EC 1.1.1.42: isocitrate dehydrogenase (NADP+)

OxidoreductasesOpen in Browse

CatLog read 437 records for EC 1.1.1.42 from 31 papers, for 19 organisms. Names in these papers: isocitrate dehydrogenase 1 (IDH1), NADP-dependent isocitrate dehydrogenase (mitochondrial), NADP-dependent isocitrate dehydrogenase, IDH1 (isocitrate dehydrogenase 1) and 25 more.

Read from the paper by an AI model and checked against the paper by a second, separate AI run; code converted the units.

CatLog also holds 273 records for EC 1.1.1.42 that are not yet re-read: from its earlier version, built from the enzyme databases and partly checked against the papers. All records for EC 1.1.1.42 in Browse.

Papers

Papers with records for EC 1.1.1.42
Paper	Organisms	Records
Molecular mechanisms of isocitrate dehydrogenase 1 (IDH1) mutations identified in tumors: The role of size and hydrophobicity at residue 132 on catalytic efficiency	Homo sapiens	115
An acidic residue buried in the dimer interface of isocitrate dehydrogenase 1 (IDH1) helps regulate catalysis and pH sensitivity	Homo sapiens	33
Single arginine mutation in two yeast isocitrate dehydrogenases: biochemical characterization and functional implication	Homo sapiens, Saccharomyces cerevisiae and 1 more	26
Kinetic mechanism of Escherichia coli isocitrate dehydrogenase	Escherichia coli	21
Mutant IDH1 enhances the production of 2-hydroxyglutarate due to its kinetic mechanism	Homo sapiens	20
The kinetics of pig heart triphosphopyridine nucleotide-isocitrate dehydrogenase. I. Initial velocity, substrate and product inhibition, and isotope exchange studies	Sus scrofa	18
Critical role of Lys212 and Tyr140 in porcine NADP-dependent isocitrate dehydrogenase	Sus scrofa	16
Location of the coenzyme binding site in the porcine mitochondrial NADP-dependent isocitrate dehydrogenase	Sus scrofa	16
A highly active decarboxylating dehydrogenase with rationally inverted coenzyme specificity	Escherichia coli	16
Ligands of the Mn2+ bound to porcine mitochondrial NADP-dependent isocitrate dehydrogenase, as assessed by mutagenesis	Sus scrofa	14
Implication by site-directed mutagenesis of Arg314 and Tyr316 in the coenzyme site of pig mitochondrial NADP-dependent isocitrate dehydrogenase	Sus scrofa	13
Thr373, Asp375, and Lys260 are in the coenzyme site of porcine NADP-dependent isocitrate dehydrogenase	Sus scrofa	11
Mutational analysis of the catalytic residues lysine 230 and tyrosine 160 in the NADP(+)-dependent isocitrate dehydrogenase from Escherichia coli	Escherichia coli	11
Identification by mutagenesis of arginines in the substrate binding site of the porcine NADP-dependent isocitrate dehydrogenase	Sus scrofa	10
Evaluation by site-directed mutagenesis of aspartic acid residues in the metal site of pig heart NADP-dependent isocitrate dehydrogenase	Sus scrofa	10
Biochemical Characterization and Complete Conversion of Coenzyme Specificity of Isocitrate Dehydrogenase from Bifidobacterium longum	Bifidobacterium longum, Bifidobacterium longum subsp. infantis	10
Point mutation (R153H or R153C) in Escherichia coli isocitrate dehydrogenase: Biochemical characterization and functional implication	Escherichia coli	10
SIRT3 and GCN5L regulation of NADP+- and NADPH-driven reactions of mitochondrial isocitrate dehydrogenase IDH2	Homo sapiens	10
Thermal stability of isocitrate dehydrogenase from Archaeoglobus fulgidus studied by crystal structure analysis and engineering of chimers	Archaeoglobus fulgidus, Escherichia coli	8
Purification and characterization of a monomeric isocitrate dehydrogenase with dual coenzyme specificity from the photosynthetic bacterium Rhodomicrobium vannielii	Rhodomicrobium vannielii	8
Mutagenesis and Laue structures of enzyme intermediates: isocitrate dehydrogenase	—	8
Studies on the regulatory mechanism of isocitrate dehydrogenase 2 using acetylation mimics	Mus musculus	6
Control of the NADPH supply and GSH recycling for oxidative stress management in hepatoma and liver mitochondria	Rattus norvegicus	5
Enzymatic characterization of a monomeric isocitrate dehydrogenase from Streptomyces lividans TK54	Streptomyces lividans	4
Purification and characterization of isocitrate dehydrogenase from a hyperthermophilic archaebacterium, Caldococcus noboribetus	Caldococcus noboribetus	4
Isocitrate dehydrogenase of Plasmodium falciparum	Plasmodium falciparum	3
Characterization of two β-decarboxylating dehydrogenases from Sulfolobus acidocaldarius	Sulfolobus acidocaldarius	3
Cloning, sequence analysis, expression, and inactivation of the Corynebacterium glutamicum icd gene encoding isocitrate dehydrogenase and biochemical characterization of the enzyme	Corynebacterium glutamicum	3
Characterization of homoisocitrate dehydrogenase involved in lysine biosynthesis of an extremely thermophilic bacterium, Thermus thermophilus HB27, and evolutionary implication of…	Thermus thermophilus	2
Biochemical and molecular characterization of the isocitrate dehydrogenase with dual coenzyme specificity from the obligate methylotroph Methylobacillus Flagellatus	Methylobacillus flagellatus	2
Biochemical and molecular characterization of the NAD(+)-dependent isocitrate dehydrogenase from the chemolithotroph Acidithiobacillus thiooxidans	Acidithiobacillus thiooxidans	1

Records

Records for EC 1.1.1.42 read from the paper
Enzyme	Organism	Substrate	k_cat (s⁻¹)	K_m (mM)	k_cat/K_m (mM⁻¹ s⁻¹)	Conditions	Paper	Open record
IDH1 (HcIDH)	Homo sapiens	D-isocitrate	15.6	0.0057	2.7 × 10³	pH 8, 25 °C	PMID 25502799	Open record: IDH1 (HcIDH), D-isocitrate
IDH1 (HcIDH)	Homo sapiens	NADP+	—	0.0114	—	pH 8, 25 °C	PMID 25502799	Open record: IDH1 (HcIDH), NADP+
IDH1 (HcIDH)variant R132A	Homo sapiens	D-isocitrate	0.22	1.540	0.1	pH 8, 25 °C	PMID 25502799	Open record: IDH1 (HcIDH) variant R132A, D-isocitrate
IDH1 (HcIDH)variant R132A	Homo sapiens	NADP+	—	0.0181	—	pH 8, 25 °C	PMID 25502799	Open record: IDH1 (HcIDH) variant R132A, NADP+
IDH1 (HcIDH)variant R132H	Homo sapiens	alpha-ketoglutarate	0.24	0.1567	2	pH 8, 25 °C	PMID 25502799	Open record: IDH1 (HcIDH) variant R132H, alpha-ketoglutarate
IDH1 (HcIDH)variant R132H	Homo sapiens	D-isocitrate	0.41	2.282	0.2	pH 8, 25 °C	PMID 25502799	Open record: IDH1 (HcIDH) variant R132H, D-isocitrate
IDH1 (HcIDH)variant R132H	Homo sapiens	NADP+	—	0.0158	—	pH 8, 25 °C	PMID 25502799	Open record: IDH1 (HcIDH) variant R132H, NADP+
IDH1 (HcIDH)variant R132H	Homo sapiens	NADPH	—	0.0067	—	pH 8, 25 °C	PMID 25502799	Open record: IDH1 (HcIDH) variant R132H, NADPH
IDH1 (isocitrate dehydrogenase 1)variant G97D	Homo sapiens	isocitrate	0.968	0.296	3.3	pH 8	PMID 23731180	Open record: IDH1 (isocitrate dehydrogenase 1) variant G97D, isocitrate
IDH1 (isocitrate dehydrogenase 1)variant G97D	Homo sapiens	NADP+	—	4.6 × 10⁻⁴	2.1 × 10³	pH 8	PMID 23731180	Open record: IDH1 (isocitrate dehydrogenase 1) variant G97D, NADP+
IDH1 (isocitrate dehydrogenase 1)variant G97D	Homo sapiens	NADPH	0.0397	2.5 × 10⁻⁴	158.7	pH 8	PMID 23731180	Open record: IDH1 (isocitrate dehydrogenase 1) variant G97D, NADPH
IDH1 (isocitrate dehydrogenase 1)variant G97D	Homo sapiens	α-ketoglutarate	0.0542	0.218	0.25	pH 8	PMID 23731180	Open record: IDH1 (isocitrate dehydrogenase 1) variant G97D, α-ketoglutarate
IDH1 (isocitrate dehydrogenase 1)variant G97N	Homo sapiens	isocitrate	0.102	4.6 × 10⁻⁴	220	pH 8	PMID 23731180	Open record: IDH1 (isocitrate dehydrogenase 1) variant G97N, isocitrate
IDH1 (isocitrate dehydrogenase 1)variant G97N	Homo sapiens	NADP+	—	6 × 10⁻⁴	170	pH 8	PMID 23731180	Open record: IDH1 (isocitrate dehydrogenase 1) variant G97N, NADP+
IDH1 (isocitrate dehydrogenase 1)variant G97N	Homo sapiens	NADPH	0.0325	1.1 × 10⁻⁴	295	pH 8	PMID 23731180	Open record: IDH1 (isocitrate dehydrogenase 1) variant G97N, NADPH
IDH1 (isocitrate dehydrogenase 1)variant G97N	Homo sapiens	α-ketoglutarate	0.042	0.295	0.15	pH 8	PMID 23731180	Open record: IDH1 (isocitrate dehydrogenase 1) variant G97N, α-ketoglutarate
IDH1 (isocitrate dehydrogenase 1)variant R132H	Homo sapiens	isocitrate	0.128	6.6	0.02	pH 8	PMID 23731180	Open record: IDH1 (isocitrate dehydrogenase 1) variant R132H, isocitrate
IDH1 (isocitrate dehydrogenase 1)variant R132H	Homo sapiens	NADP+	—	5.5 × 10⁻⁵	2.33 × 10³	pH 8	PMID 23731180	Open record: IDH1 (isocitrate dehydrogenase 1) variant R132H, NADP+
IDH1 (isocitrate dehydrogenase 1)variant R132H	Homo sapiens	NADPHNADPH varied with αKG fixed at 1 mM; Table 2	0.75	4.3 × 10⁻⁴	1.75 × 10³	pH 8	PMID 23731180	Open record: IDH1 (isocitrate dehydrogenase 1) variant R132H, NADPH
IDH1 (isocitrate dehydrogenase 1)variant R132H	Homo sapiens	NADPHNADPH varied with αKG fixed at 1 mM; Table 2	0.512	3 × 10⁻⁴	1.7 × 10³	pH 8	PMID 23731180	Open record: IDH1 (isocitrate dehydrogenase 1) variant R132H, NADPH
IDH1 (isocitrate dehydrogenase 1)variant R132H	Homo sapiens	NADPHFigure 6A	—	4 × 10⁻⁴	—	pH 8	PMID 23731180	Open record: IDH1 (isocitrate dehydrogenase 1) variant R132H, NADPH
IDH1 (isocitrate dehydrogenase 1)variant R132H	Homo sapiens	α-ketoglutarateαKG varied with NADPH fixed at 50 µM	0.713	1.08	0.67	pH 8	PMID 23731180	Open record: IDH1 (isocitrate dehydrogenase 1) variant R132H, α-ketoglutarate
IDH1 (isocitrate dehydrogenase 1)variant R132H	Homo sapiens	α-ketoglutarateαKG varied with NADPH fixed at 0.5 µM	0.532	1.33	0.4	pH 8	PMID 23731180	Open record: IDH1 (isocitrate dehydrogenase 1) variant R132H, α-ketoglutarate
IDH1 (isocitrate dehydrogenase 1)variant R132H	Homo sapiens	α-ketoglutarate	0.24	1.8	0.13 calc.	pH 8	PMID 23731180	Open record: IDH1 (isocitrate dehydrogenase 1) variant R132H, α-ketoglutarate
IDH1 (isocitrate dehydrogenase 1)variant Y139D	Homo sapiens	isocitrate	0.0118	0.0024	4.8	pH 8	PMID 23731180	Open record: IDH1 (isocitrate dehydrogenase 1) variant Y139D, isocitrate
IDH1 (isocitrate dehydrogenase 1)variant Y139D	Homo sapiens	NADP+	—	1.1 × 10⁻⁵	1.05 × 10³	pH 8	PMID 23731180	Open record: IDH1 (isocitrate dehydrogenase 1) variant Y139D, NADP+
IDH1 (isocitrate dehydrogenase 1)variant Y139D	Homo sapiens	NADPH	0.0168	1.6 × 10⁻⁴	105.2	pH 8	PMID 23731180	Open record: IDH1 (isocitrate dehydrogenase 1) variant Y139D, NADPH
IDH1 (isocitrate dehydrogenase 1)variant Y139D	Homo sapiens	α-ketoglutarate	0.0173	0.0742	0.23	pH 8	PMID 23731180	Open record: IDH1 (isocitrate dehydrogenase 1) variant Y139D, α-ketoglutarate
IDH2	Homo sapiens	isocitrate	15.5	0.005	3.1 × 10³ calc.	pH 8, 37 °C	PMID 32457458	Open record: IDH2, isocitrate
IDH2	Homo sapiens	isocitratecells co-transfected with SIRT3 WT	11.3	0.0039	2.9 × 10³ calc.	pH 8, 37 °C	PMID 32457458	Open record: IDH2, isocitrate
IDH2	Homo sapiens	isocitratecells co-transfected with inactive SIRT3 H248Y	12.3	0.0052	2.4 × 10³ calc.	pH 8, 37 °C	PMID 32457458	Open record: IDH2, isocitrate
IDH2	Homo sapiens	isocitrateIDH2-overexpressing SHSY5Y cells transfected with GCN5L	21	0.005	4.2 × 10³ calc.	pH 8, 37 °C	PMID 32457458	Open record: IDH2, isocitrate
IDH2	Homo sapiens	NADP+	23.5	0.0176	1.34 × 10³ calc.	pH 8, 37 °C	PMID 32457458	Open record: IDH2, NADP+
IDH2	Homo sapiens	NADP+cells co-transfected with SIRT3 WT	19.2	0.0119	1.61 × 10³ calc.	pH 8, 37 °C	PMID 32457458	Open record: IDH2, NADP+
IDH2	Homo sapiens	NADP+cells co-transfected with inactive SIRT3 H248Y	21.9	0.0177	1.24 × 10³ calc.	pH 8, 37 °C	PMID 32457458	Open record: IDH2, NADP+
IDH2	Homo sapiens	NADP+IDH2-overexpressing SHSY5Y cells transfected with GCN5L	26.6	0.0126	2.11 × 10³ calc.	pH 8, 37 °C	PMID 32457458	Open record: IDH2, NADP+
IDH2variant K413Q	Homo sapiens	isocitrate	4.9	0.003	1.6 × 10³ calc.	pH 8, 37 °C	PMID 32457458	Open record: IDH2 variant K413Q, isocitrate
IDH2variant K413Q	Homo sapiens	NADP+	7.9	0.0569	140 calc.	pH 8, 37 °C	PMID 32457458	Open record: IDH2 variant K413Q, NADP+
isocitrate dehydrogenase	—	D-isocitrate	38.3	2.8	14 calc.	pH 7.5	PMID 7761851	Open record: isocitrate dehydrogenase, D-isocitrate
isocitrate dehydrogenase	—	oxalosuccinatedecarboxylation of oxalosuccinate to alpha-ketoglutarate	28.3	5.2	5.4	pH 7.5	PMID 7761851	Open record: isocitrate dehydrogenase, oxalosuccinate
isocitrate dehydrogenase	—	oxalosuccinatecosubstrate NADPH	1.72	2.81	0.61	pH 7.5	PMID 7761851	Open record: isocitrate dehydrogenase, oxalosuccinate
isocitrate dehydrogenasevariant K230M	—	D-isocitrate	0.78	10.9	0.072	pH 7.5	PMID 7761851	Open record: isocitrate dehydrogenase variant K230M, D-isocitrate
isocitrate dehydrogenasevariant K230M	—	oxalosuccinate	0.421	32	0.013	pH 7.5	PMID 7761851	Open record: isocitrate dehydrogenase variant K230M, oxalosuccinate
isocitrate dehydrogenasevariant Y160F	—	D-isocitrate	0.276	0.23	1.2	pH 7.5	PMID 7761851	Open record: isocitrate dehydrogenase variant Y160F, D-isocitrate
isocitrate dehydrogenasevariant Y160F	—	oxalosuccinatedecarboxylation of oxalosuccinate to alpha-ketoglutarate	33.8	6.1	5.54	pH 7.5	PMID 7761851	Open record: isocitrate dehydrogenase variant Y160F, oxalosuccinate
isocitrate dehydrogenasevariant Y160F	—	oxalosuccinatecosubstrate NADPH	0.031	6.135	0.005	pH 7.5	PMID 7761851	Open record: isocitrate dehydrogenase variant Y160F, oxalosuccinate
isocitrate dehydrogenase	Caldococcus noboribetus	DL-isocitrate	236	0.072	3.3 × 10³ calc.	pH 7, 80 °C	PMID 9252109	Open record: isocitrate dehydrogenase, DL-isocitrate
isocitrate dehydrogenase	Caldococcus noboribetus	DL-isocitrate	201	0.08	2.5 × 10³ calc.	pH 6.6, 80 °C	PMID 9252109	Open record: isocitrate dehydrogenase, DL-isocitrate
isocitrate dehydrogenase	Caldococcus noboribetus	NADP+	—	0.043	—	pH 7, 80 °C	PMID 9252109	Open record: isocitrate dehydrogenase, NADP+
isocitrate dehydrogenase	Caldococcus noboribetus	NADP+	—	0.046	—	pH 6.6, 80 °C	PMID 9252109	Open record: isocitrate dehydrogenase, NADP+
isocitrate dehydrogenase (AfIDH)	Archaeoglobus fulgidus	Isocitrate	254.6	0.332	700	pH 8, 60 °C	PMID 17401542	Open record: isocitrate dehydrogenase (AfIDH), Isocitrate
isocitrate dehydrogenase (AfIDH)	Archaeoglobus fulgidus	NADP+	219.3	0.0165	1.33 × 10⁴	pH 8, 60 °C	PMID 17401542	Open record: isocitrate dehydrogenase (AfIDH), NADP+
isocitrate dehydrogenase (AfIDH)chimera AfIDH/EcIDHclasp	Archaeoglobus fulgidus	Isocitrate	219	0.519	400	pH 8, 60 °C	PMID 17401542	Open record: isocitrate dehydrogenase (AfIDH) chimera AfIDH/EcIDHclasp, Isocitrate
isocitrate dehydrogenase (AfIDH)chimera AfIDH/EcIDHclasp	Archaeoglobus fulgidus	NADP+	155.1	0.0157	9.8 × 10³	pH 8, 60 °C	PMID 17401542	Open record: isocitrate dehydrogenase (AfIDH) chimera AfIDH/EcIDHclasp, NADP+
isocitrate dehydrogenase (BlIDH)	Bifidobacterium longum	nicotinamide adenine dinucleotide (oxidized)	2.37	0.5522	4.3	pH 8, 25 °C	PMID 26927087	Open record: isocitrate dehydrogenase (BlIDH), nicotinamide adenine dinucleotide (oxidized)
isocitrate dehydrogenase (BlIDH)	Bifidobacterium longum	nicotinamide adenine dinucleotide phosphate (oxidized)	48.19	0.05829	830	pH 8, 25 °C	PMID 26927087	Open record: isocitrate dehydrogenase (BlIDH), nicotinamide adenine dinucleotide phosphate (oxidized)
isocitrate dehydrogenase (BlIDH)	Bifidobacterium longum subsp. infantis	nicotinamide adenine dinucleotide	11.7	3.584	3.3	pH 8, 25 °C	PMID 26927087	Open record: isocitrate dehydrogenase (BlIDH), nicotinamide adenine dinucleotide
isocitrate dehydrogenase (BlIDH)	Bifidobacterium longum subsp. infantis	nicotinamide adenine dinucleotide phosphate2 mM MgCl2	36.38	0.01945	1.87 × 10³	pH 8, 25 °C	PMID 26927087	Open record: isocitrate dehydrogenase (BlIDH), nicotinamide adenine dinucleotide phosphate
isocitrate dehydrogenase (BlIDH)	Bifidobacterium longum subsp. infantis	nicotinamide adenine dinucleotide phosphate2 mM MnCl2	—	0.05829	830	pH 8, 25 °C	PMID 26927087	Open record: isocitrate dehydrogenase (BlIDH), nicotinamide adenine dinucleotide phosphate
isocitrate dehydrogenase (BlIDH)variant D253A/S257K/K260Q/R314D/H315I/T327A	Bifidobacterium longum subsp. infantis	nicotinamide adenine dinucleotide	0.518	0.13	4	pH 8, 25 °C	PMID 26927087	Open record: isocitrate dehydrogenase (BlIDH) variant D253A/S257K/K260Q/R314D/H315I/T327A, nicotinamide adenine dinucleotide
isocitrate dehydrogenase (BlIDH)variant D253A/S257K/K260Q/R314D/H315I/T327A	Bifidobacterium longum subsp. infantis	nicotinamide adenine dinucleotide phosphate	0.307	0.3241	0.95	pH 8, 25 °C	PMID 26927087	Open record: isocitrate dehydrogenase (BlIDH) variant D253A/S257K/K260Q/R314D/H315I/T327A, nicotinamide adenine dinucleotide phosphate
isocitrate dehydrogenase (BlIDH)variant R314D	Bifidobacterium longum subsp. infantis	nicotinamide adenine dinucleotide	0.88	3.702	0.2	pH 8, 25 °C	PMID 26927087	Open record: isocitrate dehydrogenase (BlIDH) variant R314D, nicotinamide adenine dinucleotide
isocitrate dehydrogenase (BlIDH)variant R314D	Bifidobacterium longum subsp. infantis	nicotinamide adenine dinucleotide phosphate	2.15	1.102	1.9	pH 8, 25 °C	PMID 26927087	Open record: isocitrate dehydrogenase (BlIDH) variant R314D, nicotinamide adenine dinucleotide phosphate
isocitrate dehydrogenase (BlIDH)variant R314D/H315I/T327A	Bifidobacterium longum subsp. infantis	nicotinamide adenine dinucleotide	0.41	4.407	0.1	pH 8, 25 °C	PMID 26927087	Open record: isocitrate dehydrogenase (BlIDH) variant R314D/H315I/T327A, nicotinamide adenine dinucleotide
isocitrate dehydrogenase (dual coenzyme specific, monomeric)	Rhodomicrobium vannielii	nicotinamide adenine dinucleotidestandard assay: 20 mM Tris/HCl pH 8.0; NAD(P)H at 340 nm	31.5	0.77	40.92	pH 8, 30 °C	PMID 1935983	Open record: isocitrate dehydrogenase (dual coenzyme specific, monomeric), nicotinamide adenine dinucleotide
isocitrate dehydrogenase (dual coenzyme specific, monomeric)	Rhodomicrobium vannielii	nicotinamide adenine dinucleotide20 mM Tris/HCl pH 8.0; 2 mM MgCl2	29.75	3.6	8.27	pH 8, 30 °C	PMID 1935983	Open record: isocitrate dehydrogenase (dual coenzyme specific, monomeric), nicotinamide adenine dinucleotide
isocitrate dehydrogenase (dual coenzyme specific, monomeric)	Rhodomicrobium vannielii	nicotinamide adenine dinucleotide20 mM phosphate pH 8.0; 2 mM MgCl2	12.03	1.8	6.68	pH 8, 30 °C	PMID 1935983	Open record: isocitrate dehydrogenase (dual coenzyme specific, monomeric), nicotinamide adenine dinucleotide
isocitrate dehydrogenase (dual coenzyme specific, monomeric)	Rhodomicrobium vannielii	nicotinamide adenine dinucleotide phosphate	40.88	0.0025	16,353	pH 8, 30 °C	PMID 1935983	Open record: isocitrate dehydrogenase (dual coenzyme specific, monomeric), nicotinamide adenine dinucleotide phosphate
isocitrate dehydrogenase (dual coenzyme specific, monomeric)	Rhodomicrobium vannielii	thionicotinamide-adenine dinucleotide	—	3.77	—	pH 8	PMID 1935983	Open record: isocitrate dehydrogenase (dual coenzyme specific, monomeric), thionicotinamide-adenine dinucleotide
isocitrate dehydrogenase (dual coenzyme specific, monomeric)	Rhodomicrobium vannielii	thionicotinamide-adenine dinucleotide phosphate	—	0.026	—	pH 8	PMID 1935983	Open record: isocitrate dehydrogenase (dual coenzyme specific, monomeric), thionicotinamide-adenine dinucleotide phosphate
isocitrate dehydrogenase (dual coenzyme specific, monomeric)	Rhodomicrobium vannielii	threo-Ds-isocitrateNADP-linked reaction; cosubstrate NADP	—	0.0033	—	pH 8, 30 °C	PMID 1935983	Open record: isocitrate dehydrogenase (dual coenzyme specific, monomeric), threo-Ds-isocitrate
isocitrate dehydrogenase (dual coenzyme specific, monomeric)	Rhodomicrobium vannielii	threo-Ds-isocitrateNAD-linked reaction; cosubstrate NAD	—	0.0085	—	pH 8, 30 °C	PMID 1935983	Open record: isocitrate dehydrogenase (dual coenzyme specific, monomeric), threo-Ds-isocitrate
isocitrate dehydrogenase (EcIDH)	Escherichia coli	Isocitrate	106.3	0.0405	2.6 × 10³	pH 8, 40 °C	PMID 17401542	Open record: isocitrate dehydrogenase (EcIDH), Isocitrate
isocitrate dehydrogenase (EcIDH)	Escherichia coli	NADP+	88.1	0.0392	2.2 × 10³	pH 8, 40 °C	PMID 17401542	Open record: isocitrate dehydrogenase (EcIDH), NADP+
isocitrate dehydrogenase (EcIDH)chimera EcIDH/AfIDHclasp	Escherichia coli	Isocitrate	71.7	0.0261	2.7 × 10³	pH 8, 40 °C	PMID 17401542	Open record: isocitrate dehydrogenase (EcIDH) chimera EcIDH/AfIDHclasp, Isocitrate
isocitrate dehydrogenase (EcIDH)chimera EcIDH/AfIDHclasp	Escherichia coli	NADP+	86.6	0.0568	1.5 × 10³	pH 8, 40 °C	PMID 17401542	Open record: isocitrate dehydrogenase (EcIDH) chimera EcIDH/AfIDHclasp, NADP+
isocitrate dehydrogenase (ICDH)	Thermus thermophilus	homoisocitrate	5	0.114	44	pH 8, 60 °C	PMID 12427751	Open record: isocitrate dehydrogenase (ICDH), homoisocitrate
isocitrate dehydrogenase (ICDH)	Thermus thermophilus	isocitrate	68	0.067	1 × 10³	pH 8, 60 °C	PMID 12427751	Open record: isocitrate dehydrogenase (ICDH), isocitrate
isocitrate dehydrogenase (IDH)variant K344D/Y345I	Escherichia coli	NAD	2.59	3.3	0.78	pH 7.5, 21 °C	PMID 8524825	Open record: isocitrate dehydrogenase (IDH) variant K344D/Y345I, NAD
isocitrate dehydrogenase (IDH)variant K344D/Y345I	Escherichia coli	NADP	6.3	7.3	0.86	pH 7.5, 21 °C	PMID 8524825	Open record: isocitrate dehydrogenase (IDH) variant K344D/Y345I, NADP
isocitrate dehydrogenase (IDH)variant K344D/Y345I/V351A	Escherichia coli	NAD	9.39	0.85	11	pH 7.5, 21 °C	PMID 8524825	Open record: isocitrate dehydrogenase (IDH) variant K344D/Y345I/V351A, NAD
isocitrate dehydrogenase (IDH)variant K344D/Y345I/V351A	Escherichia coli	NADP	18	6.4	2.8	pH 7.5, 21 °C	PMID 8524825	Open record: isocitrate dehydrogenase (IDH) variant K344D/Y345I/V351A, NADP
isocitrate dehydrogenase (IDH)variant K344D/Y345I/V351A/Y391G/R395G	Escherichia coli	NAD	0.284	1.4	0.2	pH 7.5, 21 °C	PMID 8524825	Open record: isocitrate dehydrogenase (IDH) variant K344D/Y345I/V351A/Y391G/R395G, NAD
isocitrate dehydrogenase (IDH)variant K344D/Y345I/V351A/Y391K/R395S	Escherichia coli	NAD	6	0.29	21	pH 7.5, 21 °C	PMID 8524825	Open record: isocitrate dehydrogenase (IDH) variant K344D/Y345I/V351A/Y391K/R395S, NAD
isocitrate dehydrogenase (IDH)variant K344D/Y345I/V351A/Y391K/R395S	Escherichia coli	NADP	2	11.3	0.18	pH 7.5, 21 °C	PMID 8524825	Open record: isocitrate dehydrogenase (IDH) variant K344D/Y345I/V351A/Y391K/R395S, NADP
isocitrate dehydrogenase (IDH)variant K344D/Y345I/V351A/Y391K/R395S/C332Y	Escherichia coli	NAD	11.4	0.108	106	pH 7.5, 21 °C	PMID 8524825	Open record: isocitrate dehydrogenase (IDH) variant K344D/Y345I/V351A/Y391K/R395S/C332Y, NAD
isocitrate dehydrogenase (IDH)variant K344D/Y345I/V351A/Y391K/R395S/C332Y	Escherichia coli	NADP	3.34	2.8	1.2	pH 7.5, 21 °C	PMID 8524825	Open record: isocitrate dehydrogenase (IDH) variant K344D/Y345I/V351A/Y391K/R395S/C332Y, NADP
isocitrate dehydrogenase (IDH)variant K344D/Y345I/V351A/Y391K/R395S/C332Y/C201I	Escherichia coli	isocitrate	—	0.01	—	pH 7.5, 21 °C	PMID 8524825	Open record: isocitrate dehydrogenase (IDH) variant K344D/Y345I/V351A/Y391K/R395S/C332Y/C201I, isocitrate
isocitrate dehydrogenase (IDH)variant K344D/Y345I/V351A/Y391K/R395S/C332Y/C201I	Escherichia coli	NAD	16.2	0.099	164	pH 7.5, 21 °C	PMID 8524825	Open record: isocitrate dehydrogenase (IDH) variant K344D/Y345I/V351A/Y391K/R395S/C332Y/C201I, NAD
isocitrate dehydrogenase (IDH)variant K344D/Y345I/V351A/Y391K/R395S/C332Y/C201I	Escherichia coli	NADP	4.7	5.8	0.81	pH 7.5, 21 °C	PMID 8524825	Open record: isocitrate dehydrogenase (IDH) variant K344D/Y345I/V351A/Y391K/R395S/C332Y/C201I, NADP
isocitrate dehydrogenase (IDH)variant K344D/Y345I/V351A/Y391K/R395S/Q316L/V317P/G319S/I320L	Escherichia coli	NAD	—	—	0.96	pH 7.5, 21 °C	PMID 8524825	Open record: isocitrate dehydrogenase (IDH) variant K344D/Y345I/V351A/Y391K/R395S/Q316L/V317P/G319S/I320L, NAD
isocitrate dehydrogenase (IDH)variant K344D/Y345I/V351A/Y391K/R395S/Q316L/V317P/G319S/I320L	Escherichia coli	NADP	—	—	0.01	pH 7.5, 21 °C	PMID 8524825	Open record: isocitrate dehydrogenase (IDH) variant K344D/Y345I/V351A/Y391K/R395S/Q316L/V317P/G319S/I320L, NADP
isocitrate dehydrogenase (IDH)variant K344D/Y345I/V351A/Y391K/R395S/R292D	Escherichia coli	NAD	9.74	0.924	11	pH 7.5, 21 °C	PMID 8524825	Open record: isocitrate dehydrogenase (IDH) variant K344D/Y345I/V351A/Y391K/R395S/R292D, NAD
isocitrate dehydrogenase (IDH)variant K344D/Y345I/V351A/Y391K/R395S/R292D	Escherichia coli	NADP	0.39	32.2	0.012	pH 7.5, 21 °C	PMID 8524825	Open record: isocitrate dehydrogenase (IDH) variant K344D/Y345I/V351A/Y391K/R395S/R292D, NADP
isocitrate dehydrogenase (MfIDH)	Methylobacillus flagellatus	DL-isocitrate	—	0.008	—	pH 6, 42 °C	PMID 28423051	Open record: isocitrate dehydrogenase (MfIDH), DL-isocitrate
isocitrate dehydrogenase (MfIDH)	Methylobacillus flagellatus	nicotinamide adenine dinucleotide phosphate (oxidized)	56	0.184	300	pH 6, 42 °C	PMID 28423051	Open record: isocitrate dehydrogenase (MfIDH), nicotinamide adenine dinucleotide phosphate (oxidized)
isocitrate dehydrogenase (NADP+-dependent, ICDH-2)	Plasmodium falciparum	D-isocitratevaried D,L-isocitrate 2 µM-4 mM at 2 mM NADP+ and 5 mM Mg2+	—	0.04	—	pH 8, 30 °C	PMID 12694190	Open record: isocitrate dehydrogenase (NADP+-dependent, ICDH-2), D-isocitrate
isocitrate dehydrogenase (NADP+-dependent, ICDH-2)	Plasmodium falciparum	D-isocitrate	138	—	—	pH 8, 30 °C	PMID 12694190	Open record: isocitrate dehydrogenase (NADP+-dependent, ICDH-2), D-isocitrate
isocitrate dehydrogenase (NADP+-dependent, ICDH-2)	Plasmodium falciparum	NADP+	—	0.09	—	pH 8, 30 °C	PMID 12694190	Open record: isocitrate dehydrogenase (NADP+-dependent, ICDH-2), NADP+
isocitrate dehydrogenase 1 (IDH1)	Homo sapiens	alpha-ketoglutarate	0.019	—	—	pH 7.5, 37 °C	PMID 28330869	Open record: isocitrate dehydrogenase 1 (IDH1), alpha-ketoglutarate
isocitrate dehydrogenase 1 (IDH1)	Homo sapiens	alpha-ketoglutarate	—	0.5	—	pH 7.5, 37 °C	PMID 28330869	Open record: isocitrate dehydrogenase 1 (IDH1), alpha-ketoglutarate
isocitrate dehydrogenase 1 (IDH1)	Homo sapiens	alpha-ketoglutarate	—	—	0.04	pH 7.5, 37 °C	PMID 28330869	Open record: isocitrate dehydrogenase 1 (IDH1), alpha-ketoglutarate
isocitrate dehydrogenase 1 (IDH1)	Homo sapiens	beta-nicotinamide adenine dinucleotide phosphate	—	0.08	—	pH 7.5, 37 °C	PMID 28330869	Open record: isocitrate dehydrogenase 1 (IDH1), beta-nicotinamide adenine dinucleotide phosphate
isocitrate dehydrogenase 1 (IDH1)	Homo sapiens	beta-nicotinamide adenine dinucleotide phosphate	—	0.03	—	pH 7.5, 21 °C	PMID 28330869	Open record: isocitrate dehydrogenase 1 (IDH1), beta-nicotinamide adenine dinucleotide phosphate
isocitrate dehydrogenase 1 (IDH1)	Homo sapiens	isocitrate	85	—	—	pH 7.5, 37 °C	PMID 28330869	Open record: isocitrate dehydrogenase 1 (IDH1), isocitrate
isocitrate dehydrogenase 1 (IDH1)	Homo sapiens	isocitrate	—	0.22	—	pH 7.5, 37 °C	PMID 28330869	Open record: isocitrate dehydrogenase 1 (IDH1), isocitrate
isocitrate dehydrogenase 1 (IDH1)	Homo sapiens	isocitrate	—	—	390	pH 7.5, 37 °C	PMID 28330869	Open record: isocitrate dehydrogenase 1 (IDH1), isocitrate
isocitrate dehydrogenase 1 (IDH1)	Homo sapiens	isocitrate	11	—	—	pH 7.5, 21 °C	PMID 28330869	Open record: isocitrate dehydrogenase 1 (IDH1), isocitrate
isocitrate dehydrogenase 1 (IDH1)	Homo sapiens	isocitrate	—	0.015	—	pH 7.5, 21 °C	PMID 28330869	Open record: isocitrate dehydrogenase 1 (IDH1), isocitrate
isocitrate dehydrogenase 1 (IDH1)	Homo sapiens	isocitrate	—	—	730	pH 7.5, 21 °C	PMID 28330869	Open record: isocitrate dehydrogenase 1 (IDH1), isocitrate
isocitrate dehydrogenase 1 (IDH1)	Homo sapiens	isocitrate50 mM bis-Tris; 150 mM NaCl; buffer bis-Tris pH 6.2 at 37°C	20	0.042	480	pH 6.2, 37 °C	PMID 32729927	Open record: isocitrate dehydrogenase 1 (IDH1), isocitrate
isocitrate dehydrogenase 1 (IDH1)	Homo sapiens	isocitrate50 mM KPhos; 150 mM KCl; buffer KPhos pH 6.2 at 37°C	20.2	0.027	750	pH 6.2, 37 °C	PMID 32729927	Open record: isocitrate dehydrogenase 1 (IDH1), isocitrate
isocitrate dehydrogenase 1 (IDH1)	Homo sapiens	isocitrate50 mM bis-Tris; 150 mM NaCl; buffer bis-Tris pH 6.5 at 37°C	23.1	0.048	480	pH 6.5, 37 °C	PMID 32729927	Open record: isocitrate dehydrogenase 1 (IDH1), isocitrate
isocitrate dehydrogenase 1 (IDH1)	Homo sapiens	isocitrate50 mM KPhos; 150 mM KCl; buffer KPhos pH 6.5 at 37°C	23	0.034	680	pH 6.5, 37 °C	PMID 32729927	Open record: isocitrate dehydrogenase 1 (IDH1), isocitrate
isocitrate dehydrogenase 1 (IDH1)	Homo sapiens	isocitrate50 mM bis-Tris; 150 mM NaCl; buffer bis-Tris pH 7.0 at 37°C	32	0.075	430	pH 7, 37 °C	PMID 32729927	Open record: isocitrate dehydrogenase 1 (IDH1), isocitrate
isocitrate dehydrogenase 1 (IDH1)	Homo sapiens	isocitrate50 mM KPhos; 150 mM KCl; buffer KPhos pH 7.0 at 37°C	31.7	0.05	630	pH 7, 37 °C	PMID 32729927	Open record: isocitrate dehydrogenase 1 (IDH1), isocitrate
isocitrate dehydrogenase 1 (IDH1)	Homo sapiens	isocitrate50 mM Tris; 150 mM NaCl; buffer Tris pH 7.2 at 37°C	39	0.11	350	pH 7.2, 37 °C	PMID 32729927	Open record: isocitrate dehydrogenase 1 (IDH1), isocitrate
isocitrate dehydrogenase 1 (IDH1)	Homo sapiens	isocitrate50 mM KPhos; 150 mM KCl; buffer KPhos pH 7.2 at 37°C	35.5	0.06	590	pH 7.2, 37 °C	PMID 32729927	Open record: isocitrate dehydrogenase 1 (IDH1), isocitrate
isocitrate dehydrogenase 1 (IDH1)	Homo sapiens	isocitrate50 mM Tris; 150 mM NaCl; buffer Tris pH 7.5 at 37°C	40.4	0.03	1.4 × 10³	pH 7.5, 37 °C	PMID 32729927	Open record: isocitrate dehydrogenase 1 (IDH1), isocitrate
isocitrate dehydrogenase 1 (IDH1)	Homo sapiens	isocitrate50 mM KPhos; 150 mM KCl; buffer KPhos pH 7.5 at 37°C	37.6	0.061	620	pH 7.5, 37 °C	PMID 32729927	Open record: isocitrate dehydrogenase 1 (IDH1), isocitrate
isocitrate dehydrogenase 1 (IDH1)	Homo sapiens	isocitrate50 mM Tris; 150 mM NaCl; buffer Tris pH 7.8 at 37°C	35.4	0.035	1.01 × 10³	pH 7.8, 37 °C	PMID 32729927	Open record: isocitrate dehydrogenase 1 (IDH1), isocitrate
isocitrate dehydrogenase 1 (IDH1)	Homo sapiens	isocitrate50 mM KPhos; 150 mM KCl; buffer KPhos pH 7.8 at 37°C	40	0.066	610	pH 7.8, 37 °C	PMID 32729927	Open record: isocitrate dehydrogenase 1 (IDH1), isocitrate
isocitrate dehydrogenase 1 (IDH1)	Homo sapiens	isocitrate50 mM Tris; 150 mM NaCl; buffer Tris pH 8.0 at 37°C	38.3	0.038	1 × 10³	pH 8, 37 °C	PMID 32729927	Open record: isocitrate dehydrogenase 1 (IDH1), isocitrate
isocitrate dehydrogenase 1 (IDH1)	Homo sapiens	isocitrate50 mM KPhos; 150 mM KCl; buffer KPhos pH 8.0 at 37°C	39.2	0.067	590	pH 8, 37 °C	PMID 32729927	Open record: isocitrate dehydrogenase 1 (IDH1), isocitrate
isocitrate dehydrogenase 1 (IDH1)	Homo sapiens	isocitrate	27.5	0.04	690	pH 6.8, 37 °C	PMID 32729927	Open record: isocitrate dehydrogenase 1 (IDH1), isocitrate
isocitrate dehydrogenase 1 (IDH1)	Homo sapiens	α-ketoglutarate50 mM bis-Tris; 150 mM NaCl; buffer bis-Tris pH 6.2 at 37°C	1.6	0.04	40	pH 6.2, 37 °C	PMID 32729927	Open record: isocitrate dehydrogenase 1 (IDH1), α-ketoglutarate
isocitrate dehydrogenase 1 (IDH1)	Homo sapiens	α-ketoglutarate50 mM KPhos; 150 mM KCl; 0.1 mM dithiothreitol	3.5	0.6	6	pH 6.2, 37 °C	PMID 32729927	Open record: isocitrate dehydrogenase 1 (IDH1), α-ketoglutarate
isocitrate dehydrogenase 1 (IDH1)	Homo sapiens	α-ketoglutarate50 mM bis-Tris; 150 mM NaCl; buffer bis-Tris pH 6.5 at 37°C	3.2	0.12	27	pH 6.5, 37 °C	PMID 32729927	Open record: isocitrate dehydrogenase 1 (IDH1), α-ketoglutarate
isocitrate dehydrogenase 1 (IDH1)	Homo sapiens	α-ketoglutarate50 mM KPhos; 150 mM KCl; 0.1 mM dithiothreitol	4.1	1	4.1	pH 6.5, 37 °C	PMID 32729927	Open record: isocitrate dehydrogenase 1 (IDH1), α-ketoglutarate
isocitrate dehydrogenase 1 (IDH1)	Homo sapiens	α-ketoglutarate50 mM bis-Tris; 150 mM NaCl; buffer bis-Tris pH 6.8 at 37°C	3.3	0.14	24	pH 6.8, 37 °C	PMID 32729927	Open record: isocitrate dehydrogenase 1 (IDH1), α-ketoglutarate
isocitrate dehydrogenase 1 (IDH1)	Homo sapiens	α-ketoglutarate50 mM KPhos; 150 mM KCl; 0.1 mM dithiothreitol	4.9	0.65	7.5	pH 6.8, 37 °C	PMID 32729927	Open record: isocitrate dehydrogenase 1 (IDH1), α-ketoglutarate
isocitrate dehydrogenase 1 (IDH1)	Homo sapiens	α-ketoglutarate50 mM bis-Tris; 150 mM NaCl; buffer bis-Tris pH 7.0 at 37°C	3.8	0.14	27	pH 7, 37 °C	PMID 32729927	Open record: isocitrate dehydrogenase 1 (IDH1), α-ketoglutarate
isocitrate dehydrogenase 1 (IDH1)	Homo sapiens	α-ketoglutarate50 mM KPhos; 150 mM KCl; 0.1 mM dithiothreitol	4.1	0.71	5.8	pH 7, 37 °C	PMID 32729927	Open record: isocitrate dehydrogenase 1 (IDH1), α-ketoglutarate
isocitrate dehydrogenase 1 (IDH1)	Homo sapiens	α-ketoglutarate50 mM Tris; 150 mM NaCl; buffer Tris pH 7.2 at 37°C	3.4	0.26	13	pH 7.2, 37 °C	PMID 32729927	Open record: isocitrate dehydrogenase 1 (IDH1), α-ketoglutarate
isocitrate dehydrogenase 1 (IDH1)	Homo sapiens	α-ketoglutarate50 mM KPhos; 150 mM KCl; 0.1 mM dithiothreitol	3.87	0.28	14	pH 7.2, 37 °C	PMID 32729927	Open record: isocitrate dehydrogenase 1 (IDH1), α-ketoglutarate
isocitrate dehydrogenase 1 (IDH1)	Homo sapiens	α-ketoglutarate50 mM Tris; 150 mM NaCl; buffer Tris pH 7.5 at 37°C	3.6	0.246	15	pH 7.5, 37 °C	PMID 32729927	Open record: isocitrate dehydrogenase 1 (IDH1), α-ketoglutarate
isocitrate dehydrogenase 1 (IDH1)	Homo sapiens	α-ketoglutarate50 mM KPhos; 150 mM KCl; 0.1 mM dithiothreitol	3.8	0.46	8.3	pH 7.5, 37 °C	PMID 32729927	Open record: isocitrate dehydrogenase 1 (IDH1), α-ketoglutarate
isocitrate dehydrogenase 1 (IDH1)	Homo sapiens	α-ketoglutarate	1.87	0.87	2.1	pH 7.8, 37 °C	PMID 32729927	Open record: isocitrate dehydrogenase 1 (IDH1), α-ketoglutarate
isocitrate dehydrogenase 1 (IDH1)variant A134D	Homo sapiens	beta-nicotinamide adenine dinucleotide phosphate	—	1.2	—	pH 7.5, 37 °C	PMID 28330869	Open record: isocitrate dehydrogenase 1 (IDH1) variant A134D, beta-nicotinamide adenine dinucleotide phosphate
isocitrate dehydrogenase 1 (IDH1)variant A134D	Homo sapiens	beta-nicotinamide adenine dinucleotide phosphate	—	0.7	—	pH 7.5, 21 °C	PMID 28330869	Open record: isocitrate dehydrogenase 1 (IDH1) variant A134D, beta-nicotinamide adenine dinucleotide phosphate
isocitrate dehydrogenase 1 (IDH1)variant A134D	Homo sapiens	isocitrate	2.3	—	—	pH 7.5, 37 °C	PMID 28330869	Open record: isocitrate dehydrogenase 1 (IDH1) variant A134D, isocitrate
isocitrate dehydrogenase 1 (IDH1)variant A134D	Homo sapiens	isocitrate	—	8	—	pH 7.5, 37 °C	PMID 28330869	Open record: isocitrate dehydrogenase 1 (IDH1) variant A134D, isocitrate
isocitrate dehydrogenase 1 (IDH1)variant A134D	Homo sapiens	isocitrate	—	—	0.29	pH 7.5, 37 °C	PMID 28330869	Open record: isocitrate dehydrogenase 1 (IDH1) variant A134D, isocitrate
isocitrate dehydrogenase 1 (IDH1)variant A134D	Homo sapiens	isocitrate	0.2	—	—	pH 7.5, 21 °C	PMID 28330869	Open record: isocitrate dehydrogenase 1 (IDH1) variant A134D, isocitrate
isocitrate dehydrogenase 1 (IDH1)variant A134D	Homo sapiens	isocitrate	—	2.7	—	pH 7.5, 21 °C	PMID 28330869	Open record: isocitrate dehydrogenase 1 (IDH1) variant A134D, isocitrate
isocitrate dehydrogenase 1 (IDH1)variant A134D	Homo sapiens	isocitrate	—	—	0.074	pH 7.5, 21 °C	PMID 28330869	Open record: isocitrate dehydrogenase 1 (IDH1) variant A134D, isocitrate
isocitrate dehydrogenase 1 (IDH1)variant D273L	Homo sapiens	isocitrate	7	1.9	3.7	37 °C	PMID 32729927	Open record: isocitrate dehydrogenase 1 (IDH1) variant D273L, isocitrate
isocitrate dehydrogenase 1 (IDH1)variant D273N	Homo sapiens	isocitrate	22	19	1.2	37 °C	PMID 32729927	Open record: isocitrate dehydrogenase 1 (IDH1) variant D273N, isocitrate
isocitrate dehydrogenase 1 (IDH1)variant D273S	Homo sapiens	isocitrate	15	12	1.3	37 °C	PMID 32729927	Open record: isocitrate dehydrogenase 1 (IDH1) variant D273S, isocitrate
isocitrate dehydrogenase 1 (IDH1)variant H133Q	Homo sapiens	beta-nicotinamide adenine dinucleotide phosphate	—	0.16	—	pH 7.5, 37 °C	PMID 28330869	Open record: isocitrate dehydrogenase 1 (IDH1) variant H133Q, beta-nicotinamide adenine dinucleotide phosphate
isocitrate dehydrogenase 1 (IDH1)variant H133Q	Homo sapiens	beta-nicotinamide adenine dinucleotide phosphate	—	0.101	—	pH 7.5, 21 °C	PMID 28330869	Open record: isocitrate dehydrogenase 1 (IDH1) variant H133Q, beta-nicotinamide adenine dinucleotide phosphate
isocitrate dehydrogenase 1 (IDH1)variant H133Q	Homo sapiens	isocitrate	45	—	—	pH 7.5, 37 °C	PMID 28330869	Open record: isocitrate dehydrogenase 1 (IDH1) variant H133Q, isocitrate
isocitrate dehydrogenase 1 (IDH1)variant H133Q	Homo sapiens	isocitrate	—	0.4	—	pH 7.5, 37 °C	PMID 28330869	Open record: isocitrate dehydrogenase 1 (IDH1) variant H133Q, isocitrate
isocitrate dehydrogenase 1 (IDH1)variant H133Q	Homo sapiens	isocitrate	—	—	110	pH 7.5, 37 °C	PMID 28330869	Open record: isocitrate dehydrogenase 1 (IDH1) variant H133Q, isocitrate
isocitrate dehydrogenase 1 (IDH1)variant H133Q	Homo sapiens	isocitrate	9.4	—	—	pH 7.5, 21 °C	PMID 28330869	Open record: isocitrate dehydrogenase 1 (IDH1) variant H133Q, isocitrate
isocitrate dehydrogenase 1 (IDH1)variant H133Q	Homo sapiens	isocitrate	—	0.28	—	pH 7.5, 21 °C	PMID 28330869	Open record: isocitrate dehydrogenase 1 (IDH1) variant H133Q, isocitrate
isocitrate dehydrogenase 1 (IDH1)variant H133Q	Homo sapiens	isocitrate	—	—	35	pH 7.5, 21 °C	PMID 28330869	Open record: isocitrate dehydrogenase 1 (IDH1) variant H133Q, isocitrate
isocitrate dehydrogenase 1 (IDH1)variant K217M	Homo sapiens	isocitrate	42	0.15	280	37 °C	PMID 32729927	Open record: isocitrate dehydrogenase 1 (IDH1) variant K217M, isocitrate
isocitrate dehydrogenase 1 (IDH1)variant K217Q	Homo sapiens	isocitrate	28.7	0.25	115	37 °C	PMID 32729927	Open record: isocitrate dehydrogenase 1 (IDH1) variant K217Q, isocitrate
isocitrate dehydrogenase 1 (IDH1)variant R100Q	Homo sapiens	alpha-ketoglutarate	0.34	—	—	pH 7.5, 37 °C	PMID 28330869	Open record: isocitrate dehydrogenase 1 (IDH1) variant R100Q, alpha-ketoglutarate
isocitrate dehydrogenase 1 (IDH1)variant R100Q	Homo sapiens	alpha-ketoglutarate	—	12	—	pH 7.5, 37 °C	PMID 28330869	Open record: isocitrate dehydrogenase 1 (IDH1) variant R100Q, alpha-ketoglutarate
isocitrate dehydrogenase 1 (IDH1)variant R100Q	Homo sapiens	alpha-ketoglutarate	—	—	0.028	pH 7.5, 37 °C	PMID 28330869	Open record: isocitrate dehydrogenase 1 (IDH1) variant R100Q, alpha-ketoglutarate
isocitrate dehydrogenase 1 (IDH1)variant R100Q	Homo sapiens	alpha-ketoglutarate	0.128	—	—	pH 7.5, 21 °C	PMID 28330869	Open record: isocitrate dehydrogenase 1 (IDH1) variant R100Q, alpha-ketoglutarate
isocitrate dehydrogenase 1 (IDH1)variant R100Q	Homo sapiens	alpha-ketoglutarate	—	10	—	pH 7.5, 21 °C	PMID 28330869	Open record: isocitrate dehydrogenase 1 (IDH1) variant R100Q, alpha-ketoglutarate
isocitrate dehydrogenase 1 (IDH1)variant R100Q	Homo sapiens	alpha-ketoglutarate	—	—	0.013	pH 7.5, 21 °C	PMID 28330869	Open record: isocitrate dehydrogenase 1 (IDH1) variant R100Q, alpha-ketoglutarate
isocitrate dehydrogenase 1 (IDH1)variant R100Q	Homo sapiens	beta-nicotinamide adenine dinucleotide phosphate	—	0.18	—	pH 7.5, 37 °C	PMID 28330869	Open record: isocitrate dehydrogenase 1 (IDH1) variant R100Q, beta-nicotinamide adenine dinucleotide phosphate
isocitrate dehydrogenase 1 (IDH1)variant R100Q	Homo sapiens	beta-nicotinamide adenine dinucleotide phosphate	—	0.07	—	pH 7.5, 21 °C	PMID 28330869	Open record: isocitrate dehydrogenase 1 (IDH1) variant R100Q, beta-nicotinamide adenine dinucleotide phosphate
isocitrate dehydrogenase 1 (IDH1)variant R100Q	Homo sapiens	beta-nicotinamide adenine dinucleotide phosphate, reduced	—	0.005	—	pH 7.5, 37 °C	PMID 28330869	Open record: isocitrate dehydrogenase 1 (IDH1) variant R100Q, beta-nicotinamide adenine dinucleotide phosphate, reduced
isocitrate dehydrogenase 1 (IDH1)variant R100Q	Homo sapiens	isocitrate	5.6	—	—	pH 7.5, 37 °C	PMID 28330869	Open record: isocitrate dehydrogenase 1 (IDH1) variant R100Q, isocitrate
isocitrate dehydrogenase 1 (IDH1)variant R100Q	Homo sapiens	isocitrate	—	8	—	pH 7.5, 37 °C	PMID 28330869	Open record: isocitrate dehydrogenase 1 (IDH1) variant R100Q, isocitrate
isocitrate dehydrogenase 1 (IDH1)variant R100Q	Homo sapiens	isocitrate	—	—	0.7	pH 7.5, 37 °C	PMID 28330869	Open record: isocitrate dehydrogenase 1 (IDH1) variant R100Q, isocitrate
isocitrate dehydrogenase 1 (IDH1)variant R100Q	Homo sapiens	isocitrate	1.4	—	—	pH 7.5, 21 °C	PMID 28330869	Open record: isocitrate dehydrogenase 1 (IDH1) variant R100Q, isocitrate
isocitrate dehydrogenase 1 (IDH1)variant R100Q	Homo sapiens	isocitrate	—	9	—	pH 7.5, 21 °C	PMID 28330869	Open record: isocitrate dehydrogenase 1 (IDH1) variant R100Q, isocitrate
isocitrate dehydrogenase 1 (IDH1)variant R100Q	Homo sapiens	isocitrate	—	—	0.16	pH 7.5, 21 °C	PMID 28330869	Open record: isocitrate dehydrogenase 1 (IDH1) variant R100Q, isocitrate
isocitrate dehydrogenase 1 (IDH1)variant R132A	Homo sapiens	alpha-ketoglutarate	0.37	—	—	pH 7.5, 37 °C	PMID 28330869	Open record: isocitrate dehydrogenase 1 (IDH1) variant R132A, alpha-ketoglutarate
isocitrate dehydrogenase 1 (IDH1)variant R132A	Homo sapiens	alpha-ketoglutarate	—	0.11	—	pH 7.5, 37 °C	PMID 28330869	Open record: isocitrate dehydrogenase 1 (IDH1) variant R132A, alpha-ketoglutarate
isocitrate dehydrogenase 1 (IDH1)variant R132A	Homo sapiens	alpha-ketoglutarate	—	—	3.4	pH 7.5, 37 °C	PMID 28330869	Open record: isocitrate dehydrogenase 1 (IDH1) variant R132A, alpha-ketoglutarate
isocitrate dehydrogenase 1 (IDH1)variant R132A	Homo sapiens	isocitrate	10.4	—	—	pH 7.5, 37 °C	PMID 28330869	Open record: isocitrate dehydrogenase 1 (IDH1) variant R132A, isocitrate
isocitrate dehydrogenase 1 (IDH1)variant R132A	Homo sapiens	isocitrate	—	5.7	—	pH 7.5, 37 °C	PMID 28330869	Open record: isocitrate dehydrogenase 1 (IDH1) variant R132A, isocitrate
isocitrate dehydrogenase 1 (IDH1)variant R132A	Homo sapiens	isocitrate	—	—	1.8	pH 7.5, 37 °C	PMID 28330869	Open record: isocitrate dehydrogenase 1 (IDH1) variant R132A, isocitrate
isocitrate dehydrogenase 1 (IDH1)variant R132C	Homo sapiens	alpha-ketoglutarate	1.6	—	—	pH 7.5, 37 °C	PMID 28330869	Open record: isocitrate dehydrogenase 1 (IDH1) variant R132C, alpha-ketoglutarate
isocitrate dehydrogenase 1 (IDH1)variant R132C	Homo sapiens	alpha-ketoglutarate	—	0.36	—	pH 7.5, 37 °C	PMID 28330869	Open record: isocitrate dehydrogenase 1 (IDH1) variant R132C, alpha-ketoglutarate
isocitrate dehydrogenase 1 (IDH1)variant R132C	Homo sapiens	alpha-ketoglutarate	—	—	4.4	pH 7.5, 37 °C	PMID 28330869	Open record: isocitrate dehydrogenase 1 (IDH1) variant R132C, alpha-ketoglutarate
isocitrate dehydrogenase 1 (IDH1)variant R132C	Homo sapiens	alpha-ketoglutarate	0.84	—	—	pH 7.5, 21 °C	PMID 28330869	Open record: isocitrate dehydrogenase 1 (IDH1) variant R132C, alpha-ketoglutarate
isocitrate dehydrogenase 1 (IDH1)variant R132C	Homo sapiens	alpha-ketoglutarate	—	0.36	—	pH 7.5, 21 °C	PMID 28330869	Open record: isocitrate dehydrogenase 1 (IDH1) variant R132C, alpha-ketoglutarate
isocitrate dehydrogenase 1 (IDH1)variant R132C	Homo sapiens	alpha-ketoglutarate	—	—	2.3	pH 7.5, 21 °C	PMID 28330869	Open record: isocitrate dehydrogenase 1 (IDH1) variant R132C, alpha-ketoglutarate
isocitrate dehydrogenase 1 (IDH1)variant R132C	Homo sapiens	beta-nicotinamide adenine dinucleotide phosphate	—	0.75	—	pH 7.5, 37 °C	PMID 28330869	Open record: isocitrate dehydrogenase 1 (IDH1) variant R132C, beta-nicotinamide adenine dinucleotide phosphate
isocitrate dehydrogenase 1 (IDH1)variant R132C	Homo sapiens	beta-nicotinamide adenine dinucleotide phosphate	—	0.58	—	pH 7.5, 21 °C	PMID 28330869	Open record: isocitrate dehydrogenase 1 (IDH1) variant R132C, beta-nicotinamide adenine dinucleotide phosphate
isocitrate dehydrogenase 1 (IDH1)variant R132C	Homo sapiens	beta-nicotinamide adenine dinucleotide phosphate, reduced	—	0.01	—	pH 7.5, 37 °C	PMID 28330869	Open record: isocitrate dehydrogenase 1 (IDH1) variant R132C, beta-nicotinamide adenine dinucleotide phosphate, reduced
isocitrate dehydrogenase 1 (IDH1)variant R132C	Homo sapiens	isocitrate	4.4	—	—	pH 7.5, 37 °C	PMID 28330869	Open record: isocitrate dehydrogenase 1 (IDH1) variant R132C, isocitrate
isocitrate dehydrogenase 1 (IDH1)variant R132C	Homo sapiens	isocitrate	—	8.2	—	pH 7.5, 37 °C	PMID 28330869	Open record: isocitrate dehydrogenase 1 (IDH1) variant R132C, isocitrate
isocitrate dehydrogenase 1 (IDH1)variant R132C	Homo sapiens	isocitrate	—	—	0.54	pH 7.5, 37 °C	PMID 28330869	Open record: isocitrate dehydrogenase 1 (IDH1) variant R132C, isocitrate
isocitrate dehydrogenase 1 (IDH1)variant R132C	Homo sapiens	isocitrate	1.61	—	—	pH 7.5, 21 °C	PMID 28330869	Open record: isocitrate dehydrogenase 1 (IDH1) variant R132C, isocitrate
isocitrate dehydrogenase 1 (IDH1)variant R132C	Homo sapiens	isocitrate	—	5.3	—	pH 7.5, 21 °C	PMID 28330869	Open record: isocitrate dehydrogenase 1 (IDH1) variant R132C, isocitrate
isocitrate dehydrogenase 1 (IDH1)variant R132C	Homo sapiens	isocitrate	—	—	0.3	pH 7.5, 21 °C	PMID 28330869	Open record: isocitrate dehydrogenase 1 (IDH1) variant R132C, isocitrate
isocitrate dehydrogenase 1 (IDH1)variant R132G	Homo sapiens	alpha-ketoglutarate	1.59	—	—	pH 7.5, 37 °C	PMID 28330869	Open record: isocitrate dehydrogenase 1 (IDH1) variant R132G, alpha-ketoglutarate
isocitrate dehydrogenase 1 (IDH1)variant R132G	Homo sapiens	alpha-ketoglutarate	—	0.34	—	pH 7.5, 37 °C	PMID 28330869	Open record: isocitrate dehydrogenase 1 (IDH1) variant R132G, alpha-ketoglutarate
isocitrate dehydrogenase 1 (IDH1)variant R132G	Homo sapiens	alpha-ketoglutarate	—	—	5	pH 7.5, 37 °C	PMID 28330869	Open record: isocitrate dehydrogenase 1 (IDH1) variant R132G, alpha-ketoglutarate
isocitrate dehydrogenase 1 (IDH1)variant R132G	Homo sapiens	alpha-ketoglutarate	0.45	—	—	pH 7.5, 21 °C	PMID 28330869	Open record: isocitrate dehydrogenase 1 (IDH1) variant R132G, alpha-ketoglutarate
isocitrate dehydrogenase 1 (IDH1)variant R132G	Homo sapiens	alpha-ketoglutarate	—	0.3	—	pH 7.5, 21 °C	PMID 28330869	Open record: isocitrate dehydrogenase 1 (IDH1) variant R132G, alpha-ketoglutarate
isocitrate dehydrogenase 1 (IDH1)variant R132G	Homo sapiens	alpha-ketoglutarate	—	—	1.5	pH 7.5, 21 °C	PMID 28330869	Open record: isocitrate dehydrogenase 1 (IDH1) variant R132G, alpha-ketoglutarate
isocitrate dehydrogenase 1 (IDH1)variant R132G	Homo sapiens	beta-nicotinamide adenine dinucleotide phosphate	—	0.067	—	pH 7.5, 37 °C	PMID 28330869	Open record: isocitrate dehydrogenase 1 (IDH1) variant R132G, beta-nicotinamide adenine dinucleotide phosphate
isocitrate dehydrogenase 1 (IDH1)variant R132G	Homo sapiens	beta-nicotinamide adenine dinucleotide phosphate	—	0.14	—	pH 7.5, 21 °C	PMID 28330869	Open record: isocitrate dehydrogenase 1 (IDH1) variant R132G, beta-nicotinamide adenine dinucleotide phosphate
isocitrate dehydrogenase 1 (IDH1)variant R132G	Homo sapiens	isocitrate	9.3	—	—	pH 7.5, 37 °C	PMID 28330869	Open record: isocitrate dehydrogenase 1 (IDH1) variant R132G, isocitrate
isocitrate dehydrogenase 1 (IDH1)variant R132G	Homo sapiens	isocitrate	—	7	—	pH 7.5, 37 °C	PMID 28330869	Open record: isocitrate dehydrogenase 1 (IDH1) variant R132G, isocitrate
isocitrate dehydrogenase 1 (IDH1)variant R132G	Homo sapiens	isocitrate	—	—	1.3	pH 7.5, 37 °C	PMID 28330869	Open record: isocitrate dehydrogenase 1 (IDH1) variant R132G, isocitrate
isocitrate dehydrogenase 1 (IDH1)variant R132G	Homo sapiens	isocitrate	1	—	—	pH 7.5, 21 °C	PMID 28330869	Open record: isocitrate dehydrogenase 1 (IDH1) variant R132G, isocitrate
isocitrate dehydrogenase 1 (IDH1)variant R132G	Homo sapiens	isocitrate	—	3.6	—	pH 7.5, 21 °C	PMID 28330869	Open record: isocitrate dehydrogenase 1 (IDH1) variant R132G, isocitrate
isocitrate dehydrogenase 1 (IDH1)variant R132G	Homo sapiens	isocitrate	—	—	0.28	pH 7.5, 21 °C	PMID 28330869	Open record: isocitrate dehydrogenase 1 (IDH1) variant R132G, isocitrate
isocitrate dehydrogenase 1 (IDH1)variant R132H	Homo sapiens	alpha-ketoglutarate	4.2	—	—	pH 7.5, 37 °C	PMID 28330869	Open record: isocitrate dehydrogenase 1 (IDH1) variant R132H, alpha-ketoglutarate
isocitrate dehydrogenase 1 (IDH1)variant R132H	Homo sapiens	alpha-ketoglutarate	—	1.1	—	pH 7.5, 37 °C	PMID 28330869	Open record: isocitrate dehydrogenase 1 (IDH1) variant R132H, alpha-ketoglutarate
isocitrate dehydrogenase 1 (IDH1)variant R132H	Homo sapiens	alpha-ketoglutarate	—	—	3.8	pH 7.5, 37 °C	PMID 28330869	Open record: isocitrate dehydrogenase 1 (IDH1) variant R132H, alpha-ketoglutarate
isocitrate dehydrogenase 1 (IDH1)variant R132H	Homo sapiens	alpha-ketoglutarate	0.43	—	—	pH 7.5, 21 °C	PMID 28330869	Open record: isocitrate dehydrogenase 1 (IDH1) variant R132H, alpha-ketoglutarate
isocitrate dehydrogenase 1 (IDH1)variant R132H	Homo sapiens	alpha-ketoglutarate	—	1.8	—	pH 7.5, 21 °C	PMID 28330869	Open record: isocitrate dehydrogenase 1 (IDH1) variant R132H, alpha-ketoglutarate
isocitrate dehydrogenase 1 (IDH1)variant R132H	Homo sapiens	alpha-ketoglutarate	—	—	0.24	pH 7.5, 21 °C	PMID 28330869	Open record: isocitrate dehydrogenase 1 (IDH1) variant R132H, alpha-ketoglutarate
isocitrate dehydrogenase 1 (IDH1)variant R132H	Homo sapiens	beta-nicotinamide adenine dinucleotide phosphate	—	1.6	—	pH 7.5, 37 °C	PMID 28330869	Open record: isocitrate dehydrogenase 1 (IDH1) variant R132H, beta-nicotinamide adenine dinucleotide phosphate
isocitrate dehydrogenase 1 (IDH1)variant R132H	Homo sapiens	beta-nicotinamide adenine dinucleotide phosphate	—	1	—	pH 7.5, 21 °C	PMID 28330869	Open record: isocitrate dehydrogenase 1 (IDH1) variant R132H, beta-nicotinamide adenine dinucleotide phosphate
isocitrate dehydrogenase 1 (IDH1)variant R132H	Homo sapiens	isocitrate	2.4	—	—	pH 7.5, 37 °C	PMID 28330869	Open record: isocitrate dehydrogenase 1 (IDH1) variant R132H, isocitrate
isocitrate dehydrogenase 1 (IDH1)variant R132H	Homo sapiens	isocitrate	—	4.2	—	pH 7.5, 37 °C	PMID 28330869	Open record: isocitrate dehydrogenase 1 (IDH1) variant R132H, isocitrate
isocitrate dehydrogenase 1 (IDH1)variant R132H	Homo sapiens	isocitrate	—	—	0.57	pH 7.5, 37 °C	PMID 28330869	Open record: isocitrate dehydrogenase 1 (IDH1) variant R132H, isocitrate
isocitrate dehydrogenase 1 (IDH1)variant R132H	Homo sapiens	isocitrate	0.12	—	—	pH 7.5, 21 °C	PMID 28330869	Open record: isocitrate dehydrogenase 1 (IDH1) variant R132H, isocitrate
isocitrate dehydrogenase 1 (IDH1)variant R132H	Homo sapiens	isocitrate	—	6	—	pH 7.5, 21 °C	PMID 28330869	Open record: isocitrate dehydrogenase 1 (IDH1) variant R132H, isocitrate
isocitrate dehydrogenase 1 (IDH1)variant R132H	Homo sapiens	isocitrate	—	—	0.02	pH 7.5, 21 °C	PMID 28330869	Open record: isocitrate dehydrogenase 1 (IDH1) variant R132H, isocitrate
isocitrate dehydrogenase 1 (IDH1)variant R132K	Homo sapiens	alpha-ketoglutarate	0.57	—	—	pH 7.5, 37 °C	PMID 28330869	Open record: isocitrate dehydrogenase 1 (IDH1) variant R132K, alpha-ketoglutarate
isocitrate dehydrogenase 1 (IDH1)variant R132K	Homo sapiens	alpha-ketoglutarate	—	0.61	—	pH 7.5, 37 °C	PMID 28330869	Open record: isocitrate dehydrogenase 1 (IDH1) variant R132K, alpha-ketoglutarate
isocitrate dehydrogenase 1 (IDH1)variant R132K	Homo sapiens	alpha-ketoglutarate	—	—	0.9	pH 7.5, 37 °C	PMID 28330869	Open record: isocitrate dehydrogenase 1 (IDH1) variant R132K, alpha-ketoglutarate
isocitrate dehydrogenase 1 (IDH1)variant R132K	Homo sapiens	isocitrate	7.2	—	—	pH 7.5, 37 °C	PMID 28330869	Open record: isocitrate dehydrogenase 1 (IDH1) variant R132K, isocitrate
isocitrate dehydrogenase 1 (IDH1)variant R132K	Homo sapiens	isocitrate	—	1.1	—	pH 7.5, 37 °C	PMID 28330869	Open record: isocitrate dehydrogenase 1 (IDH1) variant R132K, isocitrate
isocitrate dehydrogenase 1 (IDH1)variant R132K	Homo sapiens	isocitrate	—	—	7	pH 7.5, 37 °C	PMID 28330869	Open record: isocitrate dehydrogenase 1 (IDH1) variant R132K, isocitrate
isocitrate dehydrogenase 1 (IDH1)variant R132N	Homo sapiens	alpha-ketoglutarate	0.79	—	—	pH 7.5, 37 °C	PMID 28330869	Open record: isocitrate dehydrogenase 1 (IDH1) variant R132N, alpha-ketoglutarate
isocitrate dehydrogenase 1 (IDH1)variant R132N	Homo sapiens	alpha-ketoglutarate	—	10	—	pH 7.5, 37 °C	PMID 28330869	Open record: isocitrate dehydrogenase 1 (IDH1) variant R132N, alpha-ketoglutarate
isocitrate dehydrogenase 1 (IDH1)variant R132N	Homo sapiens	alpha-ketoglutarate	—	—	0.08	pH 7.5, 37 °C	PMID 28330869	Open record: isocitrate dehydrogenase 1 (IDH1) variant R132N, alpha-ketoglutarate
isocitrate dehydrogenase 1 (IDH1)variant R132N	Homo sapiens	isocitrate	0.047	—	—	pH 7.5, 37 °C	PMID 28330869	Open record: isocitrate dehydrogenase 1 (IDH1) variant R132N, isocitrate
isocitrate dehydrogenase 1 (IDH1)variant R132N	Homo sapiens	isocitrate	—	1.5	—	pH 7.5, 37 °C	PMID 28330869	Open record: isocitrate dehydrogenase 1 (IDH1) variant R132N, isocitrate
isocitrate dehydrogenase 1 (IDH1)variant R132N	Homo sapiens	isocitrate	—	—	0.031	pH 7.5, 37 °C	PMID 28330869	Open record: isocitrate dehydrogenase 1 (IDH1) variant R132N, isocitrate
isocitrate dehydrogenase 1 (IDH1)variant R132Q	Homo sapiens	alpha-ketoglutarate	4.7	—	—	pH 7.5, 37 °C	PMID 28330869	Open record: isocitrate dehydrogenase 1 (IDH1) variant R132Q, alpha-ketoglutarate
isocitrate dehydrogenase 1 (IDH1)variant R132Q	Homo sapiens	alpha-ketoglutarate	—	0.26	—	pH 7.5, 37 °C	PMID 28330869	Open record: isocitrate dehydrogenase 1 (IDH1) variant R132Q, alpha-ketoglutarate
isocitrate dehydrogenase 1 (IDH1)variant R132Q	Homo sapiens	alpha-ketoglutarate	—	—	18	pH 7.5, 37 °C	PMID 28330869	Open record: isocitrate dehydrogenase 1 (IDH1) variant R132Q, alpha-ketoglutarate
isocitrate dehydrogenase 1 (IDH1)variant R132Q	Homo sapiens	isocitrate	9.2	—	—	pH 7.5, 37 °C	PMID 28330869	Open record: isocitrate dehydrogenase 1 (IDH1) variant R132Q, isocitrate
isocitrate dehydrogenase 1 (IDH1)variant R132Q	Homo sapiens	isocitrate	—	0.8	—	pH 7.5, 37 °C	PMID 28330869	Open record: isocitrate dehydrogenase 1 (IDH1) variant R132Q, isocitrate
isocitrate dehydrogenase 1 (IDH1)variant R132Q	Homo sapiens	isocitrate	—	—	12	pH 7.5, 37 °C	PMID 28330869	Open record: isocitrate dehydrogenase 1 (IDH1) variant R132Q, isocitrate
isocitrate dehydrogenase 1 (IDH1)variant R132W	Homo sapiens	alpha-ketoglutarate	0.54	—	—	pH 7.5, 37 °C	PMID 28330869	Open record: isocitrate dehydrogenase 1 (IDH1) variant R132W, alpha-ketoglutarate
isocitrate dehydrogenase 1 (IDH1)variant R132W	Homo sapiens	alpha-ketoglutarate	—	0.82	—	pH 7.5, 37 °C	PMID 28330869	Open record: isocitrate dehydrogenase 1 (IDH1) variant R132W, alpha-ketoglutarate
isocitrate dehydrogenase 1 (IDH1)variant R132W	Homo sapiens	alpha-ketoglutarate	—	—	0.659	pH 7.5, 37 °C	PMID 28330869	Open record: isocitrate dehydrogenase 1 (IDH1) variant R132W, alpha-ketoglutarate
isocitrate dehydrogenase 1 (IDH1)variant R132W	Homo sapiens	isocitrate	1.21	—	—	pH 7.5, 37 °C	PMID 28330869	Open record: isocitrate dehydrogenase 1 (IDH1) variant R132W, isocitrate
isocitrate dehydrogenase 1 (IDH1)variant R132W	Homo sapiens	isocitrate	—	3.6	—	pH 7.5, 37 °C	PMID 28330869	Open record: isocitrate dehydrogenase 1 (IDH1) variant R132W, isocitrate
isocitrate dehydrogenase 1 (IDH1)variant R132W	Homo sapiens	isocitrate	—	—	0.34	pH 7.5, 37 °C	PMID 28330869	Open record: isocitrate dehydrogenase 1 (IDH1) variant R132W, isocitrate
isocitrate dehydrogenase 2 (IDH-2)	Rattus norvegicus	isocitrateliver	—	0.031	—	pH 7.2, 37 °C	PMID 30053395	Open record: isocitrate dehydrogenase 2 (IDH-2), isocitrate
isocitrate dehydrogenase 2 (IDH-2)	Rattus norvegicus	isocitrateheart	—	0.035	—	pH 7.2, 37 °C	PMID 30053395	Open record: isocitrate dehydrogenase 2 (IDH-2), isocitrate
isocitrate dehydrogenase 2 (IDH-2)	Rattus norvegicus	NADP+mitochondria isolated from AS-30D rat hepatoma cells	—	0.025	—	pH 7.2, 37 °C	PMID 30053395	Open record: isocitrate dehydrogenase 2 (IDH-2), NADP+
isocitrate dehydrogenase 2 (IDH-2)	Rattus norvegicus	NADP+rat liver mitochondria	—	0.0174	—	pH 7.2, 37 °C	PMID 30053395	Open record: isocitrate dehydrogenase 2 (IDH-2), NADP+
isocitrate dehydrogenase 2 (IDH-2)	Rattus norvegicus	NADP+rat heart mitochondria	—	0.015	—	pH 7.2, 37 °C	PMID 30053395	Open record: isocitrate dehydrogenase 2 (IDH-2), NADP+
mitochondrial isocitrate dehydrogenase 2 (mIDH2)	Mus musculus	isocitrate	5.6	0.0544	111	pH 7.4	PMID 28852116	Open record: mitochondrial isocitrate dehydrogenase 2 (mIDH2), isocitrate
mitochondrial isocitrate dehydrogenase 2 (mIDH2)	Mus musculus	NADP+	6.36	0.0337	186	pH 7.4	PMID 28852116	Open record: mitochondrial isocitrate dehydrogenase 2 (mIDH2), NADP+
mitochondrial isocitrate dehydrogenase 2 (mIDH2)variant K256Q	Mus musculus	isocitrate	2.66	0.0304	88	pH 7.4	PMID 28852116	Open record: mitochondrial isocitrate dehydrogenase 2 (mIDH2) variant K256Q, isocitrate
mitochondrial isocitrate dehydrogenase 2 (mIDH2)variant K256Q	Mus musculus	NADP+	3.13	0.0148	205	pH 7.4	PMID 28852116	Open record: mitochondrial isocitrate dehydrogenase 2 (mIDH2) variant K256Q, NADP+
mitochondrial isocitrate dehydrogenase 2 (mIDH2)variant K413Q	Mus musculus	isocitrate	4.61	0.0555	83	pH 7.4	PMID 28852116	Open record: mitochondrial isocitrate dehydrogenase 2 (mIDH2) variant K413Q, isocitrate
mitochondrial isocitrate dehydrogenase 2 (mIDH2)variant K413Q	Mus musculus	NADP+	7.69	0.1122	59	pH 7.4	PMID 28852116	Open record: mitochondrial isocitrate dehydrogenase 2 (mIDH2) variant K413Q, NADP+
mitochondrial NADP-dependent isocitrate dehydrogenase	Sus scrofa	isocitrate100 μM NADP and 2 mM MnSO4 fixed (standard assay)	—	0.0074	—	pH 7.4	PMID 12054490	Open record: mitochondrial NADP-dependent isocitrate dehydrogenase, isocitrate
mitochondrial NADP-dependent isocitrate dehydrogenase	Sus scrofa	isocitrate1 mM NADP and 2 mM MnSO4 fixed	—	0.0101	—	pH 7.4	PMID 12054490	Open record: mitochondrial NADP-dependent isocitrate dehydrogenase, isocitrate
mitochondrial NADP-dependent isocitrate dehydrogenase	Sus scrofa	NADP	—	0.0088	3.64 × 10³	pH 7.4	PMID 12054490	Open record: mitochondrial NADP-dependent isocitrate dehydrogenase, NADP
mitochondrial NADP-dependent isocitrate dehydrogenasevariant K321Q	Sus scrofa	isocitrate	—	0.01	—	pH 7.4	PMID 12054490	Open record: mitochondrial NADP-dependent isocitrate dehydrogenase variant K321Q, isocitrate
mitochondrial NADP-dependent isocitrate dehydrogenasevariant K321Q	Sus scrofa	NADP	—	0.008	4.6 × 10³	pH 7.4	PMID 12054490	Open record: mitochondrial NADP-dependent isocitrate dehydrogenase variant K321Q, NADP
mitochondrial NADP-dependent isocitrate dehydrogenasevariant R314Q	Sus scrofa	isocitrate	—	0.0108	—	pH 7.4	PMID 12054490	Open record: mitochondrial NADP-dependent isocitrate dehydrogenase variant R314Q, isocitrate
mitochondrial NADP-dependent isocitrate dehydrogenasevariant R314Q	Sus scrofa	NADP	—	0.0919	320	pH 7.4	PMID 12054490	Open record: mitochondrial NADP-dependent isocitrate dehydrogenase variant R314Q, NADP
mitochondrial NADP-dependent isocitrate dehydrogenasevariant R323Q	Sus scrofa	isocitrate	—	0.0062	—	pH 7.4	PMID 12054490	Open record: mitochondrial NADP-dependent isocitrate dehydrogenase variant R323Q, isocitrate
mitochondrial NADP-dependent isocitrate dehydrogenasevariant R323Q	Sus scrofa	NADP	—	0.0077	4.41 × 10³	pH 7.4	PMID 12054490	Open record: mitochondrial NADP-dependent isocitrate dehydrogenase variant R323Q, NADP
mitochondrial NADP-dependent isocitrate dehydrogenasevariant Y316F	Sus scrofa	isocitrate	—	0.0059	—	pH 7.4	PMID 12054490	Open record: mitochondrial NADP-dependent isocitrate dehydrogenase variant Y316F, isocitrate
mitochondrial NADP-dependent isocitrate dehydrogenasevariant Y316F	Sus scrofa	NADP	—	0.008	4.66 × 10³	pH 7.4	PMID 12054490	Open record: mitochondrial NADP-dependent isocitrate dehydrogenase variant Y316F, NADP
mitochondrial NADP-dependent isocitrate dehydrogenasevariant Y316L	Sus scrofa	isocitrate	—	0.011	—	pH 7.4	PMID 12054490	Open record: mitochondrial NADP-dependent isocitrate dehydrogenase variant Y316L, isocitrate
mitochondrial NADP-dependent isocitrate dehydrogenasevariant Y316L	Sus scrofa	NADP	—	0.0318	230	pH 7.4	PMID 12054490	Open record: mitochondrial NADP-dependent isocitrate dehydrogenase variant Y316L, NADP
NAD+-dependent isocitrate dehydrogenase (ICDH)	Acidithiobacillus thiooxidans	D,L-isocitrate	—	0.12	—	pH 9, 30 °C	PMID 12204383	Open record: NAD+-dependent isocitrate dehydrogenase (ICDH), D,L-isocitrate
NADP+-dependent isocitrate dehydrogenase	Escherichia coli	(2R,3S)-isocitrate (Ds-threo-isocitrate)	76.2	0.0114	6.71 × 10³		PMID 7819221	Open record: NADP+-dependent isocitrate dehydrogenase, (2R,3S)-isocitrate (Ds-threo-isocitrate)
NADP+-dependent isocitrate dehydrogenase	Escherichia coli	D-2-hydroxyglutarate	7.24 × 10⁻⁴	3	2.41 × 10⁻⁴	pH 7.8	PMID 7819221	Open record: NADP+-dependent isocitrate dehydrogenase, D-2-hydroxyglutarate
NADP+-dependent isocitrate dehydrogenase	Escherichia coli	oxalosuccinate	1.41	0.34	4.15		PMID 7819221	Open record: NADP+-dependent isocitrate dehydrogenase, oxalosuccinate
NADP+-dependent isocitrate dehydrogenase	Escherichia coli	oxalosuccinate	20.6	0.22	93.6	pH 7.8	PMID 7819221	Open record: NADP+-dependent isocitrate dehydrogenase, oxalosuccinate
NADP+-dependent isocitrate dehydrogenasevariant K230M	Escherichia coli	(2R,3S)-isocitrate (Ds-threo-isocitrate)	0.85	6.03	0.141		PMID 7819221	Open record: NADP+-dependent isocitrate dehydrogenase variant K230M, (2R,3S)-isocitrate (Ds-threo-isocitrate)
NADP+-dependent isocitrate dehydrogenasevariant K230M	Escherichia coli	D-2-hydroxyglutarate	2.13 × 10⁻⁴	12.9	1.65 × 10⁻⁵	pH 7.8	PMID 7819221	Open record: NADP+-dependent isocitrate dehydrogenase variant K230M, D-2-hydroxyglutarate
NADP+-dependent isocitrate dehydrogenasevariant K230M	Escherichia coli	oxalosuccinate	0.368	2	0.184		PMID 7819221	Open record: NADP+-dependent isocitrate dehydrogenase variant K230M, oxalosuccinate
NADP+-dependent isocitrate dehydrogenasevariant Y160F	Escherichia coli	(2R,3S)-isocitrate (Ds-threo-isocitrate)	0.311	0.0096	32.3		PMID 7819221	Open record: NADP+-dependent isocitrate dehydrogenase variant Y160F, (2R,3S)-isocitrate (Ds-threo-isocitrate)
NADP+-dependent isocitrate dehydrogenasevariant Y160F	Escherichia coli	D-2-hydroxyglutarate	6.7 × 10⁻⁴	10.6	6.32 × 10⁻⁵	pH 7.8	PMID 7819221	Open record: NADP+-dependent isocitrate dehydrogenase variant Y160F, D-2-hydroxyglutarate
NADP+-dependent isocitrate dehydrogenasevariant Y160F	Escherichia coli	oxalosuccinate	0.053	0.562	0.0943		PMID 7819221	Open record: NADP+-dependent isocitrate dehydrogenase variant Y160F, oxalosuccinate
NADP+-dependent isocitrate dehydrogenasevariant Y160F	Escherichia coli	oxalosuccinate	36.2	0.22	165	pH 7.8	PMID 7819221	Open record: NADP+-dependent isocitrate dehydrogenase variant Y160F, oxalosuccinate
NADP+-dependent isocitrate dehydrogenase (EcIDH)	Escherichia coli	DL-isocitrate	51.8	0.0242	2.1 × 10³	pH 7.5, 25 °C	PMID 27406240	Open record: NADP+-dependent isocitrate dehydrogenase (EcIDH), DL-isocitrate
NADP+-dependent isocitrate dehydrogenase (EcIDH)	Escherichia coli	nicotinamide adenine dinucleotide phosphate (NADP+)	—	0.0121	—	pH 7.5, 25 °C	PMID 27406240	Open record: NADP+-dependent isocitrate dehydrogenase (EcIDH), nicotinamide adenine dinucleotide phosphate (NADP+)
NADP+-dependent isocitrate dehydrogenase (EcIDH)variant R153C	Escherichia coli	DL-isocitrate	0.3	0.0318	9	pH 7.5, 25 °C	PMID 27406240	Open record: NADP+-dependent isocitrate dehydrogenase (EcIDH) variant R153C, DL-isocitrate
NADP+-dependent isocitrate dehydrogenase (EcIDH)variant R153C	Escherichia coli	nicotinamide adenine dinucleotide phosphate (NADP+)	—	0.0176	—	pH 7.5, 25 °C	PMID 27406240	Open record: NADP+-dependent isocitrate dehydrogenase (EcIDH) variant R153C, nicotinamide adenine dinucleotide phosphate (NADP+)
NADP+-dependent isocitrate dehydrogenase (EcIDH)variant R153C	Escherichia coli	nicotinamide adenine dinucleotide phosphate, reduced (NADPH)	—	7.2 × 10⁻⁴	—	pH 7.5	PMID 27406240	Open record: NADP+-dependent isocitrate dehydrogenase (EcIDH) variant R153C, nicotinamide adenine dinucleotide phosphate, reduced (NADPH)
NADP+-dependent isocitrate dehydrogenase (EcIDH)variant R153C	Escherichia coli	α-ketoglutarate	1	2.2	0.45	pH 7.5	PMID 27406240	Open record: NADP+-dependent isocitrate dehydrogenase (EcIDH) variant R153C, α-ketoglutarate
NADP+-dependent isocitrate dehydrogenase (EcIDH)variant R153H	Escherichia coli	DL-isocitrate	0.18	0.0217	8	pH 7.5, 25 °C	PMID 27406240	Open record: NADP+-dependent isocitrate dehydrogenase (EcIDH) variant R153H, DL-isocitrate
NADP+-dependent isocitrate dehydrogenase (EcIDH)variant R153H	Escherichia coli	nicotinamide adenine dinucleotide phosphate (NADP+)	—	0.011	—	pH 7.5, 25 °C	PMID 27406240	Open record: NADP+-dependent isocitrate dehydrogenase (EcIDH) variant R153H, nicotinamide adenine dinucleotide phosphate (NADP+)
NADP+-dependent isocitrate dehydrogenase (EcIDH)variant R153H	Escherichia coli	nicotinamide adenine dinucleotide phosphate, reduced (NADPH)	—	7.1 × 10⁻⁴	—	pH 7.5	PMID 27406240	Open record: NADP+-dependent isocitrate dehydrogenase (EcIDH) variant R153H, nicotinamide adenine dinucleotide phosphate, reduced (NADPH)
NADP+-dependent isocitrate dehydrogenase (EcIDH)variant R153H	Escherichia coli	α-ketoglutarate	1	3.3	0.3	pH 7.5	PMID 27406240	Open record: NADP+-dependent isocitrate dehydrogenase (EcIDH) variant R153H, α-ketoglutarate
NADP+-dependent isocitrate dehydrogenase (ICD)	Corynebacterium glutamicum	(2R,3S)-isocitrate (D-threo-isocitrate)	—	0.012	—	pH 7.6, 30 °C	PMID 7836312	Open record: NADP+-dependent isocitrate dehydrogenase (ICD), (2R,3S)-isocitrate (D-threo-isocitrate)
NADP+-dependent isocitrate dehydrogenase (ICD)	Corynebacterium glutamicum	DL-isocitrate (racemic mixture)	—	0.023	—	pH 7.6, 30 °C	PMID 7836312	Open record: NADP+-dependent isocitrate dehydrogenase (ICD), DL-isocitrate (racemic mixture)
NADP+-dependent isocitrate dehydrogenase (ICD)	Corynebacterium glutamicum	nicotinamide adenine dinucleotide phosphate (oxidized)	—	0.024	—	pH 7.6, 30 °C	PMID 7836312	Open record: NADP+-dependent isocitrate dehydrogenase (ICD), nicotinamide adenine dinucleotide phosphate (oxidized)
NADP+-dependent monomeric isocitrate dehydrogenase (SlIDH)	Streptomyces lividans	nicotinamide adenine dinucleotide (oxidized)2 mM MgCl2 (Mg2+)	2.11	18.6	0.113	pH 8, 25 °C	PMID 19631711	Open record: NADP+-dependent monomeric isocitrate dehydrogenase (SlIDH), nicotinamide adenine dinucleotide (oxidized)
NADP+-dependent monomeric isocitrate dehydrogenase (SlIDH)	Streptomyces lividans	nicotinamide adenine dinucleotide (oxidized)2 mM MnCl2 (Mn2+)	1.37	8.49	0.161	pH 8, 25 °C	PMID 19631711	Open record: NADP+-dependent monomeric isocitrate dehydrogenase (SlIDH), nicotinamide adenine dinucleotide (oxidized)
NADP+-dependent monomeric isocitrate dehydrogenase (SlIDH)	Streptomyces lividans	nicotinamide adenine dinucleotide phosphate (oxidized)2 mM MgCl2 (Mg2+)	23.2	0.00242	9.59 × 10³	pH 8, 25 °C	PMID 19631711	Open record: NADP+-dependent monomeric isocitrate dehydrogenase (SlIDH), nicotinamide adenine dinucleotide phosphate (oxidized)
NADP+-dependent monomeric isocitrate dehydrogenase (SlIDH)	Streptomyces lividans	nicotinamide adenine dinucleotide phosphate (oxidized)2 mM MnCl2 (Mn2+)	27.6	0.00278	9.93 × 10³	pH 8, 25 °C	PMID 19631711	Open record: NADP+-dependent monomeric isocitrate dehydrogenase (SlIDH), nicotinamide adenine dinucleotide phosphate (oxidized)
NADP+-IDH (YlIDH)	Yarrowia lipolytica	D-isocitrate	26.6	0.0117	2.3 × 10³	pH 8, 25 °C	PMID 25502799	Open record: NADP+-IDH (YlIDH), D-isocitrate
NADP+-IDH (YlIDH)	Yarrowia lipolytica	NADP+	—	0.0041	—	pH 8, 25 °C	PMID 25502799	Open record: NADP+-IDH (YlIDH), NADP+
NADP+-IDH (YlIDH)variant R141A	Yarrowia lipolytica	D-isocitrate	1.2	0.3672	3	pH 8, 25 °C	PMID 25502799	Open record: NADP+-IDH (YlIDH) variant R141A, D-isocitrate
NADP+-IDH (YlIDH)variant R141A	Yarrowia lipolytica	NADP+	—	0.0096	—	pH 8, 25 °C	PMID 25502799	Open record: NADP+-IDH (YlIDH) variant R141A, NADP+
NADP+-IDH (YlIDH)variant R141H	Yarrowia lipolytica	alpha-ketoglutarate	0.43	0.0473	9	pH 8, 25 °C	PMID 25502799	Open record: NADP+-IDH (YlIDH) variant R141H, alpha-ketoglutarate
NADP+-IDH (YlIDH)variant R141H	Yarrowia lipolytica	D-isocitrate	0.14	0.0256	5	pH 8, 25 °C	PMID 25502799	Open record: NADP+-IDH (YlIDH) variant R141H, D-isocitrate
NADP+-IDH (YlIDH)variant R141H	Yarrowia lipolytica	NADP+	—	0.0153	—	pH 8, 25 °C	PMID 25502799	Open record: NADP+-IDH (YlIDH) variant R141H, NADP+
NADP+-IDH (YlIDH)variant R141H	Yarrowia lipolytica	NADPH	—	0.0032	—	pH 8, 25 °C	PMID 25502799	Open record: NADP+-IDH (YlIDH) variant R141H, NADPH
NADP+-IDH1 (ScIDH1)	Saccharomyces cerevisiae	D-isocitrate	26.3	0.0105	2.5 × 10³	pH 8, 25 °C	PMID 25502799	Open record: NADP+-IDH1 (ScIDH1), D-isocitrate
NADP+-IDH1 (ScIDH1)	Saccharomyces cerevisiae	NADP+	—	0.0174	—	pH 8, 25 °C	PMID 25502799	Open record: NADP+-IDH1 (ScIDH1), NADP+
NADP+-IDH1 (ScIDH1)variant R148A	Saccharomyces cerevisiae	D-isocitrate	12.4	2.263	5	pH 8, 25 °C	PMID 25502799	Open record: NADP+-IDH1 (ScIDH1) variant R148A, D-isocitrate
NADP+-IDH1 (ScIDH1)variant R148A	Saccharomyces cerevisiae	NADP+	—	0.0257	—	pH 8, 25 °C	PMID 25502799	Open record: NADP+-IDH1 (ScIDH1) variant R148A, NADP+
NADP+-IDH1 (ScIDH1)variant R148E	Saccharomyces cerevisiae	D-isocitrate	0.62	1.296	0.5	pH 8, 25 °C	PMID 25502799	Open record: NADP+-IDH1 (ScIDH1) variant R148E, D-isocitrate
NADP+-IDH1 (ScIDH1)variant R148E	Saccharomyces cerevisiae	NADP+	—	0.0232	—	pH 8, 25 °C	PMID 25502799	Open record: NADP+-IDH1 (ScIDH1) variant R148E, NADP+
NADP+-IDH1 (ScIDH1)variant R148H	Saccharomyces cerevisiae	alpha-ketoglutarate	0.34	0.03	11	pH 8, 25 °C	PMID 25502799	Open record: NADP+-IDH1 (ScIDH1) variant R148H, alpha-ketoglutarate
NADP+-IDH1 (ScIDH1)variant R148H	Saccharomyces cerevisiae	D-isocitrate	0.27	0.0248	11	pH 8, 25 °C	PMID 25502799	Open record: NADP+-IDH1 (ScIDH1) variant R148H, D-isocitrate
NADP+-IDH1 (ScIDH1)variant R148H	Saccharomyces cerevisiae	NADP+	—	0.0356	—	pH 8, 25 °C	PMID 25502799	Open record: NADP+-IDH1 (ScIDH1) variant R148H, NADP+
NADP+-IDH1 (ScIDH1)variant R148H	Saccharomyces cerevisiae	NADPH	—	0.0059	—	pH 8, 25 °C	PMID 25502799	Open record: NADP+-IDH1 (ScIDH1) variant R148H, NADPH
NADP-dependent isocitrate dehydrogenase	Escherichia coli	(2R)-malate	0.0082	2.1	0.0039 calc.	pH 7.3, 21 °C	PMID 8369299	Open record: NADP-dependent isocitrate dehydrogenase, (2R)-malate
NADP-dependent isocitrate dehydrogenase	Escherichia coli	(2R,3S)-isocitratecosubstrate NADP	80.5	0.011	7.3 × 10³ calc.	pH 7.3, 21 °C	PMID 8369299	Open record: NADP-dependent isocitrate dehydrogenase, (2R,3S)-isocitrate
NADP-dependent isocitrate dehydrogenase	Escherichia coli	(2R,3S)-isocitratecosubstrate NAD	3.22	0.006	540 calc.	pH 7.3, 21 °C	PMID 8369299	Open record: NADP-dependent isocitrate dehydrogenase, (2R,3S)-isocitrate
NADP-dependent isocitrate dehydrogenase	Escherichia coli	2-oxoglutarate	14.9	0.57	26 calc.	pH 7.3, 21 °C	PMID 8369299	Open record: NADP-dependent isocitrate dehydrogenase, 2-oxoglutarate
NADP-dependent isocitrate dehydrogenase	Escherichia coli	carbon dioxide	—	3.13	—	pH 7.3, 21 °C	PMID 8369299	Open record: NADP-dependent isocitrate dehydrogenase, carbon dioxide
NADP-dependent isocitrate dehydrogenase	Escherichia coli	NAD+	—	4.7	—	pH 7.3, 21 °C	PMID 8369299	Open record: NADP-dependent isocitrate dehydrogenase, NAD+
NADP-dependent isocitrate dehydrogenase	Escherichia coli	NADP+cosubstrate (2R,3S)-isocitrate	—	0.017	—	pH 7.3, 21 °C	PMID 8369299	Open record: NADP-dependent isocitrate dehydrogenase, NADP+
NADP-dependent isocitrate dehydrogenase	Escherichia coli	NADP+cosubstrate (2R)-malate	—	0.195	—	pH 7.3, 21 °C	PMID 8369299	Open record: NADP-dependent isocitrate dehydrogenase, NADP+
NADP-dependent isocitrate dehydrogenase	Escherichia coli	NADPH	—	0.007	—	pH 7.3, 21 °C	PMID 8369299	Open record: NADP-dependent isocitrate dehydrogenase, NADPH
NADP-dependent isocitrate dehydrogenasevariant S113L	Escherichia coli	(2R)-malate	4.7 × 10⁻⁴	5.2	9.0 × 10⁻⁵ calc.	pH 7.3, 21 °C	PMID 8369299	Open record: NADP-dependent isocitrate dehydrogenase variant S113L, (2R)-malate
NADP-dependent isocitrate dehydrogenasevariant S113L	Escherichia coli	(2R,3S)-isocitratecosubstrate NADP	0.36	0.025	14 calc.	pH 7.3, 21 °C	PMID 8369299	Open record: NADP-dependent isocitrate dehydrogenase variant S113L, (2R,3S)-isocitrate
NADP-dependent isocitrate dehydrogenasevariant S113L	Escherichia coli	(2R,3S)-isocitratecosubstrate NAD	6.7 × 10⁻⁴	0.103	0.0065 calc.	pH 7.3, 21 °C	PMID 8369299	Open record: NADP-dependent isocitrate dehydrogenase variant S113L, (2R,3S)-isocitrate
NADP-dependent isocitrate dehydrogenasevariant S113L	Escherichia coli	NAD+	—	4.3	—	pH 7.3, 21 °C	PMID 8369299	Open record: NADP-dependent isocitrate dehydrogenase variant S113L, NAD+
NADP-dependent isocitrate dehydrogenasevariant S113L	Escherichia coli	NADP+cosubstrate (2R,3S)-isocitrate	—	0.176	—	pH 7.3, 21 °C	PMID 8369299	Open record: NADP-dependent isocitrate dehydrogenase variant S113L, NADP+
NADP-dependent isocitrate dehydrogenasevariant S113L	Escherichia coli	NADP+cosubstrate (2R)-malate	—	0.42	—	pH 7.3, 21 °C	PMID 8369299	Open record: NADP-dependent isocitrate dehydrogenase variant S113L, NADP+
NADP-dependent isocitrate dehydrogenasevariant S113N	Escherichia coli	(2R)-malate	6.7 × 10⁻⁴	16.5	4.1 × 10⁻⁵ calc.	pH 7.3, 21 °C	PMID 8369299	Open record: NADP-dependent isocitrate dehydrogenase variant S113N, (2R)-malate
NADP-dependent isocitrate dehydrogenasevariant S113N	Escherichia coli	(2R,3S)-isocitratecosubstrate NADP	3.85	0.018	210 calc.	pH 7.3, 21 °C	PMID 8369299	Open record: NADP-dependent isocitrate dehydrogenase variant S113N, (2R,3S)-isocitrate
NADP-dependent isocitrate dehydrogenasevariant S113N	Escherichia coli	(2R,3S)-isocitratecosubstrate NAD	0.0092	0.119	0.077 calc.	pH 7.3, 21 °C	PMID 8369299	Open record: NADP-dependent isocitrate dehydrogenase variant S113N, (2R,3S)-isocitrate
NADP-dependent isocitrate dehydrogenasevariant S113N	Escherichia coli	NAD+	—	15.3	—	pH 7.3, 21 °C	PMID 8369299	Open record: NADP-dependent isocitrate dehydrogenase variant S113N, NAD+
NADP-dependent isocitrate dehydrogenasevariant S113N	Escherichia coli	NADP+cosubstrate (2R,3S)-isocitrate	—	0.291	—	pH 7.3, 21 °C	PMID 8369299	Open record: NADP-dependent isocitrate dehydrogenase variant S113N, NADP+
NADP-dependent isocitrate dehydrogenasevariant S113N	Escherichia coli	NADP+cosubstrate (2R)-malate	—	0.234	—	pH 7.3, 21 °C	PMID 8369299	Open record: NADP-dependent isocitrate dehydrogenase variant S113N, NADP+
NADP-dependent isocitrate dehydrogenase	Sus scrofa	DL-isocitrate	—	0.0043	7.2 × 10³	pH 7.4, 25 °C	PMID 10694384	Open record: NADP-dependent isocitrate dehydrogenase, DL-isocitrate
NADP-dependent isocitrate dehydrogenase	Sus scrofa	NADP+	—	0.0084	3.7 × 10³	pH 7.4, 25 °C	PMID 10694384	Open record: NADP-dependent isocitrate dehydrogenase, NADP+
NADP-dependent isocitrate dehydrogenasevariant D253N	Sus scrofa	DL-isocitrate	—	0.0024	1 × 10⁴	pH 7.4, 25 °C	PMID 10694384	Open record: NADP-dependent isocitrate dehydrogenase variant D253N, DL-isocitrate
NADP-dependent isocitrate dehydrogenasevariant D253N	Sus scrofa	NADP+	—	0.0098	2.6 × 10³	pH 7.4, 25 °C	PMID 10694384	Open record: NADP-dependent isocitrate dehydrogenase variant D253N, NADP+
NADP-dependent isocitrate dehydrogenasevariant D273N	Sus scrofa	DL-isocitrate	—	0.012	140	pH 7.4, 25 °C	PMID 10694384	Open record: NADP-dependent isocitrate dehydrogenase variant D273N, DL-isocitrate
NADP-dependent isocitrate dehydrogenasevariant D273N	Sus scrofa	NADP+	—	0.01	160	pH 7.4, 25 °C	PMID 10694384	Open record: NADP-dependent isocitrate dehydrogenase variant D273N, NADP+
NADP-dependent isocitrate dehydrogenasevariant D275N	Sus scrofa	DL-isocitrate	—	0.103	0.3	pH 7.4, 25 °C	PMID 10694384	Open record: NADP-dependent isocitrate dehydrogenase variant D275N, DL-isocitrate
NADP-dependent isocitrate dehydrogenasevariant D275N	Sus scrofa	NADP+	—	0.024	1.3	pH 7.4, 25 °C	PMID 10694384	Open record: NADP-dependent isocitrate dehydrogenase variant D275N, NADP+
NADP-dependent isocitrate dehydrogenasevariant D279N	Sus scrofa	DL-isocitrate	—	0.0014	20	pH 7.4, 25 °C	PMID 10694384	Open record: NADP-dependent isocitrate dehydrogenase variant D279N, DL-isocitrate
NADP-dependent isocitrate dehydrogenasevariant D279N	Sus scrofa	NADP+	—	0.01	2.8	pH 7.4, 25 °C	PMID 10694384	Open record: NADP-dependent isocitrate dehydrogenase variant D279N, NADP+
NADP-dependent isocitrate dehydrogenase (mitochondrial)	Sus scrofa	isocitrate	—	0.00837	—	pH 7.4, 25 °C	PMID 15975917	Open record: NADP-dependent isocitrate dehydrogenase (mitochondrial), isocitrate
NADP-dependent isocitrate dehydrogenase (mitochondrial)	Sus scrofa	NAD+	0.76	17.9	0.0423	pH 7.4, 25 °C	PMID 16712772	Open record: NADP-dependent isocitrate dehydrogenase (mitochondrial), NAD+
NADP-dependent isocitrate dehydrogenase (mitochondrial)	Sus scrofa	NADP+	—	0.00559	5.96 × 10³	pH 7.4, 25 °C	PMID 15975917	Open record: NADP-dependent isocitrate dehydrogenase (mitochondrial), NADP+
NADP-dependent isocitrate dehydrogenase (mitochondrial)variant D252C	Sus scrofa	DL-isocitrate	—	0.0087	—	pH 7.4, 25 °C	PMID 15005617	Open record: NADP-dependent isocitrate dehydrogenase (mitochondrial) variant D252C, DL-isocitrate
NADP-dependent isocitrate dehydrogenase (mitochondrial)variant D252C	Sus scrofa	NADP+	—	0.0766	—	pH 7.4, 25 °C	PMID 15005617	Open record: NADP-dependent isocitrate dehydrogenase (mitochondrial) variant D252C, NADP+
NADP-dependent isocitrate dehydrogenase (mitochondrial)variant D252H	Sus scrofa	DL-isocitrate	—	0.117	—	pH 7.4, 25 °C	PMID 15005617	Open record: NADP-dependent isocitrate dehydrogenase (mitochondrial) variant D252H, DL-isocitrate
NADP-dependent isocitrate dehydrogenase (mitochondrial)variant D252H	Sus scrofa	NADP+	—	0.0781	—	pH 7.4, 25 °C	PMID 15005617	Open record: NADP-dependent isocitrate dehydrogenase (mitochondrial) variant D252H, NADP+
NADP-dependent isocitrate dehydrogenase (mitochondrial)variant D252N	Sus scrofa	DL-isocitrate	—	1.422	—	pH 7.4, 25 °C	PMID 15005617	Open record: NADP-dependent isocitrate dehydrogenase (mitochondrial) variant D252N, DL-isocitrate
NADP-dependent isocitrate dehydrogenase (mitochondrial)variant D252N	Sus scrofa	NADP+	—	0.0924	—	pH 7.4, 25 °C	PMID 15005617	Open record: NADP-dependent isocitrate dehydrogenase (mitochondrial) variant D252N, NADP+
NADP-dependent isocitrate dehydrogenase (mitochondrial)variant D275C	Sus scrofa	DL-isocitrate	—	0.0102	—	pH 7.4, 25 °C	PMID 15005617	Open record: NADP-dependent isocitrate dehydrogenase (mitochondrial) variant D275C, DL-isocitrate
NADP-dependent isocitrate dehydrogenase (mitochondrial)variant D275C	Sus scrofa	NADP+	—	0.0129	—	pH 7.4, 25 °C	PMID 15005617	Open record: NADP-dependent isocitrate dehydrogenase (mitochondrial) variant D275C, NADP+
NADP-dependent isocitrate dehydrogenase (mitochondrial)variant D275H	Sus scrofa	DL-isocitrate	—	0.0446	—	pH 7.4, 25 °C	PMID 15005617	Open record: NADP-dependent isocitrate dehydrogenase (mitochondrial) variant D275H, DL-isocitrate
NADP-dependent isocitrate dehydrogenase (mitochondrial)variant D275H	Sus scrofa	NADP+	—	0.00425	—	pH 7.4, 25 °C	PMID 15005617	Open record: NADP-dependent isocitrate dehydrogenase (mitochondrial) variant D275H, NADP+
NADP-dependent isocitrate dehydrogenase (mitochondrial)variant D279C	Sus scrofa	DL-isocitrate	—	0.00371	—	pH 7.4, 25 °C	PMID 15005617	Open record: NADP-dependent isocitrate dehydrogenase (mitochondrial) variant D279C, DL-isocitrate
NADP-dependent isocitrate dehydrogenase (mitochondrial)variant D279C	Sus scrofa	NADP+	—	0.00414	—	pH 7.4, 25 °C	PMID 15005617	Open record: NADP-dependent isocitrate dehydrogenase (mitochondrial) variant D279C, NADP+
NADP-dependent isocitrate dehydrogenase (mitochondrial)variant D279H	Sus scrofa	DL-isocitrate	—	0.00638	—	pH 7.4, 25 °C	PMID 15005617	Open record: NADP-dependent isocitrate dehydrogenase (mitochondrial) variant D279H, DL-isocitrate
NADP-dependent isocitrate dehydrogenase (mitochondrial)variant D279H	Sus scrofa	NADP+	—	0.00885	—	pH 7.4, 25 °C	PMID 15005617	Open record: NADP-dependent isocitrate dehydrogenase (mitochondrial) variant D279H, NADP+
NADP-dependent isocitrate dehydrogenase (mitochondrial)variant D375N	Sus scrofa	NAD+	0.03	23.2	0.0011	pH 7.4, 25 °C	PMID 16712772	Open record: NADP-dependent isocitrate dehydrogenase (mitochondrial) variant D375N, NAD+
NADP-dependent isocitrate dehydrogenase (mitochondrial)variant D375N	Sus scrofa	NADP+	8.4	0.1329	60	pH 7.4, 25 °C	PMID 16712772	Open record: NADP-dependent isocitrate dehydrogenase (mitochondrial) variant D375N, NADP+
NADP-dependent isocitrate dehydrogenase (mitochondrial)variant K260Q	Sus scrofa	NAD+	0.47	31.2	0.0149	pH 7.4, 25 °C	PMID 16712772	Open record: NADP-dependent isocitrate dehydrogenase (mitochondrial) variant K260Q, NAD+
NADP-dependent isocitrate dehydrogenase (mitochondrial)variant K260Q	Sus scrofa	NADP+	1.7	0.2502	7	pH 7.4, 25 °C	PMID 16712772	Open record: NADP-dependent isocitrate dehydrogenase (mitochondrial) variant K260Q, NADP+
NADP-dependent isocitrate dehydrogenase (mitochondrial)variant K260R	Sus scrofa	NAD+	0.5	20.7	0.0242	pH 7.4, 25 °C	PMID 16712772	Open record: NADP-dependent isocitrate dehydrogenase (mitochondrial) variant K260R, NAD+
NADP-dependent isocitrate dehydrogenase (mitochondrial)variant K260R	Sus scrofa	NADP+	5.7	0.0378	150	pH 7.4, 25 °C	PMID 16712772	Open record: NADP-dependent isocitrate dehydrogenase (mitochondrial) variant K260R, NADP+
NADP-dependent isocitrate dehydrogenase (mitochondrial)variant K374Q	Sus scrofa	NADP+	—	0.0154	2.77 × 10³	pH 7.4, 25 °C	PMID 16712772	Open record: NADP-dependent isocitrate dehydrogenase (mitochondrial) variant K374Q, NADP+
NADP-dependent isocitrate dehydrogenase (mitochondrial)variant N328D	Sus scrofa	isocitrate	—	0.0114	—	pH 7.4, 25 °C	PMID 15975917	Open record: NADP-dependent isocitrate dehydrogenase (mitochondrial) variant N328D, isocitrate
NADP-dependent isocitrate dehydrogenase (mitochondrial)variant N328D	Sus scrofa	NADP+	—	0.0246	490	pH 7.4, 25 °C	PMID 15975917	Open record: NADP-dependent isocitrate dehydrogenase (mitochondrial) variant N328D, NADP+
NADP-dependent isocitrate dehydrogenase (mitochondrial)variant N328S	Sus scrofa	isocitrate	—	0.0154	—	pH 7.4, 25 °C	PMID 15975917	Open record: NADP-dependent isocitrate dehydrogenase (mitochondrial) variant N328S, isocitrate
NADP-dependent isocitrate dehydrogenase (mitochondrial)variant N328S	Sus scrofa	NADP+	—	0.119	200	pH 7.4, 25 °C	PMID 15975917	Open record: NADP-dependent isocitrate dehydrogenase (mitochondrial) variant N328S, NADP+
NADP-dependent isocitrate dehydrogenase (mitochondrial)variant R83K	Sus scrofa	isocitrate	—	0.0065	—	pH 7.4, 25 °C	PMID 15975917	Open record: NADP-dependent isocitrate dehydrogenase (mitochondrial) variant R83K, isocitrate
NADP-dependent isocitrate dehydrogenase (mitochondrial)variant R83K	Sus scrofa	NADP+	—	0.0203	1.18 × 10³	pH 7.4, 25 °C	PMID 15975917	Open record: NADP-dependent isocitrate dehydrogenase (mitochondrial) variant R83K, NADP+
NADP-dependent isocitrate dehydrogenase (mitochondrial)variant R83Q	Sus scrofa	isocitrate	—	0.014	—	pH 7.4, 25 °C	PMID 15975917	Open record: NADP-dependent isocitrate dehydrogenase (mitochondrial) variant R83Q, isocitrate
NADP-dependent isocitrate dehydrogenase (mitochondrial)variant R83Q	Sus scrofa	NADP+	—	0.0811	340	pH 7.4, 25 °C	PMID 15975917	Open record: NADP-dependent isocitrate dehydrogenase (mitochondrial) variant R83Q, NADP+
NADP-dependent isocitrate dehydrogenase (mitochondrial)variant T311A	Sus scrofa	isocitrate	—	0.0155	—	pH 7.4, 25 °C	PMID 15975917	Open record: NADP-dependent isocitrate dehydrogenase (mitochondrial) variant T311A, isocitrate
NADP-dependent isocitrate dehydrogenase (mitochondrial)variant T311A	Sus scrofa	NADP+	—	0.0749	300	pH 7.4, 25 °C	PMID 15975917	Open record: NADP-dependent isocitrate dehydrogenase (mitochondrial) variant T311A, NADP+
NADP-dependent isocitrate dehydrogenase (mitochondrial)variant T311N	Sus scrofa	isocitrate	—	0.00728	—	pH 7.4, 25 °C	PMID 15975917	Open record: NADP-dependent isocitrate dehydrogenase (mitochondrial) variant T311N, isocitrate
NADP-dependent isocitrate dehydrogenase (mitochondrial)variant T311N	Sus scrofa	NADP+	—	0.00429	61	pH 7.4, 25 °C	PMID 15975917	Open record: NADP-dependent isocitrate dehydrogenase (mitochondrial) variant T311N, NADP+
NADP-dependent isocitrate dehydrogenase (mitochondrial)variant T311S	Sus scrofa	isocitrate	—	0.00637	—	pH 7.4, 25 °C	PMID 15975917	Open record: NADP-dependent isocitrate dehydrogenase (mitochondrial) variant T311S, isocitrate
NADP-dependent isocitrate dehydrogenase (mitochondrial)variant T311S	Sus scrofa	NADP+	—	0.00968	6.61 × 10³	pH 7.4, 25 °C	PMID 15975917	Open record: NADP-dependent isocitrate dehydrogenase (mitochondrial) variant T311S, NADP+
NADP-dependent isocitrate dehydrogenase (mitochondrial)variant T373A	Sus scrofa	NADP+	—	0.0062	60	pH 7.4, 25 °C	PMID 16712772	Open record: NADP-dependent isocitrate dehydrogenase (mitochondrial) variant T373A, NADP+
NADP-dependent isocitrate dehydrogenase (mitochondrial)variant T373S	Sus scrofa	NADP+	—	0.0055	4.71 × 10³	pH 7.4, 25 °C	PMID 16712772	Open record: NADP-dependent isocitrate dehydrogenase (mitochondrial) variant T373S, NADP+
NADP-dependent isocitrate dehydrogenase (mitochondrial)variant T373V	Sus scrofa	NADP+	—	0.0121	530	pH 7.4, 25 °C	PMID 16712772	Open record: NADP-dependent isocitrate dehydrogenase (mitochondrial) variant T373V, NADP+
NADP-dependent isocitrate dehydrogenase (mitochondrial, pig heart)	Sus scrofa	DL-isocitrate	30.7	0.006	5.12 × 10³	pH 7.4, 25 °C	PMID 10681542	Open record: NADP-dependent isocitrate dehydrogenase (mitochondrial, pig heart), DL-isocitrate
NADP-dependent isocitrate dehydrogenase (mitochondrial, pig heart)	Sus scrofa	NADP+	—	0.005	—	pH 7.4, 25 °C	PMID 10681542	Open record: NADP-dependent isocitrate dehydrogenase (mitochondrial, pig heart), NADP+
NADP-dependent isocitrate dehydrogenase (mitochondrial, pig heart)variant R101Q	Sus scrofa	DL-isocitrate	1.32	0.106	12.5	pH 7.4, 25 °C	PMID 10681542	Open record: NADP-dependent isocitrate dehydrogenase (mitochondrial, pig heart) variant R101Q, DL-isocitrate
NADP-dependent isocitrate dehydrogenase (mitochondrial, pig heart)variant R101Q	Sus scrofa	NADP+	—	0.005	—	pH 7.4, 25 °C	PMID 10681542	Open record: NADP-dependent isocitrate dehydrogenase (mitochondrial, pig heart) variant R101Q, NADP+
NADP-dependent isocitrate dehydrogenase (mitochondrial, pig heart)variant R110Q	Sus scrofa	DL-isocitrate	3.09	2.6	1.19	pH 7.4, 25 °C	PMID 10681542	Open record: NADP-dependent isocitrate dehydrogenase (mitochondrial, pig heart) variant R110Q, DL-isocitrate
NADP-dependent isocitrate dehydrogenase (mitochondrial, pig heart)variant R110Q	Sus scrofa	NADP+	—	0.018	—	pH 7.4, 25 °C	PMID 10681542	Open record: NADP-dependent isocitrate dehydrogenase (mitochondrial, pig heart) variant R110Q, NADP+
NADP-dependent isocitrate dehydrogenase (mitochondrial, pig heart)variant R120Q	Sus scrofa	DL-isocitrate	27.1	0.009	3.01 × 10³	pH 7.4, 25 °C	PMID 10681542	Open record: NADP-dependent isocitrate dehydrogenase (mitochondrial, pig heart) variant R120Q, DL-isocitrate
NADP-dependent isocitrate dehydrogenase (mitochondrial, pig heart)variant R120Q	Sus scrofa	NADP+	—	0.006	—	pH 7.4, 25 °C	PMID 10681542	Open record: NADP-dependent isocitrate dehydrogenase (mitochondrial, pig heart) variant R120Q, NADP+
NADP-dependent isocitrate dehydrogenase (mitochondrial, pig heart)variant R133Q	Sus scrofa	DL-isocitrate	16.3	0.99	16.5	pH 7.4, 25 °C	PMID 10681542	Open record: NADP-dependent isocitrate dehydrogenase (mitochondrial, pig heart) variant R133Q, DL-isocitrate
NADP-dependent isocitrate dehydrogenase (mitochondrial, pig heart)variant R133Q	Sus scrofa	NADP+	—	0.011	—	pH 7.4, 25 °C	PMID 10681542	Open record: NADP-dependent isocitrate dehydrogenase (mitochondrial, pig heart) variant R133Q, NADP+
NADP-dependent isocitrate dehydrogenase (porcine heart mitochondrial)	Sus scrofa	DL-isocitrate	—	0.00747	—	pH 7.4, 25 °C	PMID 14512428	Open record: NADP-dependent isocitrate dehydrogenase (porcine heart mitochondrial), DL-isocitrate
NADP-dependent isocitrate dehydrogenase (porcine heart mitochondrial)	Sus scrofa	NADP+	—	0.00985	—	pH 7.4, 25 °C	PMID 14512428	Open record: NADP-dependent isocitrate dehydrogenase (porcine heart mitochondrial), NADP+
NADP-dependent isocitrate dehydrogenase (porcine heart mitochondrial)variant K212Q	Sus scrofa	DL-isocitrate	—	0.00976	—	pH 7.4, 25 °C	PMID 14512428	Open record: NADP-dependent isocitrate dehydrogenase (porcine heart mitochondrial) variant K212Q, DL-isocitrate
NADP-dependent isocitrate dehydrogenase (porcine heart mitochondrial)variant K212Q	Sus scrofa	NADP+	—	0.0137	—	pH 7.4, 25 °C	PMID 14512428	Open record: NADP-dependent isocitrate dehydrogenase (porcine heart mitochondrial) variant K212Q, NADP+
NADP-dependent isocitrate dehydrogenase (porcine heart mitochondrial)variant K212R	Sus scrofa	DL-isocitrate	—	0.116	—	pH 7.4, 25 °C	PMID 14512428	Open record: NADP-dependent isocitrate dehydrogenase (porcine heart mitochondrial) variant K212R, DL-isocitrate
NADP-dependent isocitrate dehydrogenase (porcine heart mitochondrial)variant K212R	Sus scrofa	NADP+	—	0.0182	—	pH 7.4, 25 °C	PMID 14512428	Open record: NADP-dependent isocitrate dehydrogenase (porcine heart mitochondrial) variant K212R, NADP+
NADP-dependent isocitrate dehydrogenase (porcine heart mitochondrial)variant K212Y	Sus scrofa	DL-isocitrate	—	0.00924	—	pH 7.4, 25 °C	PMID 14512428	Open record: NADP-dependent isocitrate dehydrogenase (porcine heart mitochondrial) variant K212Y, DL-isocitrate
NADP-dependent isocitrate dehydrogenase (porcine heart mitochondrial)variant K212Y	Sus scrofa	NADP+	—	0.00729	—	pH 7.4, 25 °C	PMID 14512428	Open record: NADP-dependent isocitrate dehydrogenase (porcine heart mitochondrial) variant K212Y, NADP+
NADP-dependent isocitrate dehydrogenase (porcine heart mitochondrial)variant Y140E	Sus scrofa	DL-isocitrate	—	7.2 × 10⁻⁴	—	pH 7.4, 25 °C	PMID 14512428	Open record: NADP-dependent isocitrate dehydrogenase (porcine heart mitochondrial) variant Y140E, DL-isocitrate
NADP-dependent isocitrate dehydrogenase (porcine heart mitochondrial)variant Y140E	Sus scrofa	NADP+	—	4.2 × 10⁻⁴	—	pH 7.4, 25 °C	PMID 14512428	Open record: NADP-dependent isocitrate dehydrogenase (porcine heart mitochondrial) variant Y140E, NADP+
NADP-dependent isocitrate dehydrogenase (porcine heart mitochondrial)variant Y140F	Sus scrofa	DL-isocitrate	—	0.0052	—	pH 7.4, 25 °C	PMID 14512428	Open record: NADP-dependent isocitrate dehydrogenase (porcine heart mitochondrial) variant Y140F, DL-isocitrate
NADP-dependent isocitrate dehydrogenase (porcine heart mitochondrial)variant Y140F	Sus scrofa	NADP+	—	0.00225	—	pH 7.4, 25 °C	PMID 14512428	Open record: NADP-dependent isocitrate dehydrogenase (porcine heart mitochondrial) variant Y140F, NADP+
NADP-dependent isocitrate dehydrogenase (porcine heart mitochondrial)variant Y140K	Sus scrofa	DL-isocitrate	—	0.00532	—	pH 7.4, 25 °C	PMID 14512428	Open record: NADP-dependent isocitrate dehydrogenase (porcine heart mitochondrial) variant Y140K, DL-isocitrate
NADP-dependent isocitrate dehydrogenase (porcine heart mitochondrial)variant Y140K	Sus scrofa	NADP+	—	5.1 × 10⁻⁴	—	pH 7.4, 25 °C	PMID 14512428	Open record: NADP-dependent isocitrate dehydrogenase (porcine heart mitochondrial) variant Y140K, NADP+
NADP-dependent isocitrate dehydrogenase (porcine heart mitochondrial)variant Y140T	Sus scrofa	DL-isocitrate	—	5.7 × 10⁻⁴	—	pH 7.4, 25 °C	PMID 14512428	Open record: NADP-dependent isocitrate dehydrogenase (porcine heart mitochondrial) variant Y140T, DL-isocitrate
NADP-dependent isocitrate dehydrogenase (porcine heart mitochondrial)variant Y140T	Sus scrofa	NADP+	—	4.6 × 10⁻⁴	—	pH 7.4, 25 °C	PMID 14512428	Open record: NADP-dependent isocitrate dehydrogenase (porcine heart mitochondrial) variant Y140T, NADP+
Saci_2375 (isocitrate-homoisocitrate dehydrogenase)	Sulfolobus acidocaldarius	homoisocitrate	37	0.011	3.2 × 10³	pH 8, 60 °C	PMID 27590116	Open record: Saci_2375 (isocitrate-homoisocitrate dehydrogenase), homoisocitrate
Saci_2375 (isocitrate-homoisocitrate dehydrogenase)	Sulfolobus acidocaldarius	isocitrate	61	0.027	2.3 × 10³	pH 8, 60 °C	PMID 27590116	Open record: Saci_2375 (isocitrate-homoisocitrate dehydrogenase), isocitrate
Saci_2375 (isocitrate-homoisocitrate dehydrogenase)	Sulfolobus acidocaldarius	NADP+	—	0.05	—	pH 8, 60 °C	PMID 27590116	Open record: Saci_2375 (isocitrate-homoisocitrate dehydrogenase), NADP+
TPN-isocitrate dehydrogenase	Sus scrofa	2-oxoglutaratecosubstrate TPNH and CO2; average of the supernatant	—	0.038	—	pH 6.8, 25 °C	PMID 4151308	Open record: TPN-isocitrate dehydrogenase, 2-oxoglutarate
TPN-isocitrate dehydrogenase	Sus scrofa	2-oxoglutarateCO2 and α-ketoglutarate varied at fixed 10 µM TPNH; Table I	—	0.025	—	pH 6.8, 25 °C	PMID 4151308	Open record: TPN-isocitrate dehydrogenase, 2-oxoglutarate
TPN-isocitrate dehydrogenase	Sus scrofa	2-oxoglutaratecosubstrate CO2 9.5 mM; TPNH varied; Table I	—	0.054	—	pH 6.8, 25 °C	PMID 4151308	Open record: TPN-isocitrate dehydrogenase, 2-oxoglutarate
TPN-isocitrate dehydrogenase	Sus scrofa	2-oxoglutaratecosubstrate CO2 9.5 mM; TPNH varied; Table I	—	0.056	—	pH 6.8, 25 °C	PMID 4151308	Open record: TPN-isocitrate dehydrogenase, 2-oxoglutarate
TPN-isocitrate dehydrogenase	Sus scrofa	carbon dioxideTPNH and α-ketoglutarate; in the text	—	2.2	—	pH 6.8, 25 °C	PMID 4151308	Open record: TPN-isocitrate dehydrogenase, carbon dioxide
TPN-isocitrate dehydrogenase	Sus scrofa	carbon dioxideCO2 and α-ketoglutarate varied at fixed 10 µM TPNH; Table I	—	2.7	—	pH 6.8, 25 °C	PMID 4151308	Open record: TPN-isocitrate dehydrogenase, carbon dioxide
TPN-isocitrate dehydrogenase	Sus scrofa	carbon dioxideα-ketoglutarate fixed; TPNH varied; Table I	—	2.1	—	pH 6.8, 25 °C	PMID 4151308	Open record: TPN-isocitrate dehydrogenase, carbon dioxide
TPN-isocitrate dehydrogenase	Sus scrofa	carbon dioxideCO2 and α-ketoglutarate varied at fixed 10 µM TPNH; Table I	—	1.9	—	pH 6.8, 25 °C	PMID 4151308	Open record: TPN-isocitrate dehydrogenase, carbon dioxide
TPN-isocitrate dehydrogenase	Sus scrofa	reduced triphosphopyridine nucleotide (NADPH)α-ketoglutarate and CO2; average of the supernatant	—	0.0014	—	pH 6.8, 25 °C	PMID 4151308	Open record: TPN-isocitrate dehydrogenase, reduced triphosphopyridine nucleotide (NADPH)
TPN-isocitrate dehydrogenase	Sus scrofa	reduced triphosphopyridine nucleotide (NADPH)α-ketoglutarate fixed; CO2 varied; Table I	—	0.0014	—	pH 6.8, 25 °C	PMID 4151308	Open record: TPN-isocitrate dehydrogenase, reduced triphosphopyridine nucleotide (NADPH)
TPN-isocitrate dehydrogenase	Sus scrofa	reduced triphosphopyridine nucleotide (NADPH)CO2 9.5 mM; α-ketoglutarate varied; Table I	—	0.0023	—	pH 6.8, 25 °C	PMID 4151308	Open record: TPN-isocitrate dehydrogenase, reduced triphosphopyridine nucleotide (NADPH)
TPN-isocitrate dehydrogenase	Sus scrofa	reduced triphosphopyridine nucleotide (NADPH)CO2 9.5 mM; α-ketoglutarate varied; Table I	—	0.0033	—	pH 6.8, 25 °C	PMID 4151308	Open record: TPN-isocitrate dehydrogenase, reduced triphosphopyridine nucleotide (NADPH)
TPN-isocitrate dehydrogenase	Sus scrofa	threo-Ds-isocitratecosubstrate TPN; average of the supernatant; in the text	—	0.0011	—	pH 6.8, 25 °C	PMID 4151308	Open record: TPN-isocitrate dehydrogenase, threo-Ds-isocitrate
TPN-isocitrate dehydrogenase	Sus scrofa	threo-Ds-isocitratecosubstrate TPN (varied); Table I	—	5.6 × 10⁻⁴	—	pH 6.8, 25 °C	PMID 4151308	Open record: TPN-isocitrate dehydrogenase, threo-Ds-isocitrate
TPN-isocitrate dehydrogenase	Sus scrofa	threo-Ds-isocitratecosubstrate TPN (varied); Table I	—	0.0012	—	pH 6.8, 25 °C	PMID 4151308	Open record: TPN-isocitrate dehydrogenase, threo-Ds-isocitrate
TPN-isocitrate dehydrogenase	Sus scrofa	threo-Ds-isocitratecosubstrate TPN (varied); Table I	—	0.0015	—	pH 6.8, 25 °C	PMID 4151308	Open record: TPN-isocitrate dehydrogenase, threo-Ds-isocitrate
TPN-isocitrate dehydrogenase	Sus scrofa	triphosphopyridine nucleotide (NADP+)cosubstrate threo-Ds-isocitrate; average of the supernatant	—	2.5 × 10⁻⁴	—	pH 6.8, 25 °C	PMID 4151308	Open record: TPN-isocitrate dehydrogenase, triphosphopyridine nucleotide (NADP+)
TPN-isocitrate dehydrogenase	Sus scrofa	triphosphopyridine nucleotide (NADP+)cosubstrate threo-Ds-isocitrate (varied)	—	1.9 × 10⁻⁴	—	pH 6.8, 25 °C	PMID 4151308	Open record: TPN-isocitrate dehydrogenase, triphosphopyridine nucleotide (NADP+)