CatLogenzyme kinetics catalog

Values CatLog read from this paper

An acidic residue buried in the dimer interface of isocitrate dehydrogenase 1 (IDH1) helps regulate catalysis and pH sensitivity

PMID 32729927doi:10.1042/bcj20200311Open in Browse

The paper itself is not on this site: read it at the publisher. This page lists only the values CatLog read from it.

CatLog read 33 records (99 values) from this paper: isocitrate dehydrogenase 1 (IDH1) from Homo sapiens.

Read from the paper by an AI model and checked against the paper by a second, separate AI run; code converted the units. Values are in CatLog's units; each record opens in Browse with the line the paper prints and the checks.

EC 1.1.1.42

EnzymeOrganismSubstratekcat (s⁻¹)Km (mM)kcat/Km (mM⁻¹ s⁻¹)Conditions
isocitrate dehydrogenase 1 (IDH1)Homo sapiensisocitrate50 mM bis-Tris; 150 mM NaCl; buffer bis-Tris pH 6.2 at 37°C200.042480pH 6.2, 37 °COpen
isocitrate dehydrogenase 1 (IDH1)Homo sapiensisocitrate50 mM KPhos; 150 mM KCl; buffer KPhos pH 6.2 at 37°C20.20.027750pH 6.2, 37 °COpen
isocitrate dehydrogenase 1 (IDH1)Homo sapiensisocitrate50 mM bis-Tris; 150 mM NaCl; buffer bis-Tris pH 6.5 at 37°C23.10.048480pH 6.5, 37 °COpen
isocitrate dehydrogenase 1 (IDH1)Homo sapiensisocitrate50 mM KPhos; 150 mM KCl; buffer KPhos pH 6.5 at 37°C230.034680pH 6.5, 37 °COpen
isocitrate dehydrogenase 1 (IDH1)Homo sapiensisocitrate50 mM bis-Tris; 150 mM NaCl; buffer bis-Tris pH 7.0 at 37°C320.075430pH 7, 37 °COpen
isocitrate dehydrogenase 1 (IDH1)Homo sapiensisocitrate50 mM KPhos; 150 mM KCl; buffer KPhos pH 7.0 at 37°C31.70.05630pH 7, 37 °COpen
isocitrate dehydrogenase 1 (IDH1)Homo sapiensisocitrate50 mM Tris; 150 mM NaCl; buffer Tris pH 7.2 at 37°C390.11350pH 7.2, 37 °COpen
isocitrate dehydrogenase 1 (IDH1)Homo sapiensisocitrate50 mM KPhos; 150 mM KCl; buffer KPhos pH 7.2 at 37°C35.50.06590pH 7.2, 37 °COpen
isocitrate dehydrogenase 1 (IDH1)Homo sapiensisocitrate50 mM Tris; 150 mM NaCl; buffer Tris pH 7.5 at 37°C40.40.031.4 × 10³pH 7.5, 37 °COpen
isocitrate dehydrogenase 1 (IDH1)Homo sapiensisocitrate50 mM KPhos; 150 mM KCl; buffer KPhos pH 7.5 at 37°C37.60.061620pH 7.5, 37 °COpen
isocitrate dehydrogenase 1 (IDH1)Homo sapiensisocitrate50 mM Tris; 150 mM NaCl; buffer Tris pH 7.8 at 37°C35.40.0351.01 × 10³pH 7.8, 37 °COpen
isocitrate dehydrogenase 1 (IDH1)Homo sapiensisocitrate50 mM KPhos; 150 mM KCl; buffer KPhos pH 7.8 at 37°C400.066610pH 7.8, 37 °COpen
isocitrate dehydrogenase 1 (IDH1)Homo sapiensisocitrate50 mM Tris; 150 mM NaCl; buffer Tris pH 8.0 at 37°C38.30.0381 × 10³pH 8, 37 °COpen
isocitrate dehydrogenase 1 (IDH1)Homo sapiensisocitrate50 mM KPhos; 150 mM KCl; buffer KPhos pH 8.0 at 37°C39.20.067590pH 8, 37 °COpen
isocitrate dehydrogenase 1 (IDH1)Homo sapiensisocitrate27.50.04690pH 6.8, 37 °COpen
isocitrate dehydrogenase 1 (IDH1)Homo sapiensα-ketoglutarate50 mM bis-Tris; 150 mM NaCl; buffer bis-Tris pH 6.2 at 37°C1.60.0440pH 6.2, 37 °COpen
isocitrate dehydrogenase 1 (IDH1)Homo sapiensα-ketoglutarate50 mM KPhos; 150 mM KCl; 0.1 mM dithiothreitol3.50.66pH 6.2, 37 °COpen
isocitrate dehydrogenase 1 (IDH1)Homo sapiensα-ketoglutarate50 mM bis-Tris; 150 mM NaCl; buffer bis-Tris pH 6.5 at 37°C3.20.1227pH 6.5, 37 °COpen
isocitrate dehydrogenase 1 (IDH1)Homo sapiensα-ketoglutarate50 mM KPhos; 150 mM KCl; 0.1 mM dithiothreitol4.114.1pH 6.5, 37 °COpen
isocitrate dehydrogenase 1 (IDH1)Homo sapiensα-ketoglutarate50 mM bis-Tris; 150 mM NaCl; buffer bis-Tris pH 6.8 at 37°C3.30.1424pH 6.8, 37 °COpen
isocitrate dehydrogenase 1 (IDH1)Homo sapiensα-ketoglutarate50 mM KPhos; 150 mM KCl; 0.1 mM dithiothreitol4.90.657.5pH 6.8, 37 °COpen
isocitrate dehydrogenase 1 (IDH1)Homo sapiensα-ketoglutarate50 mM bis-Tris; 150 mM NaCl; buffer bis-Tris pH 7.0 at 37°C3.80.1427pH 7, 37 °COpen
isocitrate dehydrogenase 1 (IDH1)Homo sapiensα-ketoglutarate50 mM KPhos; 150 mM KCl; 0.1 mM dithiothreitol4.10.715.8pH 7, 37 °COpen
isocitrate dehydrogenase 1 (IDH1)Homo sapiensα-ketoglutarate50 mM Tris; 150 mM NaCl; buffer Tris pH 7.2 at 37°C3.40.2613pH 7.2, 37 °COpen
isocitrate dehydrogenase 1 (IDH1)Homo sapiensα-ketoglutarate50 mM KPhos; 150 mM KCl; 0.1 mM dithiothreitol3.870.2814pH 7.2, 37 °COpen
isocitrate dehydrogenase 1 (IDH1)Homo sapiensα-ketoglutarate50 mM Tris; 150 mM NaCl; buffer Tris pH 7.5 at 37°C3.60.24615pH 7.5, 37 °COpen
isocitrate dehydrogenase 1 (IDH1)Homo sapiensα-ketoglutarate50 mM KPhos; 150 mM KCl; 0.1 mM dithiothreitol3.80.468.3pH 7.5, 37 °COpen
isocitrate dehydrogenase 1 (IDH1)Homo sapiensα-ketoglutarate1.870.872.1pH 7.8, 37 °COpen
isocitrate dehydrogenase 1 (IDH1)variant D273LHomo sapiensisocitrate71.93.737 °COpen
isocitrate dehydrogenase 1 (IDH1)variant D273NHomo sapiensisocitrate22191.237 °COpen
isocitrate dehydrogenase 1 (IDH1)variant D273SHomo sapiensisocitrate15121.337 °COpen
isocitrate dehydrogenase 1 (IDH1)variant K217MHomo sapiensisocitrate420.1528037 °COpen
isocitrate dehydrogenase 1 (IDH1)variant K217QHomo sapiensisocitrate28.70.2511537 °COpen