CatLogenzyme kinetics catalog

Values CatLog read from this paper

Substrate interaction defects in histidyl-tRNA synthetase linked to dominant axonal peripheral neuropathy

PMID 29235198doi:10.1002/humu.23380Open in Browse

The paper itself is not on this site: read it at the publisher. This page lists only the values CatLog read from it.

CatLog read 10 records (26 values) from this paper: histidyl-tRNA synthetase (HARS) from Homo sapiens.

Read from the paper by an AI model and checked against the paper by a second, separate AI run; code converted the units. Values are in CatLog's units; each record opens in Browse with the line the paper prints and the checks.

EC 6.1.1.21

EnzymeOrganismSubstratekcat (s⁻¹)Km (mM)kcat/Km (mM⁻¹ s⁻¹)Conditions
histidyl-tRNA synthetase (HARS)Homo sapiensATP5.80.0442130pH 7.5Open
histidyl-tRNA synthetase (HARS)variant S356NHomo sapiensATP——0.15pH 7.5Open
histidyl-tRNA synthetase (HARS)variant S356NHomo sapienshistidine0.390.010840pH 7.5Open
histidyl-tRNA synthetase (HARS)variant S356NHomo sapienstRNAHis0.31.99 × 10⁻⁴1.5 × 10³pH 7.5Open
histidyl-tRNA synthetase (HARS)variant V155GHomo sapiensATP——0.38pH 7.5Open
histidyl-tRNA synthetase (HARS)variant V155GHomo sapienshistidine2.080.68723pH 7.5Open
histidyl-tRNA synthetase (HARS)variant V155GHomo sapienstRNAHis3.059.79 × 10⁻⁴3.1 × 10³pH 7.5Open
histidyl-tRNA synthetase (HARS)variant Y330CHomo sapiensATP0.481.7630.272pH 7.5Open
histidyl-tRNA synthetase (HARS)variant Y330CHomo sapienshistidine0.740.20294pH 7.5Open
histidyl-tRNA synthetase (HARS)variant Y330CHomo sapienstRNAHis0.563.3 × 10⁻⁴1.7 × 10³pH 7.5Open