Values CatLog read from this paper
Functional analysis of human cytochrome P450 21A2 variants involved in congenital adrenal hyperplasia
PMID 28539365doi:10.1074/jbc.m117.792465Open in Browse
The paper itself is not on this site: read it at the publisher. This page lists only the values CatLog read from it.
CatLog read 27 records (77 values) from this paper: cytochrome P450 21A2 from Homo sapiens.
Read from the paper by an AI model and checked against the paper by a second, separate AI run; code converted the units. Values are in CatLog's units; each record opens in Browse with the line the paper prints and the checks. CatLog calculated the 2 kcat/Km values marked “calc.” from kcat and Km; no printed kcat/Km was read for those records.
| Enzyme | Organism | Substrate | kcat (s⁻¹) | Km (mM) | kcat/Km (mM⁻¹ s⁻¹) | Conditions | Open record |
|---|---|---|---|---|---|---|---|
| cytochrome P450 21A2 | Homo sapiens | 17α-hydroxyprogesterone | — | — | 2.7 × 10³ | Open record: cytochrome P450 21A2, 17α-hydroxyprogesterone | |
| cytochrome P450 21A2 | Homo sapiens | progesteronewithout cytochrome b5 | 7.3 | 0.0017 | 4.3 × 10³ calc. | Open record: cytochrome P450 21A2, progesterone | |
| cytochrome P450 21A2 | Homo sapiens | progesteronewith 0.6 µM cytochrome b5 | 2 | 0.0013 | 1.5 × 10³ calc. | Open record: cytochrome P450 21A2, progesterone | |
| cytochrome P450 21A2variant G292C | Homo sapiens | 17α-hydroxyprogesterone | 4.3 × 10⁻⁵ | 0.0036 | 0.122 | Open record: cytochrome P450 21A2 variant G292C, 17α-hydroxyprogesterone | |
| cytochrome P450 21A2variant G292C | Homo sapiens | progesterone | 7.7 × 10⁻⁴ | 0.012 | 0.063 | Open record: cytochrome P450 21A2 variant G292C, progesterone | |
| cytochrome P450 21A2variant G292S | Homo sapiens | 17α-hydroxyprogesterone | 0.063 | 0.0046 | 13.7 | Open record: cytochrome P450 21A2 variant G292S, 17α-hydroxyprogesterone | |
| cytochrome P450 21A2variant G292S | Homo sapiens | progesterone | 0.2 | 0.0047 | 43 | Open record: cytochrome P450 21A2 variant G292S, progesterone | |
| cytochrome P450 21A2variant G65E | Homo sapiens | 17α-hydroxyprogesterone | 0.032 | 0.013 | 2.3 | Open record: cytochrome P450 21A2 variant G65E, 17α-hydroxyprogesterone | |
| cytochrome P450 21A2variant G65E | Homo sapiens | progesterone | 0.06 | 0.0055 | 11.2 | Open record: cytochrome P450 21A2 variant G65E, progesterone | |
| cytochrome P450 21A2variant I172N | Homo sapiens | 17α-hydroxyprogesterone | 0.003 | 0.0049 | 0.62 | Open record: cytochrome P450 21A2 variant I172N, 17α-hydroxyprogesterone | |
| cytochrome P450 21A2variant I172N | Homo sapiens | progesterone | 0.00145 | 0.0018 | 0.82 | Open record: cytochrome P450 21A2 variant I172N, progesterone | |
| cytochrome P450 21A2variant L108R | Homo sapiens | 17α-hydroxyprogesterone | 3.3 × 10⁻⁵ | 0.0017 | 0.02 | Open record: cytochrome P450 21A2 variant L108R, 17α-hydroxyprogesterone | |
| cytochrome P450 21A2variant L108R | Homo sapiens | progesterone | 9.8 × 10⁻⁵ | 0.0027 | 0.037 | Open record: cytochrome P450 21A2 variant L108R, progesterone | |
| cytochrome P450 21A2variant P31L | Homo sapiens | 17α-hydroxyprogesterone | 1.4 | 0.0017 | 820 | Open record: cytochrome P450 21A2 variant P31L, 17α-hydroxyprogesterone | |
| cytochrome P450 21A2variant P31L | Homo sapiens | progesterone | 0.38 | 0.0012 | 320 | Open record: cytochrome P450 21A2 variant P31L, progesterone | |
| cytochrome P450 21A2variant P31Q | Homo sapiens | 17α-hydroxyprogesterone | 2.2 × 10⁻⁴ | 0.0073 | 0.03 | Open record: cytochrome P450 21A2 variant P31Q, 17α-hydroxyprogesterone | |
| cytochrome P450 21A2variant P31Q | Homo sapiens | progesterone | 1.27 × 10⁻⁴ | 0.0096 | 0.0133 | Open record: cytochrome P450 21A2 variant P31Q, progesterone | |
| cytochrome P450 21A2variant R357W | Homo sapiens | 17α-hydroxyprogesterone | 4.5 × 10⁻⁴ | 0.022 | 0.02 | Open record: cytochrome P450 21A2 variant R357W, 17α-hydroxyprogesterone | |
| cytochrome P450 21A2variant R357W | Homo sapiens | progesterone | 2.7 × 10⁻⁴ | 0.022 | 0.0122 | Open record: cytochrome P450 21A2 variant R357W, progesterone | |
| cytochrome P450 21A2variant R409C | Homo sapiens | 17α-hydroxyprogesterone | 0.03 | 4.4 × 10⁻⁴ | 67 | Open record: cytochrome P450 21A2 variant R409C, 17α-hydroxyprogesterone | |
| cytochrome P450 21A2variant R409C | Homo sapiens | progesterone | 0.02 | 3.9 × 10⁻⁴ | 50 | Open record: cytochrome P450 21A2 variant R409C, progesterone | |
| cytochrome P450 21A2variant T296N | Homo sapiens | 17α-hydroxyprogesterone | 0.028 | 4.6 × 10⁻⁴ | 100 | Open record: cytochrome P450 21A2 variant T296N, 17α-hydroxyprogesterone | |
| cytochrome P450 21A2variant T296N | Homo sapiens | progesterone | 0.0077 | 0.0011 | 7 | Open record: cytochrome P450 21A2 variant T296N, progesterone | |
| cytochrome P450 21A2variant V282L | Homo sapiens | 17α-hydroxyprogesterone | 0.033 | 0.014 | 62 | Open record: cytochrome P450 21A2 variant V282L, 17α-hydroxyprogesterone | |
| cytochrome P450 21A2variant V282L | Homo sapiens | progesterone | 1.03 | 0.0038 | 270 | Open record: cytochrome P450 21A2 variant V282L, progesterone | |
| cytochrome P450 21A2variant W303R | Homo sapiens | 17α-hydroxyprogesterone | 3.8 × 10⁻⁵ | 0.0024 | 0.0158 | Open record: cytochrome P450 21A2 variant W303R, 17α-hydroxyprogesterone | |
| cytochrome P450 21A2variant W303R | Homo sapiens | progesterone | 1.32 × 10⁻⁴ | 0.011 | 0.012 | Open record: cytochrome P450 21A2 variant W303R, progesterone |