CatLogenzyme kinetics catalog

Values CatLog read from this paper

Molecular mechanisms of isocitrate dehydrogenase 1 (IDH1) mutations identified in tumors: The role of size and hydrophobicity at residue 132 on catalytic efficiency

PMID 28330869doi:10.1074/jbc.m117.776179Open in Browse

The paper itself is not on this site: read it at the publisher. This page lists only the values CatLog read from it.

CatLog read 115 records (115 values) from this paper: isocitrate dehydrogenase 1 (IDH1) from Homo sapiens.

Read from the paper by an AI model and checked against the paper by a second, separate AI run; code converted the units. Values are in CatLog's units; each record opens in Browse with the line the paper prints and the checks.

EC 1.1.1.42

EnzymeOrganismSubstratekcat (s⁻¹)Km (mM)kcat/Km (mM⁻¹ s⁻¹)Conditions
isocitrate dehydrogenase 1 (IDH1)Homo sapiensalpha-ketoglutarate0.019——pH 7.5, 37 °COpen
isocitrate dehydrogenase 1 (IDH1)Homo sapiensalpha-ketoglutarate—0.5—pH 7.5, 37 °COpen
isocitrate dehydrogenase 1 (IDH1)Homo sapiensalpha-ketoglutarate——0.04pH 7.5, 37 °COpen
isocitrate dehydrogenase 1 (IDH1)Homo sapiensbeta-nicotinamide adenine dinucleotide phosphate—0.08—pH 7.5, 37 °COpen
isocitrate dehydrogenase 1 (IDH1)Homo sapiensbeta-nicotinamide adenine dinucleotide phosphate—0.03—pH 7.5, 21 °COpen
isocitrate dehydrogenase 1 (IDH1)Homo sapiensisocitrate85——pH 7.5, 37 °COpen
isocitrate dehydrogenase 1 (IDH1)Homo sapiensisocitrate—0.22—pH 7.5, 37 °COpen
isocitrate dehydrogenase 1 (IDH1)Homo sapiensisocitrate——390pH 7.5, 37 °COpen
isocitrate dehydrogenase 1 (IDH1)Homo sapiensisocitrate11——pH 7.5, 21 °COpen
isocitrate dehydrogenase 1 (IDH1)Homo sapiensisocitrate—0.015—pH 7.5, 21 °COpen
isocitrate dehydrogenase 1 (IDH1)Homo sapiensisocitrate——730pH 7.5, 21 °COpen
isocitrate dehydrogenase 1 (IDH1)variant A134DHomo sapiensbeta-nicotinamide adenine dinucleotide phosphate—1.2—pH 7.5, 37 °COpen
isocitrate dehydrogenase 1 (IDH1)variant A134DHomo sapiensbeta-nicotinamide adenine dinucleotide phosphate—0.7—pH 7.5, 21 °COpen
isocitrate dehydrogenase 1 (IDH1)variant A134DHomo sapiensisocitrate2.3——pH 7.5, 37 °COpen
isocitrate dehydrogenase 1 (IDH1)variant A134DHomo sapiensisocitrate—8—pH 7.5, 37 °COpen
isocitrate dehydrogenase 1 (IDH1)variant A134DHomo sapiensisocitrate——0.29pH 7.5, 37 °COpen
isocitrate dehydrogenase 1 (IDH1)variant A134DHomo sapiensisocitrate0.2——pH 7.5, 21 °COpen
isocitrate dehydrogenase 1 (IDH1)variant A134DHomo sapiensisocitrate—2.7—pH 7.5, 21 °COpen
isocitrate dehydrogenase 1 (IDH1)variant A134DHomo sapiensisocitrate——0.074pH 7.5, 21 °COpen
isocitrate dehydrogenase 1 (IDH1)variant H133QHomo sapiensbeta-nicotinamide adenine dinucleotide phosphate—0.16—pH 7.5, 37 °COpen
isocitrate dehydrogenase 1 (IDH1)variant H133QHomo sapiensbeta-nicotinamide adenine dinucleotide phosphate—0.101—pH 7.5, 21 °COpen
isocitrate dehydrogenase 1 (IDH1)variant H133QHomo sapiensisocitrate45——pH 7.5, 37 °COpen
isocitrate dehydrogenase 1 (IDH1)variant H133QHomo sapiensisocitrate—0.4—pH 7.5, 37 °COpen
isocitrate dehydrogenase 1 (IDH1)variant H133QHomo sapiensisocitrate——110pH 7.5, 37 °COpen
isocitrate dehydrogenase 1 (IDH1)variant H133QHomo sapiensisocitrate9.4——pH 7.5, 21 °COpen
isocitrate dehydrogenase 1 (IDH1)variant H133QHomo sapiensisocitrate—0.28—pH 7.5, 21 °COpen
isocitrate dehydrogenase 1 (IDH1)variant H133QHomo sapiensisocitrate——35pH 7.5, 21 °COpen
isocitrate dehydrogenase 1 (IDH1)variant R100QHomo sapiensalpha-ketoglutarate0.34——pH 7.5, 37 °COpen
isocitrate dehydrogenase 1 (IDH1)variant R100QHomo sapiensalpha-ketoglutarate—12—pH 7.5, 37 °COpen
isocitrate dehydrogenase 1 (IDH1)variant R100QHomo sapiensalpha-ketoglutarate——0.028pH 7.5, 37 °COpen
isocitrate dehydrogenase 1 (IDH1)variant R100QHomo sapiensalpha-ketoglutarate0.128——pH 7.5, 21 °COpen
isocitrate dehydrogenase 1 (IDH1)variant R100QHomo sapiensalpha-ketoglutarate—10—pH 7.5, 21 °COpen
isocitrate dehydrogenase 1 (IDH1)variant R100QHomo sapiensalpha-ketoglutarate——0.013pH 7.5, 21 °COpen
isocitrate dehydrogenase 1 (IDH1)variant R100QHomo sapiensbeta-nicotinamide adenine dinucleotide phosphate—0.18—pH 7.5, 37 °COpen
isocitrate dehydrogenase 1 (IDH1)variant R100QHomo sapiensbeta-nicotinamide adenine dinucleotide phosphate—0.07—pH 7.5, 21 °COpen
isocitrate dehydrogenase 1 (IDH1)variant R100QHomo sapiensbeta-nicotinamide adenine dinucleotide phosphate, reduced—0.005—pH 7.5, 37 °COpen
isocitrate dehydrogenase 1 (IDH1)variant R100QHomo sapiensisocitrate5.6——pH 7.5, 37 °COpen
isocitrate dehydrogenase 1 (IDH1)variant R100QHomo sapiensisocitrate—8—pH 7.5, 37 °COpen
isocitrate dehydrogenase 1 (IDH1)variant R100QHomo sapiensisocitrate——0.7pH 7.5, 37 °COpen
isocitrate dehydrogenase 1 (IDH1)variant R100QHomo sapiensisocitrate1.4——pH 7.5, 21 °COpen
isocitrate dehydrogenase 1 (IDH1)variant R100QHomo sapiensisocitrate—9—pH 7.5, 21 °COpen
isocitrate dehydrogenase 1 (IDH1)variant R100QHomo sapiensisocitrate——0.16pH 7.5, 21 °COpen
isocitrate dehydrogenase 1 (IDH1)variant R132AHomo sapiensalpha-ketoglutarate0.37——pH 7.5, 37 °COpen
isocitrate dehydrogenase 1 (IDH1)variant R132AHomo sapiensalpha-ketoglutarate—0.11—pH 7.5, 37 °COpen
isocitrate dehydrogenase 1 (IDH1)variant R132AHomo sapiensalpha-ketoglutarate——3.4pH 7.5, 37 °COpen
isocitrate dehydrogenase 1 (IDH1)variant R132AHomo sapiensisocitrate10.4——pH 7.5, 37 °COpen
isocitrate dehydrogenase 1 (IDH1)variant R132AHomo sapiensisocitrate—5.7—pH 7.5, 37 °COpen
isocitrate dehydrogenase 1 (IDH1)variant R132AHomo sapiensisocitrate——1.8pH 7.5, 37 °COpen
isocitrate dehydrogenase 1 (IDH1)variant R132CHomo sapiensalpha-ketoglutarate1.6——pH 7.5, 37 °COpen
isocitrate dehydrogenase 1 (IDH1)variant R132CHomo sapiensalpha-ketoglutarate—0.36—pH 7.5, 37 °COpen
isocitrate dehydrogenase 1 (IDH1)variant R132CHomo sapiensalpha-ketoglutarate——4.4pH 7.5, 37 °COpen
isocitrate dehydrogenase 1 (IDH1)variant R132CHomo sapiensalpha-ketoglutarate0.84——pH 7.5, 21 °COpen
isocitrate dehydrogenase 1 (IDH1)variant R132CHomo sapiensalpha-ketoglutarate—0.36—pH 7.5, 21 °COpen
isocitrate dehydrogenase 1 (IDH1)variant R132CHomo sapiensalpha-ketoglutarate——2.3pH 7.5, 21 °COpen
isocitrate dehydrogenase 1 (IDH1)variant R132CHomo sapiensbeta-nicotinamide adenine dinucleotide phosphate—0.75—pH 7.5, 37 °COpen
isocitrate dehydrogenase 1 (IDH1)variant R132CHomo sapiensbeta-nicotinamide adenine dinucleotide phosphate—0.58—pH 7.5, 21 °COpen
isocitrate dehydrogenase 1 (IDH1)variant R132CHomo sapiensbeta-nicotinamide adenine dinucleotide phosphate, reduced—0.01—pH 7.5, 37 °COpen
isocitrate dehydrogenase 1 (IDH1)variant R132CHomo sapiensisocitrate4.4——pH 7.5, 37 °COpen
isocitrate dehydrogenase 1 (IDH1)variant R132CHomo sapiensisocitrate—8.2—pH 7.5, 37 °COpen
isocitrate dehydrogenase 1 (IDH1)variant R132CHomo sapiensisocitrate——0.54pH 7.5, 37 °COpen
isocitrate dehydrogenase 1 (IDH1)variant R132CHomo sapiensisocitrate1.61——pH 7.5, 21 °COpen
isocitrate dehydrogenase 1 (IDH1)variant R132CHomo sapiensisocitrate—5.3—pH 7.5, 21 °COpen
isocitrate dehydrogenase 1 (IDH1)variant R132CHomo sapiensisocitrate——0.3pH 7.5, 21 °COpen
isocitrate dehydrogenase 1 (IDH1)variant R132GHomo sapiensalpha-ketoglutarate1.59——pH 7.5, 37 °COpen
isocitrate dehydrogenase 1 (IDH1)variant R132GHomo sapiensalpha-ketoglutarate—0.34—pH 7.5, 37 °COpen
isocitrate dehydrogenase 1 (IDH1)variant R132GHomo sapiensalpha-ketoglutarate——5pH 7.5, 37 °COpen
isocitrate dehydrogenase 1 (IDH1)variant R132GHomo sapiensalpha-ketoglutarate0.45——pH 7.5, 21 °COpen
isocitrate dehydrogenase 1 (IDH1)variant R132GHomo sapiensalpha-ketoglutarate—0.3—pH 7.5, 21 °COpen
isocitrate dehydrogenase 1 (IDH1)variant R132GHomo sapiensalpha-ketoglutarate——1.5pH 7.5, 21 °COpen
isocitrate dehydrogenase 1 (IDH1)variant R132GHomo sapiensbeta-nicotinamide adenine dinucleotide phosphate—0.067—pH 7.5, 37 °COpen
isocitrate dehydrogenase 1 (IDH1)variant R132GHomo sapiensbeta-nicotinamide adenine dinucleotide phosphate—0.14—pH 7.5, 21 °COpen
isocitrate dehydrogenase 1 (IDH1)variant R132GHomo sapiensisocitrate9.3——pH 7.5, 37 °COpen
isocitrate dehydrogenase 1 (IDH1)variant R132GHomo sapiensisocitrate—7—pH 7.5, 37 °COpen
isocitrate dehydrogenase 1 (IDH1)variant R132GHomo sapiensisocitrate——1.3pH 7.5, 37 °COpen
isocitrate dehydrogenase 1 (IDH1)variant R132GHomo sapiensisocitrate1——pH 7.5, 21 °COpen
isocitrate dehydrogenase 1 (IDH1)variant R132GHomo sapiensisocitrate—3.6—pH 7.5, 21 °COpen
isocitrate dehydrogenase 1 (IDH1)variant R132GHomo sapiensisocitrate——0.28pH 7.5, 21 °COpen
isocitrate dehydrogenase 1 (IDH1)variant R132HHomo sapiensalpha-ketoglutarate4.2——pH 7.5, 37 °COpen
isocitrate dehydrogenase 1 (IDH1)variant R132HHomo sapiensalpha-ketoglutarate—1.1—pH 7.5, 37 °COpen
isocitrate dehydrogenase 1 (IDH1)variant R132HHomo sapiensalpha-ketoglutarate——3.8pH 7.5, 37 °COpen
isocitrate dehydrogenase 1 (IDH1)variant R132HHomo sapiensalpha-ketoglutarate0.43——pH 7.5, 21 °COpen
isocitrate dehydrogenase 1 (IDH1)variant R132HHomo sapiensalpha-ketoglutarate—1.8—pH 7.5, 21 °COpen
isocitrate dehydrogenase 1 (IDH1)variant R132HHomo sapiensalpha-ketoglutarate——0.24pH 7.5, 21 °COpen
isocitrate dehydrogenase 1 (IDH1)variant R132HHomo sapiensbeta-nicotinamide adenine dinucleotide phosphate—1.6—pH 7.5, 37 °COpen
isocitrate dehydrogenase 1 (IDH1)variant R132HHomo sapiensbeta-nicotinamide adenine dinucleotide phosphate—1—pH 7.5, 21 °COpen
isocitrate dehydrogenase 1 (IDH1)variant R132HHomo sapiensisocitrate2.4——pH 7.5, 37 °COpen
isocitrate dehydrogenase 1 (IDH1)variant R132HHomo sapiensisocitrate—4.2—pH 7.5, 37 °COpen
isocitrate dehydrogenase 1 (IDH1)variant R132HHomo sapiensisocitrate——0.57pH 7.5, 37 °COpen
isocitrate dehydrogenase 1 (IDH1)variant R132HHomo sapiensisocitrate0.12——pH 7.5, 21 °COpen
isocitrate dehydrogenase 1 (IDH1)variant R132HHomo sapiensisocitrate—6—pH 7.5, 21 °COpen
isocitrate dehydrogenase 1 (IDH1)variant R132HHomo sapiensisocitrate——0.02pH 7.5, 21 °COpen
isocitrate dehydrogenase 1 (IDH1)variant R132KHomo sapiensalpha-ketoglutarate0.57——pH 7.5, 37 °COpen
isocitrate dehydrogenase 1 (IDH1)variant R132KHomo sapiensalpha-ketoglutarate—0.61—pH 7.5, 37 °COpen
isocitrate dehydrogenase 1 (IDH1)variant R132KHomo sapiensalpha-ketoglutarate——0.9pH 7.5, 37 °COpen
isocitrate dehydrogenase 1 (IDH1)variant R132KHomo sapiensisocitrate7.2——pH 7.5, 37 °COpen
isocitrate dehydrogenase 1 (IDH1)variant R132KHomo sapiensisocitrate—1.1—pH 7.5, 37 °COpen
isocitrate dehydrogenase 1 (IDH1)variant R132KHomo sapiensisocitrate——7pH 7.5, 37 °COpen
isocitrate dehydrogenase 1 (IDH1)variant R132NHomo sapiensalpha-ketoglutarate0.79——pH 7.5, 37 °COpen
isocitrate dehydrogenase 1 (IDH1)variant R132NHomo sapiensalpha-ketoglutarate—10—pH 7.5, 37 °COpen
isocitrate dehydrogenase 1 (IDH1)variant R132NHomo sapiensalpha-ketoglutarate——0.08pH 7.5, 37 °COpen
isocitrate dehydrogenase 1 (IDH1)variant R132NHomo sapiensisocitrate0.047——pH 7.5, 37 °COpen
isocitrate dehydrogenase 1 (IDH1)variant R132NHomo sapiensisocitrate—1.5—pH 7.5, 37 °COpen
isocitrate dehydrogenase 1 (IDH1)variant R132NHomo sapiensisocitrate——0.031pH 7.5, 37 °COpen
isocitrate dehydrogenase 1 (IDH1)variant R132QHomo sapiensalpha-ketoglutarate4.7——pH 7.5, 37 °COpen
isocitrate dehydrogenase 1 (IDH1)variant R132QHomo sapiensalpha-ketoglutarate—0.26—pH 7.5, 37 °COpen
isocitrate dehydrogenase 1 (IDH1)variant R132QHomo sapiensalpha-ketoglutarate——18pH 7.5, 37 °COpen
isocitrate dehydrogenase 1 (IDH1)variant R132QHomo sapiensisocitrate9.2——pH 7.5, 37 °COpen
isocitrate dehydrogenase 1 (IDH1)variant R132QHomo sapiensisocitrate—0.8—pH 7.5, 37 °COpen
isocitrate dehydrogenase 1 (IDH1)variant R132QHomo sapiensisocitrate——12pH 7.5, 37 °COpen
isocitrate dehydrogenase 1 (IDH1)variant R132WHomo sapiensalpha-ketoglutarate0.54——pH 7.5, 37 °COpen
isocitrate dehydrogenase 1 (IDH1)variant R132WHomo sapiensalpha-ketoglutarate—0.82—pH 7.5, 37 °COpen
isocitrate dehydrogenase 1 (IDH1)variant R132WHomo sapiensalpha-ketoglutarate——0.659pH 7.5, 37 °COpen
isocitrate dehydrogenase 1 (IDH1)variant R132WHomo sapiensisocitrate1.21——pH 7.5, 37 °COpen
isocitrate dehydrogenase 1 (IDH1)variant R132WHomo sapiensisocitrate—3.6—pH 7.5, 37 °COpen
isocitrate dehydrogenase 1 (IDH1)variant R132WHomo sapiensisocitrate——0.34pH 7.5, 37 °COpen