EC 3.1.3.86: phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase
HydrolasesOpen in Browse
CatLog read 27 records for EC 3.1.3.86 from 2 papers, for 1 organism. Names in these papers: SHIP2 (SH2-containing inositol 5-phosphatase 2), SHIP1 (Src homology 2 domain-containing inositol 5-phosphatase 1).
Read from the paper by an AI model and checked against the paper by a second, separate AI run; code converted the units.
CatLog also holds 13 records for EC 3.1.3.86 that are not yet re-read: from its earlier version, built from the enzyme databases and partly checked against the papers. All records for EC 3.1.3.86 in Browse.
Papers
| Paper | Organisms | Records |
|---|---|---|
| Structural basis for interdomain communication in SHIP2 providing high phosphatase activity | Homo sapiens | 20 |
| Functional Characterization of the SHIP1-Domains Regarding Their Contribution to Inositol 5-Phosphatase Activity | Homo sapiens | 7 |
Records
| Enzyme | Organism | Substrate | kcat (s⁻¹) | Km (mM) | kcat/Km (mM⁻¹ s⁻¹) | Conditions | Paper | Open record |
|---|---|---|---|---|---|---|---|---|
| SHIP1 (Src homology 2 domain-containing inositol 5-phosphatase 1) | Homo sapiens | 1,2-dioctanoyl-sn-glycero-3-phospho-(1'-myo-inositol-3',4',5'-trisphosphate) | 1729 | 0.03584 | 4.82 × 10⁴ | pH 7.2, 37 °C | PMID 39858499 | Open record: SHIP1 (Src homology 2 domain-containing inositol 5-phosphatase 1), 1,2-dioctanoyl-sn-glycero-3-phospho-(1'-myo-inositol-3',4',5'-trisphosphate) |
| SHIP1 (Src homology 2 domain-containing inositol 5-phosphatase 1)5PPase (5PPase domain construct) | Homo sapiens | 1,2-dioctanoyl-sn-glycero-3-phospho-(1'-myo-inositol-3',4',5'-trisphosphate) | 308.2 | 0.2937 | 1.05 × 10³ | pH 7.2, 37 °C | PMID 39858499 | Open record: SHIP1 (Src homology 2 domain-containing inositol 5-phosphatase 1) 5PPase (5PPase domain construct), 1,2-dioctanoyl-sn-glycero-3-phospho-(1'-myo-inositol-3',4',5'-trisphosphate) |
| SHIP1 (Src homology 2 domain-containing inositol 5-phosphatase 1)5PPase-C2 (5PPase-C2 domain construct) | Homo sapiens | 1,2-dioctanoyl-sn-glycero-3-phospho-(1'-myo-inositol-3',4',5'-trisphosphate) | 431.9 | 0.0276 | 1.56 × 10⁴ | pH 7.2, 37 °C | PMID 39858499 | Open record: SHIP1 (Src homology 2 domain-containing inositol 5-phosphatase 1) 5PPase-C2 (5PPase-C2 domain construct), 1,2-dioctanoyl-sn-glycero-3-phospho-(1'-myo-inositol-3',4',5'-trisphosphate) |
| SHIP1 (Src homology 2 domain-containing inositol 5-phosphatase 1)PHL-5PPase-C2 (PHL-5PPase-C2 domain construct) | Homo sapiens | 1,2-dioctanoyl-sn-glycero-3-phospho-(1'-myo-inositol-3',4',5'-trisphosphate) | 1036 | 0.1057 | 9.81 × 10³ | pH 7.2, 37 °C | PMID 39858499 | Open record: SHIP1 (Src homology 2 domain-containing inositol 5-phosphatase 1) PHL-5PPase-C2 (PHL-5PPase-C2 domain construct), 1,2-dioctanoyl-sn-glycero-3-phospho-(1'-myo-inositol-3',4',5'-trisphosphate) |
| SHIP1 (Src homology 2 domain-containing inositol 5-phosphatase 1)variant ΔPRR (SH2-linker-PHL-5PPase-C2) | Homo sapiens | 1,2-dioctanoyl-sn-glycero-3-phospho-(1'-myo-inositol-3',4',5'-trisphosphate) | 1456 | 0.05244 | 2.78 × 10⁴ | pH 7.2, 37 °C | PMID 39858499 | Open record: SHIP1 (Src homology 2 domain-containing inositol 5-phosphatase 1) variant ΔPRR (SH2-linker-PHL-5PPase-C2), 1,2-dioctanoyl-sn-glycero-3-phospho-(1'-myo-inositol-3',4',5'-trisphosphate) |
| SHIP1 (Src homology 2 domain-containing inositol 5-phosphatase 1)variant ΔSH2 (linker-PHL-5PPase-C2-PRR) | Homo sapiens | 1,2-dioctanoyl-sn-glycero-3-phospho-(1'-myo-inositol-3',4',5'-trisphosphate) | 989.4 | 0.01345 | 7.36 × 10⁴ | pH 7.2, 37 °C | PMID 39858499 | Open record: SHIP1 (Src homology 2 domain-containing inositol 5-phosphatase 1) variant ΔSH2 (linker-PHL-5PPase-C2-PRR), 1,2-dioctanoyl-sn-glycero-3-phospho-(1'-myo-inositol-3',4',5'-trisphosphate) |
| SHIP1 (Src homology 2 domain-containing inositol 5-phosphatase 1)variant ΔSH2-linker (PHL-5PPase-C2-PRR) | Homo sapiens | 1,2-dioctanoyl-sn-glycero-3-phospho-(1'-myo-inositol-3',4',5'-trisphosphate) | 1424 | 0.1239 | 1.15 × 10⁴ | pH 7.2, 37 °C | PMID 39858499 | Open record: SHIP1 (Src homology 2 domain-containing inositol 5-phosphatase 1) variant ΔSH2-linker (PHL-5PPase-C2-PRR), 1,2-dioctanoyl-sn-glycero-3-phospho-(1'-myo-inositol-3',4',5'-trisphosphate) |
| SHIP2 (SH2-containing inositol 5-phosphatase 2) | Homo sapiens | dioctanoyl phosphatidylinositol 3,4,5-trisphosphate400 nM enzyme | 0.69 | 0.043 | 16 calc. | pH 7, 23 °C | PMID 28792888 | Open record: SHIP2 (SH2-containing inositol 5-phosphatase 2), dioctanoyl phosphatidylinositol 3,4,5-trisphosphate |
| SHIP2 (SH2-containing inositol 5-phosphatase 2) | Homo sapiens | dioctanoyl phosphatidylinositol 3,4,5-trisphosphate | 7.83 | 0.094 | 83 calc. | pH 7, 23 °C | PMID 28792888 | Open record: SHIP2 (SH2-containing inositol 5-phosphatase 2), dioctanoyl phosphatidylinositol 3,4,5-trisphosphate |
| SHIP2 (SH2-containing inositol 5-phosphatase 2) | Homo sapiens | inositol 1,3,4,5-tetrakisphosphateisolated 5-phosphatase domain (Ptase) of human SHIP2 | 1.32 | 0.098 | 13 calc. | pH 7, 23 °C | PMID 28792888 | Open record: SHIP2 (SH2-containing inositol 5-phosphatase 2), inositol 1,3,4,5-tetrakisphosphate |
| SHIP2 (SH2-containing inositol 5-phosphatase 2) | Homo sapiens | inositol 1,3,4,5-tetrakisphosphate | 2.02 | 0.115 | 17.6 calc. | pH 7, 23 °C | PMID 28792888 | Open record: SHIP2 (SH2-containing inositol 5-phosphatase 2), inositol 1,3,4,5-tetrakisphosphate |
| SHIP2 (SH2-containing inositol 5-phosphatase 2)variant D613A/D615A | Homo sapiens | dioctanoyl phosphatidylinositol 3,4,5-trisphosphate | 7.1 | 0.1 | 71 calc. | pH 7, 23 °C | PMID 28792888 | Open record: SHIP2 (SH2-containing inositol 5-phosphatase 2) variant D613A/D615A, dioctanoyl phosphatidylinositol 3,4,5-trisphosphate |
| SHIP2 (SH2-containing inositol 5-phosphatase 2)variant D613A/D615A | Homo sapiens | inositol 1,3,4,5-tetrakisphosphate | 1.45 | 0.076 | 19 calc. | pH 7, 23 °C | PMID 28792888 | Open record: SHIP2 (SH2-containing inositol 5-phosphatase 2) variant D613A/D615A, inositol 1,3,4,5-tetrakisphosphate |
| SHIP2 (SH2-containing inositol 5-phosphatase 2)variant F593D/L597D | Homo sapiens | dioctanoyl phosphatidylinositol 3,4,5-trisphosphateisolated 5-phosphatase domain (Ptase) of human SHIP2 | 4.44 | 0.061 | 73 calc. | pH 7, 23 °C | PMID 28792888 | Open record: SHIP2 (SH2-containing inositol 5-phosphatase 2) variant F593D/L597D, dioctanoyl phosphatidylinositol 3,4,5-trisphosphate |
| SHIP2 (SH2-containing inositol 5-phosphatase 2)variant F593D/L597D | Homo sapiens | dioctanoyl phosphatidylinositol 3,4,5-trisphosphate | 4.79 | 0.122 | 39.3 calc. | pH 7, 23 °C | PMID 28792888 | Open record: SHIP2 (SH2-containing inositol 5-phosphatase 2) variant F593D/L597D, dioctanoyl phosphatidylinositol 3,4,5-trisphosphate |
| SHIP2 (SH2-containing inositol 5-phosphatase 2)variant F593D/L597D | Homo sapiens | inositol 1,3,4,5-tetrakisphosphateisolated 5-phosphatase domain (Ptase) of human SHIP2 | 1.2 | 0.082 | 15 calc. | pH 7, 23 °C | PMID 28792888 | Open record: SHIP2 (SH2-containing inositol 5-phosphatase 2) variant F593D/L597D, inositol 1,3,4,5-tetrakisphosphate |
| SHIP2 (SH2-containing inositol 5-phosphatase 2)variant F593D/L597D | Homo sapiens | inositol 1,3,4,5-tetrakisphosphate | 1.39 | 0.073 | 19 calc. | pH 7, 23 °C | PMID 28792888 | Open record: SHIP2 (SH2-containing inositol 5-phosphatase 2) variant F593D/L597D, inositol 1,3,4,5-tetrakisphosphate |
| SHIP2 (SH2-containing inositol 5-phosphatase 2)variant R649A | Homo sapiens | dioctanoyl phosphatidylinositol 3,4,5-trisphosphate400 nM enzyme | 1.35 | 0.059 | 23 calc. | pH 7, 23 °C | PMID 28792888 | Open record: SHIP2 (SH2-containing inositol 5-phosphatase 2) variant R649A, dioctanoyl phosphatidylinositol 3,4,5-trisphosphate |
| SHIP2 (SH2-containing inositol 5-phosphatase 2)variant R649A | Homo sapiens | dioctanoyl phosphatidylinositol 3,4,5-trisphosphate | 6.37 | 0.1 | 64 calc. | pH 7, 23 °C | PMID 28792888 | Open record: SHIP2 (SH2-containing inositol 5-phosphatase 2) variant R649A, dioctanoyl phosphatidylinositol 3,4,5-trisphosphate |
| SHIP2 (SH2-containing inositol 5-phosphatase 2)variant R649A | Homo sapiens | inositol 1,3,4,5-tetrakisphosphateisolated 5-phosphatase domain (Ptase) of human SHIP2 | 1.64 | 0.126 | 13.0 calc. | pH 7, 23 °C | PMID 28792888 | Open record: SHIP2 (SH2-containing inositol 5-phosphatase 2) variant R649A, inositol 1,3,4,5-tetrakisphosphate |
| SHIP2 (SH2-containing inositol 5-phosphatase 2)variant R649A | Homo sapiens | inositol 1,3,4,5-tetrakisphosphate | 1.79 | 0.11 | 16 calc. | pH 7, 23 °C | PMID 28792888 | Open record: SHIP2 (SH2-containing inositol 5-phosphatase 2) variant R649A, inositol 1,3,4,5-tetrakisphosphate |
| SHIP2 (SH2-containing inositol 5-phosphatase 2)variant R665A | Homo sapiens | dioctanoyl phosphatidylinositol 3,4,5-trisphosphate400 nM enzyme | 0.23 | 0.043 | 5.3 calc. | pH 7, 23 °C | PMID 28792888 | Open record: SHIP2 (SH2-containing inositol 5-phosphatase 2) variant R665A, dioctanoyl phosphatidylinositol 3,4,5-trisphosphate |
| SHIP2 (SH2-containing inositol 5-phosphatase 2)variant R665A | Homo sapiens | dioctanoyl phosphatidylinositol 3,4,5-trisphosphate | 7.02 | 0.119 | 59.0 calc. | pH 7, 23 °C | PMID 28792888 | Open record: SHIP2 (SH2-containing inositol 5-phosphatase 2) variant R665A, dioctanoyl phosphatidylinositol 3,4,5-trisphosphate |
| SHIP2 (SH2-containing inositol 5-phosphatase 2)variant R665A | Homo sapiens | inositol 1,3,4,5-tetrakisphosphateisolated 5-phosphatase domain (Ptase) of human SHIP2 | 0.53 | 0.119 | 4.5 calc. | pH 7, 23 °C | PMID 28792888 | Open record: SHIP2 (SH2-containing inositol 5-phosphatase 2) variant R665A, inositol 1,3,4,5-tetrakisphosphate |
| SHIP2 (SH2-containing inositol 5-phosphatase 2)variant R665A | Homo sapiens | inositol 1,3,4,5-tetrakisphosphate | 2.07 | 0.094 | 22 calc. | pH 7, 23 °C | PMID 28792888 | Open record: SHIP2 (SH2-containing inositol 5-phosphatase 2) variant R665A, inositol 1,3,4,5-tetrakisphosphate |
| SHIP2 (SH2-containing inositol 5-phosphatase 2)variant R682A | Homo sapiens | dioctanoyl phosphatidylinositol 3,4,5-trisphosphate | 1.74 | 0.093 | 19 calc. | pH 7, 23 °C | PMID 28792888 | Open record: SHIP2 (SH2-containing inositol 5-phosphatase 2) variant R682A, dioctanoyl phosphatidylinositol 3,4,5-trisphosphate |
| SHIP2 (SH2-containing inositol 5-phosphatase 2)variant R682A | Homo sapiens | inositol 1,3,4,5-tetrakisphosphate | 0.27 | — | — | pH 7, 23 °C | PMID 28792888 | Open record: SHIP2 (SH2-containing inositol 5-phosphatase 2) variant R682A, inositol 1,3,4,5-tetrakisphosphate |