CatLogenzyme kinetics catalog

Values CatLog read from this paper

Structural basis for interdomain communication in SHIP2 providing high phosphatase activity

PMID 28792888doi:10.7554/elife.26640Open in Browse

The paper itself is not on this site: read it at the publisher. This page lists only the values CatLog read from it.

CatLog read 20 records (39 values) from this paper: SHIP2 (SH2-containing inositol 5-phosphatase 2) from Homo sapiens.

Read from the paper by an AI model and checked against the paper by a second, separate AI run; code converted the units. Values are in CatLog's units; each record opens in Browse with the line the paper prints and the checks. CatLog calculated the 19 kcat/Km values marked “calc.” from kcat and Km; no printed kcat/Km was read for those records.

EC 3.1.3.86

EnzymeOrganismSubstratekcat (s⁻¹)Km (mM)kcat/Km (mM⁻¹ s⁻¹)Conditions
SHIP2 (SH2-containing inositol 5-phosphatase 2)Homo sapiensdioctanoyl phosphatidylinositol 3,4,5-trisphosphate400 nM enzyme0.690.04316 calc.pH 7, 23 °COpen
SHIP2 (SH2-containing inositol 5-phosphatase 2)Homo sapiensdioctanoyl phosphatidylinositol 3,4,5-trisphosphate7.830.09483 calc.pH 7, 23 °COpen
SHIP2 (SH2-containing inositol 5-phosphatase 2)Homo sapiensinositol 1,3,4,5-tetrakisphosphateisolated 5-phosphatase domain (Ptase) of human SHIP21.320.09813 calc.pH 7, 23 °COpen
SHIP2 (SH2-containing inositol 5-phosphatase 2)Homo sapiensinositol 1,3,4,5-tetrakisphosphate2.020.11517.6 calc.pH 7, 23 °COpen
SHIP2 (SH2-containing inositol 5-phosphatase 2)variant D613A/D615AHomo sapiensdioctanoyl phosphatidylinositol 3,4,5-trisphosphate7.10.171 calc.pH 7, 23 °COpen
SHIP2 (SH2-containing inositol 5-phosphatase 2)variant D613A/D615AHomo sapiensinositol 1,3,4,5-tetrakisphosphate1.450.07619 calc.pH 7, 23 °COpen
SHIP2 (SH2-containing inositol 5-phosphatase 2)variant F593D/L597DHomo sapiensdioctanoyl phosphatidylinositol 3,4,5-trisphosphateisolated 5-phosphatase domain (Ptase) of human SHIP24.440.06173 calc.pH 7, 23 °COpen
SHIP2 (SH2-containing inositol 5-phosphatase 2)variant F593D/L597DHomo sapiensdioctanoyl phosphatidylinositol 3,4,5-trisphosphate4.790.12239.3 calc.pH 7, 23 °COpen
SHIP2 (SH2-containing inositol 5-phosphatase 2)variant F593D/L597DHomo sapiensinositol 1,3,4,5-tetrakisphosphateisolated 5-phosphatase domain (Ptase) of human SHIP21.20.08215 calc.pH 7, 23 °COpen
SHIP2 (SH2-containing inositol 5-phosphatase 2)variant F593D/L597DHomo sapiensinositol 1,3,4,5-tetrakisphosphate1.390.07319 calc.pH 7, 23 °COpen
SHIP2 (SH2-containing inositol 5-phosphatase 2)variant R649AHomo sapiensdioctanoyl phosphatidylinositol 3,4,5-trisphosphate400 nM enzyme1.350.05923 calc.pH 7, 23 °COpen
SHIP2 (SH2-containing inositol 5-phosphatase 2)variant R649AHomo sapiensdioctanoyl phosphatidylinositol 3,4,5-trisphosphate6.370.164 calc.pH 7, 23 °COpen
SHIP2 (SH2-containing inositol 5-phosphatase 2)variant R649AHomo sapiensinositol 1,3,4,5-tetrakisphosphateisolated 5-phosphatase domain (Ptase) of human SHIP21.640.12613.0 calc.pH 7, 23 °COpen
SHIP2 (SH2-containing inositol 5-phosphatase 2)variant R649AHomo sapiensinositol 1,3,4,5-tetrakisphosphate1.790.1116 calc.pH 7, 23 °COpen
SHIP2 (SH2-containing inositol 5-phosphatase 2)variant R665AHomo sapiensdioctanoyl phosphatidylinositol 3,4,5-trisphosphate400 nM enzyme0.230.0435.3 calc.pH 7, 23 °COpen
SHIP2 (SH2-containing inositol 5-phosphatase 2)variant R665AHomo sapiensdioctanoyl phosphatidylinositol 3,4,5-trisphosphate7.020.11959.0 calc.pH 7, 23 °COpen
SHIP2 (SH2-containing inositol 5-phosphatase 2)variant R665AHomo sapiensinositol 1,3,4,5-tetrakisphosphateisolated 5-phosphatase domain (Ptase) of human SHIP20.530.1194.5 calc.pH 7, 23 °COpen
SHIP2 (SH2-containing inositol 5-phosphatase 2)variant R665AHomo sapiensinositol 1,3,4,5-tetrakisphosphate2.070.09422 calc.pH 7, 23 °COpen
SHIP2 (SH2-containing inositol 5-phosphatase 2)variant R682AHomo sapiensdioctanoyl phosphatidylinositol 3,4,5-trisphosphate1.740.09319 calc.pH 7, 23 °COpen
SHIP2 (SH2-containing inositol 5-phosphatase 2)variant R682AHomo sapiensinositol 1,3,4,5-tetrakisphosphate0.27——pH 7, 23 °COpen