyltransferasevariant L208V | Homo sapiens | histamine | — | 0.0011 | — | pH 8, 25 °C | Open record: histamine N-methyltransferase variant L208V, histamine |
| histamine N-methyltransferasevariant L208V | Homo sapiens | S-adenosylmethionine | 0.23 | 0.0068 | 34 calc. | pH 8, 25 °C | Open record: histamine N-methyltransferase variant L208V, S-adenosylmethionine |