EC 1.14.14.16: steroid 21-monooxygenase
OxidoreductasesOpen in Browse
CatLog read 37 records for EC 1.14.14.16 from 3 papers, for 2 organisms. Names in these papers: cytochrome P450 21A2, cytochrome P450 21A2 (steroid 21-hydroxylase).
Read from the paper by an AI model and checked against the paper by a second, separate AI run; code converted the units.
CatLog also holds 17 records for EC 1.14.14.16 that are not yet re-read: from its earlier version, built from the enzyme databases and partly checked against the papers. All records for EC 1.14.14.16 in Browse.
Papers
| Paper | Organisms | Records |
|---|---|---|
| Functional analysis of human cytochrome P450 21A2 variants involved in congenital adrenal hyperplasia | Homo sapiens | 27 |
| Human Cytochrome P450 21A2, the Major Steroid 21-Hydroxylase: STRUCTURE OF THE ENZYME·PROGESTERONE SUBSTRATE COMPLEX AND RATE-LIMITING C-H BOND CLEAVAGE | Bos taurus, Homo sapiens | 6 |
| Research Resource: Correlating Human Cytochrome P450 21A2 Crystal Structure and Phenotypes of Mutations in Congenital Adrenal Hyperplasia | Homo sapiens | 4 |
Records
| Enzyme | Organism | Substrate | kcat (s⁻¹) | Km (mM) | kcat/Km (mM⁻¹ s⁻¹) | Conditions | Paper | Open record |
|---|---|---|---|---|---|---|---|---|
| cytochrome P450 21A2 | Homo sapiens | 17α-hydroxyprogesterone | — | — | 2.7 × 10³ | PMID 28539365 | Open record: cytochrome P450 21A2, 17α-hydroxyprogesterone | |
| cytochrome P450 21A2 | Homo sapiens | progesteronewithout cytochrome b5 | 7.3 | 0.0017 | 4.3 × 10³ calc. | PMID 28539365 | Open record: cytochrome P450 21A2, progesterone | |
| cytochrome P450 21A2 | Homo sapiens | progesteronewith 0.6 µM cytochrome b5 | 2 | 0.0013 | 1.5 × 10³ calc. | PMID 28539365 | Open record: cytochrome P450 21A2, progesterone | |
| cytochrome P450 21A2variant G292C | Homo sapiens | 17α-hydroxyprogesterone | 4.3 × 10⁻⁵ | 0.0036 | 0.122 | PMID 28539365 | Open record: cytochrome P450 21A2 variant G292C, 17α-hydroxyprogesterone | |
| cytochrome P450 21A2variant G292C | Homo sapiens | progesterone | 7.7 × 10⁻⁴ | 0.012 | 0.063 | PMID 28539365 | Open record: cytochrome P450 21A2 variant G292C, progesterone | |
| cytochrome P450 21A2variant G292S | Homo sapiens | 17α-hydroxyprogesterone | 0.063 | 0.0046 | 13.7 | PMID 28539365 | Open record: cytochrome P450 21A2 variant G292S, 17α-hydroxyprogesterone | |
| cytochrome P450 21A2variant G292S | Homo sapiens | progesterone | 0.2 | 0.0047 | 43 | PMID 28539365 | Open record: cytochrome P450 21A2 variant G292S, progesterone | |
| cytochrome P450 21A2variant G65E | Homo sapiens | 17α-hydroxyprogesterone | 0.032 | 0.013 | 2.3 | PMID 28539365 | Open record: cytochrome P450 21A2 variant G65E, 17α-hydroxyprogesterone | |
| cytochrome P450 21A2variant G65E | Homo sapiens | progesterone | 0.06 | 0.0055 | 11.2 | PMID 28539365 | Open record: cytochrome P450 21A2 variant G65E, progesterone | |
| cytochrome P450 21A2variant I172N | Homo sapiens | 17α-hydroxyprogesterone | 0.003 | 0.0049 | 0.62 | PMID 28539365 | Open record: cytochrome P450 21A2 variant I172N, 17α-hydroxyprogesterone | |
| cytochrome P450 21A2variant I172N | Homo sapiens | progesterone | 0.00145 | 0.0018 | 0.82 | PMID 28539365 | Open record: cytochrome P450 21A2 variant I172N, progesterone | |
| cytochrome P450 21A2variant L108R | Homo sapiens | 17α-hydroxyprogesterone | 3.3 × 10⁻⁵ | 0.0017 | 0.02 | PMID 28539365 | Open record: cytochrome P450 21A2 variant L108R, 17α-hydroxyprogesterone | |
| cytochrome P450 21A2variant L108R | Homo sapiens | progesterone | 9.8 × 10⁻⁵ | 0.0027 | 0.037 | PMID 28539365 | Open record: cytochrome P450 21A2 variant L108R, progesterone | |
| cytochrome P450 21A2variant P31L | Homo sapiens | 17α-hydroxyprogesterone | 1.4 | 0.0017 | 820 | PMID 28539365 | Open record: cytochrome P450 21A2 variant P31L, 17α-hydroxyprogesterone | |
| cytochrome P450 21A2variant P31L | Homo sapiens | progesterone | 0.38 | 0.0012 | 320 | PMID 28539365 | Open record: cytochrome P450 21A2 variant P31L, progesterone | |
| cytochrome P450 21A2variant P31Q | Homo sapiens | 17α-hydroxyprogesterone | 2.2 × 10⁻⁴ | 0.0073 | 0.03 | PMID 28539365 | Open record: cytochrome P450 21A2 variant P31Q, 17α-hydroxyprogesterone | |
| cytochrome P450 21A2variant P31Q | Homo sapiens | progesterone | 1.27 × 10⁻⁴ | 0.0096 | 0.0133 | PMID 28539365 | Open record: cytochrome P450 21A2 variant P31Q, progesterone | |
| cytochrome P450 21A2variant R357W | Homo sapiens | 17α-hydroxyprogesterone | 4.5 × 10⁻⁴ | 0.022 | 0.02 | PMID 28539365 | Open record: cytochrome P450 21A2 variant R357W, 17α-hydroxyprogesterone | |
| cytochrome P450 21A2variant R357W | Homo sapiens | progesterone | 2.7 × 10⁻⁴ | 0.022 | 0.0122 | PMID 28539365 | Open record: cytochrome P450 21A2 variant R357W, progesterone | |
| cytochrome P450 21A2variant R409C | Homo sapiens | 17α-hydroxyprogesterone | 0.03 | 4.4 × 10⁻⁴ | 67 | PMID 28539365 | Open record: cytochrome P450 21A2 variant R409C, 17α-hydroxyprogesterone | |
| cytochrome P450 21A2variant R409C | Homo sapiens | progesterone | 0.02 | 3.9 × 10⁻⁴ | 50 | PMID 28539365 | Open record: cytochrome P450 21A2 variant R409C, progesterone | |
| cytochrome P450 21A2variant T296N | Homo sapiens | 17α-hydroxyprogesterone | 0.028 | 4.6 × 10⁻⁴ | 100 | PMID 28539365 | Open record: cytochrome P450 21A2 variant T296N, 17α-hydroxyprogesterone | |
| cytochrome P450 21A2variant T296N | Homo sapiens | progesterone | 0.0077 | 0.0011 | 7 | PMID 28539365 | Open record: cytochrome P450 21A2 variant T296N, progesterone | |
| cytochrome P450 21A2variant V282L | Homo sapiens | 17α-hydroxyprogesterone | 0.033 | 0.014 | 62 | PMID 28539365 | Open record: cytochrome P450 21A2 variant V282L, 17α-hydroxyprogesterone | |
| cytochrome P450 21A2variant V282L | Homo sapiens | progesterone | 1.03 | 0.0038 | 270 | PMID 28539365 | Open record: cytochrome P450 21A2 variant V282L, progesterone | |
| cytochrome P450 21A2variant W303R | Homo sapiens | 17α-hydroxyprogesterone | 3.8 × 10⁻⁵ | 0.0024 | 0.0158 | PMID 28539365 | Open record: cytochrome P450 21A2 variant W303R, 17α-hydroxyprogesterone | |
| cytochrome P450 21A2variant W303R | Homo sapiens | progesterone | 1.32 × 10⁻⁴ | 0.011 | 0.012 | PMID 28539365 | Open record: cytochrome P450 21A2 variant W303R, progesterone | |
| cytochrome P450 21A2 (steroid 21-hydroxylase)variant C3B21RA | Bos taurus | 17α-hydroxyprogesterone | 0.67 | 4.4 × 10⁻⁴ | 1.57 × 10³ | pH 7.4, 37 °C | PMID 25855791 | Open record: cytochrome P450 21A2 (steroid 21-hydroxylase) variant C3B21RA, 17α-hydroxyprogesterone |
| cytochrome P450 21A2 (steroid 21-hydroxylase)variant C3B21RA | Bos taurus | progesterone | 0.78 | 5 × 10⁻⁴ | 1.52 × 10³ | pH 7.4, 37 °C | PMID 25855791 | Open record: cytochrome P450 21A2 (steroid 21-hydroxylase) variant C3B21RA, progesterone |
| cytochrome P450 21A2 (steroid 21-hydroxylase) | Homo sapiens | 17α-hydroxyprogesterone | 4 | 0.0015 | 2.67 × 10³ | pH 7.4, 37 °C | PMID 25855791 | Open record: cytochrome P450 21A2 (steroid 21-hydroxylase), 17α-hydroxyprogesterone |
| cytochrome P450 21A2 (steroid 21-hydroxylase) | Homo sapiens | 21,21,21-trideuterio-17α-hydroxyprogesterone | 0.5 | 0.001 | 500 | pH 7.4, 37 °C | PMID 25855791 | Open record: cytochrome P450 21A2 (steroid 21-hydroxylase), 21,21,21-trideuterio-17α-hydroxyprogesterone |
| cytochrome P450 21A2 (steroid 21-hydroxylase) | Homo sapiens | 21,21,21-trideuterioprogesterone | 0.43 | 3.7 × 10⁻⁴ | 1.17 × 10³ | pH 7.4, 37 °C | PMID 25855791 | Open record: cytochrome P450 21A2 (steroid 21-hydroxylase), 21,21,21-trideuterioprogesterone |
| cytochrome P450 21A2 (steroid 21-hydroxylase) | Homo sapiens | progesterone | 2.8 | 2.1 × 10⁻⁴ | 1.33 × 10⁴ | pH 7.4, 37 °C | PMID 25855791 | Open record: cytochrome P450 21A2 (steroid 21-hydroxylase), progesterone |
| cytochrome P450 21A2 (steroid 21-hydroxylase)variant G65E | Homo sapiens | 17α-hydroxyprogesterone | 0.032 | 0.013 | 2.3 | PMID 26172259 | Open record: cytochrome P450 21A2 (steroid 21-hydroxylase) variant G65E, 17α-hydroxyprogesterone | |
| cytochrome P450 21A2 (steroid 21-hydroxylase)variant G65E | Homo sapiens | progesterone | 0.062 | 0.0055 | 11.2 | PMID 26172259 | Open record: cytochrome P450 21A2 (steroid 21-hydroxylase) variant G65E, progesterone | |
| cytochrome P450 21A2 (steroid 21-hydroxylase)variant T296N | Homo sapiens | 17α-hydroxyprogesterone | 0.045 | 4.6 × 10⁻⁴ | 100 | PMID 26172259 | Open record: cytochrome P450 21A2 (steroid 21-hydroxylase) variant T296N, 17α-hydroxyprogesterone | |
| cytochrome P450 21A2 (steroid 21-hydroxylase)variant T296N | Homo sapiens | progesterone | 0.0077 | 0.0011 | 7 | PMID 26172259 | Open record: cytochrome P450 21A2 (steroid 21-hydroxylase) variant T296N, progesterone |